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2022

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Investigating Granulopoiesis Of Neutrophils From Myeloblasts In The Bone Marrow Post Novel Anti-Schistosoma Compound Treatment, Sarah Alsuleiman, Paul Davis Aug 2022

Investigating Granulopoiesis Of Neutrophils From Myeloblasts In The Bone Marrow Post Novel Anti-Schistosoma Compound Treatment, Sarah Alsuleiman, Paul Davis

Theses/Capstones/Creative Projects

Schistosomiasis, a commonly neglected tropical disease, is a waterborne parasitic worm infection able to infect through direct skin penetration. This disease affects approximately 270 million people worldwide and ranks only second to malaria as a leading infectious disease. Although some possible alternatives are emerging, currently, the most effective drug treatment is praziquantel (PZQ). However, PZQ is only effective against the adult stage of the worm, allowing juvenile worms to progress in the infection. Additionally, Schistosoma worms are developing resistance to this drug as reduced efficacy has been noted. Thus, the need for drug discovery and testing is increased. SA01, a …

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“Vivid And Traumatizing”: Impact Of Breastfeeding Difficulties On Maternal-Well Being, Grace Watson, Jamie Smith Aug 2022

“Vivid And Traumatizing”: Impact Of Breastfeeding Difficulties On Maternal-Well Being, Grace Watson, Jamie Smith

Graduate Independent Studies - Communication Sciences and Disorders

No abstract provided.

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Effective Sequence Models And Graph Neural Networks For Molecular Data Analysis, Chaochao Yan Aug 2022

Effective Sequence Models And Graph Neural Networks For Molecular Data Analysis, Chaochao Yan

Computer Science and Engineering Dissertations - Archive

Drug discovery is the process of discovering new candidate medications. New drugs are continually developed by pharmaceutical industries to address increasing medical needs. Drug discovery involves a series of processes including target identification and validation, hit identification, lead generation and optimization, and finally the identification of a candidate for further development. The development further includes optimization of chemical synthesis and its formulation, toxicological studies in animals, clinical trials, and eventually regulatory approval. Both of these processes are time-consuming and cost-expensive. Computer-aided drug discovery mainly relies on modern computers to model drug molecules, which can speed up the process of drug …

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Cyborgs And The Americans With Disabilities Act, Lou Colasanti Aug 2022

Cyborgs And The Americans With Disabilities Act, Lou Colasanti

Student Scholarship

Medical technology is advancing at lightning speed with the potential to drastically benefit the disabled. These new technologies will result in humans who will use a wide array of assistive technologies and will likely be labelled as Cyborgs. Assistive technologies such as self-driving cars, robots, computer chip implants, insertable medical hardware, and exoskeletons are already well developed. The day is rapidly approaching when Cyborgs as a class will be large and influential. Critically, the Americans with Disabilities Act (ADA), the judges tasked with enforcing this legislation, and the legislature itself are all ill equipped to handle the speed of this …

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Veterinary Reporting And Immunity Laws In The United States: How This Model Law Could Positively Impact National Veterinary Practices And International Animal Law, Rachel Al-Alami Aug 2022

Veterinary Reporting And Immunity Laws In The United States: How This Model Law Could Positively Impact National Veterinary Practices And International Animal Law, Rachel Al-Alami

Global Business Law Review

This Note highlights the importance of animal law, including its impact on human violence and international businesses involving animals. The issues in veterinary reporting of suspected animal abuse must be addressed, as it has a direct effect on exposing the link between animal violence and human violence. Each state is encouraged to adopt the legislation proposed by this Note; it aims to reform the laws surrounding veterinary reporting of suspected animal abuse, and it provides veterinary professionals with immunity for reporting in good faith. This Note discusses the background of animal law, including the current state of affairs for both …

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The Influence Of Water Stress And Rootstocks On Nutrient Uptake And Gas Exchange Of Young Peach Trees, Naif Alshammari Aug 2022

The Influence Of Water Stress And Rootstocks On Nutrient Uptake And Gas Exchange Of Young Peach Trees, Naif Alshammari

All Theses

Young peach trees are often rainfed in the southeastern U.S. and periods of dry weather can cause tree water deficit that can be detrimental to orchard productivity. There is a lack of understanding of the influence of water regimes and rootstocks on the nutritional status and gas exchange of the peach tree. Most peach growers in Southeastern United States do not irrigate their young peach trees because they do not produce fruit until the third leaf. In this region, peach growers use Guardian as a rootstock, although MP-29 is also interesting for growers with orchards that have Armillaria root rot …

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Modeling Hierarchical Porous Electrodes With Tailored Anisotropic Structure, Debanjan Sarker Aug 2022

Modeling Hierarchical Porous Electrodes With Tailored Anisotropic Structure, Debanjan Sarker

All Theses

Modern electric vehicles and consumer electronics applications demand high specific energy from Li-ion batteries, which can be charged and discharged faster. In the search for high specific energy, researchers have tried to make thicker battery electrodes which contain a greater proportion of active material. While chemical and structural modification of electrodes can help to increase the electronic conductivity of active material, the microstructure of porous electrodes can be engineered to enhance ion transport for fast charge and discharge. Previous research has shown that macropores introduced by directional freeze tape casting can enhance the performance of thick porous electrodes. For instance, …

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Reproductive Ecology And Microbial Communities From Wood Duck Nest Boxes In Georgia And Florida, Jake Shurba Aug 2022

Reproductive Ecology And Microbial Communities From Wood Duck Nest Boxes In Georgia And Florida, Jake Shurba

All Theses

Wood ducks (Aix sponsa) are an important game species throughout the Atlantic Flyway that was nearly extirpated by the early 20th century due to overhunting and the loss of habitat. Wood ducks are secondary cavity-nesters that utilize artificial nest boxes and natural cavities. It is reported that the use of nest boxes is likely what led to re-establishment of the species in North America. Where boxes are numerous, overuse of boxes by multiple hens throughout a nesting season can occur and result in a buildup of bacteria, parasites and other potentially detrimental pathogens that can impact egg …

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Surmounting Perceived Barriers For Missouri Female Superintendents: A Phenomenological Study, Leslee Kristina Smith Aug 2022

Surmounting Perceived Barriers For Missouri Female Superintendents: A Phenomenological Study, Leslee Kristina Smith

Dissertations

Female superintendents throughout the United States disproportionately represent superintendents of public school districts (Cassidy et al., 2021; Gullo & Sperandio, 2020). This research study utilized the theoretical frameworks of feminism and the structured organization of institutions (Acker, 1990). In addition, the qualitative study used the phenomenological design. An open-ended survey was utilized, as well as a follow-up interview with open-ended questions to solicit deeper, lived experiences of self-imposed barriers and the strategies lead female superintendents in a Midwest state employed to surmount those barriers. Forty-four female lead superintendents in a Midwest state shared stories of their journeys to a lead …

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Gardner-Webb Pre-Med Student Participates In Elite Research Opportunity, Office Of University Communications Aug 2022

Gardner-Webb Pre-Med Student Participates In Elite Research Opportunity, Office Of University Communications

Gardner-Webb NewsCenter Archive

While gaining lab experience for medical school, Jared Reeder, of Asheboro, N.C., is participating in pre-eminent research. The Gardner-Webb University senior biology major is working with a synthetic chemistry project, studying how bacterial surface sugars are structure.

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Reactive Motion Planning Of Autonomous Vehicles In 3-Dimensional Environments Using Collision And Rendezvous Cones, Kashish Dhal Aug 2022

Reactive Motion Planning Of Autonomous Vehicles In 3-Dimensional Environments Using Collision And Rendezvous Cones, Kashish Dhal

Mechanical and Aerospace Engineering Dissertations - Archive

This dissertation presents a collision cone/rendezvous cone-based approach for reactive motion planning in three-dimensional dynamic environments. Collision avoidance is fundamental to robot motion planning. In dynamic environments, the path and velocities of obstacles are not known a-priori, and hence it is a common practice to use reactive planners. Reactive planners should be computationally inexpensive because they need to act fast to avoid potential collisions. To reduce the computational load, a majority of motion planning algorithms model the shapes of the robots and obstacles as a circle/sphere. However, when the objects are elongated more in one direction than another, the spherical …

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Computational Materials Chemistry: From Polymer Precursors To Ceramics And High-Pressure Materials, Shariq Haseen Aug 2022

Computational Materials Chemistry: From Polymer Precursors To Ceramics And High-Pressure Materials, Shariq Haseen

Chemistry & Biochemistry Dissertations - Archive

With advances in computing power, the field of computational chemistry has flourished. Using current computational resources, atomistic simulations of billion atoms and trillions of atoms have been performed. Computational techniques can be used to support experimental investigations into new materials as well as independently predict the existence of new materials. Furthermore, computational techniques are becoming instrumental in investigations. This work is split into two parts. Part I focuses on high-pressure and materials chemistry. We investigate the cristobalite-rutile transformation for SiO2, GeO2, and TiO2, and predict conditions at which cristobalite-GeO2 and cristobalite-TiO2 may be synthesized (Chapter 1), we provide supporting calculations …

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Stimuli-Responsive Peptide Self-Assembly For Therapeutic Delivery, Su Yang Aug 2022

Stimuli-Responsive Peptide Self-Assembly For Therapeutic Delivery, Su Yang

Chemistry & Biochemistry Dissertations - Archive

Peptide self-assembly offers an effective method to generate supramolecular nanomaterials with much higher stability than traditional monomeric peptides. The materials exhibit well-organized hierarchical structures and high resistance toward proteolysis and have been utilized extensively in various biomedical applications. Furthermore, due to the prevalence of non-covalent interactions, these structures are highly dynamic. The dynamic nature is beneficial for the design and synthesis of smart, trigger-responsive peptide selfassembly under specific stimulus, in particular various stimuli associated with disease conditions. In Chapter 1, I will introduce different types of peptide building blocks used for the construction of peptide self-assembly. I will further discuss …

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Remediation Of Contaminated Dumpsite Soil: An Evaluation Of Soil Amendments In Combination With Phytoremediation, Sasha Shanda Karen Jones Aug 2022

Remediation Of Contaminated Dumpsite Soil: An Evaluation Of Soil Amendments In Combination With Phytoremediation, Sasha Shanda Karen Jones

Earth & Environmental Sciences Dissertations - Archive

Contamination of soils and water from open dump site leachate is a frequent problem in developing nations. Water supplies are threatened when water percolates through the waste, bringing with it a variety of substances, such as metals, bacteria, viruses, flammables, organic chemicals, and other toxics. Metals in particular are complex in terms of the pathways they can choose in the environment; unlike organics, they do not degrade within the environment. Due to increases in population and affluence, the generation of waste has increased, meaning that leachate treatment will become an increasing problem. The overarching research goal was to evaluate a …

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Boundary Conditions For A Late Triassic Climate Simulation Using Cesm1.2-Som, James Alden Breen Aug 2022

Boundary Conditions For A Late Triassic Climate Simulation Using Cesm1.2-Som, James Alden Breen

Earth & Environmental Sciences Theses - Archive

Climate models have been widely adapted to reconstruct the environmental changes and associated mass extinction events across geologic times, such as the Younger Dryas (~12.9 Kyr), the Paleocene-Eocene Thermal Maxima (~55 Ma), and the Permian-Triassic Mass Extinction Event (~251 Ma). However, few studies have utilized climate models to investigate the potential climatic triggers of the large biological decline at the end-Triassic Mass Extinction (ETE; ~201 Ma). In this study, global boundary conditions for the end-Triassic hothouse climate are developed in order to allow a common framework for paleoclimate simulation and to study to internal climate variability in order to better …

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Towards On-Chip Integrated Sensors: Photonic Crystal Optical Sensors And Lasers, Zhonghe Liu Aug 2022

Towards On-Chip Integrated Sensors: Photonic Crystal Optical Sensors And Lasers, Zhonghe Liu

Electrical Engineering Dissertations - Archive

Supervising Professor: Weidong Zhou The field of compact integrated optical platform has developed into a new era in the past two decades. On one hand, the semiconductor optoelectronic devices are becoming smaller and cheaper thanks to the development of complementary metal-oxide semiconductor (CMOS) fabrication technologies; on the other hand, the applications of optoelectronics have been deeply coupled to other fields to realize more complicated implementations. Photonic crystal slab (PCS) structure has been playing an increasingly important role in these optical devices, active or passive, by enabling a variety of light-matter interaction mechanisms. The objective of this dissertation is to investigate …

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An Intimate Relationship: Medical Theory, The Environment, And Hospitals, Devin Williams Aug 2022

An Intimate Relationship: Medical Theory, The Environment, And Hospitals, Devin Williams

History Theses - Archive

Prior to the full acceptance of bacteriology in the late nineteenth to early twentieth century, medicine relied heavily upon the natural environment and cultivating flora from various regions around the world to implement in therapeutics. As a result of various medical theories and practices during the long nineteenth century the hospital became the physical embodiment of such practices and became modified as these medical theories advanced toward an acceptance of bacteriology. Initially serving as a marker for the boundary between the built and natural environments, hospitals also relied heavily upon the natural environment in the treatment of patients and became …

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Niche And Dispersal Effects On Biodiversity, Community Composition And Species Co-Occurrences In Stream Ecosystems, Joseph Leonardo Mruzek Aug 2022

Niche And Dispersal Effects On Biodiversity, Community Composition And Species Co-Occurrences In Stream Ecosystems, Joseph Leonardo Mruzek

Biology Dissertations - Archive

Niche and dispersal processes are major ecological drivers of freshwater communities but their relative roles across latitudinal gradients, scales, and organismal groups are not well understood. Thus, we performed three studies with sub-continental datasets of stream algae, insects, and fish. In chapter 2 we predicted that: i) niche processes would dominate at high latitudes due to increased climatic stress, consistent with the physiological tolerance hypothesis and the Dobzhansky-MacArthur hypothesis and ii) dispersal limitation would prevail at low latitudes due to narrower niches and smaller range sizes, consistent with the dispersal-ecological specialization tradeoff hypothesis, the latitude-niche breadth hypothesis, and Rapoport’s rule. …

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Lasso Based State Transition Modeling With Interactions In Adaptive Interdisciplinary Pain Management, Amith Viswanatha Aug 2022

Lasso Based State Transition Modeling With Interactions In Adaptive Interdisciplinary Pain Management, Amith Viswanatha

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

The Eugene McDermott Center for Pain Management at the University of Texas Southwestern Medical Center has an interdisciplinary pain management program for chronic pain. This program treats patients with a holistic view of reducing chronic pain and improving their physical, mental, and social well-being through treatment interventions. The development of an adaptive treatment decision tool is main goal of the research project. This program is modeled as a two-stage adaptive treatment decision problem, with state transition models representing the transition of patient state, treatment, and outcome variables from stage 1 to stage 2. Interactions between the patient state and treatments …

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Abrading The Enigma Of The Wound Healing Process: Modeling The Inflammation, Proliferation, And Maturation Stage, Amanda Patrick Aug 2022

Abrading The Enigma Of The Wound Healing Process: Modeling The Inflammation, Proliferation, And Maturation Stage, Amanda Patrick

Mathematics Dissertations - Archive

Wound healing encompasses a group of processes categorized into overlapping stages known as the inflammation, proliferation, and maturation/remodeling stage. The dynamics of these processes are important in studying outcomes of wound care and determining factors that contribute to certain wound outcomes. A system of ordinary differential equations is constructed for the inflammation, proliferation, and remodeling stage. Parameter sets for this model are investigated based on output dynamics according to the literature and based on experimental data. A bifurcation analysis is conducted to determine sudden changes that can occur in the inflammation system. Fourier Amplitude Sensitivity Test (FAST) is implemented to …

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Exploring The Relationship Between Rural Health Disparities And Income, Mortality, Insurance And Hospital Access, Jacob Ingram Aug 2022

Exploring The Relationship Between Rural Health Disparities And Income, Mortality, Insurance And Hospital Access, Jacob Ingram

2022 Spring Honors Capstone Projects - Archive

There is limited information about how social determinants of health relate to mortality rates in rural and urban areas. The purpose of this study was to determine ruralurban differences in, and correlations between, county-level mortality and social determinants of health variables (i.e., income, number of hospitals, being with or without insurance). The design was secondary, cross-sectional, descriptive, and correlational. There are 82 urban and 172 rural Texas counties. Mean county-level mortality rate was significantly higher in rural counties (M=108, SD=36.4 per 10,000 population) compared to urban (M=90.9, SD=25.6). In rural counties, uninsured rates were higher, insured rates were lower, and …

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Immune Variation Through Mhc Gene Analysis Of The Mourning Gecko (Lepidodactylus Lugubris), Elizabeth Rose Weeresinghe Aug 2022

Immune Variation Through Mhc Gene Analysis Of The Mourning Gecko (Lepidodactylus Lugubris), Elizabeth Rose Weeresinghe

2022 Spring Honors Capstone Projects - Archive

A Major histocompatibility complex (MHC) is a cell-surface molecule encoded by a large gene family in all vertebrate DNA (deoxyribonucleic acid). The MHC determines susceptibility to autoimmune diseases. These genes are highly polymorphic, meaning that in a non-endogamic population, each organism has a unique set of MHC genes and molecules. Evolution of the MHC through polymorphism ensures a population will not succumb to a new or mutated pathogen, because some individuals will develop an adequate immune response to defeat the pathogen. Because of this, finding MHC genes in transcriptomes is important for finding genetic variability in the immune systems of …

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Buffering Or Perpetuating: The Perceived Role Of Academic Institutions In Chinese International Doctoral Students’ Double Pandemics Experiences In The United States Aug 2022

Buffering Or Perpetuating: The Perceived Role Of Academic Institutions In Chinese International Doctoral Students’ Double Pandemics Experiences In The United States

Journal of Comparative & International Higher Education

No abstract provided.

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Full Issue 14(3b) 2022, Rosalind Latiner Raby Aug 2022

Full Issue 14(3b) 2022, Rosalind Latiner Raby

Journal of Comparative & International Higher Education

No abstract provided.

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Translating Particulate Hexavalent Chromium-Induced Chromosome Instability From Human Lung Cells To Experimental Animals, Human Lung Tumors And Whale Cells., Haiyan Lu Aug 2022

Translating Particulate Hexavalent Chromium-Induced Chromosome Instability From Human Lung Cells To Experimental Animals, Human Lung Tumors And Whale Cells., Haiyan Lu

Electronic Theses and Dissertations

Lung cancer is a major human health problem. While smoking is the most well-known cause of lung cancer, people who never smoked develop the disease. Understanding how non-tobacco environmental carcinogens cause lung cancer is key to combating this disease. Hexavalent chromium [Cr(VI)] is a well-established human lung carcinogen, but its carcinogenic mechanism is uncertain. Chromosome instability (CIN) is a hallmark of lung cancer and a major factor in Cr(VI)-induced lung cancer. Studies in human lung cells show Cr(VI) induces DNA double strand breaks and suppresses homologous recombination (HR) repair by targeting RAD51, resulting in CIN. We translated these outcomes to …

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The Effects Of Gang Membership And Transitions In A Gang On Within-Individual Changes In Offending., Leon Sergio Garduno Aug 2022

The Effects Of Gang Membership And Transitions In A Gang On Within-Individual Changes In Offending., Leon Sergio Garduno

Electronic Theses and Dissertations

Researchers have established that joining a gang exposes individuals to factors and environments that promote and increase antisocial and illegal behaviors, which decrease after leaving the gang (Decker & Van Winkle, 1994; Melde & Esbensen, 2014; Thornberry, Krohn et al., 1993). Scholars, by analyzing qualitative data, bivariate statistics, and by comparing gang members with non-gang members, have found that as individuals join and leave a gang they experience changes in the frequency with which they carry firearms, sell drugs, and engage in property crimes (Bjerregaard & Lizotte, 1995; Hagedorn, 1994; Thornberry et al., 1993). Researchers also have established that within-individuals’ …

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Applications Of Nuclear Magnetic Resonance Spectroscopy: From Drug Discovery To Protein Structure And Dynamics., Mark Vincent C. Dela Cerna Aug 2022

Applications Of Nuclear Magnetic Resonance Spectroscopy: From Drug Discovery To Protein Structure And Dynamics., Mark Vincent C. Dela Cerna

Electronic Theses and Dissertations

The versatility of nuclear magnetic resonance (NMR) spectroscopy is apparent when presented with diverse applications to which it can contribute. Here, NMR is used i) as a screening/ validation tool for a drug discovery program targeting the Phosphatase of Regenerating Liver 3 (PRL3), ii) to characterize the conformational heterogeneity of p53 regulator, Murine Double Minute X (MDMX), and iii) to characterize the solution dynamics of guanosine monophosphate kinase (GMPK). Mounting evidence suggesting roles for PRL3 in oncogenesis and metastasis has catapulted it into prominence as a cancer drug target. Yet, despite significant efforts, there are no PRL3 small molecule inhibitors …

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Determination Of The Functional Role Of Rab-Ggt In Physcomitrium Patens., Hyun Jin Jung Aug 2022

Determination Of The Functional Role Of Rab-Ggt In Physcomitrium Patens., Hyun Jin Jung

Electronic Theses and Dissertations

Protein prenylation, a common lipid post-translational modification, is required for growth and development in eukaryotes. Rab geranylgeranylation involves the addition of one or two 20-carbon geranylgeranyl moieties to Rab-GTPase target proteins, which regulate intracellular vesicle trafficking. The reaction is carried out by heterodimeric Rab geranylgeranyltransferase (Rab-GGT), which is composed of two associated α- and β-subunits, with the assistance of an additional protein called Rab escort protein (REP). Loss of function of the Rab-GGT α subunit RGTA1 has not been reported in any plant. While knockout of either of the two β subunits RGTB1 or RGTB2 results in …

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Classifying The 2022 Status Of Tsuga Canadensis (Eastern Hemlock) Along The Kentucky Portion Of The Pine Mountain Wildlands Corridor., Grace M. Embree Aug 2022

Classifying The 2022 Status Of Tsuga Canadensis (Eastern Hemlock) Along The Kentucky Portion Of The Pine Mountain Wildlands Corridor., Grace M. Embree

Electronic Theses and Dissertations

The invasion of the Hemlock Woolly Adelgid (HWA) (Adelges tsugae) has posed a continual threat in the United States to the Eastern Hemlock (Tsuga canadensis) trees since the 1950s. HWA feed on eastern hemlock needles, reducing the amount of healthy photosynthesizing vegetative area. The use of satellite imagery has been instrumental in identifying areas of eastern hemlock presence. Satellite platforms like Landsat and AVIRIS are commonly used for identification, classification, and mapping of eastern hemlock. Sentinel-2 imagery was released in 2015 for free access. It has a finer spatial grain of with the majority of the …

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The A-Word: Destigmatizing Abortion In American Culture., Kathryn Lafferty Danner Aug 2022

The A-Word: Destigmatizing Abortion In American Culture., Kathryn Lafferty Danner

Electronic Theses and Dissertations

This dissertation uses an interdisciplinary perspective and explores the topic of abortion through legal, medical, philosophical, and cultural perspectives, providing alternative ways to talk about abortion. In some states, especially since the overturning of Roe, abortion has become almost impossible to access, particularly in the South and Midwest. Abortion as a medical procedure is highly stigmatized and although it is a common procedure, it is taboo to discuss in American culture. Exploring how different media work to destigmatize abortion in the United States can lead to a deeper, more nuanced understanding of an overly politicized topic. The introduction is a …

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