Digital Commons Network^™

Biomechanical Analysis Of Skeletal Open Bite Treatment Methods: A Comparative Finite Element Study ​, Ömer Faruk Sari, Muhammed Hi̇lmi̇ Buyukcavus

Turkish Journal of Medical Sciences

Background/aim: The biomechanical effects of zygomatic anchorage plates, vertical chin-caps, and occipital headgear on dentofacial structures in patients with skeletal anterior open bite malocclusion were compared using three-dimensional finite element analysis.

Materials and methods: Three-dimensional finite element models were constructed based on computed tomography data obtained from a patient with skeletal anterior open bite. Simulation models representing zygomatic anchorage-supported intrusion, vertical chin-cap, and occipital headgear were generated under fixed orthodontic conditions. In each scenario, a unilateral force of 200 g (1.96 N) was applied along clinically relevant force vectors. Stress distributions in craniofacial bones, sutural structures, teeth, roots, and temporomandibular …

Neural Signaling Contributes To Heart Formation And Growth In The Invertebrate Chordate, Ciona Robusta, Hannah N. Gruner, C. J. Pickett, Jasmine Yimeng Bao , '24, Richard Garcia , '24, A. Hozumi, T. D. Scully, Sydney Popsuj, Shaoyang Ning, Mavis Gao , '26, Gia Bautista , '23, Keren Meze , '24, Haeun Karissa Lim , '25, T. Osugi, Mae Collins-Doijode , '26, Ofubofu Cairns , '24, Gabriel Levis , '23, Shu Yi Chen , '24, Taixi Gong , '24, H. Satake, A. M. Klein, Y. Sasakura, Bradley Justin Davidson

Biology Faculty Works

Neurons contribute to the complex interplay of signals that mediate heart development and homeostasis. Although a limited set of studies suggest that neuronal peptides impact vertebrate heart growth, the specific contributions of these peptides to cardiomyocyte progenitor differentiation or proliferation have not been elucidated. Here, we show that the neuropeptide tachykinin along with canonical Wnt signaling regulate cardiomyocyte progenitor proliferation in the chordate model Ciona robusta. In C. robusta, the heart continues to grow throughout adulthood and classic histological studies indicate that a line of undifferentiated cells may serve as a reserve progenitor lineage. We found that this line of …

Predictive Analytics In Oncology And Ophthalmology: Machine Learning Applications For Diabetic Retinopathy And Breast Cancer, Ali Abidalkareem

Electronic Theses and Dissertations

The convergence of artificial intelligence and healthcare represents one of the most transformative developments in modern medicine, with deep learning technologies emerging as powerful tools for addressing complex diagnostic challenges. This dissertation develops and validates machine learning frameworks that address critical challenges in medical diagnosis through innovative approaches to data augmentation, feature learning, and classification, focusing on two fundamental problems: Diabetic Retinopathy (DR) severity classification using multi-model convolutional neural networks (CNNs), and breast cancer stage identification using microRNA (miRNA) gene expression biomarkers. For diabetic retinopathy classification, this work proposes an ensemble deep learning framework that integrates Diffusion-based data augmentation for …

Global Impact Of Germline Structural Variation On The Cancer Proteome, Fengju Chen, Yiqun Zhang, Luis F Paulin, Darshan S Chandrashekar, Sooryanarayana Varambally, Fritz J Sedlazeck, Chad J Creighton

Faculty, Staff and Students Publications

Proteome and transcriptome data combined can help assess the relevance of non-coding germline variants. Here, we combine germline Structural Variants (SVs) with mass spectrometry-based proteomics on tumors from 1637 cancer patients spanning various tumor tissues of origin to determine the extent SV breakpoint patterns involve differential protein expression of nearby genes. Rare and singleton SVs disrupting protein expression of known cancer susceptibility genes collectively involve 6% of patients. About 24% of the hundreds of genes with SV-associated non-coding cis-regulatory alterations at the mRNA level are similarly associated at the protein level. Both rare and common SVs may associate with differential …

Dapk2 Regulates Pkm2 Phosphorylation At Threonine 45 To Facilitate Disturbed Flow-Induced Atherosclerosis, Shuai Guo, Long Xu, Yixin Chen, Yuan Zhao, Yuting Zhang, Runfa Yu, Kaixiang Cao, Litao Wang, Wenjia Ai, Jiang-Yun Luo, Lu Lu, Jun He, Yuan Zhou, Li Wang, Andrew H Baker, Yuqing Huo, Yiming Xu

Faculty, Staff and Students Publications

Background: Oscillatory shear stress (OSS), resulting from disturbed blood flow, is implicated in atherosclerotic plaque formation by incompletely understood mechanisms. This study aims to elucidate the involvement of death-associated protein kinase (DAPK) 2 in OSS-induced endothelial cell (EC) activation and atherosclerosis.

Methods: Publicly available resources, including genome-wide microarray, RNA sequencing, and single-cell RNA sequencing, were utilized to identify key OSS-sensitive regulatory factors. Techniques such as mass spectrometry, immunoprecipitation, proximity ligation assay, and RNA sequencing were employed to identify pyruvate kinase M2 (PKM2) as the binding protein of DAPK2 and determine the specific site of PKM2 phosphorylation by DAPK2. To assess …

Artificial Intelligence In Low-Dose Computed Tomography Lung Cancer Screening: Clinical Integration, Validation, And Translational Challenges, Valeria Vanessa Varela Betancourt, Archana Acharya, Nusrat Jahan, Udit Kapahi, Insharah Khalid, Syed Maaz Shah, Hassan Ibrahim, Bushra Nawaz, Shazma Shayan, Maia Valls Palacios Reese, Sheeza Nadeem, Manju Rai

Student Publications

Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Low-dose computed tomography (LDCT) screening has demonstrated significant mortality reduction in high-risk populations; however, its widespread implementation is limited by high false-positive rates, inter-reader variability, and substantial workflow burden. Artificial intelligence (AI) has emerged as a promising adjunct to address these challenges by enhancing diagnostic consistency, efficiency, and risk stratification in LDCT-based screening. This narrative review aims to synthesize current evidence on AI methodologies, clinical applications, validation studies, and translational challenges in LDCT-based lung cancer screening. A structured literature search was conducted across PubMed, Scopus, …

Semiochemicals And Odorant Receptors Underlying Potato Cultivar Susceptibility And Resistance To Potato Tuber Moth, Ruipeng Chen, Wangtao Hu, Qin Hu, Junjie Yan, Jiao Yin, Fathiya M. Khamis, Yulin Gao, Walter S. Leal

All Peer-Reviewed Publications

Infestation of potato by the potato tuber moth (Phthorimaea operculella) varies markedly among cultivars, yet the chemical and molecular mechanisms underlying this variation remain poorly understood. Here, we combine field surveys, chemical ecology, functional genomics, and structural modeling to reveal how cultivar-specific volatile profiles shape moth oviposition behavior and pest outcomes. Field and laboratory assays identified marked differences in adult attraction, oviposition, and larval damage among potato cultivars, which correlated with distinct blends of emitted volatile organic compounds (VOCs). Behavioral analyses revealed that among other VOCs, trans-nerolidol and β-ionone act as attractants, whereas 3-carene and benzyl tiglate function as oviposition …

The Effects Of Dietary Protein Manipulation On Operant Demand, Brianna R. Lilly

LSU Master's Theses

Previous work with dietary protein restriction in rodents has demonstrated that rodents fed a low protein diet exhibit physiological effects such as lower rates of weight gain and increased levels of circulating fibroblast growth factor 21 (FGF21). Dietary protein restriction also produces behavioral effects. Compared to rodents that are not protein-restricted, rodents that are protein-restricted exhibit increased food intake and higher preference for a protein vs. carbohydrate solution. Additionally, protein-restricted rodents will respond at higher levels for a protein reinforcer than non-restricted rodents. The current study assessed the effect of dietary protein restriction on operant protein demand during and after …

Enhanced Dietary Monitoring Using Fecal Genomics For Childhood Malnutrition Interventions, Ammara Aqeel, Najeeha T Iqbal, Sanam Iram Soomro, Sheraz Ahmed, Teresa K Mcdonald, Olivia Osborne, Sharon Jiang, Nolan Ives, Kazi Ahsan, Fayaz Umrani, Michael J Barratt, Jeffrey I Gordon, Syed Asad Ali, Lawrence A David

2020-Current year OA Pubs

Ready-to-use therapeutic and supplementary foods (RUTF/RUSF) are a primary treatment for childhood malnutrition in Community Management of Acute Malnutrition (CMAM) programs. However, measuring intervention compliance is labor intensive and unreliable. We applied FoodSeq, a fecal genomic dietary assessment biomarker, in malnourished infants (3-15 months) from Matiari, Pakistan. FoodSeq identified a significant increase in the abundance of DNA from chickpea, a primary RUSF ingredient, during RUSF administration and captured region-specific complementary feeding practices, including age-inappropriate feeding practices such as wide-spread tea consumption. Our findings highlight the potential of dietary genomics as an empirical and scalable tool for compliance monitoring and dietary …

Herpes Simplex Virus Type 1 R-Loops Are Targets For Apobec-Mediated Mutagenesis, Márton Miskei, Dóra Varga, Lilla Hornyák, Éva Sipos, Éva Nagy, Qiuzhen Li, Zsolt Karányi, Zoltán Szabó, Rachel Deweerd, Abby M Green, Dávid Szüts, Eszter Csoma, Lóránt Székvölgyi

2020-Current year OA Pubs

APOBEC3 enzymes are key effectors of antiviral immunity that introduce mutations into viral genomes. We show that viral R-loops serve as preferred substrates for APOBEC3-mediated mutagenesis during herpes simplex virus type 1 (HSV-1) infection. APOBEC3 enzymes are recruited to viral R-loops, generating clustered C-to-T mutations in genes critical for viral assembly. Importantly, R-loops alone are not mutagenic, and APOBEC3 enzymes do not edit HSV-1 without an R-loop; mutagenesis occurs when R-loops and APOBEC3 enzymes interact. These findings identify endogenous R-loops formed during the HSV-1 life cycle as focal vulnerabilities and highlight R-loop-APOBEC3 coupling as a mechanism for antiviral mutagenesis.

Drawing-Based Story Telling Influence On Children Language Development And Social Aspect, Hariddha Yuni Sulistyaningrum, Imanuel Hitipeuw, Triyono Triyono

Jurnal Pendidikan Humaniora

Language and social development of children plays an important role in influencing further development. The objectives of this research are to determine the effect of drawing based on story- telling toward language development and social development of children age 5–6 years. Single subject research with reversal design ABAB was used in this experimental research. Four kindergarten children identified having language and social problems became the subjects. The observation was used to col- lect data. In addition, the data were put into graphs to be analyzed by using visual inspection. The results showed that drawing activities based on story telling could …

Blended Learning Method Within Indonesian Higher Education Institutions, Zamzami Zainuddin, Cut Muftia Keumala

Jurnal Pendidikan Humaniora

This article aims to explore the potential development of a Blended learning model in Indonesian higher education institutions. The paper attempts to explain the concept of the Blended learning in terms of theory and practice, based on the literature discussed in several reputable international jour- nals. Initially, this method proposes to improve the deficiencies of a traditional learning model which is lack of technological resources and at the same time to improve the gap of e-learning practice which is lack of a face-to-face learning experience. In the blended instruction, students will learn through a face- to-face interaction in the classroom …

Pre-Service Teachers’ Concept Of Sustainable Development And Its Integration In Science Lessons, Darryl Roy Montebon T.

Jurnal Pendidikan Humaniora

Sustainable development is a “durable development” that is systematic and long-term devel- opment of countries ensuring strong relationship between societal and environmental security with economic progress. The concept of sustainable development is essential for pre-service teachers to realize because the country is on its way to progress and industrialization and their role as future teach- ers is important. Hence, this paper investigates aims to determine pre-service teachers’ concept of sus- tainable development. It is important that the concept of sustainable development should be clear to teachers because it determines how effective they can teach the concept to their students. A …

Drainage Proximity And Sinkhole Occurrence In Sivrihisar (Central Turkey): A Comparative Analysis Of Linear, Poisson, And Negative Binomial Regression Models, Bilge Bingül, Emrah Pekkan, Resul Çömert

International Journal of Speleology

This study investigates the relationship between sinkhole occurrence and distance to drainage in the Sivrihisar region (Central Turkey) and evaluates the suitability of different regression approaches for modeling clustered count data in karst terrains. A comprehensive inventory of 104 sinkholes developed within the Neogene lacustrine limestones of the Akpınar Formation was compiled using official records, remote sensing analyses, and detailed field surveys. Sinkhole occurrences were analyzed relative to a drainage network derived from a high-resolution Digital Surface Model and grouped by proximity to drainage lines. Linear Regression (LM), Poisson Regression (PR), and Negative Binomial Regression (NBR) models were comparatively applied …

The Impact Of Teacher Burnout On Learning Ability In Elementary Children With Aces, Kassidy Lake Patterson

INSPIRE Student Research and Engagement Conference

Adverse Childhood Experiences (ACEs) impact individuals both psychologically and physically into adulthood. Children with ACEs often face challenges in learning, emotional regulation, and behavioral outbursts. Consequently, teachers supporting these students may experience Secondary Traumatic Stress and burnout. This examines the relationship between teacher burnout and students' ACEs. Using a mixed-methods approach guided by the Transactional model, the research discusses Allostatic Load and Toxic Stress theories. Teachers in the Waterloo area (n=10) completed the Professional Quality of Life Survey and the Trauma Informed Education Knowledge Survey. Findings indicate that teachers exhibit moderate burnout levels and possess high trauma knowledge, particularly those …

Watershed Studies Institute: 17th Annual Research Symposium, Watershed Studies Institute

Scholars Week

Wednesday, April 15, 2026

Barkley Room, Curris Center

Session Chair: Dr. Howard Whiteman

Apprenticing Towards Deeper Learning In The Ela Classroom: Using Young Adult Literature To Support Students’ Mastery, Identity, And Creativity, Julianna Kershen, Kacy M. Price, Nynke Wimp, Evie Jackson, Kaitlin Rogers

Virginia English Journal

This practitioner focused article highlights the perspectives of pre-service teachers and undergraduate researchers investigating the kinds of learning interactions and instructional decisions that result in deeper learning outcomes for high school students. Deeper learning outcomes are often described as 21^st century skills, including mastery learning, support of holistic and scholarly student identities, and the ability to engage collaboratively with critical and creative problem-solving skills. The authors suggest a series of young adult literature texts that can serve as springboards into project-based learning opportunities that provide authentic and real world-connected activities, iterative cycles of learning, peer-peer collaboration, and in-depth disciplinary …

Lessons From The Field On The Science Of Reading: School And Classroom Stories Across Contexts

Occasional Paper Series

No abstract provided.

La Gran Historia De Dilly Meets The Science Of Reading: A Cuento Of Scripts, Skills, And Silenced Selves, Elenita Irizarry Ramos, Ysaaca D. Axelrod

Occasional Paper Series

This article offers a deep dive into two lessons of a structured literacy curriculum to interrogate how current SoR–aligned mandates materialize in a Spanish dual-language first-grade classroom. Using Critical Discourse Analysis and Curriculum as a Discourse as both our conceptual frame and analytical method, we examine (a) La gran historia de Dilly—a retelling of The Ugly Duckling translated into Spanish—and (b) the teacher-facing lesson plan supplied by a major commercial publisher. Four patterns emerged: (1) reading is reduced to quantifiable skills (Lexile badges, sight-word drills) while the tale naturalizes biologically ‘correct’ identities, erasing hybrid selves; (2) scripted directives recast teachers …

Lessons From The Field On The Science Of Reading: An Introduction, Gail Boldt, Patricia Enciso

Occasional Paper Series

No abstract provided.

“Das Muttermal” - “The Birthmark” - “דער מוטער־צײכן”, Kristin K. Mlay-Kuhns

Vernacular: New Connections in Language, Literature, & Culture

“Das Muttermal / The Birthmark / דער מוטער־צײכן” is a trilingual work of transcreative poetry that stages translation as a method of mourning, cultural memory, and feminist inheritance. Composed first in German and then translated into English and Yiddish, the poem explores the catastrophic rupture of maternal loss and the slow transformation of trauma into understanding. The central metaphor of the birthmark—Muttermal, the “mother-mark”—figures the maternal body as both wound and connective tissue, binding ancestors and descendants through a physical trace that persists across generations, geographies, and languages. Formally, the project demonstrates how translation unveils the layered meanings embedded in …

Du Désespoir À L’Insoumission : La Mort Comme Langage De Résistance Chez Les Esclaves, Kolade M. Kenneth

Vernacular: New Connections in Language, Literature, & Culture

L’expérience de la mort pendant l’époque de l’esclavage constitue un phénomène à la fois complexe et profondément tragique. Pour les esclaves, la mort était souvent inévitable, résultant de conditions de vie inhumaines, de mauvais traitements, de maladies ou des dangers liés aux tentatives d’évasion. Les individus réduits en esclavage étaient soumis à un travail extrême dans les plantations ou d’autres environnements dangereux, sans considération pour leur santé ou leur bien-être. La malnutrition, le surmenage et les punitions brutales entraînaient fréquemment des décès prématurés. Cette étude ne considère pas la mort seulement comme un événement biologique, mais comme une forme de …

The Efficacy Of Manganese Sulfate As A Negative Contrast Agent For Magnetic Resonance Cholangiopancreatography, Zainab Abdulla Mankhi

Karbala International Journal of Modern Science

The current study aims to find an alternate oral contrast media for use in magnetic resonance cholangiopancreatography (MRCP) that satisfies the following criteria, the greatest imaging quality safety, no or few side effects, and low cost. The present study created an oral contrast agent sample (solution) by dissolving a one tablet of manganese sulfate supplement (taken daily dose) in 200 ml of distilled water. Thirty-three volunteers assessed the sample using MRCP examine pre and post contrast. By evaluating the signal intensity to compute contrast (C), signal to noise ratios (SNR), and contrast to noise ratio (CNR), the resulting MR images …

Antioxidant And Antifungal Activity Of Lactuca Serriola L. Plant And Silver Nanoparticles Against Aspergillus Species., Sakar Abdulqadr Saheed, Badr Qader Ismael

Karbala International Journal of Modern Science

Medicinal plants remain a valuable source of antifungal agents, and recent developments in green nanotechnology have increased the prospects for Lactuca serriola L. as a useful bioresource. In the current study, leaves and roots were extracted by ultrasonic-assisted chloroform, ethanol, and aqueous extraction methods for the biological mediation of silver nanoparticles (Ag NPs). Screening of Phytochemicals for extracts revealed the present secondary metabolites. Ag NPs were verified through UV-visible spectroscopy, indicating a peak at (408-423 nm) corresponding to a surface plasmon resonance, FT-IR functional groups of O–H, C=O, and C–N binding. The morphological analysis revealed an irregular-to-quasi-spherical shape, with an …

Plaques Collection Finding Aid

Finding Aids

No abstract provided.

Wanita Dan Kejahatan : Antara Teori Dan Realitas, I Nyoman Nurjaya

Jurnal Hukum & Pembangunan

Abstract

Stylemys Nebrascensis Predation Hypothesis, Noah Lohrmeyer, Amanda Peng

SACAD: Scholarly Activities

In 2008 a fossilized tortoise shell was brought into the Sternberg Museum of Natural History. As we prepared the fossil, we observed markings that resembled predation. We are trying to find what species from the White River Formation could preyed on the tortoise. There are few publications on predation for this species. With few publications, we want to find what predator would hunt these species. We cross referenced the site of the tortoise and observed several carnivorous species. We used straight carapace length (Hermanson et al., 2024) and a regression formula (Wilson et al., 2016) to analyze the species we …

Sustainable Land Use Optimization In Radioactively Contaminated Landscapes Of Ukrainian Polissia, Iryna Mcdonald, Liudmyla Raichuk

SACAD: Scholarly Activities

Sustainable Land Use Optimization in Radioactively Contaminated Landscapes of Ukrainian Polissia

Dr. Iryna McDonald¹, Dr. Liudmyla Raichuk²

¹Fort Hays State University, Department of Agriculture, Hays, KS, USA

²Institute of Agroecology and Environmental Management of the NAAS, Kyiv, Ukraine

Abstract

The radioecological situation in territories contaminated due to the Chornobyl Nuclear Power Plant accident remains challenging, particularly in the Zhytomyr, Kyiv, and Rivne regions, where certain products continue to exhibit elevated levels of radionuclide content. Contemporary challenges –  such as the full-scale war, which has led to the loss of productive lands in southern and eastern …

David Berkowitz, Enzyme-Assisted Organic Synthesis & Nsf Officer, Mark A. Griep, David B. Berkowitz

Department of Chemistry: Faculty Interviews

Dr. Dave Berkowitz was born in Urbana, Illinois. He earned his bachelor's degree in chemistry from the University of Chicago, where he did undergraduate research. Next, he earned his doctorate from Harvard University. However, his advisor, Steve Benner, moved from Harvard to ETH Zurich, also called the Swiss Federal Institute of Technology. Dave accompanied him to Zurich, where he completed his dissertation work. When Dave returned to the U.S., he did a postdoc with the legendary Samuel Danishefsky at Yale University. In 1991, he joined UNL as an assistant professor of chemistry and quickly rose through the ranks. Dave is …

Heavy Metal In Water Resources, Zuming Bi, Jeanne Sumrall

SACAD: Scholarly Activities

Heavy metal pollution in surface water has posed a serious threat to human health. The goals of this research are to analyze the concentration and distribution of key heavy metals and compare the measured values with global standards. This study analyzed major heavy metals like Fe, Mn, Cu, Pb, and Ag across several test points in Kansas and converted them to standard units mg/L. Based on the statistical graph, heavy metal iron and manganese levels are exceeded USEPA and WHO limits several times,  while other heavy metals stay in the safe range. The results indicate that the pollution in Kansas …