Digital Commons Network^™

Parallel Networks That Govern The Transcriptional Response To Stress, Serene Anne Durham

Legacy Theses & Dissertations (2009 - 2024)

The transcription factor, p53, plays a pivotal role in the oversight of many stimulus-dependent pathways. Its ability to respond to a wide variety of cellular stress stimuli by activating a broad range of target genes has led it to be characterized as a stress-dependent transcription factor. Our research focuses on deconvoluting the varied transcriptional response to distinct stress signals in an attempt to define the regulatory strategies leading to gene activation after cell stress. We have found that distinct stress response networks, some of which are p53-independent, are converging at activation of a common set of target genes. Our data …

Early Childhood Development In Uganda: Investing In Human And National Development – Reflections From The Covid-19 Pandemic, Anil Khamis

Book Chapters / Conference Papers

This chapter presents an analysis of the development of early childhood development in Uganda from policy to programme development in the light of the COVID-19 pandemic. It highlights the achievements and challenges as well as the opportunities for government and its partners whilst navigating an evolving and increasingly competitive political economy. The chapter identifies gaps that need to be addressed in terms of human development, which is argued to be the basis of national development. The United Nations Sustainable Development Goals are presented as an acceptable and agreed framework by all stakeholders as Uganda and other nations confront uncertain futures. …

Diagnostic Utility Of Il-6 And Some Biomarker Correlated With The Diseases Severity Of Covid‐19 Patients, Ekhlas Saddam Falih, Suhad Hassan Obaid

Al-Nisour Journal for Medical Sciences

Coronavirus disease 2019 (COVID-19) SARS-2 is a respiratory tract infection with a newly recognized coronavirus thought to have originated as a zoonotic virus that has mutated or otherwise adapted in ways that allow human pathogenicity. This study describe the association between IL-6, D-dimer, C-reactive protein (CRP, Ferritin, erythrocyte sedimentation rate (ESR), and hematological marker in a cohort of COVID-19 patients. The baseline characteristics of the studied samples according to age and gender with a comparison of significance in studied groups show that a total of 65 individuals were divided into three groups according to the severity of disease (17 milds, …

Antimicrobial Action Of Some Types Of Homemade And Commercial Oils Extracts Against Bacterial Clinical Isolates, Ali Shaker F. Hadad, Jaleel Samanje

Al-Nisour Journal for Medical Sciences

The concentrated natural plant extracts are important sources of oils, which were proven to be good bioactive compound sources with antimicrobial and antioxidative characteristics. The current study aims to study the antimicrobial actions of public extracts of some commercial essential oils sold in market agaisnt a panel of some gram negative and positive clinicaly isolated bacteria. İn our study, fifteen types of commerical extracts were sold from local market and their antimicrobial action was tested against Pseudomonas. aeruginosa, Klebsiella. pneumoniae, Proteus. vulgaris, Escherichia. coli, Staphylococcus. aureus, Streptococcus. agalactiae and Enterococcus. faecalis. All the selected pathogens were tested for antibiotic senesitivty …

Measuring The Levels Of C5a In Induced Wound Infection With Staphylococcus Aureus, Athraa Hassan Al-Khafaji, Kifah Fadhil Al-Shabaa

Al-Nisour Journal for Medical Sciences

Animal models are standard tools for studying a wide range of traumatic wound infections. This paper aims to study the effect of Staphylococcus aureus (SA) in the wound and how the innate immune system interacts with this infection, by measuring C5a, and there are roles on wound healing. Fiftyone (females) Albino Rats at the age 6-9 week. The animals were divided into three groups (17 animal in the group) Group I (healthy control), Group II (control wound), and Group III (infection contamination, wound group), To mimic clinically occurring infections caused by SA infection, excision wound was made on the dorsal …

Evaluation Of Il-6 And Tnfα In Iraqi Patients With Chronic Renal Failure, Athraa Zaidan Hassan, Najah Ali Moha

Al-Nisour Journal for Medical Sciences

Chronic kidney disease (CKD) is a major social health problem. CKD is ranked –5 rd amongst life threatening disease in Iraq, the death rate in 2015 of about 6879 patients because of renal failure according to the statistics of the Republic of Iraqi-Ministry of Health/Environment. We aimed to evaluated (IL-6 & TNF-α) in Iraqi patients with chronic renal failure and assess some biochemical parameters include (urea, creatinine, sodium, potassium and calcium).This study included 60 cases and classified as 30 patients with chronic renal failure, these patients with age range (15years and above) who were admitted to the Al-kadimyiah Teaching Hospital, …

Mercury-Mediated Cyclization To 2-Isoxazolines, Abigail Palmer

Master's Theses

The isoxazoline ring has been utilized in many therapeutic agents. For example, it is the key structure in ISO-1, an anti-inflammatory agent with unique anti-Type 1 diabetes activity. There are two primary methods used for the synthesis of isoxazolines: transition metal free cycloadditions and transition metal-mediated cycloadditions and cyclizations. Most transition metal-mediated syntheses employ the use of palladium, gold, silver, or copper complexes as catalysts. The syntheses often require long reaction times and result in low yields with many impurities. In general, mercury-mediated syntheses typically have shorter reaction times and result in products with higher purity. This research investigated the …

The Role Of Hostile Attribution Bias In The Relationship Between Parental Adversity Exposure And Observed Parental Sensitivity, Ashley Lauren Waters

USC Aiken Psychology Theses

Exposure to adversity throughout the lifespan, including poverty, has been shown to influence parental sensitivity, or a caregiver’s ability to perceive, accurately interpret, and then respond appropriately to a child’s bids or behaviors. Given that adverse experiences can influence social cognition, it may be that hostile attribution bias (HAB, the tendency to interpret ambiguous social information as hostile), may be a mechanism accounting for the association between adversity exposure and parental behavior. The study aimed to contribute to the understanding of the determinants of sensitive parenting by evaluating the relationship between parents’ adversity (selfreported childhood, adulthood, and lifetime cumulative exposure …

Compliance With Ostracism: How Excluding A Member Of A Despised Outgroup Affects Psychological Need Satisfaction, Emma Nettles

USC Aiken Psychology Theses

Ostracism is a social process through which individuals are excluded or ignored (Williams, 1998). While recent research has slowly shifted toward the perpetrators of ostracism, relative to the targets, there is still little research on the effects of complying with ostracism. While previous research suggests engaging in ostracism leads to negative affect and thwarted need satisfaction, ostracism was directed toward an otherwise underserving target (Legate et al., 2013). The current research examined the effects of being instructed to ostracize a member of a despised outgroup on affect and need satisfaction. Seventy-one participants were recruited to play Cyberball, in which they …

Examining The Impact Of Attachment And Parent Socialization Of Emotion In Childhood On Emotion Regulation In Maltreated Adults, Nikki Major

USC Aiken Psychology Theses

Objectives: The aim of the current study was to examine the relationship between child maltreatment and adult emotion regulation by examining parenting processes of emotion socialization and attachment security as possible mechanisms accounting for this relationship. It was hypothesized that maltreated adults would retrospectively report more unsupportive responses from parents/caregivers, greater attachment insecurity, more difficulty with emotion regulation, and using expressive suppression more than cognitive reappraisal. It was also hypothesized that unsupportive responses to emotions and attachment security would both indirectly effect the relationship between child maltreatment and adult emotion dysregulation.

Method: A sample of 226 participants from Amazon Mechanical …

The Effect Of Mindfulness Meditation On Mu-Rhythm Suppression And Pain Empathy, Michael Settepani

USC Aiken Psychology Theses

Objective: The current study investigated the effects of a 15-minute mindfulness meditation on mu suppression during a pain empathy task to determine if mindfulness meditation can impact empathy and its neural correlates. The current study also included a behavioral portion to investigate the effect of mindfulness meditation on self-report empathy for pain.

Method: In the EEG portion of the study, 50 Participants were enrolled in the EEG portion of this task, and 31 for the behavioral portion. Both groups were randomly assigned to listen to a 15-minute mindfulness meditation, or a control recording. Both groups completed a pain empathy …

Veratrum Parviflorum: An Underexplored Source For Bioactive Steroidal Alkaloids, Jared T. Seale, Owen M. Mcdougal

Chemistry and Biochemistry Faculty Publications and Presentations

Plants of the Veratrum genus have been used throughout history for their emetic properties, rheumatism, and for the treatment of high blood pressure. However, inadvertent consumption of these plants, which resemble wild ramps, induces life-threatening side effects attributable to an abundance of steroidal alkaloids. Several of the steroidal alkaloids from Veratrum spp. have been investigated for their ability to antagonize the Hedgehog (Hh) signaling pathway, a key pathway for embryonic development and cell proliferation. Uncontrolled activation of this pathway is linked to the development of various cancers; most notably, basal cell carcinoma and acute myeloid leukemia. Additional investigation of Veratrum …

Isolation Of Proteins And Extracellular Vesicles Via Capillary-Channeled Polymer Fiber Stationary Phases, Lacey Billotto

All Theses

Capillary-channeled polymer (C-CP) fiber stationary phases have been developed by the Marcus lab as an alternative approach to traditional, commercially-available silica-based supports for biomacromolecule separations. C-CP columns are created with natural and synthetic base polymers in a variety of chemistries and shapes, allowing for customization of separations, while providing low material costs and ease of construction. The stationary phase is virtually nonporous with respect to the size of proteins and can operate under high linear velocities (~100 mm s^-1) while maintaining relatively low backpressures. As a result of these hydrodynamic benefits, low flow resistance at high volume flow …

The Negotiation Of Muslimah Identity In Hijab Cosplay Phenomenon, Hilda Balqis Hasba

JURNAL KOMUNIKASI INDONESIA

The identity of Muslimah is often associated with the idea of using hijab as a form of obedience to religion. This research examines the experiences of hijab women who use cosplay culture to represent their talents and creativity by creating a new culture. This research uses circuit of culture theory by Paul du Gay and Stuart Hall to analyze hijab cosplayers’ experiences in making hijab cosplay. The method used in this research is the qualitative research method and photo study technique to collect the data. This research shows that the process of creating hijab cosplay passes through identity, production, consumption, …

Diversity Of Gay Identity And Gender Expression On Social Media, Nadissa Fadhila

JURNAL KOMUNIKASI INDONESIA

The purpose of this research is to provide perspective on being a gay in Indonesia and his point of view on how he tries to express his diverse identities through social media Instagram. Also, how he tries to be unattached from the negative profiling and imagery of being a gay that exists in society in Indonesia. The focus of this research is the practice of posting and uploading content on Instagram from Magistus Miftah, an Indonesian fashion designer. This research is qualitative research with descriptive design and social semiotics analysis. This research concludes that the gender expression that Magistus Miftah …

On Some Problems In Sparse Hybrid Imaging, Non-Standard Finite Difference Methods, And Fokker-Planck Frameworks In Esophageal Cancer, Madhu Gupta

Mathematics Dissertations - Archive

In this thesis, we first discuss nonlinear optimization frameworks for the sparsity- based on nonlinear reconstruction of parameters in hybrid imaging modalities such as current density impedance imaging (CDII) and two-photon photoacoustic computed tomography (2P-PACT). The framework comprises minimizing an objective functional involving a least square fit and some regularization terms that promote sparsity patterns and enhance the edges to facilitate high contrast and resolution. Next, we show the construction and analysis of the second-order nonstandard finite difference methods (NSFD) scheme for theta methods and explicit Runge-Kutta method. Finally, we present an application of the NSFD scheme for Fokker-Planck (FP) …

Research, Analysis And Conservation Treatment Of A 19th Century Watercolor, Abby Schleicher

Art Conservation Master's Projects

This project focused on a watercolor from the mid- nineteenth century referred to as [Sailboats and Windmill] by Edward Tucker. The research concentrated on the popularity of watercolors in Britain in the 18th and 19th century along with the techniques and materials developed around this time. Visual examination along with multi-modal imaging techniques and scientific analysis utilizing X-ray fluorescence and Micro-Attenuated Total Reflection Fourier Spectroscopy aided understanding and identification of materials.

Swosu Standing Committees 2022-2023, Southwestern Oklahoma State University

University Standing Committees

No abstract provided.

Regional-Scale Climate-Induced Variation In Ant Physiology And Morphology, Daniel E. Murphy

Biology Theses

The biology of ectotherms such as insects is influenced by ambient thermal conditions. Ants are a ubiquitous and ecologically important group of insects and are well-established as bioindicators of thermal conditions. Ants are sensitive to the thermal extremes that vary with latitude, elevation, and land use, and these thermal gradients influence their spatial and temporal distributions. As a result, ants have evolved physiological and morphological thermal adaptations in response to the thermal environment of their habitats. These adaptations include increased physiological and morphological tolerance for temperature extremes. In Western New York (WNY), temperatures are temporally and spatially heterogeneous, changing with …

Combining Historic Records And Multi-Criteria Habitat Suitability Analysis For The Potential Reintroduction Of Lake Sturgeon (Acipenser Fulvescens Rafinesque) Into Tributaries Of Lake Erie, Kylie P. Wirebach, Christopher Pennuto, Dimitry Gorsky

Biology Theses

Predicting the location and quality of habitat for imperiled species is an increasingly important application of modeling technology. The Lake Sturgeon (Acipenser fulvescens) is a widely-extirpated fish of the Laurentian Great Lakes whose recovery is dependent on the availability and connectivity of suitable stream habitat today. This is especially true in Lake Erie, where the largest Lake Sturgeon fishery was once found. I predicted that modern habitat suitability would be dependent on land use legacies from the past 200 years, with western Lake Erie tributaries having less suitable habitat compared to the eastern Lake Erie tributaries. I developed a multi-criteria …

Characterization And Selection Of Hop Cultivars Adapted To Nebraska, Kristina Alas

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Hop (Humulus lupulus L.) is an ingredient in the beer brewing industry that provides beer its flavor and aroma. High demand from the brewing industry has encouraged production outside of the traditional Pacific Northwest, the primary production region. Producers in the Midwest are attempting to grow cultivars adapted to the Pacific Northwest, but environmental differences have caused low yields and changes in secondary metabolite content. To aid producers, a regional breeding program was initiated to develop cultivars adapted to the Midwest. Success of any breeding program relies on the selection of genetically superior parents to generate progeny with the …

Mycorrhizae In Maize (Zea Mays L.) Cropping Systems Respond Differently To Nitrogen Fertilization Under Increasing Crop Rotational Diversity, Morgan R. Mcpherson

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

Arbuscular mycorrhizal fungi (AMF) remain a vital obligate symbiont of nearly all plants. It is well established that the symbiosis between AMF and host plant improves plant nutrient acquisition, alleviates abiotic and biotic environmental stressors, defends against plant pathogens, and contributes to overall plant fitness and productivity through modification of the soil habitat. Modifications include increased soil aggregation and stability, carbon sequestration through provision of fungal wall precursors to soil organic matter (SOM) formation, and enhanced nutrient cycling in the mycorrhizosphere. The goal of this dissertation was to assess how AMF respond to nitrogen (N) fertilization regimes in maize cropping …

The Health Effects Of A Plant-Based Diet On The Human Gut Microbiome, Bryant T. Bell

Student Papers, Posters & Projects

The popularity of a plant-based diet is sweeping the western world. Markets and social media influencers are promoting and encouraging this dietary lifestyle. With people switching diets, research is needed to see how one’s gut microbiome and health are affected. In this review article, the health effect of a plant-based diet on the gut microbiota is evaluate. Over 15 articles contained research on the physiology of the gastrointestinal system, microbes in the gut, nutrition, and diets affecting health issues. It is concluded that a plant-based diet promotes good health and gut microbiome; however, there are some nutritional deficiencies that may …

Data Privacy In The Time Of Plague, Cason Schmit, Brian N. Larson, Hye-Chung Kum

Faculty Scholarship

Data privacy is a life-or-death matter for public health. Beginning in late fall 2019, two series of events unfolded, one everyone talked about and one hardly anyone noticed: The greatest world-health crisis in at least 100 years, the COVID-19 pandemic; and the development of the Personal Data Protection Act Committee by the Uniform Law Commissioners (ULC) in the United States. By July 2021, each of these stories had reached a turning point. In the developed, Western world, most people who wanted to receive the vaccine against COVID- 19 could do so. Meanwhile, the ULC adopted the Uniform Personal Data Protection …

Activation Of The Ppar Nuclear Receptors By Oxylipins And Their Potential Effects On Differentiation And Gene Expression In Myocytes, Jazmine Eccles

All Theses

Obesity and non-alcoholic fatty liver diseases are a growing issue worldwide. Decreased expression of CYP2B6 is associated with obesity in humans and Cyp2b-null mice are diet-induced obese; however fatty liver disease is worse in humanized CYP2B6 transgenic mice than WT or Cyp2b-null mice despite lower obesity. CYP2B6 produces several oxylipins with preference for metabolism at the 9- and 13-positions with 9-HODE and 13-HODE (from linoleic acid; n-6), and 9-HOTrE and 13-HOTrE (from a-linolenic acid; n-3) preferentially produced. Oxylipins serve as signaling molecules for many processes, such as inflammatory pathways, lipid distribution, and lipid metabolism. Due to their diversity, oxylipins can …

Bioleaching Of Arsenic From Agricultural Soils, Zachary Gilstrap

All Theses

Arsenic is a ubiquitous trace metalloid. However, increasing concentrations of arsenic in soil and water is a problem the world faces due to inputs from anthropogenic sources such as mining, milling, agriculture, and coal ash. One method of remediation for these arsenic-contaminated sites is bioleaching. While it is most often used to extract metals from raw ore, it is a viable and environmentally friendly method to remove the same metals from soil. Bioleaching removes metals by cultivating living organisms such as the fungi Aspergillus niger (A.niger) or the bacterium Thiobacillus ferrooxidans (T.ferrooxidans). This research aimed to investigate A. …

A 3d Tissue Engineering Model To Study Mitral Valve Annulus Calcification Under Diabetic Conditions, Erin James

All Theses

The most complex heart valve is the mitral valve (MV). Many pathologies can affect the MV, including stenosis, regurgitation, prolapse, and mitral annulus calcification (MAC). MAC is chronic degeneration of the annulus, which is the fibrous, saddle-shaped “ring” that can contract and relax with the myocardium. The prevalence of MAC is around 15% but increases in patients with other cardiovascular diseases and risk factors. It is also thought to increase in patients with type 2 diabetes, but MAC has not been properly characterized within this population because of confounding factors such as cardiac disease and kidney disease. The goal of …

An Evaluation Of Energy Consumption Comparing Conventional Water Treatment Plants To Microfiltration And Ultrafiltration Water Treatment Plants, Danielle Larsen

All Theses

The use of low-pressure, hollow fiber microfiltration (MF) and ultrafiltration (UF) membranes has become increasingly prominent in drinking water treatment plant configurations over the past 30 years. At the same time, the topics of energy efficiency and sustainability in industry are becoming progressively more important. Although MF and UF are highly successful in filtration, they are generally thought of as significant energy consumers; however, the data have not yet been available to compare multiple plants in various contexts to determine the factors that most affect energy use. This research compares the energy use of MF and UF treatment plants to …

Development Of A New Affinity Membrane For Rapidly Purifying Non-Antibody Proteins, Friendship Edioma

All Theses

This thesis project describes the modification and evaluation of a new affinity membrane for rapid chromatographic purification of non-antibody proteins. The affinity membrane utilizes Im7/CL7 coupling technology developed by Dr. Vassylyev's lab at the University of Alabama Birmingham (UAB), licensed by TriAltus Bioscience. The behavior of the membrane was evaluated using purified CL7-tagged Cas9 as my model protein for static and dynamic binding capacity analysis.

Chapter one provides an overview on biopharmaceutical drug production process development. I discuss how protein drugs are produced, isolated, and purified from the cell supernatant after upstream phases are completed. Despite increasing demands for biologics, …

The Evacuation Simulation Of Wheelchair Users In A Building Fire: An Initial Dynamic Characterization Of Structural Egress Components, Haley Hostetter

All Theses

People with disabilities are one of the most vulnerable groups involved in building fires. According to the U.S. Fire Administration, in the United States alone, an estimated 700 home fires involve people with physical disabilities each year while over 1700 involve those with mental health disorders. Despite this, the current body of literature shows few studies focused on the evacuation of disabled people. This is a direct result of past and present social injustice on people with disabilities and has resulted in high injury and death rates during fires. To combat this, enrich the literature, and improve their experiences in …