Digital Commons Network^™

Postindustrial Spectacle Reconnecting Image And Function, Patrick Ruggiero, Jr.

IntAR Interventions Adaptive Reuse

No abstract provided.

Cathedrals Of Consumerism Experiencing Corporate Interiors And Brands, Sylvia Leydecker

IntAR Interventions Adaptive Reuse

No abstract provided.

A Visual History Of Dining A Timeline, Eli Feldman

IntAR Interventions Adaptive Reuse

No abstract provided.

The Changing Roles Retail In The Experience Economy, Ann Petermans, Bie Plevoets, Koenraad Van Cleemopoel

IntAR Interventions Adaptive Reuse

No abstract provided.

Approximations To A Working Space Around But Not Inside El Museo De Los Sures, Laura F. Gibellini

IntAR Interventions Adaptive Reuse

No abstract provided.

New Pasts, Old Experiences The Spectacle Of Authenticity At Cairo's Museum Of Agriculture, Samaa Elimam

IntAR Interventions Adaptive Reuse

No abstract provided.

Identification Of Lethal Inhibitors And Inhibitor Combinations For Mono-Driver Versus Multi-Driver Triple-Negative Breast Cancer Cells, Geng Chia Ku, Abygail G. Chapdelaine, Marina K. Ayrapetov, Gongqin Sun

Cell and Molecular Biology Faculty Publications

There are no signaling-based targeted therapies for triple-negative breast cancer. The development of targeted cancer therapy relies on identifying oncogenic signaling drivers, understanding their contributions to oncogenesis and developing inhibitors to block such drivers. In this study, we determine that DU-4475 is a mono-driver cancer cell line relying on BRAF and the mitogen-activated protein kinase pathway for viability and proliferation. It is fully and lethally inhibited by BRAF or Mek inhibitors at low nM concentrations, but it is resistant to inhibitors targeting other signaling pathways. The inhibitory lethality caused by blocking Mek or BRAF is through apoptosis. In contrast, MDA-MB-231 …

A Science-Based Policy For Managing Free-Roaming Cats, David Hunter, Christopher A. Lepczyk, David C. Duffy, David M. Bird, Michael Calver, Dmitry Cherkassky, Linda Cherkassky, Christopher R. Dickman, David Jessup, Travis Longcore, Scott R. Loss, Kerrie Anne T. Loyd, Peter P. Marra, John M. Marzluff, Reed F. Noss, Daniel Simberloff, Grant C. Sizemore, Stanley A. Temple, Yolanda Van Heezik

Scholarly Articles in Law Reviews & Journals

Free-roaming domestic cats (i.e., cats that are owned or unowned and are considered ‘at large’) are globally distributed non-native species that have marked impacts on biodiversity and human health. Despite clear scientific evidence of these impacts, free-roaming cats are either unmanaged or managed using scientifically unsupported and ineffective approaches (e.g., trap-neuter-release [TNR]) in many jurisdictions around the world. A critical first initiative for effective, science-driven management of cats must be broader political and legislative recognition of free-roaming cats as a non-native, invasive species. Designating cats as invasive is important for developing and implementing science-based management plans, which should include efforts …

A Global Assessment Of The Mixed Layer In Coastal Sediments And Implications For Carbon Storage, Shasha Song, Isaac R. Santos, Huaming Yu, Faming Wang, William C. Burnett, Thomas S. Bianchi, Junyu Dong, Ergang Lian, Bin Zhao, Lawrence Mayer, Qingzhen Yao, Zhigang Yu, Bochao Xu

Center for Coastal and Ocean Mapping

The sediment-water interface in the coastal ocean is a highly dynamic zone controlling biogeochemical fluxes of greenhouse gases, nutrients, and metals. Processes in the sediment mixed layer (SML) control the transfer and reactivity of both particulate and dissolved matter in coastal interfaces. Here we map the global distribution of the coastal SML based on excess 210Pb (210Pbex) profiles and then use a neural network model to upscale these observations. We show that highly dynamic regions such as large estuaries have thicker SMLs than most oceanic sediments. Organic carbon preservation and SMLs are inversely related as mixing stimulates oxidation in sediments …

Steap1-4 (Six-Transmembrane Epithelial Antigen Of The Prostate 1-4) And Their Clinical Implications For Prostate Cancer, Michael Xu, Latese Evans, Candice L Bizzaro, Fabio Quaglia, Cecilia E Verrillo, Li Li, Julia Stieglmaier, M J Schiewer, Lucia R Languino, William Kevin Kelly

Department of Urology Faculty Papers

Six-Transmembrane Epithelial Antigen of the Prostate 1-4 (STEAP1-4) compose a family of metalloproteinases involved in iron and copper homeostasis and other cellular processes. Thus far, five homologs are known: STEAP1, STEAP1B, STEAP2, STEAP3, and STEAP4. In prostate cancer, STEAP1, STEAP2, and STEAP4 are overexpressed, while STEAP3 expression is downregulated. Although the metalloreductase activities of STEAP1-4 are well documented, their other biological functions are not. Furthermore, the properties and expression levels of STEAP heterotrimers, homotrimers, heterodimers, and homodimers are not well understood. Nevertheless, studies over the last few decades have provided sufficient impetus to investigate STEAP1-4 as potential biomarkers and therapeutic …

Patriotic Graduation, University Of Dayton

Materials from the University of Dayton Magazine Website

The University of Dayton Magazine looked back in the University Archives to see what it was like at graduation in 1914.

Practical Approaches To Improve Vancomycin-Related Patient Outcomes In Pediatrics- An Alternative Strategy When Auc/Mic Is Not Feasible, Kashif Hussain, Muhammad Sohail Salat, Shahzad Rauf, Manoj Rathi, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Rahila Ikram, Gul Ambreen

Department of Biological & Biomedical Sciences

Background: Anecdotal experience and studies have shown that most pediatric patients fail to reach target therapeutic vancomycin trough levels (VTLs) and required higher total daily doses (TDD). This retrospective study aims to evaluate the frequency of hospitalized children who achieved target VTLs with a vancomycin (VNCO) dosing regimen of 40-60 mg/kg/d q6h and to assess the VNCO-TDD required to attain the target and their effects on clinical outcomes in pediatric patients.
Methods: After ethical approval, patients of 3 month-12 years were evaluated in this chart review study who received ≥ 3 intravenous-VNCO doses and appropriately drawn blood samples of VTLs …

Partialing Alters Interpersonal Correlates Of Negative Affective Symptoms And Traits: A Circumplex Illustration, Steven E. Carlson, Timothy W. Smith, Paula G. Williams, Kimberly A. Parkhurst, Ruben Tinajero, Christian Goans, Michiyo Hirai, John M. Ruiz

Psychological Science Faculty Publications

Introduction

Negative affective symptoms (e.g., anxiety, depression, and anger) are correlated and have parallel associations with outcomes, as do related personality traits (i.e., facets of neuroticism), often prompting statistical control (i.e., partialing) to determine independent effects. However, such adjustments among predictor variables can alter their construct validity. In three studies, the interpersonal circumplex (IPC) and a related analytic approach (i.e., Structural Summary Method) were used to evaluate changes in interpersonal correlates of negative affective characteristics resulting from partialing.

Methods

Samples of undergraduates (Sample 1 n = 3283; Sample 2 = 688) and married couples (n = 300 couples) completed …

Mimibrick.Jl: A Julia Package For The Brick Model For Sea-Level Change In The Mimi Integrated Modeling Framework, Tony E. Wong, Lisa Rennels, Vivek Srikrishnan, Alexander Bakker, Klaus Keller, David Anthoff

Articles

BRICK is a semi-empirical model for global and local mean sea-level change (Wong et al., 2017). The core model includes component sub-models for the major contributors to global mean sea-level change - glaciers and ice caps, thermal expansion, land water storage, and the Greenland and Antarctic ice sheets. The resulting global mean sea levels can be downscaled via a data set that represents the “fingerprint” of each sea-level component on local mean sea level (Slangen et al., 2014). In this way, BRICK provides information about local sea-level changes, including characterizations of key uncertainties. BRICK is flexible and efficient enough to …

Thoughts On Space Science Development, Yidong Gu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Space science is a large-scale activity by using space vehicles to explore the universe and natural laws and carry out special experiments, which has made great contributions to the development of contemporary science. This paper outlines the major breakthroughs in international space science, analyzes the context and new trends of space science and manned exploration activities, reviews the development achievements of space science in China in the past 20 years, puts forward existing problems and gaps, and emphasizes the strategic position of space science and its importance to China's science and technology, aerospace and the national long-term development. It is …

Connecting The Last Mile To Speed Up Space Science Development Of China—Review And Prospect Of The Funding Practices For Space Science By Nsfc, Zengqian Hou, Yupeng Yao, Guoxuan Dong, Sheng Yu

Bulletin of Chinese Academy of Sciences (Chinese Version)

Strengthening the basic scientific research in an all-round way and achieving more breakthroughs from zero to one as soon as possible are the major strategic needs of building a world leading power in science and technology in the new era. As the main channel funding basic research in China, the National Natural Science Foundation of China (NSFC) has always focused on the basic frontiers and major scientific issues in space science, carried out strategic research on the planning of relevant disciplines, sorted out key scientific questions, defined the priority development direction, and provided continuous and stable funding through major, key, …

Systematic Study On Carbon Emission Reduction Of Municipal Solid Waste Treatment, Jisheng Long, Hailiang Du, Xin Zou, Jingying Huang

Bulletin of Chinese Academy of Sciences (Chinese Version)

Under the context of China's carbon peak and carbon neutrality, the treatment of municipal solid waste (MSW) is facing new challenge to reduce carbon emission. This study suggests that significant carbon emission reduction and dual cycle of mass and energy can be realized, under the context of MSW classification, by the collaborative treatment of multi-source solid waste in Eco-Industrial Park. Results showed that in 2020, the incineration and landfilling of MSW in China reduced 5.18 million tons of CO2 emission, at the same year, 15 million tons of CO2 emission could have been reduced if the wet waste was treated …

Current Situation And Improvement Suggestions Of Archives Management Of Cas Field Stations, Miao Li, Hao Liang, Tian Ye, Linjing Meng, Mingliang Tan, Xiao Yue, Xingjuan Li, Shengnan Li, Ping Yang, Yanan Pan

Bulletin of Chinese Academy of Sciences (Chinese Version)

The archives resources of field stations of Chinese Academy of Sciences (CAS) are important basic scientific and technological resources of the country. In the new era, China has put forward new requirements for the work of scientific research archives. The open sharing and network construction of field stations pose new challenges to the archives management of field stations. In order to deal with the new problems of field station archives management, based on the investigation of the data, documents, and archives management of 137 field stations and 50 supporting affiliations of CAS, this paper analyzes the current situation and problems …

The Lived Experiences Of Middle Eastern Immigrant Women During Their Cancer Survivorship Journey: A Phenomenological Study, Enam Alsrayheen, Khaldoun Aldiabat, Catherine Aquino-Russell

The Qualitative Report

The number of Middle Eastern immigrant women (MEIW) living in Canada has significantly increased. However, this group of women is underrepresented in health research and there is a gap in knowledge of their cancer survivorship experiences in Canada. This phenomenological qualitative approach was employed to uncover the meaning of the lived experiences of MEIW during their cancer survivorship journey (CSJ). Data were collected through unstructured interviews and one written description from three MEIW. The participants' perspectives of cancer risk factors were believed to be the cause of their cancer, and their CSJ was fear-inducing and anxiety-provoking. There appears to be …

Detection Of Pancreatic Cancer Mirna With Biocompatible Nitrogen-Doped Graphene Quantum Dots, Ryan Ajgaonkar, Bong Lee, Alina Valimukhametova, Steven Nguyen, Roberto Gonzalez-Rodriguez, Jeffery Coffer, Giridhar R. Akkaraju, Anton V. Naumov

School of Medicine Publications

Early-stage pancreatic cancer remains challenging to detect, leading to a poor five-year patient survival rate. This obstacle necessitates the development of early detection approaches based on novel technologies and materials. In this work, the presence of a specific pancreatic cancer-derived miRNA (pre-miR-132) is detected using the fluorescence properties of biocompatible nitrogen-doped graphene quantum dots (NGQDs) synthesized using a bottom-up approach from a single glucosamine precursor. The sensor platform is comprised of slightly positively charged (1.14 ± 0.36 mV) NGQDs bound via π-π stacking and/or electrostatic interactions to the negatively charged (-22.4 ± 6.00 mV) bait ssDNA; together, they form a …

Life And Precarity In The Border Zone Of War: Insights From Ramtha, Jordan, Yazan Doughan

Emancipations: A Journal of Critical Social Analysis

No abstract provided.

Six Ways To Misunderstand Precarity: Reflections On Social Angst And Its Political Offspring, Albena Azmanova

Emancipations: A Journal of Critical Social Analysis

These reflections develop a comprehensive conceptualization of precarity as a condition of politically and systemically generated economic and social vulnerability caused by insecurity of livelihoods – a form of disempowerment, experienced as incapacity to cope, itself rooted in a misalignment between responsibility and power. Precarity, thus understood, is a transversal social injustice cutting across differences in social class, education, employment, and income. It harms people’s material and psychological welfare and hampers society’s capacity to manage adversity and govern itself.

The article elaborates on the above conceptualization by addressing six fallacies in debates on precarity:

1: “There is nothing particularly new …

Obesity As A Risk Factor For Covid-19, Gabriela Hermes, Mir Saleem

Mako: NSU Undergraduate Student Journal

The coronavirus pandemic has presented a wide range of challenges for healthcare systems in the world. COVID-19 has infected millions of people, with approximately 90% of the population showing mild or no symptoms. The disease has some risk factors that increase its severity, such as obesity, age, diabetes, cardiovascular diseases, suppressed immune system, and pulmonary disorders. Obese individuals have higher chances of having symptomatic COVID-19 infection with excessive rates of hospitalization and ICU admission. Understanding the mechanisms defining the link between COVID-19 and obesity is necessary to develop preventive measures and therapeutic interventions for people with obesity. Patients with obesity …

Medical School Watercooler Newsletter - August 19, 2022, Lindsey Lyle

Watercooler Newsletter

This is the August 19, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• New students begin Basic Medical Sciences Graduate Program
• Whiddon College of Medicine announces leadership changes in Department of Internal Medicine
• Cooper recognized for top academic performance in doctoral program
• Meet a Ph.D. Student: Christian Macarilla

2022-2023 Operating Budget, Southern University And A & M College. Office Of Finance & Administration.

All Southern University System Budgets

2022-2023 Operating Budget of Southern University, Baton Rouge Campus.

The Transcriptional Regulator Ctra Controls Gene Expression In Alphaproteobacteria Phages: Evidence For A Lytic Deferment Pathway, Elia Mascolo, Satish Adhikari, Steven M. Caruso, Tagide Decarvalho, Anna Folch Salvador, Joan Serra-Sagristà, Ry Young, Ivan Erill, Patrick D. Curtis

Faculty and Student Publications

Pilitropic and flagellotropic phages adsorb to bacterial pili and flagella. These phages have long been used to investigate multiple aspects of bacterial physiology, such as the cell cycle control in the Caulobacterales. Targeting cellular appendages for adsorption effectively constrains the population of infectable hosts, suggesting that phages may have developed strategies to maximize their infective yield. Brevundimonas phage vB_BsubS-Delta is a recently characterized pilitropic phage infecting the Alphaproteobacterium Brevundimonas subvibrioides. Like other Caulobacterales, B. subvibrioides divides asymmetrically and its cell cycle is governed by multiple transcriptional regulators, including the master regulator CtrA. Genomic characterization of phage vB_BsubS-Delta identified the presence …

Jcctl Mailer - August 19, 2022, Josef Brandauer

JCCTL Mailers

Updates on training and support and useful pedagogical resources compiled and sent by the JCCTL on August 19, 2022.

Contents:

Upcoming Events:

• Strategies for an Effective First Day of Class

Resource Guides:

• Practical Ideas for Creating Effective Syllabi (attached)
• Setting Up Your Moodle Gradebook (attached)

Newsletter Spring/Summer 2022, Annette Kluck, Margaret Savoie, Ethan Booker

Newsletters of the Graduate School

No abstract provided.

Self-Enhancement And The Medial Prefrontal Cortex: The Convergence Of Clinical And Experimental Findings, Saeed Yasin, Anjel Fierst, Harper Keenan, Amelia Knapp, Katrina Gallione, Tessa Westlund, Sydney Kirschner, Sahana Vaidya, Christina Qiu, Audrey Rougebec, Elodie Morss, Jack Lebiedzinski, Maya Dejean, Julian Paul Keenan

Department of Biology Faculty Scholarship and Creative Works

Self-enhancement (SE) is often overlooked as a fundamental cognitive ability mediated via the Prefrontal Cortex (PFC). Here, we present research that establishes the relationship between the PFC, SE, and the potential evolved beneficial mechanisms. Specifically, we believe there is now enough evidence to speculate that SE exists to provide significant benefits and should be considered a normal aspect of the self. Whatever the metabolic or social cost, the upside of SE is great enough that it is a core and fundamental psychological construct. Furthermore, though entirely theoretical, we suggest that a critical reason the PFC has evolved so significantly in …

Genome Architecture And Diverged Selection Shaping Pattern Of Genomic Differentiation In Wild Barley, Wenying Zhang, Cong Tan, Haifei Hu, Rui Pan, Yuhui Xiao, Kai Ouyang, Yong Jia, Xiao-Qi Zhang, Camilla Hill, Penghao Wang, Brett Chapman, Yong Han, Gaofeng Zhou, Le Xu, Yanhao Xu, Tefera Angessa, Hao Luo, Sharon Westcott, Darshan Sharma, Eviatar Nevo, Roberto Barrero, Matthew I. Bellgard, Tianhua He, Xiaohai Tian, Chengdao Li

Grain and Other Field Crops Research Articles

Divergent selection of populations in contrasting environments leads to functional genomic divergence. However, the genomic architecture underlying heterogeneous genomic differentiation remains poorly understood. Here, we de novo assembled two high-quality wild barley (Hordeum spontaneum K. Koch) genomes and examined genomic differentiation and gene expression patterns under abiotic stress in two populations. These two populations had a shared ancestry and originated in close geographic proximity but experienced different selective pressures due to their contrasting micro-environments. We identified structural variants that may have played significant roles in affecting genes potentially associated with well-differentiated phenotypes such as flowering time and drought response between …