Digital Commons Network^™

Nadh Flim Reveals Cellular Bioenergetics And Mitochondrial Morphology During Drosophila Convergent Extension, Maria Espana Pena

Graduate Theses and Dissertations

Mitochondria are dynamic organelles that can fragment or fuse to support different bioenergetic demands and cellular processes, although the role of mitochondrial fission and fusion during embryonic development is not well understood. Fluorescence lifetime imaging (FLIM) of the mitochondrial cofactor NADH can be used to visualize mitochondrial networks and infer aspects of cellular bioenergetics in a label-free manner. We used NADH FLIM to test whether germband cells undergo changes in cellular metabolism during Drosophila convergent extension (CE)––a process in which hundreds of epithelial cells undergo coordinated intercalation to elongate the embryo. Contrary to our expectations, we did not observe significant …

Mind The Gap: Exploring Sociocultural And Educational Factors Contributing To The Gender-Based Achievement Gap In Early Elementary Ela, William Matthew Mcgee

Graduate Theses and Dissertations

This study examined the sociocultural and educational factors contributing to the gender-based achievement gap in early elementary English Language Arts (ELA). While research has examined the gender-based achievement gap related to female-identifying students in STEM disciplines, there is less emphasis on the underperformance of male-identifying students in ELA. Earlier research often emphasized biological explanations rather than the influence of environment and instructional practices. This study was guided by the Expectancy-Value Theory and Social Role Theory to better understand how home environments, gender norms, instructional practices, and student perception of literacy influence student engagement and performance in Kindergarten through third grade. …

From Phenology To Yield Zones: Functional Clustering Of Satellite Time Series For Crop Growth Monitoring, Ikram Morso

Graduate Theses and Dissertations

Remote sensing and land surface phenology provide a strong basis for characterizing crop development, but their usefulness for within-field yield-zone delineation depends on whether crop development is analyzed as a phenological trajectory and whether the resulting zones are evaluated with spatially defensible statistics. These questions are especially relevant in soybean production because soybean is one of the most important row crops in the United States and the country’s dominant oilseed crop. This relevance is strong in Arkansas, where soybean is a major component of agricultural production. In soybean production, within-field yield variability reflects the combined influence of soil properties, stand …

Lumbopelvic Kinematics And Muscular Co-Contractions In Walking Prior To And Immediately Following A Bout Of Prolonged Standing., Stephanie Cotariu

Graduate Theses and Dissertations

Background: Prolonged standing is a common daily activity in a wide array of occupations, and approximately 44% of sample populations develop low back pain (LBP) during prolonged standing. Prolonged standing-induced LBP developers (“Pain Developers”) are three times more likely to develop clinical LBP and can therefore be considered a pre-clinical LBP population. Changes in typical gait have been observed in LBP patients, and walking has been hypothesized as being protective or preventive against LBP development. However, it is unknown whether Pain Developers exhibit similar kinematic adaptations to chronic LBP patients during common daily activities, such as walking. The exact muscular …

Effects Of Wetting And Drying On Nutrient Mobilization In Aquatic Systems, Karessa Grace De La Paz

Graduate Theses and Dissertations

Wetting and drying cycles are a fundamental, but underexplored, control on nutrient mobilization and transport in aquatic ecosystems. Such intermittency impacts approximately 60% of the world's streams and rivers, and the extent is expected to increase with future climate change. Additionally, aging reservoir infrastructure is driving restoration efforts, like large-scale drawdowns, that can expose benthic sediments to extended dry periods before refilling. Despite the prevalence of wet-dry cycles, how they influence nutrient transport and mobilization across different aquatic ecosystems remains poorly understood. To address this gap, this thesis presents two complementary studies exploring nutrient dynamics in Arkansas aquatic ecosystems that …

A Rare Case Of Gastric Ascariasis, Sharon Pan, Kevin Yu, Blaine A Mathison, Yan Gao, Marc Roger Couturier, Salem Muayad, Violeta Chávez, Ranya Selim

Faculty, Staff and Student Publications

Background: Ascariasis, caused by the parasitic roundworm Ascaris lumbricoides, is one of the most common helminthic infections globally. Spread by contaminated soil through the fecal-oral route, A. lumbricoides typically infects the small intestine and has rarely been reported to infect the stomach.

Case summary: We describe an unusual case of a male in his 30s with a history of neuroendocrine tumor (NET) who immigrated from Colombia and who underwent esophagogastroduodenoscopy (EGD) and colonoscopy for further evaluation of abdominal pain. He was incidentally found to have a female Ascaris worm in his stomach that was retrieved during the EGD.

Conclusion: …

Porous Hydrophobic Adsorbent Coatings For Carbon Dioxide Capture, Samuel Babatunde Olushola

Theses and Dissertations

This work presents the development of a porous, hydrophobic zeolite 13X coating for the separation of carbon dioxide (CO₂) from flue gas or natural gas. Zeolite 13X was combined with yeast, glucose, and sodium alginate as pore-forming agents, and with polytetrafluoroethylene (PTFE) and Polydimethylsiloxane (PDMS) as hydrophobicity-inducing agents to enhance water resistance while maintaining CO₂ access to the adsorbent. The study explored PTFE/13X mass ratios ranging from 0 to 2.33 to investigate the interplay between hydrophobicity and CO₂ uptake. The wettability of the coating was characterized by using a temporal water contact angle (WCA) measurement. Increasing …

Too Cruel For School: How Parental Rights Doctrine Can Help Protect Against Book Bans, Tessa K. Wild

William & Mary Law Review

This Note argues that parents’ rights protections are crucial to protecting against broad censorship in public schools, and that if states want to effectively regulate book removals, they should preemptively adopt laws similar to Minnesota’s section 134.51.

[...]

Part I of this Note will provide background information about book removals as a freedom of speech issue, as well as a history of how parents’ rights rhetoric is tied to book-removal issues. Part II will address both the history and legal standards of parents’ rights protections. Finally, Part III, using Minnesota and Utah as case studies, will apply parents’ rights law …

Research "Junkification" Is Caused By Researchers, Not Journals, Simon Sebastian Groome, Jose C. Yong, Norman P. Li

Research Collection School of Social Sciences

Concerns about declining research quality have increasingly been framed as “junkification,” whereby academic output expands in volume while declining in epistemic value. A recent paper by Rhodes and Linnenluecke (2025) attributes this trend to changes in publishing, arguing that research quality erodes as journals and publishers become increasingly oriented toward output quantity and metrics, driven by monetization. In 2009, Nobel Laureate James Watson remarked that scientific publishing in the mid-twentieth century was both easier and of a higher standard than today (Web of Stories, 2017). If publishing is much easier of late, as Rhodes and Linnenelucke (R&L) argued, then how …

Adoption And The Illusion Of Choice After Dobbs V. Jackson Women’S Health, Solangel Maldonado

Cardozo Law Review

Thalia, a twenty-eight-year-old mother of two, has struggled with a substance use disorder for several years. Her children, ages five and seven, are in foster care. Thalia was homeless when she learned that she was fourteen weeks pregnant. She wanted to have an abortion, but her state banned abortions after the Supreme Court’s decision in Dobbs v. Jackson Women’s Health Organization. The closest abortion care provider in a neighboring state was 400 miles away, and a medical (non-surgical) abortion was no longer an option.

Unable to access abortion care, Thalia was forced to carry the pregnancy to term. Her …

The Rhythm Of Reform, Michael Waldman

Cardozo Law Review

This year, we celebrate the 250th anniversary of our independence. In January 1776, Thomas Paine published Common Sense. Paine was an immigrant who had arrived only two years before. The pamphlet went viral, a widely bootlegged bestseller with 120,000 copies sold in its first three months in print. It galvanized support for independence and argued that the collection of colonies should become a republic. Paine wrote: “[I]n America THE LAW IS KING.”

Is that still true? We are finding out.

Today our Constitution and the institutions of self-government face extraordinary pressure. In the first two months of 2026 alone, …

Bridging The Urban Moat In Downtown Fargo: Downtown Riverfront Reconnection, Haitham Al Nemri

Architecture Theses

Downtown Fargo is the city's cultural and economic hub, but it is currently constrained by a lack of riverfront activation and an outdated limited variety of building typologies and uses along the eastern downtown edge. The main issue is the lack of a clear physical connection bridging the infrastructure that cuts the civic core off from the Red River. This thesis tackles this problem by proposing a "Reconnection Framework" that combines reusing existing infrastructure, adapting to the harsh "Winter City" climate, and adding mid-scale residential housing, to expand housing options in Fargo downtown. The design proposal transforms the downtown riverfront, …

Cold Climate Urban Riverfront Development: Using People-First Design To Connect Fargo's Downtown To The River, Jade Biewer

Architecture Theses

This thesis examines the intersection of urban design, riverfront development, and cold climate design to establish a framework for a mixed-use riverfront project in Fargo’s Downtown. By synthesizing theories on public space revitalization, key considerations in waterfront development and research on climatic responses for cold weather cities, this research identifies key principles to support year-round urban life along the riverfront. By using downtown Fargo and the Red River as a reference this research synthesizes knowledge on these subjects in order to work towards creating a design proposal for an urban riverfront development prioritizing outdoor space, year-round use, resiliency, and a …

Adaptive Reuse At The Hmongtown Marketplace: Using Food As An Agent For Gathering Through A Closed-Loop Circular Food System, Sulia Sheng Lee

Architecture Theses

This thesis explores the built environment through social and architectural lenses: examining how food connects communities, particularly ethnic and diasporic groups like the Hmong, and how adaptive interventions can create spaces that foster closed-loop food systems.

Research into the Hmong diasporic journey has shown that growing, making, and sharing food has been a central aspect to the community. The Hmong community's food assimilation in the United States has replaced traditional agrarian lifestyles with reliance on local American grocery stores. These stores operate within linear "take, make, use, waste" systems that disconnect consumers from food origins. However, spaces like the HmongTown …

Erasing Boundaries: Strategies For Universities And Cities In Developing Integrated Planning, Jack Quinn

Architecture Theses

The population of the Fargo-Moorhead area is steadily growing per year, however since 2010 both Concordia and Minnesota State University Moorhead have seen a steady decrease in students. Factors such as President Trump’s immigration policies, lower birth rates, and high school students who are doubting the value of a college education has set the stage for a difficult future for universities in the United States of America. This thesis will explore Town-Gown relations, studentification, and the strategies behind the best designed campuses in America. It will explore the relationship between neighboring schools, P3 developments, dive into what the Metro college …

Architecture Of Healing Beyond The Institution: A New Model For Veteran Care, Megan Lyn Welk

Architecture Theses

The transition from military to civilian life presents unique challenges for veterans navigating trauma, yet traditional clinical settings often aggravate anxiety and disconnection through sterile, institutional design. This thesis addresses the critical “mismatch” between current healthcare environments and the neurological needs of veterans suffering from Post-Traumatic Stress Disorder (PTSD) and Traumatic Brain Injury (TBI). Arguing that architecture must evolve from a passive vessel to an active therapeutic partner, this research proposes a comprehensive rehabilitation center located on O’ahu, Hawai’i, which integrates the island’s profound cultural connection to the ‘aina (land) with evidence-based design strategies.

The design methodology synthesizes three core …

Climate-Adaptive Urban Arboretum: Designing Tree Diversity And Landscape Resilience Against Climate-Related Tree Diseases In Fargo, North Dakota, Rojin Ghafori Dehgolan

Landscape Architecture Theses

This thesis explores how climate change may influence the severity of Oak Wilt Disease and Dutch Elm Disease in Fargo, North Dakota, and how landscape design can respond to future urban forest health challenges. Urban trees are essential components of green landscapes because they provide shade, aesthetic value, ecological benefits, and social comfort. However, climate change is altering environmental conditions such as temperature, precipitation, soil moisture, humidity, drought, and flooding, all of which can influence plant disease development. This research focuses on two major tree diseases: Oak Wilt Disease, caused by Bretziella fagacearum, and Dutch Elm Disease, caused by …

Living Shorelines: A Regenerative Landscape Approach To Coastal Protection And Community Resilience In Bhasan Char, Bangladesh, Anamul Hoque Mojumder

Landscape Architecture Theses

Bhasan Char is a newly formed, unstable silt island in Bangladesh which is home for more than one million Rohingya refugees—an ethnic Muslim minority from Myanmar who have fled decades of systematic persecution and violence—suffering from an ecological and humanitarian crisis. This community faces extreme vulnerability from cyclones and sea-level rise on a landscape of profound precarity.

Traditional hard-engineered defenses are costly, ecologically damaging, and ineffective against the island’s dynamic geomorphology. This research proposes a regenerative "Living Shorelines" model, intersecting coastal resilience with refugee empowerment through Blue-Green Infrastructure. Drawing on successful global precedents in Vietnam and the USA, the study …

Gardens In The Sky: Rooftop Landscaping Design In The Chicago Downtown Environment, Noah Olson

Landscape Architecture Theses

Cities around the world are becoming increasingly more susceptible to heat, largely due to the urban heat island effect (UHI). Green roofs, which essentially turn building tops into planted gardens, can be an effective and creative way for landscape architects to combat these problems. This thesis will use a literature review of peer-reviewed studies to examine green roof materials, designs, and performance in reducing UHI impacts and stormwater runoff. Findings show surface temperature reductions of 20-30°C, air cooling of 1-2°C, and 17-51% runoff retention. These results have been applied to redesign three terraces at the St. Regis Chicago: the 11th-floor …

Border Patches: Reconnecting Ecology And Human Experiences At The U.S.-Mexico Border, Shima Goodarzi

Landscape Architecture Theses

International borders are among the most engineered and ecologically fragmented landscapes in the world. Along the U.S.-Mexico border, infrastructure systems such as walls, patrol roads, and cleared enforcement zones have disrupted wildlife movement, fragmented habitats, altered hydrological systems, and limited social interaction between neighboring communities.

This thesis develops a digital environmental twin framework to evaluate ecological and social connectivity within the San Diego-Tijuana border region. Using ArcGIS Pro and ArcGIS Urban, spatial datasets including land cover, habitat suitability, hydrology, circulation networks, and urban density were analyzed to identify areas with high ecological potential and opportunities for intervention.

The research informed …

Birds, Bees, + Butterflies: Restoring Suburban Wildlife Homes And Habitats In Bismarck, Nd, Elena Joubert

Landscape Architecture Theses

For centuries humanity has been expanding its borders, stretching in and across a wide range of ecosystems, optimizing the land for human use and habitation. Animal-aided design is a possible solution to the loss of habitats; a new methodology of designing green spaces for the use of specific native species. Green spaces are vital to the mental and physical well-being of people, and the presence of native species such as songbirds or butterflies can further increase those benefits. Only 4.2% of North Dakota is developed land, referring to urban and industrial usage, but within these spaces are opportunities to conserve …

Accentuating Wetlands: Designing Restorative Wetlands To Clean The Red River Of The North Near Selkirk, Manitoba, Grace Stein

Landscape Architecture Theses

Research was conducted looking into how wetlands clean water with a focus on nutrient removal through plant uptake, sedimentation, and absorption. Additional research was done to determine the methods of constructing a wetland. This thesis focuses on improving water quality for the Red River of the North by intaking 720,000 gallons of water per day out of the river and treating it for different agricultural runoff pollutants. This is achieved by using a series of constructed wetlands, each designed to remove a specific nutrient from the water. After nutrients have been removed, the water will be pumped back into the …

Forging Resiliency: Designing For Wildfire Defenses In The Pyrocene Age In Paradise, California, Rebecca Anne Heide

Landscape Architecture Theses

Wildfires are becoming larger, hotter, and more destructive. California has been strongly impacted by large-scale wildfire disasters, with a number of fires in recent history resulting in significant loss of life and infrastructure. The Camp Fire, which destroyed over 85% of the town of Paradise, California in 2018, is one such event. Landscape architecture is a discipline uniquely positioned to address wildfire disaster resilience. This project uses case studies and ArcGIS data to reimagine a 1,600-acre site directly East of the town of Paradise, California. By using a multi-layered wildfire management strategy that uses the principles of resist, co-create, and …

Manned Exploration Of Satellites Of The Outer Planets: An Analysis Of Current Technologies And A Discussion Of Advancements Required, Joshua Carson Meador

Theses and Dissertations

The Solar System’s outer planets have many satellites, some of which are known to be the most likely places to find extraterrestrial life in our celestial backyard. Multiple scientific missions have been sent to glean information from these satellites, yet the possibility of a manned expedition has long been exclusive to science fiction stories. This paper intends to collect and analyze the current state of space travel technology to explore the feasibility of such a mission with modern technology and to discuss which future advancements should be the focal point for making such missions a reality. To begin, data on …

Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante

Theses and Dissertations

This thesis presents the design and simulation of an 8-tube single-ring anti-resonant hollow-core fiber for sensing applications, with particular emphasis on methane gas detection at the fundamental absorption wavelength of 3.3 µm. Conventional solid-core silica optical fibers exhibit strong multi-phonon material absorption beyond 2.5 µm, rendering them fundamentally unsuitable for efficient light guidance and direct gas sensing at mid-infrared wavelengths. Anti-resonant hollow-core fibers overcome this limitation by guiding light predominantly through an air-filled hollow core via the anti-resonant reflecting optical waveguide mechanism, in which the thin silica glass walls of the cladding tubes act as Fabry-Pérot etalons that confine the …

Soil Property Responses To Push-Pull Cropping In East Africa, Grace Mercy Amboka, Mattias Jonsson, Celina Apel, David Meinhof, Adomas Liepa, Frank Chidawanyika, Andargachew Detebo, Felipe Librán-Embid, Emily A. Martin, Ingolf Steffan-Dewenter, Marcell K. Peters, Jie Zhang, Michael Thiel, Michael Otim, James Mugisha, Ghebremedhin Belay Bahta, Fredah Maina, Alice Murage, Benjamin Feit, A. Sigrun Dahlin

All Peer-Reviewed Publications

Push-pull technology is increasingly promoted in sub-Saharan Africa, particularly for pest management and enhancing crop productivity. However, its influence on soil properties remains understudied, despite its potential implications for soil health and sustainable soil fertility management. This study examines soil properties in push-pull and conventional non-push-pull cropping systems. Soil samples were collected from push-pull and conventional plots in Ethiopia, Kenya, Rwanda, and Uganda. We examined the associations between soil physicochemical properties and cropping systems, along with key components of push-pull, namely Desmodium coverage and plot age, and manure and mineral fertiliser application. Overall, there were a few differences in soil …

High-Penetrance Rare Variants Underlying Familial Lung Cancer Risk: Insights From Genetic Epidemiology Of Lung Cancer Consortium, Yanhong Liu, Yafang Li, Jinyoung Byun, Vikram R Shaw, Claudio Pikielny, Bo Peng, Chao Cheng, Spiridon Tsavachidis, Xiangjun Xiao, Dakai Zhu, Younghun Han, Ivan P Gorlov, Olga Y Gorlova, Michael Cole, Colette R Gaba, Erin L Crawford, Kristen Purrington, Ellen L Goode, Ping Yang, James Mckay, John K Field, Geoffrey Liu, Rayjean J Hung, Jun Xia, Jiyeon Choi, Matthew B Schabath, Jaclyn Lopiccolo, David C Christiani, Joan Bailey-Wilson, Ann G Schwartz, James C Willey, Diptasri Mandal, Susan M Pinney, Christopher I Amos

Faculty, Staff and Students Publications

Introduction: Rare, deleterious germline variants are key contributors to inherited lung cancer (LC) risk. The Genetic Epidemiology of LC Consortium (GELCC) has curated valuable high-risk LC families and is uniquely positioned to uncover rare, high-penetrance variants underlying familial LC (FLC).

Methods: We performed whole-genome and exome sequencing on germline DNA from 120 high-risk LC families (177 FLC cases, 309 unaffected relatives). We prioritized rare (allele frequency < 1% in the genome aggregation database), potentially deleterious variants present in two or more FLC cases. These variants were then validated in 10,085 sporadic LC (SLC) cases and 612,970 controls.

Results: We identified 118 candidate variants, 28 of which were validated in SLC with strong statistical support. We discovered a novel pathogenic axis of three truncating variants in GALNT6, MUC4, and ERBB3 genes, which …

Phenotypic Diversity And Outcomes In Pediatric Nmda Receptor Encephalitis: A 15-Year Retrospective Study From The Largest Children's Hospital In The United States, Alexander J Sandweiss, Timothy Erickson, Yike Jiang, Varun Kannan, Jonathan M Yarimi, Kristen S Fisher, Nikita Shukla, Tim Lotze, Eyal Muscal, Kristy O Murray

Faculty, Staff and Students Publications

Anti‐NMDAR encephalitis (NMDARE) is an autoantibody‐mediated disorder characterized by seizures, movement disorders, neurocognitive deficits, and psychosis, but the complete phenotypic heterogeneity, and outcomes are incompletely understood in children. This single‐center retrospective analysis of NMDARE at the largest pediatric hospital in the United States between 2009 and 2024 screened 115 patients diagnosed with NMDARE. 103 had sufficient clinical data available for analyses. Two‐thirds were Hispanic, disproportionate to the Houston metro area demographics, and Hispanic patients had a higher CSF white cell count and antibody titer. Approximately one‐half of the patients with idiopathic NMDARE presented with a focal cortical phenotype that localized …

Interplay Between Genetic Ancestry, Self-Reported Race And Ethnicity, And Clinical Factors In Pediatric Acute Lymphoblastic Leukemia: A Redial Consortium Report, Pragati Kore, Jennifer M Geris, Maria Leon-Camarena, Maria I Castellanos, Olga A Taylor, Veronica Garcia-Morales, Austin L Brown, Pagna Sok, Jeremy M Schraw, Van Huynh, Kathleen F Ludwig, Laura J Klesse, Sandi L Pruitt, Amy E Hughes, Kevin Tien, Kenneth M Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Maria M Gramatges, Elizabeth G Atkinson, Philip J Lupo, Michael E Scheurer, Karen R Rabin

Faculty, Staff and Students Publications

Background: Pediatric acute lymphoblastic leukemia (ALL) is the most common cancer in children, and its incidence and outcomes vary by race and ethnicity.

Methods: The Reducing Ethnic Disparities in Acute Leukemia (REDIAL) Consortium has assembled a cohort of patients < 25 years at diagnosis to examine genetic and neighborhood-level factors influencing ALL. As the cohort is ongoing, for this report, we examined sociodemographic and cytogenetic factors that might be associated with ALL outcome disparities.

Results: Among 2,512 patients diagnosed between 2005 and 2020, we observed distinct patterns of genetic ancestry and residential characteristics across self-reported race and ethnicity. Latino children, who comprised 55.3% of the cohort, had a mean Amerindigenous ancestry proportion of 50.9%, whereas non-Latino White children exhibited a predominantly European ancestry (mean = 78%). Neighborhood-level analysis revealed significant socioeconomic and geographic differences by …

Dolutegravir Developmental Toxicity Is Mitigated By Magnesium And Folate In Zebrafish Embryos, Robert M Cabrera, Ahmed Mohamed, Ryoko Minowa, Katheryn A Neugebauer, Daniel A Gorelick

Faculty, Staff and Students Publications

Integrase strand transfer inhibitors have transformed human immunodeficiency virus (HIV) therapy, yet the widely prescribed drug dolutegravir (DTG) has been linked to developmental toxicity, and its teratogenic mechanism remains unclear. Here, we used zebrafish to dissect DTG toxicity during early vertebrate development. DTG exposure from 2-4 h post-fertilization (hpf) to 24 hpf produced high mortality and abnormal morphology. Co-treatment with folates partially restored normal morphology, whereas calcium had no effect. Strikingly, supplementation with magnesium (Mg) partially rescued DTG-exposed embryos, implicating Mg availability in protection. In competitive binding assays, Mg increased binding of folate to purified folate receptor (FOLR1) by 30% …