Digital Commons Network^™

Novel Dominant And Recessive Variants In Human Robo1 Cause Distinct Neurodevelopmental Defects Through Different Mechanisms, Yan Huang, Mengqi Ma, Xiao Mao, Davut Pehlivan, Oguz Kanca, Feride Un-Candan, Li Shu, Gulsen Akay, Tadahiro Mitani, Shenzhao Lu, Sukru Candan, Hua Wang, Bo Xiao, James R Lupski, Hugo J Bellen

Duncan NRI Faculty and Staff Publications

The Roundabout (Robo) receptors, located on growth cones of neurons, induce axon repulsion in response to the extracellular ligand Slit. The Robo family of proteins controls midline crossing of commissural neurons during development in flies. Mono- and bi-allelic variants in human ROBO1 (HGNC: 10249) have been associated with incomplete penetrance and variable expressivity for a breath of phenotypes, including neurodevelopmental defects such as strabismus, pituitary defects, intellectual impairment, as well as defects in heart and kidney. Here, we report two novel ROBO1 variants associated with very distinct phenotypes. A homozygous missense p.S1522L variant in three affected siblings with nystagmus; and …

Genome-Wide Interaction Analysis Identified Low-Frequency Variants With Sex Disparity In Lung Cancer Risk, Yafang Li, Xiangjun Xiao, Jianrong Li, Jinyoung Byun, Chao Cheng, Yohan Bossé, James Mckay, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E Bojesen, Maria T Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John K Field, Michael P A Davies, Sanjay S Shete, Loic Le Marchand, Olle Melander, Hans Brunnström, Geoffrey Liu, Rayjean J Hung, Angeline S Andrew, Lambertus A Kiemeney, Hongbing Shen, Ryan Sun, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Dawn M Teare, Yun-Chul Hong, Philip Lazarus, Matthew B Schabath, Melinda C Aldrich, Ann G Schwartz, Ivan Gorlov, Kristen Purrington, Ping Yang, Yanhong Liu, Younghun Han, Joan E Bailey-Wilson, Susan M Pinney, Diptasri Mandal, James C Willey, Colette Gaba, Paul Brennan, Christopher I Amos, Integral-Ilcco Lung Cancer Consortium

Faculty, Staff and Students Publications

Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adopting a stringent two-stage analysis strategy, we performed a genome-wide gene-sex interaction analysis using genotypes from a lung cancer cohort including ~ 47 000 individuals with European ancestry. Three low-frequency variants (minor allele frequency < 0.05), rs17662871 [odds ratio (OR) = 0.71, P = 4.29×10-8); rs79942605 (OR = 2.17, P = 2.81×10-8) and rs208908 (OR = 0.70, P = 4.54×10-8) were identified with different risk effect of lung cancer between men and women. Further expression quantitative trait loci and functional annotation analysis suggested rs208908 affects lung cancer risk through differential regulation of Coxsackie virus and adenovirus receptor gene expression in lung tissues between men and women. Our study is one of the first studies to provide novel insights about the genetic and molecular basis for sex disparity in lung cancer development.

Layer-Specific Developmentally Precise Axon Targeting Of Transient Suppressed-By-Contrast Retinal Ganglion Cells (Tsbc Rgcs), Nai-Wen Tien, Carmela Vitale, Tudor C Badea, Daniel Kerschensteiner

2020-Current year OA Pubs

The mouse retina encodes diverse visual features in the spike trains of >40 retinal ganglion cell (RGC) types. Each RGC type innervates a specific subset of the >50 retinorecipient brain areas. Our catalog of RGC types and feature representations is nearing completion. Yet, we know little about where specific RGC types send their information. Furthermore, the developmental strategies by which RGC axons choose their targets and pattern their terminal arbors remain obscure. Here, we identify a genetic intersection (

C10pred: A First Machine Learning Based Tool To Predict C10 Family Cysteine Peptidases Using Sequence-Derived Features, Adeel Malik, Nitin Mahajan, Tanveer Ali Dar, Chang-Bae Kim

2020-Current year OA Pubs

No abstract provided.

Back To The Future The Spatial Dimension Of Water Management, Kees Lokman

IntAR Interventions Adaptive Reuse

No abstract provided.

Clavibacter Nebraskensis Causing Goss's Wilt Of Maize: Five Decades Of Detaining The Enemy In The New World, Ebrahim Osdaghi, Alison E. Robertson, Tamra Jackson-Ziems, Hamid Abachi, Xiang Li, Robert M. Harveson

Department of Plant Pathology: Faculty Publications

Goss's bacterial wilt and leaf blight of maize (Zea mays) caused by the gram-positive coryneform bacterium Clavibacter nebraskensis is an economically important disease in North America. C. nebraskensis is included within the high-risk list of quarantine pathogens by several plant protection organizations (EPPO code: CORBMI), hence it is under strict quarantine control around the world. The causal agent was reported for the first time on maize in Nebraska (USA) in 1969. After an outbreak during the 1970s, prevalence of the disease decreased in the 1980s to the early 2000s, before the disease resurged causing a serious threat to …

Henry Kissinger, Ragnar Redbeard, & The Implications Of American Morality., Austin Hart

The Mall

No abstract provided.

**Surveilling Potential Uses And Abuses Of Artificial Intelligence In Correctional Spaces**, Justin Iverson

Lincoln Memorial University Law Review Archive

No abstract provided.

**Risk-Taking Or Risk-Negotiating Model Of Vaccine Liability? Legal And Policy Considerations For Pandemic Vaccines**, Yu-Wei Chen

Lincoln Memorial University Law Review Archive

Vaccine liability determines vaccine availability. The allocation of vaccine liability is a determinant in reaching a procurement contract. Particularly during a pandemic, vaccine accelerated production poses new challenges to vaccine safety, quality, and efficacy. Solving the issue of vaccine liability is as equally important as vaccine equity in ensuring access to vaccines. For COVID-19 vaccine procurements, there are two discernible models of liability allocation around the globe: the United States risk-taking model and the European Union risk-negotiating model. The United States' risk-taking model shows that vaccine liability is borne by the government; in contrast, the European Union's risk-negotiating model shows …

**A Way Out For Europe: How Can Europe Combat Discrimination By Automated Decision-Making Systems?**, Elvin E. Dalkılıç

Lincoln Memorial University Law Review Archive

No abstract provided.

**The Internet-Of-Bodies/Human Mind Unification: Its Threat To Democracy And The Need For A Legal Response**, Zachary Atchley

Lincoln Memorial University Law Review Archive

No abstract provided.

Novel Designer Benzodiazepines: Comprehensive Review Of Evolving Clinical And Adverse Effects., Amber N. Edinoff, Catherine A. Nix, Amira S. Odisho, Caroline P. Babin, Alyssa G. Derouen, Salim C. Lutfallah, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan David Kaye

School of Pharmacy Faculty Articles

As tranquilizers, benzodiazepines have a wide range of clinical uses. Recently, there has been a significant rise in the number of novel psychoactive substances, including designer benzodiazepines. Flubromazolam(8-bromo-6-(2-fluorophenyl)-1-methyl-4

Microplastics: Water And Oyster Data For The Indian River Lagoon, Linda Walters, Casey Craig

CEELAB Research Data

Microplastic (MP) abundances in surface waters and tissues of the oyster Crassostrea virginica were examined for one year in the Indian River Lagoon (IRL), a 251-km long estuary on the east coast of central FL, USA to better understand spatial and temporal variability. A total of 3755 MP were found in 44% of lagoon-wide water samples. Mean density (± CI) was 1.47 ± 0.09 MP/L. Central IRL sites had the lowest MP abundance, while the south had the most, likely associated with proximity to urbanization, inlets (MP sinks) and tributaries (MP sources). More MP were found in water …

Whole Genome Association Study Of The Plasma Metabolome Identifies Metabolites Linked To Cardiometabolic Disease In Black Individuals, Usman A. Tahir, Daniel H. Katz, Julian Avila-Pachecho, Alexander G. Bick, Akhil Pampana, Jeremy M. Robbins, Zhi Yu, Zsu-Zsu Chen, Mark D. Benson, Daniel E. Cruz, Debby Ngo, Shuliang Deng, Xu Shi, Shuning Zheng, Aaron S. Eisman, Laurie Farrell, Michael E. Hall, Adolfo Correa, Russell P. Tracy, Peter Durda, Mark A. Sarzynski Ph.D., Faha, Facsm, Et. Al.

Faculty Publications

Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known metabolites, with the majority of the profiled peaks left unannotated. Here, we perform a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study. We identify 519 locus-metabolite associations for 427 metabolite peaks and validate our findings in two multi-ethnic cohorts. A significant proportion of these …

Mekki Awarded Scholarship From The American Chemical Society, Brianna Hoge

Browse All News

No abstract provided.

Clavibacter Nebraskensis Causing Goss's Wilt Of Maize: Five Decades Of Detaining The Enemy In The New World, Ebrahim Osdaghi, Alison E. Robertson, Tamra Jackson-Ziems, Hamid Abachi, Xiang Li, Robert M. Harveson

Department of Plant Pathology: Faculty Publications

Goss's bacterial wilt and leaf blight of maize (Zea mays) caused by the gram-positive coryneform bacterium Clavibacter nebraskensis is an economically important disease in North America. C. nebraskensis is included within the high-risk list of quarantine pathogens by several plant protection organizations (EPPO code: CORBMI), hence it is under strict quarantine control around the world. The causal agent was reported for the first time on maize in Nebraska (USA) in 1969. After an outbreak during the 1970s, prevalence of the disease decreased in the 1980s to the early 2000s, before the disease resurged causing a serious threat to …

Clavibacter Nebraskensis Causing Goss's Wilt Of Maize: Five Decades Of Detaining The Enemy In The New World, Ebrahim Osdaghi, Alison E. Robertson, Tamra A. Jackson-Ziems, Hamid Abachi, Xiang Li, Robert M. Harveson

Department of Plant Pathology: Faculty Publications

Goss's bacterial wilt and leaf blight of maize (Zea mays) caused by the gram-positive coryneform bacterium Clavibacter nebraskensis is an economically important disease in North America. C. nebraskensis is included within the high-risk list of quarantine pathogens by several plant protection organizations (EPPO code: CORBMI), hence it is under strict quarantine control around the world. The causal agent was reported for the first time on maize in Nebraska (USA) in 1969. After an outbreak during the 1970s, prevalence of the disease decreased in the 1980s to the early 2000s, before the disease resurged causing a serious threat to maize production …

Nup211 Plays An Important Role In Regulating Mrna Export And Stress Response, Ayana Ikenouchi

Theses and Dissertations

Nup211 is a nuclear pore basket component in Schizosaccharomyces pombe and roles in the gating functions of NPCs. Using RT-qPCR, I found that in nup211-shutoff cells, the transcript levels of genes in mRNA export and stress-response pathways were significantly changed, suggesting nup211 is involved in regulating stress response pathways.

Identification Of Lithocholic Acid As A Molecular Glass Host For Room-Temperature Phosphorescent Materials, John J. Flynn, Zachary M. Marsh, Douglas M. Krein, Steven M. Wolf, Joy E. Haley, Erick S. Vasquez, Thomas M. Cooper, Nicholas P. Godman, Tod A. Grusenmeyer

Chemical and Materials Engineering Faculty Publications

Lithocholic acid was identified as a molecular glass host material for room temperature phosphorescent (RTP) chromophores. Differential scanning calorimetry (DSC) was performed on a series of structurally similar, biologically sourced molecules, including lithocholic acid, β-estradiol, cholesterol, and β-sitosterol, in an effort to identify new amorphous molecular glasses independent of plasticizing additives. DSC analysis revealed lithocholic acid and β-estradiol form stable molecular glasses post thermal processing unlike neat cholesterol and β-sitosterol. The ability of lithocholic acid and β-estradiol to stabilize high wt. % loadings of d10-pyrene and a mixture of d10-pyrene and an iridium chromophore, bis(2,4-difluorophenylpyridinato)-tetrakis(1-pyrazolyl)borate iridium(III) (FIr6), was also investigated. …

Associations Of Rare Caddisflies With The Western Dwarf Salamander Eurycea Paludicola, Lillie Hawkins

Biology Theses

There is limited information on the three species of caddisflies Philopotamidae Chimarra holzenthali, Hydropsychidae Cheumatopsyche morsei, Hydroptilidae Hydroptila ouachita and the western dwarf salamander Eurycea paludicola. In particular, there is a lack of any habitat associations between these caddisflies and the western dwarf salamander. Museum specimens of the caddisflies are scarce; however, the literature suggests they are spring dwelling like the western dwarf salamander. The goal of this project was to sample previously known and new habitats where these organisms might be found and report overall quality of the habitats and whether the caddisflies were associated with …

Snapping Shrimp Have Helmets That Protect Their Brains By Dampening Shock Waves, Alexandra C.N. Kingston, Sarah A. Woodin, David S. Wethey, Daniel Isaac Speiser

Faculty Publications

Shock waves are supersonic high-amplitude pressure waves that cause barotrauma when they transfer kinetic energy to the tissues of animals.1, 2, 3, 4 Snapping shrimp (Alpheidae) produce shock waves and are exposed to them frequently, so we asked if these animals have evolved mechanisms of physical protection against them. Snapping shrimp generate shock waves by closing their snapping claws rapidly enough to form cavitation bubbles that release energy as an audible “snap” and a shock wave when they collapse.5, 6, 7, 8 We tested if snapping shrimp are protected from shock waves by a helmet-like extension of their exoskeleton termed …

Using Nanoparticles To Treat Cancer, Rukhsora Akramova

International Programs

In this paper we briefly discuss methods of cancer treatment, such as surgery, radiation therapy, and chemotherapy for further comparison, with new cancer nanotechnology methods. The paper presents positive and negative aspects of the use of nanoparticles for the cancer treatment . In addition, this article describes a method for selecting a spectrum of irradiation and nanoparticle size for therapy and diagnosis of oncological diseases. Using computer calculations, the research demonstrates that particle size at optimal radiation wavelength affects absorption and scattering coefficients in low-absorbing biological media.

Novel Designer Benzodiazepines: Comprehensive Review Of Evolving Clinical And Adverse Effects, Amber N. Edinoff, Catherine A. Nix, Amira S. Odisho, Caroline P. Babin, Alyssa G. Derouen, Salim C. Lutfallah, Elyse M. Cornett, Kevin S. Murnane, Adam M. Kaye, Alan D. Kaye

School of Medicine Faculty Publications

As tranquilizers, benzodiazepines have a wide range of clinical uses. Recently, there has been a significant rise in the number of novel psychoactive substances, including designer benzodiazepines. Flubromazolam(8-bromo-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazeZpine) is a triazolo-analogue of flubromazepam. The most common effects noted by recreational users include heavy hypnosis and sedation, long-lasting amnesia, and rapid development of tolerance. Other effects included anxiolysis, muscle-relaxing effects, euphoria, loss of control, and severe withdrawals. Clonazolam, or 6-(2-chlorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-α]-[1,4]-benzodiazepine, is a triazolo-analog of clonazepam. It is reported to be over twice as potent as alprazolam. Deschloroetizolam (2-Ethyl-9-methyl-4-phenyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine) is part of the thienodiazepine drug class, which, like benzodiazepines, stimulates GABA-A receptors. …

The Daily Gamecock, Welcome Home, August 2022, University Of South Carolina, Office Of Student Media

August

No abstract provided.

Relationships Between And Student Perceptions Of Self-Efficacy, Growth Mindset, And Mathematics Identity Of Adolescents In A Rural South Georgia Charter School, Carrie Cooper Pierce

Theses and Dissertations

This mixed methods study investigated the relationships between the constructs of self-efficacy, growth mindset, and mathematics identity among middle school students at a South Georgia charter school. Constructivist grounded theory was used to investigate the strength of these constructs along with student perceptions of what factors make one a math person. The study was an explanatory sequential design consisting of an online survey followed by student interviews. Ninety-one students participated in the survey. Multiple linear regression was used to determine whether a correlation existed between the variables as well as among student subgroups. Self-efficacy was found to be a predictor …

The Effects Of Task Novelty On Memory For Everyday Meal Preparation Tasks Among Young Adults And Older Adults, Michael Persin

Psychology and Counseling Theses

The use of nonsensical information in the study of learning and memory goes back to the beginning of the field of psychology. Nonsensical information makes it difficult to rely on previous learning, increasing task novelty and providing insight into the learning of new tasks. However, little research exists investigating the role of task novelty in everyday activities such as cooking, which involve overlearned skills. This study aims to investigate the role of task novelty in everyday memory for meal preparation tasks in virtual reality. Young adults (n = 41; age M = 18.77, SD = 1.40) and older adults …

The Guardian The Week Of August 22, 2022, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of August 22, 2022. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Hashimoto’S Thyroiditis Minimizes Lymph Node Metastasis In Braf Mutant Papillary Thyroid Carcinomas, Peter P. Issa, Mahmoud Omar, Yusef Buti, Chad P. Issa, Bert Chabot, Christopher J. Carnabatu, Ruhul Munshi, Mohammad Hussein, Mohamed Aboueisha, Mohamed Shama, Ralph L. Corsetti, Eman Toraih, Emad Kandil

School of Medicine Faculty Publications

Hashimoto’s thyroiditis (HT) (autoimmune thyroiditis) is a clinicopathological entity associated with chronic lymphocytic infiltration resulting in hypothyroidism. HT is a double-edged sword that increases the risk of papillary thyroid cancer (PTC), yet it serves as a protective factor for PTC progression. BRAF mutation in PTCs is associated with rapid cell growth, aggressive tumor characteristics, and higher mortality rates. Here, we aimed to analyze the influence of HT in patients with PTCs and its effect on lymph node metastasis (LNM) in BRAF mutant tumors. Adults diagnosed with PTC between 2008 and January 2021 were retrospectively included. A total of 427 patients, …

Intouch August 22, 2022, New York Medical College

InTouch

• GSBMS Celebrates Renaming and Welcomes New Students
• City of White Plains Youth Bureau Gets Insightful Look at NYMC
• Join NYMC and TU for 21st COVID-19 Symposium on August 23
• Sabrina Martinez, GSBMS Class of 2023, Is Building a Foundation in Basic Sciences With Dreams of Medical School

The Global Spread Of Misinformation On Spiders, Stefano Mammola, Jagoba Malumbres-Olarte, Valeria Arabesky, Diego Alejandro Barrales-Alcalá, Aimee Lynn Barrion-Dupo, Marco Antonio Benamú, Tharina L. Bird, Maria Bogomolova, Pedro Cardoso, Maria Chatzaki, Ren Chung Cheng, Tien Ai Chu, Leticia M. Classen-Rodríguez, Iva Čupić, Naufal Urfi Dhiya'ulhaq, André Philippe Drapeau Picard, Hisham K. El-Hennawy, Mert Elverici, Caroline S. Fukushima, Zeana Ganem, Efrat Gavish-Regev, Naledi T. Gonnye, Axel Hacala, Charles R. Haddad, Thomas Hesselberg, Tammy Ai Tian Ho, Thanakorn Into, Marco Isaia, Dharmaraj Jayaraman, Nanguei Karuaera, Rajashree Khalap, Kiran Khalap, Dongyoung Kim, Tuuli Korhonen, Laura Segura-Hernández, Et Al.

School of Biological Sciences: Faculty Publications

In the internet era, the digital architecture that keeps us connected and informed may also amplify the spread of misinformation. This problem is gaining global attention, as evidence accumulates that misinformation may interfere with democratic processes and undermine collective responses to environmental and health crises1,2. In an increasingly polluted information ecosystem, understanding the factors underlying the generation and spread of misinformation is becoming a pressing scientific and societal challenge3. Here, we studied the global spread of (mis-)information on spiders using a high-resolution global database of online newspaper articles on spider–human interactions, covering stories of spider–human encounters and biting events published …