Digital Commons Network^™

The Effects Of Short Chain Fatty Acids On Clostridioides Difficile Growth, Sporulation, And Toxin Production, Michelle Baldassare

All Theses

Short chain fatty acids (SCFAs) are products of bacterial fermentation that help maintain important gut functions such as the intestinal barrier, signaling, and immune homeostasis. The main SCFAs acetate, propionate, and butyrate have demonstrated beneficial effects for the host, including importance in combatting infections caused by pathogens such as Clostridioides difficile. C. difficile infection (CDI) is a public health concern and causes 30,000 deaths each year mainly due to the overuse of antibiotics. Despite the potential role of SCFAs in mitigating C. difficile infection, their direct effect on C. difficile remains unclear. Through a set of in-vitro experiments, we …

Characterization Of Thermal Gelation Properties In Bioresorbable Thermally Activated Hydrogel Polymers For Hernia Surgery Applications, Alexander Mayfield

All Theses

Hydrogel adhesives are a new class of materials with excellent biocompatibility, which makes them very attractive for biomaterial applications. It has been previously shown that Tetronic T1107, a four-arm poly (propylene oxide)-poly (ethylene oxide) (PPO-PEO) block copolymer, is useful as a chemical crosslinking thermo-responsive hydrogel for bioadhesive applications. The end groups of this polymer are modified with acrylate and N-hydroxysuccinimide (NHS) functional groups. The acrylate end group gives the polymer cohesive properties with long-range chemical crosslinking using dithiothreitol (DTT), while the NHS end group gives the polymer adhesive properties through bonding with amines found in organic tissue. It was found …

Climbing The Masculine Hierarchy: Examining Constructions Of Masculinity Through Incel Identities, Alyssa Jewel Davis

All Theses

In a gender-segregated digital space known as the Manosphere, a group of men calling themselves “Incels,” or involuntary celibates, express feelings of hostility and hatred towards women. Incels hold a low position on a masculine hierarchy where the men who hold the most power in society are those who have access to women’s emotional and sexual services. Incels are characterized by feelings of entitlement to women’s services and aggrievement by their inability to access them. As a result, they often appear to fantasize about or engage in acts of violence to compensate for their lack of masculine privilege. However, there …

Spring Gobbling Chronology And Turkey Habitat Use In Upstate South Carolina, Janelle Grehan

All Theses

Wild turkey (Meleagris gallopavo) is a highly popular game species harvested primarily during the reproductive season, which has driven substantial efforts to understand patterns of springtime habitat use and gobbling activity. Autonomous recording units (ARUs) have enabled researchers to collect unprecedented amounts of gobbling data, yet post hoc processing of audio data has been time-intensive due to false detection rates. Gobbling activity has been studied in the South Carolina Coastal Plain, but data for the Upstate are lacking. My objectives were to assess seasonal and weekly gobbling activity and turkey habitat use in Upstate South Carolina relative to …

The Physical Properties And Handling Characteristics Of Pelletized Biomass Materials, Ryan Dean

All Theses

Biomass and feed pellets can be handled and stored using similar equipment used for other bulk materials; however, their unique physical characteristics can lead to handling challenges. Understanding the flow characteristics of these materials is essential for handling and storage system design, but these characteristics are not well defined in less-than-ideal conditions. The overall objective of this study was to evaluate how moisture content and level of fines influence the angle of repose (AoR) of hardwood, pine bedding, and feed pellets along with determining the impacts of displacement on the shear stress of fuel pellets utilizing a modified linear wall …

Evaluating The Impact Of Intersecting Research And Outreach Marine Science Programs On Elementary And Undergraduate Students, Randi J. Sims

All Theses

Climate change is one of the most destructive forces our ocean is currently experiencing. Despite this, many students are not taught the basics of climate change science and ocean literacy in public school systems. My work seeks to combat these deficits through educational experiences in marine science for undergraduate and local elementary students through three studies incorporating marine-science based research and outreach. (1) Through undergraduate marine science research and outreach, students enrolled for long durations or with positive mentorship increased their conceptual understanding of marine science concepts, altered their attitudes towards climate change and science, and were more likely to …

Allelopathic Effect Of Cereal Straw Extracts On Growth Of Raphidocelis Subcapitata And Microcystis Aeruginosa, Holly Wren

Graduate Theses and Dissertations

Harmful algal blooms are increasing in size, duration, and intensity around the globe. For several decades, cereal straws have been recognized as a viable algal control method, though the mechanisms by which cereal straws inhibit algae remain a topic of research. The objectives of this study were to evaluate the effectiveness of decomposing cereal straw extract, particularly rice (Oryza sativa) and barley (Hordeum vulgare) straw extract, to inhibit the green alga Raphidocelis subcapitata or cyanobacteria Microcystis aeruginosa in bioassays and to determine if the effectiveness of decomposing rice straw extract is altered by the presence of natural organic matter or …

Lgbtq Youth And The Promise Of The Kennedy Quartet, Michael J. Higdon

Cardozo Law Review

The Supreme Court has only issued four opinions endorsing the constitutional rights of sexual minorities, each of them authored by Justice Anthony Kennedy. These four cases, which this Article refers to collectively as “the Kennedy Quartet,” have done much to advance the equality of LGBTQ adults in the United States. The question remains, however, as to what extent those cases likewise protect LGBTQ children. Far from simply being an academic question, this issue has taken on increased urgency as legislators in a number of states—thwarted by the Kennedy Quartet in their ability to target LGBTQ adults—have turned their attentions to …

Assessment In Undergraduate Research, Jill Singer, Daniel Weiler, Bridget Zimmerman, Sean Fox, Elizabeth L. Ambos

Earth Sciences Faculty Publications

This chapter focuses on assessment as an integral element of the continued success and sustainability of undergraduate research (UR) and describes the EvaluateUR method, a proven approach to assessing the skills and competencies of UR students, which also contributes directly to student learning. The chapter concludes with brief remarks on the assessment of course-based UR and two projects now in progress that are adapting the EvaluateUR method to these assessments.

359 Public Sunscreen Dispenser Distribution In The United States: Continued Covid-19 Trends During 2021, M. D. Szeto, R. Kokoska, Jalal Maghfour, C. Rundle, C. Presley, T. Harp, A. Hamp, V. Wegener, J. Hugh, R. Dellavalle

Dermatology Meeting Abstracts

The COVID-19 pandemic may have significantly affected consumer preferences and societal behavior regarding sun protection and skin cancer. IMPACT Melanoma is a United States nonprofit organization for skin cancer prevention/education, and a prominent nationwide sunscreen distributor. Substantial decreases in the distribution of public dispensers and sunscreen were noted at the onset of the pandemic in 2020, especially to public health departments and parks/recreation facilities. Analysis of 2021 data has revealed that total distribution remained at similar levels relative to 2020. However, private business (-77%), public health department (-71%), and healthcare facility (-41%) orders decreased the most, while nonprofits (+612%) and …

623 Variations In In Vivo Visible Light Phototesting Methodologies, Indermeet Kohli

Dermatology Meeting Abstracts

While previously regarded as nonsignificant with minimal to no photobiologic effects, visible light (VL) has now been shown to have biologic effects on skin in subjects with all skin phototypes. However, currently there are no standardized guidelines to perform VL phototesting. A review of the published in vivo VL phototesting methodologies was performed to compare the various phototesting parameters. The methodologies were found to vary at multiple levels including spectral output of the irradiation sources, irradiance level, dosage, single vs. multiple exposures, assessment methods, assessment time points after irradiation, and calculation procedure for VL protection factor (VL-PF) among other variables. …

542 Murine Epidermis Harbors Functionally Distinct Langerhans Cell Subsets, Peter Dimitrion, Indra Adrianto, Yi Yao, Michael Pawlitz, Ian Loveless, Hongmei Peng

Dermatology Meeting Abstracts

Epidermal Langerhans cells (LCs) derive from embryonic myeloid progenitors at the steady-state and monocyte progenitors under inflammatory conditions. LCs have the capacity to induce both immunity and tolerance in the skin, but how a single population of LCs mediates both these functions has perplexed researchers for decades. We hypothesized that LCs in murine epidermis have functionally heterogenous subpopulations. We employed single-cell RNA sequencing (scRNAseq) and scATACseq to identify transcriptional and epigenetic heterogeneity in LCs during late embryonic development, adult steady-state and inflamed-state. We found three transcriptionally distinct clusters in adult at steady-state: ATF3hiCD207lo (cLC1), ATF3loCD207hi (cLC2), and CD207+ cells expressing …

A Faunal Composition Of The Late Cretaceous Blue Springs Site In Northeastern Mississippi And Evidence For Potential Paleoenvironmental Differences Between Beds, Ginger Trochesset

Honors Theses

The Maastrichtian-age Blue Springs locality of the Coon Creek Member of the Ripley Formation is known for abundant, well-preserved marine fossils, including many genera of microfossils, bivalves, gastropods, decapods, cephalopods, actinopterygians, and other vertebrate organisms. This research contributes to the understanding of the paleontology of the site, as well as the changing paleoenvironmental conditions of the beds throughout deposition.

This project analyzed bulk material collected in 2021 from three fossiliferous beds at Blue Springs: the Lower Corbula Bed (Bed C), the Pebble Bed (Bed G), and the Exogyra-Pycnodonte Bed (Bed J). Unconsolidated material from Beds C and J was processed …

Modeling And Performance Analysis Of Deb Based Hydrogen Getters, John A. Matteson

Chemical and Biological Engineering ETDs

Hydrogen getter materials are used to irreversibly absorb hydrogen gas in sealed environments. The DEB based getter system, despite finding widespread use in this application, still posses challenges with respect to experimental performance analysis and fundamental understanding of reaction mechanism. The second chapter of this report addresses the experimental challenges of this getter system by demonstrating the utility and experimental strengths of a custom magnetic suspension balance (MSB) based gravimetric sorption system. This apparatus enables performance evaluation in process relevant conditions including dilute mixed gas environments which our results indicate is necessary for accurate performance evaluation of getter systems. Chapter …

Student Attitudes Contribute To The Effectiveness Of A Genomics Cure, David Lopatto, Anne G. Rosenwald, Rebecca C. Burgess, Catherine Silver Key, Melanie Van Stry, Matthew Wawersik, Justin R. Diangelo, Amy T. Hark, Matthew Skerritt, Anna K. Allen, Consuelo Alvarez, Sara Anderson, Cindy Arrigo, Andrew Arsham, Daron Barnard, James E. Bedard, Indrani Bose, John M. Braverman, Martin G. Burg, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A. Escobar, Michael Foulk, Thomas Giarla, Rivka L. Glaser, Anya L. Goodman, Yuying Gosser, Adam Haberman, Charles Hauser, Shan Hays, Carina E. Howell

Biology, Agriculture and Chemistry Faculty Publications and Presentations

The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work and science, interest in science, and grit. We found, in general, that the attitudes students bring with them into the classroom contribute to two outcome measures, namely, learning as assessed by a pre- and postquiz and perceived self-reported benefits. While the GEP CURE produces positive outcomes overall, the students with more positive attitudes toward science, particularly with respect …

Parallel Algorithms For Scalable Graph Mining: Applications On Big Data And Machine Learning, Naw Safrin Sattar

LSU New Orleans Theses and Dissertations

Parallel computing plays a crucial role in processing large-scale graph data. Complex network analysis is an exciting area of research for many applications in different scientific domains e.g., sociology, biology, online media, recommendation systems and many more. Graph mining is an area of interest with diverse problems from different domains of our daily life. Due to the advancement of data and computing technologies, graph data is growing at an enormous rate, for example, the number of links in social networks is growing every millisecond. Machine/Deep learning plays a significant role for technological accomplishments to work with big data in modern …

Trauma Treatment For Youth In Foster Care: A Mixed-Methods Study Of Clinician Perspectives And Treatment Model Use, Allison Blake Smith

Graduate Theses and Dissertations

Youth in foster care experience trauma exposure and subsequent trauma-related disorders at much higher rates than their peers, with prevalence rates comparable with veterans of war. Although youth in foster care appear to receive services at higher rates than their peers, little is known about what outpatient care consists of, particularly for trauma-related disorders. Furthermore, although several evidence-based treatments exist for the treatment of child and adolescent trauma, little is known about how appropriate and effective existing treatment approaches are for youth in foster care. The current study used a mixed methods approach to examine a) the range of evidence-based …

Evaluation Of Factors That Contribute To Injury To Quizalofop-Resistant Rice From Quizalofop Applied Postemergence, Navdeep Godara

Graduate Theses and Dissertations

Quizalofop-resistant rice technology allows for over-the-top applications of quizalofop, an acetyl-coenzyme A carboxylase-inhibiting herbicide. However, quizalofop caused significant injury to quizalofop-resistant rice in some Arkansas fields during the first year of commercialization. Experiments evaluated the effect of early-season soil moisture and nitrogen availability; pre-exposure to low rates of glyphosate and imazethapyr; planting date; and environmental conditions including, soil moisture content, air temperature, and light intensity on quizalofop-resistant rice tolerance to quizalofop applications. All experiments assessed sequential quizalofop applications made to 2-leaf followed by 5-leaf stage of rice. Sequential quizalofop applications alone and with surface irrigation or nitrogen application at the …

Histomonosis In Turkeys – Factors Influencing Transmission, Pathogenesis, And The Search For Prophylactic Or Therapeutic Compounds, Thainá Landim De Barros

Graduate Theses and Dissertations

The incidence of histomonosis has been increasing in poultry since the ban of prophylactic and therapeutic compounds. Histomonosis is caused by the protozoa Histomonas meleagridis. The objective of this dissertation was to investigate factors impacting the pathogenesis and transmission of histomonosis and to evaluate compounds that could potentially prevent or reduce the severity of histomonosis in turkeys. In the first study, the effect of sodium chlorate and sodium nitrate on reducing histomonads growth was tested in vitro and added to a basal turkey diet. A decrease in the growth of histomonads in vitro was observed, but no in vivo effect …

Sex Differences In Cancer Cachexia And A Novel Mitochondrial Target For Cancer-Induced Muscle Wasting, Seongkyun Lim

Graduate Theses and Dissertations

Cancer cachexia (CC) is a devastating wasting syndrome characterized by marked weight loss including skeletal muscle atrophy that affects approximately 80% of cancer patients. Current therapeutic treatments including pharmacological and nutritional intervention are insufficient to prevent or reverse it. Prior studies demonstrated lower muscle mass, impaired muscle function, and mitochondrial health in the development of CC. Specifically, mitochondrial fusion protein, Optic atrophy 1 (OPA1) which plays a significant role in skeletal muscle health, is suppressed in the development of CC. Furthermore, most pre-clinical CC studies were mainly focused on males although there are distinct phenotypical differences in skeletal muscle between …

The Effects Of Physical Function And Genetics On Cognition And Blood Biomarkers In Individuals At-Risk For Alzheimer’S Disease And Related Dementias, Joshua Louis Gills

Graduate Theses and Dissertations

Alzheimer’s disease and related dementia (ADRD) rates are expected to triple by the year 2050. Early detection and specific mitigation efforts are warranted to blunt the alarming rate. Physical function (PF) declines with age, but higher physical function is associated with better cognitive functioning in middle-to- older age individuals. Moreover, greater physical activity (PA) is associated with better global cognition; however, Apoliporotein e4 carriers may not gain the same benefits with exercise. Additionally, plasma phosphorylated tau 217 (p-tau217) has been identified as a novel diagnostic ADRD biomarker which needs further research to examine associations with risk factors. Therefore, the aims …

Characterization Of Blueberry (Poly)Phenolics In Foods, Their Metabolites In Human Biological Samples And Anti-Inflammatory Effects Of Phytochemicals In Vitro, Laura Felgus-Lavefve

Graduate Theses and Dissertations

Blueberries’ popularity is in part supported by the health benefits associated with their consumption. Research has strongly focused on their polyphenol and anthocyanin concentration, one of the highest amongst commonly consumed foods. Polyphenols have demonstrated antioxidant effects in vitro, and consuming polyphenol-rich foods is associated with protective effects towards non-communicable diseases, but their direct bioactivity in the human body remains to be fully understood. It is estimated that about 90 to 95% of the initial polyphenol intake reaches the colon without being absorbed. Instead, phenolic compounds go through extensive biotransformations, consisting of catabolism into smaller compounds mostly carried out by …

Catalytic Activity Of Tungsten-Dioxo And Tungsten-Diimido Complexes, Kayla Denike

Graduate Theses and Dissertations

Due to the significant decline in the availability of petrochemical resources and the increasing demand for the useful olefin mixtures extracted from oil, a sustainable and efficient alternative to these materials has become vital. Fortunately, renewable biomass derived materials may serve as a sustainable solution to the limited resources problem. Molecules derived from the degradation of biomasses are highly oxygenated and highly functionalized. Developing processes to efficiently defunctionalize these oxygen-rich materials will lead to potential up-conversion to carbon chemicals. Homogeneous catalytic deoxygenation processes present an opportunity to access valuable carbon commodity chemicals from biomass derived polyols. This dissertation details the …

Modeling The Impact And Accelerating The Process Of Transitioning To A Sustainable Healthy Diet Through Decision Support Systems, Prince Agyemang

Graduate Theses and Dissertations

Food production and consumption are essential in human existence, yet they are implicated in the high occurrences of preventable chronic diseases and environmental degradation. Although healthy food may not necessarily be sustainable and vice versa, there is an opportunity to make our food both healthy and sustainable. Attempts have been made to conceptualize how sustainable healthy food may be produced and consumed; however, available data suggest a rise in the prevalence of health-related and negative environmental consequences of our food supply. Thus, the transition from conceptual frameworks to implementing these concepts has not always been effective. This paper explores the …

Technology Agency On Usage: Grounded Theory And Measurement Of Technology Induced Usage Behavior, Sandip Kumar Sarkar

Graduate Theses and Dissertations

Most of today’s software applications involve a dyadic interplay between human and technology agency. The use of algorithms driven by user can alter users' interaction patterns by affording them novel and relevant technology action possibilities. I argue that algorithmic activities and features embedded in apps can keep users on IT applications (apps) for longer periods of time. I refer to the behavior of interacting with the apps for longer time than planned as technology-induced excessive use. While practitioners are beginning to recognize characteristics of technology-induced excessive use, research on this topic is very limited. I used a multimethod approach to …

The Effect Of Water Management And Ratoon Rice Cropping On Methane Emissions And Harvest Yield In Arkansas, Marguerita Leavitt

Graduate Theses and Dissertations

Sustainable intensification of rice farming is crucial to meeting human food needs while reducing environmental impacts. Rice produces 8% of all anthropogenic CH4, which is a potent greenhouse gas. CH4 emissions can potentially be reduced by cultivation practices that minimize the number of days the fields are saturated, such as dry-seeding instead of water-seeding and irrigation using the alternate wetting and drying (AWD) technique instead of delayed, continuous flooding (DF). Ratoon cropping, wherein a second crop of rice is grown from the harvested stubble of the first crop, can be used to produce additional yield with minimal labor, but may …

Effects Of An Injectable Zinc Solution At Weaning As An Alternative Castration Method In Beef Cattle, Reagan Nicole Cauble

Graduate Theses and Dissertations

Two experiments were conducted to investigate a 1 mL intratesticular zinc (100 mg Zn) injection administered into each testicle at weaning (Z) and its effects on growth, health, behavior and testosterone. In the first experiment, beef bulls were assigned randomly to treatment at birth: 1) surgically castrated at birth (S; n = 37) or 2) Z (n = 37). Testicular thickness differed by day (P < 0.01) for Z. Testosterone concentrations were greater in Z by d 77 and remained so through d 280 (P = 0.02) compared to S. Zinc injected calves were heavier at the trail’s conclusion (P ≤ 0.04), had greater ADG overall (P < 0.01), heavier hot carcass weight (P = 0.01), and greater lean muscle area (P = 0.01) compared to S; but a lower marbling score (P < 0.01). Yield Grade, dressed carcass yield and fat thickness were similar (P ≥ 0.14). Zinc injected calves had greater haptoglobin (Hp) concentrations (P < 0.01). Zinc injected calves had greater concentrations of white blood cells on d 1 and 2 and greater concentrations and proportions of neutrophils on d 1, 2 and 3 (P < 0.01). Conversely, S had a greater percentage of lymphocytes on d 1, 2 and 3 and a lower ratio of neutrophils to lymphocytes during that same time (P < 0.01). Zinc injected calves spent more time on their side or sternum on d 1 and more time on their side on d 2 while S spend more time standing during that time (P < 0.01). During d 3, 4, 5, and 6, Z stood more while S laid on their sternum (P < 0.01). In trail 2, beef bulls were allocated randomly to treatment one week post weaning: 1) banded (B; n = 42) or 2) Z (n = 39). Body weights were similar (P ≥ 0.39) but ADG improved for Z compared to B (P = 0.05). Testosterone concentrations were greater in Z compared to B (P ≤ 0.02). Testicular width in Z differed by d (P < 0.01). Zinc castrated calves spent more time on their side compared to B one day post castration (P = 0.03) until d 3 and 4 where B spent more time on their side (P ≤ 0.02). Banded calves stood more the first two days (P ≤ 0.01). On days 3, 4, 5, and 6, Z stood more (P ≤ 0.01) while B were on their sternum (P ≤ 0.03). Banded calves had lower Hp concentrations compared to Z (P ≤ 0.01). Total white blood cell concentrations, proportions and concentrations of neutrophils, and proportion of lymphocytes were greater in Z compared to B on d 1, 2, and 3 (P ≤ 0.01). There was no interaction between treatments over time for IL1β, IL6, and TNFα expression (P ≥ 0.83). The findings in both studies indicate that intratesticular Zn injections at weaning can improve growth performance and some carcass attributes but produce a heightened inflammatory and immune response and cause discomfort. Injecting zinc, as formulated and administered in these trails, does not result in complete castration of beef calves at this age and therefore cannot be considered a true castration alternative.

Closing The Gender Gap In Entrepreneurship Education, Carolyn J. Rodeffer

Graduate Theses and Dissertations

Entrepreneurship education in higher education has been cited as a key strategy in filling the entrepreneurship talent pool, preparing students with the skills and confidence needed to start new ventures (Westhead & Solesvik, 2016). However, outcomes of entrepreneurship education for female students are less positive than for their male counterparts (Shinnar et al., 2012; Westhead & Solesvik, 2016; Wilson et al., 2007). Working within the frameworks of Bandura’s self-efficacy theory (1977), Azjen’s theory of planned behavior (1991), and Steele and Aronson’s stereotype threat theory (1995), this quantitative study utilized an experimental research design to assess the impact of role model …

Competing Behaviors Of Thermoregulation And Ambush Foraging In The Timber Rattlesnake (Crotalus Horridus Horridus): A Mechanistic Assessment Of Thermal Conduction, Larry K. Kamees

Graduate Theses and Dissertations

The interaction between the biophysical environment and ectotherm morphology elicits behaviors designed to maintain internal body temperature (Tb) within a range that promotes physiological functions. The short-term requirements of mass (energy requirements) and heat balance are subject to tradeoffs imposed by the organisms current physiological (heat and mass budgets) and environmental (biophysical, demographic, social, and predation) constraints and available resources. In temperate forests, extreme temperatures are common in summer even with intermittent sun exposure due to dense canopy cover. In Spring and Fall, temperatures can range from below freezing to 35 ℃ in 24 hrs. An ambush predator like the …

Collaborating With Big Brothers Big Sisters And Parents To Develop Caregiver-Initiated Mentoring, Meredith J. Scafe

Graduate Theses and Dissertations

Research shows that youth enrolled in formal mentoring programs often wait months before being matched with a mentor. This paper describes the development and pilot test of Caregiver-Initiated Mentoring (CG-IM), a program originally designed to equip caregivers to assist Big Brothers Big Sisters (BBBS) mentoring program staff in identifying and recruiting mentors from their social network. Using a mixed-methods design, the initial efficacy of the CG-IM program was evaluated via a small pilot test. I broadly explored caregivers’ experiences participating in the CG-IM program and a BBBS staff member’s experience implementing it. Caregivers completed a post-survey that included quantitative measures …