Digital Commons Network^™

Defining The Importance Of The Hnrnp I Interaction To The Sindbis Virus Subgenomic Viral Rna Using An Innovative Tethering Approach., Claire Westcott

Electronic Theses and Dissertations

Old World alphaviruses cause significant outbreaks of illness and debilitating multi-joint arthritis for prolonged periods. Currently, there are no FDA approved vaccines or antiviral therapies; and thus, there is a critical need to identify and characterize the molecular biology of alphaviruses. Alphaviruses rely on the host cell machinery to complete the viral lifecycle and are dependent on interactions with host RNA binding proteins. Accordingly, several host heterogenous nuclear ribonucleoprotein proteins (hnRNPs) have been found to bind to the Sindbis virus (SINV) RNAs. Disrupting the interaction sites in the viral RNAs of these RNA:Protein interactions results in decreased viral titers in …

“…You Can't Unknow It, It's A New Reality": A Case Study Exploring A Social Justice Public Health Intervention's Impact On Critical Consciousness Development In Youth., Monique Williams

Electronic Theses and Dissertations

Even though public health purports to be rooted in social justice, it is not clear how social justice frameworks are integrated in public health research and intervention. The discipline focuses on groups/populations on the margins, without integrating the social and political factors that cause marginalization into the intervention. Seeing communities, and individuals, as assets and experts in their own experiences is key to population-level health improvement. Particularly for public health youth intervention, how youth are labeled and engaged in social change is critical to their healthy development. While public health lags in practically applying asset-based approaches to youth intervention, research …

The Combined Benefits Of Dispositional Mindfulness And Trait Self-Compassion As Potential Buffers Of The Effects Of Perceived Stress On Sleep Quality In College-Aged Young Adults., Jackie Ma

Electronic Theses and Dissertations

Using a nonclinical sample of 108 undergraduates between the ages of 18 to 25 years old, this cross-sectional study investigated the relationship between dispositional mindfulness (as measured by the Five Facet Mindfulness Questionnaire; Baer et al., 2006) and sleep quality (as measured by the Pittsburgh Sleep Quality Index; Buysse et al., 1989). Second, it evaluated the association between trait self-compassion (as measured by the Self-Compassion Scale; Neff, 2003b) and sleep quality. Third, it aimed to test for an interaction effect between dispositional mindfulness and trait self-compassion as buffers against the adverse effects of perceived stress on sleep quality. Results showed …

Induction Of Trained Immunity By Particulate Β-Glucan Controls Cancer Metastasis Through The Sphingolipids-Mediated Mitochondrial Fission Pathway., Rejeena Shrestha

Electronic Theses and Dissertations

Metastasis is the leading cause of cancer-related deaths and innate immune cells are critical players in the metastatic microenvironment. Here, we explore the implications of harnessing the pre-metastatic niche myeloid cells through induction of trained immunity using a natural compound yeast-derived whole β-glucan particle (WGP). WGP training in macrophages results in an increased responsiveness to not only the conventional secondary stimulus LPS but also specifically to tumor cells and tumor-derived factors. WGP in vivo treatment leads to a trained immunity phenotype in lung interstitial macrophages (IMs). Induction of trained immunity by WGP inhibits tumor metastasis and enhances tumor-free survival in …

Investigating The Shared And Unique Mechanisms Of The Development Of Comorbid Eating Disorder-Anxiety Symptoms During Adolescence., Leigh Cara Brosof

Electronic Theses and Dissertations

Introduction: Eating disorders are associated with significant morbidity, psychiatric comorbidity, and impairment. Despite the detrimental outcomes associated with eating disorders, effective treatments for eating disorders are lacking. One factor that has impeded the identification of targets for intervention in eating disorders is the high comorbidity rate with other psychiatric disorders. Comorbidity models can inform treatments by showing which mechanisms are shared in comorbidity and which mechanisms are unique to specific disorders. Anxiety disorders are the most frequently co-occurring disorders with eating disorders, as 85% of individuals with eating disorders have a comorbid anxiety disorder. One mechanistic process in both anxiety …

Pediatric Oncology Social Work Job Analysis., Alyssa Ashlyn Middleton

Electronic Theses and Dissertations

This dissertation is an examination of the tasks most important to the pediatric oncology social work role. It begins with an argument that pediatric oncology social work is a blend of four social work specialties: generalist medical social work, oncology social work, pediatric social work, and hospice and palliative care social work. Studies report pediatric oncology social workers feel unprepared for numerous tasks related to their role. Despite calls for increased education and training opportunities, few are available. Until now, there has been no study evaluating the tasks that pediatric oncology social workers deem most important to their role, nor …

Dimension And Ramsey Results In Partially Ordered Sets., Sida Wan

Electronic Theses and Dissertations

In this dissertation, there are two major parts. One is the dimension results on different classes of partially ordered sets. We developed new tools and theorems to solve the bounds on interval orders using different number of lengths. We also discussed the dimension of interval orders that have a representation with interval lengths in a certain range. We further discussed the interval dimension and semi dimension for posets. In the second part, we discussed several related results on the Ramsey theory of grids, the results involve the application of Product Ramsey Theorem and Partition Ramsey Theorem

Role Of Deep Learning Techniques In Non-Invasive Diagnosis Of Human Diseases., Hisham Abouelseoud Elsayem Abdeltawab

Electronic Theses and Dissertations

Machine learning, a sub-discipline in the domain of artificial intelligence, concentrates on algorithms able to learn and/or adapt their structure (e.g., parameters) based on a set of observed data. The adaptation is performed by optimizing over a cost function. Machine learning obtained a great attention in the biomedical community because it offers a promise for improving sensitivity and/or specificity of detection and diagnosis of diseases. It also can increase objectivity of the decision making, decrease the time and effort on health care professionals during the process of disease detection and diagnosis. The potential impact of machine learning is greater than …

Alkylthiocarbamate Metal Complexes With Antiproliferation Activity., Kritika Bajaj

Electronic Theses and Dissertations

Bis(thiosemicarbazones) (BTSCs) and their metal complexes have been extensively studied for various applications including catalysis for hydrogen evolution reactions, treatment of neurodegenerative diseases, hypoxia imaging, and a wide range of pharmacological purposes including antitumor, antiviral, antibacterial, and antifungal agents. The paramount property that makes BTSC metal complexes interesting for their use in these applications is the reduction potential of the coordinated metal, which can be selectively tuned by varying the substituents present on the ligand framework. Although the BTSCs have shown a great deal of success as potential cancer therapeutic agents, they lack selectivity towards cancer cells. For this matter, …

An Analysis Of Public Comments On The Implementation Of The Ngss In Kentucky., Matthew David Trzaskus

Electronic Theses and Dissertations

Feedback has been a highly effective means to enact change. In the classroom teachers provide feedback to students concerning their performance, how they compare to the learning goal, and what students need to achieve those goals. For teachers, they utilize feedback from students to examine content focus and instructional practice in order to reflect and make positive changes. In this study, feedback is once again provided in order to enact change. Kentucky stakeholders, mainly teachers, in science education offered feedback about the implementation of the Next Generation Science Standards (NGSS). In their feedback they highlighted the challenges that occurred after …

Characterization Of Microbotryum Lychnidis-Dioicae Secreted Effector Proteins That Manipulate Its Host Plant, Silene Latifolia., Ming-Chang Tsai

Electronic Theses and Dissertations

The smut fungal species Microbotryum lychnidis-dioicae is an obligate phytopathogen colonizing the plant host, Silene latifolia. A significant feature of M. lychnidis-dioicae infection is that the fungus can replace pollen on the anthers of susceptible host plants with fungal teliospores, thus earning the fungus the name: anther smut disease of flowers. The fungus synthesizes and secretes effector proteins into the cells of the plant host during infection, and the protein-protein interactions may interfere with and modify metabolism, plant development, and gene expression of the host to allow fungal colonization. Two potential fungal effector proteins, MVLG_06175 and MVLG_05122, were identified …

Cultivating The Human Narrative: On Nietzsche, Science Fiction, And The Aesthetics Of Life., Derek Carpenter

Electronic Theses and Dissertations

In this dissertation, I will argue that there is a specific model of morality which can account for the intuition about moral features that we take to be intrinsic to the human type. This model of morality is that of Virtue Ethics, but not a conventional kind of Virtue Ethics. Instead, I will argue that the moral philosophy of Friedrich Nietzsche presents a model of cultivating narrative types that we take to be grounded in the kinds of beings we are, without resorting to any problematic metaphysical systems. This will require that I defend a novel interpretation of Nietzsche’s ethics …

A New Sir Model With Mobility., Ciana Applegate

Electronic Theses and Dissertations

In this paper, a mobility-based SIR model is built to understand the spread of the pandemic. A traditional SIR model used in epidemiology describes the transition of particles among states, such as susceptible, infected, and recovered states. However, the traditional model has no movement of particles. There are many variations of SIR models when it comes to the factor of mobility, the majority of studies use mobility intensity or population density as a measure of mobility. In this paper, a new dynamical SIR model, including the spatial motion of three-type particles, is constructed and the long-time behavior of the first …

Ecological Differences In The Associations Between Air Pollution, Greenness, And Risk Of Stroke: The Regards Study., Daniel W. Riggs

Electronic Theses and Dissertations

The adverse health effects of air pollution have long been recognized, with the majority of morbidity and mortality due to its effects on the cardiovascular system. Alternatively, living in areas with higher greenness has been found to be beneficial to a wide range of health outcomes. However, few studies have considered that these relationships may vary depending on the surrounding ecosystem. The purpose of this dissertation was to examine the effects of long-term exposure to air pollution and greenness on incidence of stroke, and how these relationships vary with the major ecological regions of the United States. We utilized the …

A Scoping Review Of Penile Implant Biofilms-What Do We Know And What Remains Unknown?, Joon Yau Leong, Courtney E Capella, Maria J D'Amico, Selin Isguven, Caroline Purtill, Priscilla Machado, Lauren J Delaney, Gerard D Henry, Noreen J Hickok, Flemming Forsberg, Paul H Chung

Department of Urology Faculty Papers

Background: Penile prosthesis (PP) is a gold standard for treatment of erectile dysfunction given its reliability and efficacy. Infection remains the most feared complication of prosthetic surgery, which usually results in device removal, and places a significant economic burden on the healthcare system. While biofilms have shown to support the persistence of microorganisms, the degree by which this matrix is truly pathogenic remains unknown given its high prevalence even in asymptomatic patients. We aim to review and summarize the current literature pertaining to biofilm formation in the setting of PP surgeries in clinically infected and non-infected cases.

Methods: Searches were …

Rectifying Wrongful Convictions Through The Dormant Grand Jury Clause, Colin Miller

Faculty Publications

In 1995, Lamar Johnson was convicted of a murder in St. Louis. Twenty-two years later, St. Louis Circuit Attorney Kimberly Gardner created a Conviction Integrity Unit (CIU) to review possible wrongful convictions. After reviewing Johnson’s case, the CIU concluded that Johnson was innocent. Then, consistent with her special responsibility as a prosecutor to seek to remedy wrongful convictions, Gardner filed a motion for a new trial. The court, however, denied the motion, holding that there was no enabling legislation in Missouri authorizing CIUs to seek relief for wrongful convictions. Gardner is not alone in her inability to rectify wrongful convictions. …

Application Of A 14c-Assay To Assess Methanotrophic Biodegradation Of Tce In Low Ph Groundwater, Evan Groome

All Theses

Current biological strategies for remediating trichloroethylene (TCE) in low pH aquifers (i.e., pH14C-TCE assay was developed to determine pseudo first-order rate constants for the degradation of TCE in microcosms containing soil and groundwater from the Boeing Michigan Aeronautical Research Center (BOMARC) superfund site, where the pH ranges from 4.1 to 4.9. The ¹⁴C-TCE assay was also adapted to calculate soil-normalized rate constants for data from this site, as well as data that Szwast²¹ collected from the Beltsville Agricultural Research Center (BARC). In addition to natural attenuation, biostimulation through amendments of methane and nutrients were also assessed. This treatment …

Recruitment, Cost Indexes, And Management Of Box-Nesting Wood Ducks In South Carolina And North Carolina, Emily Miller

All Theses

The wood duck (Aix sponsa) has experienced one of the most significant declines and recoveries among species of North American waterfowl (Anatidae). With enactment of the Migratory Bird Treaty Act (1918) and installation of hundreds of thousands of artificial nest structures for this cavity-nesting species in North America, wood duck populations have recovered and remain a sustainable harvested resource. However, long-term research on box-nesting wood ducks conducted at the Savannah River Ecology Laboratory, Aiken, South Carolina, has revealed uncertainty as to whether recruitment rates of yearling females from natal box-nesting populations are self-sustaining without immigration of hens from …

Simulating The Changes Of Invasive Phragmites Australis In A Pristine Wetland Complex With A Grey System Coupled System Dynamic Model: A Remote Sensing Practice, Danlin Yu, Nicholas A. Procopio, Chuanglin Fang

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Biological invasion has been one of the reasons that coastal wetlands gradually lose their ecological services. The current study investigates the spread of a commonly found invasive species in coastal wetlands in Northeastern US, the Phragmites australis. Within a relatively pristine wetland complex in coastal New Jersey, we collected high-resolution multispectral remote sensing images for eight years (2011–2018), in both winter and summer seasons. The land cover/land use status in this wetland complex is relatively simple, contains only five identifiable vegetation covers and water. Applying high accuracy machine learning algorithms, we are able to classify the land use/land cover in …

Investigating The Relation Between Genetic Variation In Fads1 & Fads2 With The Lcpufa Content Of Extracellular Vesicles From Human Milk, Natalie Paterson

Food Science (MS) Theses

As human milk supports growth and development, the World Health Organization and the American Academy of Pediatrics advise exclusive consumption of human milk for the first six months of life. Human milk contains numerous bioactive components, including extracellular vesicles (EVs). Single nucleotide polymorphisms (SNPs) in the FADS gene cluster that encodes the enzymes FADS1 and FADS2 may impact the concentrations of long-chain polyunsaturated fatty acids (LCPUFA) in human milk EVs. As integral components of the lipid membrane, the specific composition or balance of LCPUFAs may impact the bioavailability of EVs in newborns consuming human milk. The objective of this study …

The Online Environments Of Sexual And Gender Minority Youth: Contexts Of Risk And Resilience, Alexa Martin-Storey, Alicia A. Lapointe, Alice Girouard, Marie-Michèle Paquette, Sophie Bergeron

Journal of Family Strengths

Adolescents, in general, are spending more time in online environments, and understanding how youth navigate these contexts may be particularly important for addressing and improving outcomes among sexual and gender minority youth. Taking a developmental perspective, this review discusses online environments as contexts of both risk and resilience for youth in gender and sexual minority communities. In particular, we review literature highlighting how online environments provide a context for many salient aspects of adolescent development, including the promotion of identity development and the exploration of intimate, romantic and sexual behavior. The potential for online environments to serve as contexts for …

2022-August-01-Etsu Again Offering Free Pharmacy Dual Enrollment Class, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – East Tennessee State University Bill Gatton College of Pharmacy is offering a free college class for dual enrollment high school students across the region to learn more about the pharmacy profession and how to get into pharmacy school. The course will be free for all students who have a 3.0 high school GPA or above and are dual enrolled.

This course will be online and asynchronous, meaning students can participate at any point.

“Training future pharmacists to serve in our region is part of our mission, and we are excited to once again offer these free enrollment …

2022-August-01-Etsu's Dr. Cerrone Foster Wins Distinguished Faculty Award In Teaching, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – Dr. Cerrone Foster, a scientist teaching at East Tennessee State University for more than a decade, has won the university’s Distinguished Faculty Award for Teaching.  

It is the highest teaching honor that ETSU presents to a faculty member. 

“I have been nothing but inspired by Cerrone’s passion to contribute to the ETSU community, not only through her teaching but also through a diverse number of activities including research mentorship and community service,” wrote a fellow faculty member and Foster’s nominator.  

Foster earned a bachelor’s degree in biology from The College of New Jersey in 2001 and …

2022-August-01-Partnership Classes Offer Real-World Training At Etsu, University Marketing And Communication, East Tennessee State University

ETSU News

He plants new shrubs and flowers, ensuring the vegetation gets the appropriate amount of water and sunlight. He cultivates newly planted trees, pruning and assessing the health of the saplings. He helps craft plans for a range of extreme weather events, including droughts and floods.  

 

East Tennessee State University’s Travis Watson is the campus arborist. He’s also a graduate student working toward a certificate in geospatial analysis. 

  

“Community projects are huge for me, and I get a lot of personal enjoyment from that,” said Watson, who recently graduated with a master’s degree in biology. “My graduate training at ETSU gave …

Impact Of Spray Coating On The Performance Of Hydrophobic Membranes, Dominick J. Maiorano, Hamid Fattahijuybari, David Warsinger

Discovery Undergraduate Interdisciplinary Research Internship

Membrane distillation (MD) is a rapidly emerging water treatment technology used to combat the global water crisis. Membrane pore wetting is a primary barrier to widespread industrial use of MD. The primary causes of membrane wetting are membrane fouling and an exceedance of liquid entry pressure. The development of different types of polymer membranes and the use of pretreatment have led to significant movement towards the prevention of wetting in MD. We sought to take a new approach to combat membrane wetting that involves coating these membranes with hydrophilic chemical compounds, which consequently would decrease their air permeability. Pulling data …

Standardized Neon Organismal Data For Biodiversity Research, Daijiang Li, Sydne Record, Eric R. Sokol, Matthew E. Bitters, Melissa Y. Chen, Ruvi Jaimes, Matthew R. Helmus, Lara Jansen, Marta A. Jarzyna, Multiple Additional Authors

Environmental Science and Management Faculty Publications and Presentations

Understanding patterns and drivers of species distribution and abundance, and thus biodiversity, is a core goal of ecology. Despite advances in recent decades, research into these patterns and processes is currently limited by a lack of standardized, high-quality, empirical data that span large spatial scales and long time periods. The NEON fills this gap by providing freely available observational data that are generated during robust and consistent organismal sampling of several sentinel taxonomic groups within 81 sites distributed across the United States and will be collected for at least 30 years. The breadth and scope of these data provide a …

Empathy: The Unspoken Language Of Humanity: A Systematic Review Protocol, Yasmin Khaled Al-Zubi

Social Work Theses - Archive

Prolonged exposure to violence may result in habituation or desensitization, which has negative impacts. Desensitization to real-life violence is a reduced initial arousal response to real-life violence. Real-life violence includes physical abuse, sexual abuse, domestic violence, intimate partner violence, peer violence, and community violence. Children who have been exposed to violence-related adverse childhood experiences (ACEs) are more likely to achieve violence desensitization, by definition. As a result of ACEs, children are at risk of mental health complications, health-related problems, and risk for maladaptive behavior. Children who have reached violence desensitization are more likely to exhibit externalized symptoms such as aggression …

Positive Ageing And Death Or Dying: A Scoping Review, Robin Otto

Social Work Theses - Archive

This scoping review aims to examine the extent and how research that utilizes successful, active, productive, and healthy ageing framework(s) include death or dying. An examination of peer-reviewed academic articles published between 1980 and 2021 were reviewed following Joanna Briggs Institute's methodological standards for scoping reviews and conforming to Arskey and O'Malley's five-stage framework. The initial search resulted in 1,759 articles for review, and following the rigorous screening, 35 studies were included for the final review. A thematic analysis was the qualitative method employed to identify how research utilizes the concepts of death and dying in the context of four …

Investigating Gene Expression Changes In Daphnia: The Role Of Ems-Induced Mutations And Reproductive Modes, Marelize Snyman

Biology Dissertations - Archive

Gene expression variation is a common source of phenotypic variation between species. Understanding how changes in gene expression are associated with a particular phenotype will aid in understanding the molecular basis and evolution of complex traits. For the first chapter, I investigated the role that changes in gene expression play in the origin of obligate parthenogenesis using the microcrustacean Daphnia pulex. I conducted a genome-wide differential expression and splicing analysis comparing early subitaneous and early resting egg production in OP D. pulex isolates to investigate the genes and mechanisms underlying these parthenogenetic modes. Results from the KEGG pathway and GO …

Distribution And Management Of Phytophthora Species On Lavender In The United States, Daniel Dlugos

All Dissertations

Phytophthora root and crown rot (PRCR) is currently the most important disease on lavender (Lavandula spp.) in the United States. The disease was first described on English lavender (L. angustifolia) in a Maryland nursery in 1991, with Phytophthora nicotianae as the causal agent. Since that time, the disease has been reported on multiple continents and as caused by several species of Phytophthora. This study examined the distribution and pathogenicity of Phytophthora species on lavender in the United States, requested lavender grower feedback regarding their production and concerns, and examined efficacy of selected management options. Lavender …