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The Cowl - V. 89 N. 18 - April 16, 2026 Apr 2026

The Cowl - V. 89 N. 18 - April 16, 2026

The Cowl

The Cowl - student newspaper of Providence College. Vol. 89 No. 18 - April 16, 2026. 20 pages.

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Characterizing The Unique Chemical Imprint Of On-Axis, Lower-Temperature Hydrothermal Flow To The Deep Ocean (Southern East Pacific Rise, 16.5°–18.0°S), Laura E. Moore, Randelle M. Bundy, Joseph A. Resing, Scott M. White, Tamara Baumberger, Peter N. Sedwick, Nathaniel J. Buck, Anson M. Antriasian, Isaac Keohane Apr 2026

Characterizing The Unique Chemical Imprint Of On-Axis, Lower-Temperature Hydrothermal Flow To The Deep Ocean (Southern East Pacific Rise, 16.5°–18.0°S), Laura E. Moore, Randelle M. Bundy, Joseph A. Resing, Scott M. White, Tamara Baumberger, Peter N. Sedwick, Nathaniel J. Buck, Anson M. Antriasian, Isaac Keohane

Faculty Publications

In addition to high-temperature vents, lower-temperature flow (LTF) (< 300°C) is abundant along mid-ocean ridges and contributes globally-important fluxes of heat and water along with largely-unconstrained geochemical influences on the ocean. We examined the impact of on-axis LTF on the chemical composition of the overlying water column (< 40 m above seafloor) along the 16.5°–18.0°S sector of the ultrafast-spreading southern East Pacific Rise using autonomous underwater vehicle Sentry surveys and conductivity-temperature-depth rosette casts. LTF sites were typically spatially isolated from high-temperature systems and imparted unique chemical signatures to the overlying ocean. Water column samples impacted by LTF exhibited low particulate iron:sulfur ratios and high methane: total-dissolvable manganese ratios, whereas samples influenced by high-temperature venting exhibited opposite trends. We confirmed that LTF imparts a distinct and measurable chemical signature to the water column, independent from high-temperature vents. Isolated, on-axis LTF will be important to consider when assessing hydrothermal circulation impacts upon ocean biogeochemistry.

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Experiences Of Maternal Care In The Gypsy, Roma, And Traveller Population In The United Kingdom: A Cultural Care Model, Sarah Englebert Crowson Apr 2026

Experiences Of Maternal Care In The Gypsy, Roma, And Traveller Population In The United Kingdom: A Cultural Care Model, Sarah Englebert Crowson

Walden Dissertations and Doctoral Studies

Gypsy, Roma, and Traveller women (GRT) in the United Kingdom face persistent maternal health disparities and show poor engagement with healthcare services. Exclusion, discrimination, and a lack of cultural competence from healthcare professionals contribute to poor health outcomes including preterm births; and GRT women have more babies born with congenital anomalies than non-GRT women in the United Kingdom. The purpose of this focused ethnographic qualitative study was to explore how self-identified GRT women living in the United Kingdom experienced maternal care and how cultural identity and social structures influenced their interactions with healthcare providers based on Madeleine Leininger’s cultural care …

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Effects Of Gnrh And Hcg Administration On Conception Rate And The Subsequent Estrous Cycle On Day 12 Following Artificial Insemination In Holstein Cows, Mustafa Hi̇lmi̇ Yaranoğlu, Hüseyi̇n Erdem Apr 2026

Effects Of Gnrh And Hcg Administration On Conception Rate And The Subsequent Estrous Cycle On Day 12 Following Artificial Insemination In Holstein Cows, Mustafa Hi̇lmi̇ Yaranoğlu, Hüseyi̇n Erdem

Turkish Journal of Veterinary & Animal Sciences

The present study investigates the effects of gonadotropin-releasing hormone (GnRH) and human chorionic gonadotropin administration on the conception rate of cows 12 days after artificial insemination (AI). Included in the study were 150 high milkyielding Holstein cows housed under the same husbandry and feeding conditions. All had calved at least once between the ages of 2.5 and 6 years, and were between 90 and 220 days in milk. In accordance with the farm’s reproductive management approach, a controlled internal drug release (CIDR) device was inserted into the vagina concurrent with a GnRH injection (day 0), and the device was removed …

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The Effects Of Sodium Perborate Tetrahydrate On Digestibility And Nutrient Transporters In Rats, Büşra Özmen, Emre Şahi̇n, Muhammed Tokmak, Veysi̇ Kayri̇, Ramazan Özmen, Kazi̇m Şahi̇n Apr 2026

The Effects Of Sodium Perborate Tetrahydrate On Digestibility And Nutrient Transporters In Rats, Büşra Özmen, Emre Şahi̇n, Muhammed Tokmak, Veysi̇ Kayri̇, Ramazan Özmen, Kazi̇m Şahi̇n

Turkish Journal of Veterinary & Animal Sciences

Boron (B) is an essential micronutrient involved in hormone activity, energy metabolism, antioxidant defense, bone development, wound healing, and immune function. The present study explores the effects of sodium perborate tetrahydrate (SPT) on nutrient digestibility and the modulation of specific nutrient transporters in the jejunum and ileum of rats. A total of 40 rats were divided into four equal groups: 1) control, 2) SPT 0.5 (0.5 mg B/kg body weight [BW]), 3) SPT 1 (1 mg B/kg BW), and 4) SPT 2 (2 mg B/kg BW), and were fed the respective diets for a period of 4 weeks. The digestibility …

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Morphology And Histology Of The Developing Ovary In Malaysian Village Chicken (Gallus Gallus Domesticus) Chicks, Nur Athirah Lope Abdul Rashid, Mazlina Mazlan, Intan Shameha Abdul Razak, Rozaini Mohd Zohdi, Awang Hazmi Awang Junaidi Apr 2026

Morphology And Histology Of The Developing Ovary In Malaysian Village Chicken (Gallus Gallus Domesticus) Chicks, Nur Athirah Lope Abdul Rashid, Mazlina Mazlan, Intan Shameha Abdul Razak, Rozaini Mohd Zohdi, Awang Hazmi Awang Junaidi

Turkish Journal of Veterinary & Animal Sciences

The Malaysian village chicken (MVC; Gallus gallus domesticus) is an indigenous breed derived from the red junglefowl (Gallus gallus), exhibiting slower growth and reproductive rates. The MVC plays an important ecological role in local farming systems and represents a valuable genetic resource. However, detailed information on ovarian development in this breed remains limited. This study provides the first comprehensive morphological and histological characterization of the developing ovary in MVC chicks. A total of 20 chicks aged 1, 2, 4, and 8 weeks (n = 5 per age group) were examined. These MVC chicks possessed a single functional left ovary positioned …

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Age-Related Estimates Of Genetic Parameters For Growth And Ultrasonic M. Longissimus Thoracis Et Lumborum Muscle Traits In Eşme Lambs, İbrahi̇m Cemal, Orhan Karaca, Onur Yilmaz, Nezi̇h Ata Apr 2026

Age-Related Estimates Of Genetic Parameters For Growth And Ultrasonic M. Longissimus Thoracis Et Lumborum Muscle Traits In Eşme Lambs, İbrahi̇m Cemal, Orhan Karaca, Onur Yilmaz, Nezi̇h Ata

Turkish Journal of Veterinary & Animal Sciences

The growth performance and ultrasonic M. longissimus thoracis et lumborum (LTL) muscle traits of 2397 Eşme lambs raised in the Eşme district of Uşak province, an important lamb production area in Western Anatolia, were evaluated at 3 months (n = 1690) and 5 months (n = 707) of age. The average age of the lambs at the time of the first measurement (at weaning) was 100.15 days, and 152.37 days at the second. At 3 months of age, the average live weight (LW) was 29.34 kg and the average daily gain (ADG) was 248.35 g/day. By month 5, the LW …

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Housing System And Gender Effect On Carcass And Meat Quality Characteristics In Turkish Pekin Ducks, Hasan Önder, Uğur Şen, Mi̇ne Yilmaz, Si̇bel Bozkurt, Eli̇f Ci̇lavdaroğlu, Di̇lek Gökçek, Ahmet Uçar, Kadi̇r Erensoy, Burcu Kurnaz Apr 2026

Housing System And Gender Effect On Carcass And Meat Quality Characteristics In Turkish Pekin Ducks, Hasan Önder, Uğur Şen, Mi̇ne Yilmaz, Si̇bel Bozkurt, Eli̇f Ci̇lavdaroğlu, Di̇lek Gökçek, Ahmet Uçar, Kadi̇r Erensoy, Burcu Kurnaz

Turkish Journal of Veterinary & Animal Sciences

Improving meat quality is one of the most important aims for scientists and breeders. This study aimed to evaluate the effects of housing system (indoor vs. free-range) and gender on carcass and meat quality traits in Pekin ducks. The animal material consisted of 20 male and 20 female birds in each housing system. Our results show cold carcass weights of 3174.10 ± 80.65 g and 2672.60 ± 59.63 g for male and female birds in the indoor housing system and 2821.10 ± 50.53 g and 2306.90 ± 43.32 g for male and female birds in the free-range housing system. The …

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Spartan Daily, April 16, 2026, San Jose State University, School Of Journalism And Mass Communications Apr 2026

Spartan Daily, April 16, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 34

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April 16, 2026, The Daily Mississippian Apr 2026

April 16, 2026, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

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Kenyon Collegian - April 16, 2026 Apr 2026

Kenyon Collegian - April 16, 2026

The Kenyon Collegian

No abstract provided.

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Modulatory Effects Of Garlic Nanoparticles On Cell Cycle Progression And Apoptosis In N-Nitrosodiethylamine-Induced Hepatocarcinoma In Rats, Asmaa A. M. Elwakil, Omayma A. R. Abo Zaid, Mohamed K. Mahfouz Apr 2026

Modulatory Effects Of Garlic Nanoparticles On Cell Cycle Progression And Apoptosis In N-Nitrosodiethylamine-Induced Hepatocarcinoma In Rats, Asmaa A. M. Elwakil, Omayma A. R. Abo Zaid, Mohamed K. Mahfouz

Al-Farahidi Biomedical Journal

Background: Hepatocellular carcinoma (HCC) is considered a major cause of cancer-related mortality worldwide, which is resistant to several anticancer treatments. Associated with oxidative stress and reduced apoptotic regulation. Garlic displays powerful antioxidant effects and anti-tumor potential. In this study, we investigated the chemo preventive and therapeutic effectiveness of a novel garlic/ZnO/CTAB nanoparticles against diethyl nitrosamine (DEN)-induced hepatocarcinoma, focusing on their influence on cell cycle dynamics and apoptosis. Methods: Sixty male Wistar rats were divided into six groups: normal control, garlic nanoparticles normal-treated, DEN control, DEN + garlic nanoparticle protected, DEN + garlic nanoparticle treated, and DEN + doxorubicin treated as …

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Gc-Ms Analysis Of Bioactive Components From Syzygium Aromaticum And Its Inhibition To Pathogenic Staphylococcus Sciuri Obtained From Aquatic Sources, Seham Abdel-Shafi, Mostafa I. Abdelglil, Mohamed F Ghaly, Saida Amer, Sobhy El Sawy Elsilk, Maysa M. Mohamed, Khaled Ali Apr 2026

Gc-Ms Analysis Of Bioactive Components From Syzygium Aromaticum And Its Inhibition To Pathogenic Staphylococcus Sciuri Obtained From Aquatic Sources, Seham Abdel-Shafi, Mostafa I. Abdelglil, Mohamed F Ghaly, Saida Amer, Sobhy El Sawy Elsilk, Maysa M. Mohamed, Khaled Ali

Al-Farahidi Biomedical Journal

Antibiotic-resistant pathogenic microorganisms contaminate aquatic habitats. To prevent harmful bacteria isolated from pond and sewage water, this study assessed the green manufacturing of nanoparticles. A bioactive natural extract of Syzygium aromaticum inhibits the growth of bacteria in vitro. This study involved the isolation, purification, and identification of harmful microorganisms from aquatic sources. Traditional methods of identifying bacteria include Gram staining, bacterial cell morphology, colony shape, and biochemical assays, which are verified by 16S rRNA. The agar diffusion method is used to determine the minimum inhibitory concentration (MIC) of Syzygium aromaticum (cloves) on isolated samples. Cloves were used to biosynthesize …

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Pyrimidine Scaffolds In Modern Medicinal Chemistry: A Review Of Biological Activities And Therapeutic Potential, Mohamed Tamer, Wesam S. Shehab, Doaa A. Elsayed, Abd-Elnasser A. Mohamed, Ali M. Al-Erian, Mostafa I. Abdelglil, Maysa M. Mohamed Apr 2026

Pyrimidine Scaffolds In Modern Medicinal Chemistry: A Review Of Biological Activities And Therapeutic Potential, Mohamed Tamer, Wesam S. Shehab, Doaa A. Elsayed, Abd-Elnasser A. Mohamed, Ali M. Al-Erian, Mostafa I. Abdelglil, Maysa M. Mohamed

Al-Farahidi Biomedical Journal

Pyrimidine derivatives represent an important class of nitrogen-containing heterocycles that play a central role in medicinal chemistry due to their structural diversity and broad spectrum of biological activities. Compounds containing the pyrimidine nucleus have been widely reported to exhibit antibacterial, anticancer, anti-inflammatory, antiviral, antidiabetic, and neuroprotective properties. The versatility of the pyrimidine scaffold arises from its ability to accommodate various substitutions and fused ring systems, which enables the modulation of physicochemical and pharmacological properties. This review summarizes recent advances in the synthesis of pyrimidine and fused pyrimidine derivatives, highlighting representative synthetic strategies and modern methodologies. In addition, the major pharmacological …

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Design And Theoretical Evaluation Of Dihydropyrido[2,3-D]Pyrimidine Derivatives Synthesized Via Tio2 Nano Catalysis For Antidepressant Activity, Doaa A. Elsayed, Mostafa I. Abdelglil, Omar Metwally Apr 2026

Design And Theoretical Evaluation Of Dihydropyrido[2,3-D]Pyrimidine Derivatives Synthesized Via Tio2 Nano Catalysis For Antidepressant Activity, Doaa A. Elsayed, Mostafa I. Abdelglil, Omar Metwally

Al-Farahidi Biomedical Journal

Nowadays, depression is a severe neuropsychiatric disorder affecting millions of people worldwide and has profound impacts on individuals, the economy, and society. Due to several limitations of currently available antidepressant drugs, including delayed onset of action, limited efficacy, and various side effects, there is a continuing need for the development of innovative, effective, and safer therapeutic agents. In this context, the present work describes a green and sustainable approach for the synthesis of dihydropyrido[2,3-d]pyrimidine derivatives using TiO2 nanoparticles as an efficient and reusable catalytic system. The one-pot multicomponent reaction was carried out under mild conditions and demonstrated several advantages …

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Effect Of Different Pellet Binders On Palm Kernel On Growth Performance And Nutrient Digestibility In Broiler Chicken, Nuun Marfuah, Burhanudin Sundu, Rusdi Rusdi, Sugiarto Sugiarto Apr 2026

Effect Of Different Pellet Binders On Palm Kernel On Growth Performance And Nutrient Digestibility In Broiler Chicken, Nuun Marfuah, Burhanudin Sundu, Rusdi Rusdi, Sugiarto Sugiarto

Jurnal Ilmu Ternak Universitas Padjadjaran

Feed plays a paramount role in supporting growth, metabolism, and production performance. Their high price encourages the utilization of inexpensive and alternative feed ingredients. PKM, one such feed ingredient, is produced by palm oil industries. However, there is still a very limited application because of its high crude fiber content, which needs processing technologies like pelletization with binder addition. Based on this background, this experiment has been conducted to study the effect of various types of natural and commercial binders in 15% PKM-based pellets on performance and nutrient digestibility of broilers. The study was done for five weeks using 150 …

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Evaluating The Impact Of K135t Mutation On Malate Dehydrogenase Kinetic Activity, Emily Frost, Kaitlyn Mello Apr 2026

Evaluating The Impact Of K135t Mutation On Malate Dehydrogenase Kinetic Activity, Emily Frost, Kaitlyn Mello

Undergraduate Research Symposium (2026- )

Malate Dehydrogenase (MDH) is a key protein in the citric acid cycle; its dysregulation can have catastrophic impacts, such as neurological and metabolic disorders, and various cancers. MDH catalyzes the reversible oxidation-reduction reaction between malate and oxaloacetate, also reducing NAD+ to NADH in the process. The citric acid cycle is one of the central metabolic pathways, connecting to other essential pathways, such as amino acid and fatty acid biosynthesis, highlighting the importance of understanding how MDH works. A key site in MDH is the flexible loop region (amino acids 119-137), responsible for substrate binding, catalysis, and orientation. The flexibility of …

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Characterizing The Macroinvertebrate Community In Crissy Lake, An Impounded Reach Of The Pomme De Terre River, Prior To Channel Modification, Max Lundgren Apr 2026

Characterizing The Macroinvertebrate Community In Crissy Lake, An Impounded Reach Of The Pomme De Terre River, Prior To Channel Modification, Max Lundgren

Undergraduate Research Symposium (2026- )

The aging Crissy Lake Dam, on the Pomme de Terre River in Morris, has altered natural stream flow and impeded upstream passage of several fish species since 1939. In late 2026 the Minnesota Department of Natural Resources will replace the dam with stone arch rapids and facilitate river channel formation upstream of the dam. In order to evaluate the river modification project, we characterized the macroinvertebrate community in Crissy Lake, the impoundment upstream of the dam before implementation of channel modification. In September 2025 we collected benthic macroinvertebrates from two sets of Ekman grab samples. We found 12 taxa (average …

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Proline To Serine Mutation In Flexible Loop Region Of Malate Dehydrogenase, Anna Molstad, Hannah Robertson Apr 2026

Proline To Serine Mutation In Flexible Loop Region Of Malate Dehydrogenase, Anna Molstad, Hannah Robertson

Undergraduate Research Symposium (2026- )

Malate Dehydrogenase (MDH) is an essential enzyme that converts malate to oxaloacetate using the reduction of NAD+ to NADH. In humans, MDH plays a role in energy metabolism by catalyzing a key step of the citric acid cycle, important for energy production. Other indirect roles for MDH include gluconeogenesis and reoxidizing NADH from fatty-acid β-oxidation. An important feature of MDH is a flexible loop region that can alter substrate binding and enzyme activity, but its role is not well understood. Our study investigated how Pro123 to Ser (P123S) mutation in the flexible loop region affects MDH function. We hypothesized that …

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Evaluating Differences In The Dynamic Growth Patterns Of Cvi And Ler Genetic Strains Of Arabidopsis During Seedling Establishment, Emily Frost Apr 2026

Evaluating Differences In The Dynamic Growth Patterns Of Cvi And Ler Genetic Strains Of Arabidopsis During Seedling Establishment, Emily Frost

Undergraduate Research Symposium (2026- )

Seedling establishment is the process by which seedlings transition from depending on seed nutrients to making their own through photosynthesis. An important aspect is photomorphogenesis, the growth of plants in response to light, transitioning from rapid embryonic stem growth to a slower rate focused on root growth and leaf formation. The process is influenced by many genetic and environmental factors, making better characterization essential to understand plant development. For our research, we examined the dynamic growth of two Arabidopsis genetic strains (Cvi and Ler) over time in response to darkness, then to the change in response when light is introduced. …

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Appalachian Therapies, Emma Marie Wilson Apr 2026

Appalachian Therapies, Emma Marie Wilson

Dr. Jay W. Boland Research Day

It is predicted that by 2050, deaths due to antibiotic resistance will supersede cancer and cardiovascular disease as the number one cause of death in the world. The present research aims to study the polymicrobial interactions of microbial communities in the Appalachian region. Microbial samples were obtained from mountains surrounding East Tennessee State University, isolated and screened against common human opportunistic bacteria. One particular bacterium, S1S4-10, was found to be antagonistic against Bacillus subtilis and created zones-of-inhibition on agar media. Reverse testing found that the B. subtilis did not have a counter inhibition against S1S4-10. Co-cultures found that S2S4-10 could …

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Association Between Distance From A Children’S Hospital And Time To Access Healthcare In Children Presenting With Rash., Rebekah Lassiter Apr 2026

Association Between Distance From A Children’S Hospital And Time To Access Healthcare In Children Presenting With Rash., Rebekah Lassiter

Dr. Jay W. Boland Research Day

Locations farther from a hospital may be under-resourced due to their geographic isolation and increased spread of resources, communities, physicians, medications, and health care settings. We hypothesize that pediatric patients, with EM- or EM-like rashes, from distant locations, will present with more severe illness, due to the lack of resources and specialists. We performed a retrospective chart review of all Emergency Department or inpatient encounters with an ICD-10 code of L51 between 01/2013 and 10/2022. Our primary outcome was the duration of symptoms. Secondary outcomes included visits with a primary care provider (PCP) prior to seeking hospital care. We used …

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Land Epistemic Ethic: Exploring The Complex Intersection Of Human Bodies, Land, And Identity In Middle Belt Nigeria Cosmologies, Fwangmun Oscar Danladi Apr 2026

Land Epistemic Ethic: Exploring The Complex Intersection Of Human Bodies, Land, And Identity In Middle Belt Nigeria Cosmologies, Fwangmun Oscar Danladi

International Journal on Responsibility

The Indigenous cosmologies of Nigeria’s Middle Belt emphasize the relationship between human bodies and the land, transcending Western epistemological binaries and revealing profound socio-religious insights into environmental responsibility. Practices such as the burial of newborns’ umbilical cords, often dismissed as animistic or fetishistic, embody a sacred connection to the land that emphasizes belonging rather than ownership. Using an autoethnographic approach, this study critically examines these cosmologies and identifies how the sacredness of land can serve as a repository of communal memory and potential. By reframing land not as a possession but as a relational entity, this research challenges dominant narratives …

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Plant Genetic Engineering For Cost-Effective Expression Of Therapeutic Proteins, Bikram Giri Apr 2026

Plant Genetic Engineering For Cost-Effective Expression Of Therapeutic Proteins, Bikram Giri

Dr. Jay W. Boland Research Day

Plant expression system offers a versatile platform for producing bioactive molecules, including monoclonal antibodies (mAb) and therapeutic proteins, offering a scalable, rapid, and cost-effective alternative to mammalian cell systems. Aim 1 of this project is to achieve a high expression level of therapeutic proteins. As a proof-of-concept, we selected Rituximab, a commercialized therapeutic mAb, to expressin N. tabacum. We also developed IgG Fc tag fusion constructs for cancer targeting protein production. However, one limitation of plant expression systems is that plant-specific N-glycans, such as β1,2-xylose and core α1,3-fucose, limit clinical translation, altering antibody effector functions eliciting immunogenic responses in humans. …

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Synthesis And Evaluation Of Dirhodium(Ii) Acetate Tolunitrile Complexes As Catalysts In Cyclopropanation Reactions, Kimia Ataran Apr 2026

Synthesis And Evaluation Of Dirhodium(Ii) Acetate Tolunitrile Complexes As Catalysts In Cyclopropanation Reactions, Kimia Ataran

Dr. Jay W. Boland Research Day

In nature, chrysanthemum flowers naturally produce pyrethrin, a naturally occurring insecticide. A key feature of its chemical structure is a three-membered ring called cyclopropane. Synthesizing cyclopropane rings in the laboratory presents challenges, as a catalyst is required to facilitate the reaction. As a metal catalyst, dirhodium(II) tetraacetate has been used since 1976. Based on the structure of rhodium acetate bis-tolunitrile, one compound has a methyl group in the meta position and the other has a methyl in the para position. The hypothesis was that the meta-tolunitrile complex would facilitate the synthesis of cis-cyclopropane over trans-cyclopropane. The two isomers of rhodium …

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Self-Compassion And Health In Sexual Minorities: Do Reductions In Internalized Homophobia, Better Sleep, And Less Depression Explain The Link?, Jordan Godfrey Apr 2026

Self-Compassion And Health In Sexual Minorities: Do Reductions In Internalized Homophobia, Better Sleep, And Less Depression Explain The Link?, Jordan Godfrey

Dr. Jay W. Boland Research Day

Purpose: LGBTQIA+ (lesbian, gay, bisexual, transgender, queer, intersex, and asexual) individuals experience persistent health disparities, including poor general health. Internalized homophobia, or negative attitudes directed toward one’s identity, is related to such outcomes, potentially via its deleterious impact on sleep and mood. However, self-compassion, encompassing self-kindness, common humanity, and mindfulness, may mitigate these effects. Methods: We hypothesized that self-compassion would be positively associated with general health, and that this association would be serially mediated by internalized homophobia, sleep quality, and depression. Our national sample (N = 441) completed self-report measures. We conducted bivariate correlation and serial mediation regression analyses, covarying …

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Product Of Arachidonic Acid Oxidation Inhibits Neutrophil Migration By Forming The Inflammatory Substrate For Integrin Αmβ2, Jared Casteel Apr 2026

Product Of Arachidonic Acid Oxidation Inhibits Neutrophil Migration By Forming The Inflammatory Substrate For Integrin Αmβ2, Jared Casteel

Dr. Jay W. Boland Research Day

Oxidation of arachidonic acid generates biologically active derivatives that play a critical role in shaping the inflammatory response. One such derivative, carboxypropylpyrrole (CPP), is a stable end-product of arachidonic acid oxidation that has been previously described and detected in inflamed tissues; however, its pathophysiological contribution to inflammation has not been investigated. CPP forms covalent adducts with the extracellular matrix and plasma proteins, altering their biochemical properties and receptor-binding characteristics. Here, we examined how CPP formation impacts neutrophil migration during acute inflammation. Using cell adhesion assays and biolayer interferometry, we identified integrins αMβ2 and αDβ2 as receptors for CPP-modified proteins. Among …

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Appalachian Therapies, Emma Marie Wilson Apr 2026

Appalachian Therapies, Emma Marie Wilson

Dr. Jay W. Boland Research Day

It is predicted that by 2050, deaths due to antibiotic resistance will supersede cancer and cardiovascular disease as the number one cause of death in the world. The present research aims to study the polymicrobial interactions of microbial communities in the Appalachian region. Microbial samples were obtained from mountains surrounding East Tennessee State University, isolated and screened against common human opportunistic bacteria. One particular bacterium, S1S4-10, was found to be antagonistic against Bacillus subtilis and created zones-of-inhibition on agar media. Reverse testing found that the B. subtilis did not have a counter inhibition against S1S4-10. Co-cultures found that S2S4-10 could …

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Using Comparative Auditory Morphology To Explore Sensory Adaptation In Extinct And Extant Red Pandas, David Johnson Apr 2026

Using Comparative Auditory Morphology To Explore Sensory Adaptation In Extinct And Extant Red Pandas, David Johnson

Dr. Jay W. Boland Research Day

Modern red pandas (Ailurus fulgens) persist today across fragmented habitats of the eastern Himalayas, whereas extinct members of the family (Ailuridae) were more broadly distributed across much of the Northern Hemisphere during the late Miocene and early Pliocene. This disparity is likely the result of differences in ecological tolerances and/or behavior. Unfortunately, most fossil ailurids are fragmentary and/or poorly preserved. However, Pristinailurus bristoli, from the Gray Fossil Site of eastern TN, is represented by two nearly complete skeletons, including unusually well-preserved skulls, affording the opportunity to test that hypothesis. Preliminary analysis of dental morphology and locomotor adaptations of P. bristoli …

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Family Structure And Elementary Students’ English Language Arts (Ela) Achievement: A Quantitative Case Study, Sophia Coulter Apr 2026

Family Structure And Elementary Students’ English Language Arts (Ela) Achievement: A Quantitative Case Study, Sophia Coulter

Dr. Jay W. Boland Research Day

There are many factors that affect a child’s literacy abilities, especially their family structure. Research shows that children in two-parent homes, particularly ones where parents are married and are the biological parents, have greater academic success. However, little research has examined how the number of caregivers, rather than household structure, relates to literacy achievement. This undergraduate honors thesis study seeks to address this gap by examining patterns in English Language Arts (ELA) standardized test scores of students in third grade and the number of adult caregivers in the home. Understanding these patterns may contribute to the ability of educators to …

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