Digital Commons Network^™

Single-Nuclei Transcriptomic Profiling Of Human Myocardium In Long-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Deficiency, Hanna J Tadros, Diwakar Turaga, Yi Zhao, Chang-Ru Tsai, Lalita Wadhwa, Debra L Kearney, Iki Adachi, Xiao Li, James F Martin

Faculty, Staff and Students Publications

No abstract provided.

The "Hallett Sign" Of Functional Jerky Movement Disorder, Jon Stone, Anthony E Lang, Joseph Jankovic, Michele Tinazzi, Barbara A Dworetzky, Alan Carson, Marina A J Tijssen

Faculty, Staff and Students Publications

No abstract provided.

Antibiotics Aren’T Enough, Andrew R Dinardo, Christoph Lange

Faculty, Staff and Students Publications

No abstract provided.

Risk Factors For The Development Of Food Allergy In Infants And Children: A Systematic Review And Meta-Analysis, Nazmul Islam, Alexandro W L Chu, Falana Sheriff, Farid Foroutan, Gordon H Guyatt, Romina Brignardello-Petersen, Paul Oykhman, Alfonso Iorio, Ariel Izcovich, Katherine M Morrison, Yetiani Roldan Benitez, Rachel J Couban, Dorota Borovsky, Yiming Zhang, Leonardo Ologundudu, Keerthana Pasumarthi, Syed Fahad Farooq, Kyle Tong, Wang-Choi Tang, Haseeb Faisal, Muhammad Faran Khalid, Mohammad Saad Asif, Shannon French, Susan Waserman, R Sharon Chinthrajah, Hugh A Sampson, S Shahzad Mustafa, Jay A Lieberman, Kirsi M Järvinen, Sally Bailey, Philippe Bégin, Scott H Sicherer, Jennifer Gerdts, Melanie Carver, Lynda Mitchell, Kelly Cleary, Matthew J Greenhawt, Julie Wang, Aikaterini Anagnostou, Marcus S Shaker, Anita Chandra-Puri, Patricia C Fulkerson, Robert A Wood, Derek K Chu

Faculty, Staff and Students Publications

Importance: The incidence and risk (predictive) factors for early life food allergy development remain uncertain.

Objective: To estimate the incidence and quantify risk factors for food allergy development.

Data sources: MEDLINE and Embase were systematically searched to January 1, 2025. Data were analyzed from June 1, 2025, to November 25, 2025.

Study selection: Incidence estimates included studies confirming food allergy via food challenge. Risk factor analyses included cohort, case-control, and cross-sectional studies in any language assessing children younger than 6 years using multivariable analyses.

Data extraction and synthesis: Paired reviewers independently extracted data. Random-effects meta-analyses pooled incidence and adjusted odds …

Plasma Proteins Associated With Psychosocial Factors And Heart Disease: The Jackson Heart Study, Sara N O'Brien, Madeline G Gillman, Michael D Green, Daniel E Cruz, James S Floyd, Susan Hankinson, Daniel H Katz, Xiaojuan Liu, Michelle C Odden, Bruce M Psaty, Alexander P Reiner, Jerome I Rotter, Stephen S Rich, Robert E Gerszten, Amil Shah, Mario Sims, Usman A Tahir, Lesley F Tinker, Alexis C Wood, Bing Yu, Anthony S Zannas, Laura M Raffield, Láshauntá M Glover

Faculty, Staff and Students Publications

Background: Knowledge of proteomic mechanisms explaining the link between psychosocial stress and cardiovascular disease is limited. This study aimed to (1) identify plasma proteins associated with psychosocial factors and (2) assess associational pathways between psychosocial factors, identified proteins, and incident cardiovascular disease events in a discovery cohort, JHS (Jackson Heart Study), and 2 replication cohorts, the CHS (Cardiovascular Health Study), and the MESA (Multi-Ethnic Study of Atherosclerosis).

Methods: JHS participants from exam 1 (2000-2004) with SomaScan 1.3k platform proteomics data were included (n=2143, mean age=55.3). Depressive symptoms and perceived stress scores were measured via the 20-item Center for Epidemiological Studies …

Race To Mitigate Aortic Dissection: Exercise, Pde5a, And The Dissecting Aorta, Siddharth K Prakash

Faculty, Staff and Student Publications

No abstract provided.

Quantitative Muscle Magnetic Resonance Imaging Demonstrates Resolution Of Muscle Edema In Refractory Dermatomyositis: A Post Hoc Analysis Of A Proof-Of-Concept Clinical Trial Of Tofacitinib, Mona Dabiri, Anshula Nallapati, Marwin Groener, Patrick Debs, Jemima Albayda, Eleni Tiniakou, Lisa Christopher-Stine, Laura Fayad, Julie J Paik

Faculty, Staff and Student Publications

Objective: To evaluate changes in muscle edema using short-tau inversion recovery (STIR) imaging and quantitative diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping in patients with refractory dermatomyositis (DM) treated with tofacitinib.

Methods: This post hoc imaging analysis included patients from a 12-week, open-label trial of tofacitinib 11 mg daily in refractory DM. Bilateral thigh magnetic resonance imaging was obtained at baseline and week 12 using standardized STIR, T1-weighted, and DWI sequences. Muscle edema (ME) and fascial edema were assessed qualitatively on STIR imaging. ADC values were measured in muscles demonstrating baseline STIR hyperintensity using three nonoverlapping regions of …

Severe, Non-Apneic Respiratory Dysfunction And Hypoxia Following Generalized Convulsive Seizures, Haley E Pysick, Rup K Sainju, Roshni Nair, Deidre N Dragon, Eduardo Bravo, Laura Vilella, Xiaojin Li, Samden D Lhatoo, George B Richerson, Brian K Gehlbach

Faculty, Staff and Student Publications

Objective: Sudden unexpected death in epilepsy (SUDEP) is a devastating consequence of some generalized convulsive seizures (GCS). Recent work has focused on seizure related apnea as a biomarker of SUDEP risk, frequently without characterizing the adequacy of non-apneic ventilation or identifying other dysfunctional breathing patterns. We hypothesized that GCS frequently induce immediate, severe, non-apneic respiratory dysfunction that can induce critical hypoxia and bradycardia and sought to characterize breathing patterns after GCS.

Methods: Adult patients admitted to an epilepsy monitoring unit were studied. The effects of GCS on breathing and heart rate were analyzed using nasal pressure transducers, chest and abdominal …

Neurointerventional Advances In 2025, Amol Mehta, Sunil A Sheth, Ashutosh P Jadhav

Faculty, Staff and Student Publications

No abstract provided.

Optimized Ultrasound Imaging Of Phase-Change Nanodroplets, Charles R Dyall, Dmitry Nevozhay, Andy Liu, Trevor M Mitcham, George J Lu, Konstantin V Sokolov, Richard R Bouchard

Faculty, Staff and Student Publications

Phase-change nanodroplets (PCNDs) continue to generate significant research interest due to their potential to extravasate into tissue, to be targeted for molecular imaging and drug delivery, and to undergo an induced phase-change to "activated" microbubbles (MBs) for ultrasound (US) imaging. To accurately quantify molecular markers, however, one assumes a consistent proportion of PCNDs in a region of interest (ROI) are stably activated and imaged. Herein we present a framework for developing a diagnostic sequence that is optimized for PCND activation uniformity, contrast, and acquisition time. To develop this framework, activation was examined at three scales of increasing complexity: single, adjacent, …

Multidisciplinary Approach To Complex Lower Extremity Limb Salvage In Pyogenic Arthritis, Pyoderma Gangrenosum, And Acne (Papa) Syndrome: A Case Report, Michael M Talanker, Anthony V Basta, Tien Do, Robert Tung, Addison Allen, Morgan Martin, Bryan L Ruygrok, Patrick J Kellam, Jeffrey G Trost, Mohin A Bhadkamkar

Faculty, Staff and Student Publications

Limb salvage using free tissue transfer in patients with rare autoinflammatory syndromes is poorly described, and the safety of microvascular reconstruction in this population remains uncertain. Hereditary pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome is characterized by dysregulated inflammation, pathergy, and impaired wound healing, raising concern for flap compromise and postoperative complications. We report a rare case of lower extremity free tissue transfer in a patient with PAPA syndrome. A 66-year-old woman with rheumatoid arthritis and PAPA syndrome presented with rapid wound breakdown, violaceous ulceration, exposed hardware, and periprosthetic joint infection following left total knee arthroplasty (TKA). Examination revealed …

Potential Impact Of Parasites In The Transmission Of Chronic Wasting Disease, Paulina Soto, Rodrigo Morales

Faculty, Staff and Student Publications

No abstract provided.

Attachment And Betrayal: Post-Infidelity Attachment Issues With A Focus On Gender, Taylor Forsythe

Electronic Theses and Dissertations

Infidelity represents a significant relational trauma that may disturb attachment processes such as trust, emotional intimacy, and closeness. There is a gap in the literature on how different infidelity exposures may relate to these attachment responses; more so, there is a dearth of information on the gender differences for attachment issues following any kind of infidelity. The purpose of this study aimed to examine differences in avoidant and anxious attachment across infidelity groups (no infidelity, non-sexual infidelity, sexual infidelity), and a further comparison of gender differences in those groups. Participants (N = 151) completed online surveys in a larger study …

"Am I A Man Or A Muppet": A Rhetorical Analysis Of Generative Ai’S Representation Of Gender, Jessica Boaz

Electronic Theses and Dissertations

This thesis examines how generative artificial intelligence constructs and performs gender roles through a rhetorical analysis of the fully AI-generated podcast Fairytale Forensics. Drawing on theories of constitutive rhetoric, stereotyping, and McLuhan’s approach to the medium, this thesis investigates how AI-generated hosts interpret classic fairy tales while simultaneously reproducing and negotiating gender norms through the lens of prosopopoeia, metonymy and synecdoche. These performances rely on normative gender stereotypes that align with broader societal expectations, thereby potentially reinforcing existing cultural assumptions about masculinity and femininity. Ultimately, it demonstrates that AI-generated discourse does not merely reflect human biases but actively participates in …

Why Followership Matters In Psychiatry: Rebalancing Our Obsession With Leadership, Rohit Shankar, Richard Laugharne, Regi Alexander, Kenneth R. Kaufman, Derek K. Tracy, Fabida Aria, Mayura Deshpande, Matthew Frost

Peninsula Medical School

SummaryPsychiatry emphasises leadership development, but neglects the equally universal and essential role of followership. Although most clinicians spend more time as followers than leaders, literature overwhelmingly favours leadership. Drawing on healthcare, socio-religious traditions and management science, the authors reframe followership as an active, values-driven role grounded in trust, motivation and moral courage rather than passive compliance. This editorial argues that effective followership is active, ethical and courageous. Nurturing good followers in mental health services is essential for good patient care, organisational integrity and sustainable leadership. Cultivating active followership strengthens safeguarding, transparency and organisational legitimacy. The editorial calls for psychiatry and …

Flicking Fibres: Microfibres Act As Sensory Disruptors In A Marine Crustacean, Ari Drummond, Alexander D.M. Wilson, Lucy M. Turner, Mark Briffa

School of Biological and Marine Sciences

Anthropogenic inputs to the environment—including microplastics and microfibres—are global stressors known to impair multiple facets of organismal biology. However, the effects of these pollutants on sensory structures remain critically understudied. Sensory systems mediate organism-environment interactions, and pollution-derived impairment at these interfaces may cascade through bioprocessing, from information acquisition to behaviour and ultimately fitness. Microfibres, in particular, pose an additional threat, potentially physically obstructing sensory organs and chemically interfering with sensory processes. Using an invertebrate model of sensory biology, Pagurus bernhardus, we tested whether dryer lint—a complex, heterogeneous mix of treated microplastic and cellulose fibres, and other anthropogenic contaminants—acts as a …

Visual Cues Elicit Differential Aggression Towards Female And Female Mimics In The Corkwing Wrasse, Benjamin A. Ellis, Tonje K. Sørdalen, Mark Briffa, Anne Berit Skiftesvik, Alexander D.M. Wilson, Kim A.T. Halvorsen

School of Biological and Marine Sciences

Alternative reproductive tactics (ARTs) are consistent intrasexual differences in behavior that maximize reproductive success through different means. In corkwing wrasse (Symphodus melops), smaller males mimic female visual morphology (hereafter sneakers) to steal fertilizations from nest-building parental males (hereafter nesting males). We investigated whether this visual mimicry effectively deceived 47 nesting males across 4 sites by quantifying 2 agonistic responses (attack latency and attack frequency) to models depicting unfamiliar females, sneakers and rival nesting males. Contrary to expectations, nesting males exhibited faster agonistic responses towards female models, with lower attack latencies compared with both male types. Additionally, the relationship between model …

Long Covid Persistence And Surveillance Gaps Across 58 Us Hospitals, Jiazi Tian, Alaleh Azhir, Matthew Decaro, Ngan Chau, Jonas Hügel, Michele Morris, Jingya Cheng, Pedram Fard, Ingrid V Bassett, Douglas S Bell, Elmer V Bernstam, Shyam Visweswaran, Jeffrey G Klann, Shawn N Murphy, Hossein Estiri

Faculty, Staff and Student Publications

Importance: Surveillance of postacute sequelae of SARS-CoV-2 infection (PASC) depends on diagnostic coding systems that capture fewer than one-half of affected individuals, rendering millions invisible to health systems and policymakers.

Objective: To quantify the gap between true PASC burden and diagnostic code-based estimates, determine the proportion representing chronic disease, and characterize organ system heterogeneity and temporal trends across diverse populations.

Design, setting, and participants: This retrospective cohort study used electronic health record data from 58 hospitals and affiliated clinics in 4 US regions, from 2017 to 2025. Adults (aged ≥18 years) with laboratory-confirmed SARS-CoV-2 infection or a COVID-19 diagnosis code …

Ucva Ontology: Standardizing Local Context Factors To Support The Analysis Of Unwarranted Clinical Variation, Apollo Mcowiti, Xubing Hao, Rebecca Z Lin, Laila Rasmy-Bekhet, Cui Tao, Susan Fenton

Faculty, Staff and Student Publications

Objectives: Unwarranted clinical variation (UCV), defined as care provided to a patient that is not proportional to the patient's needs, clinical characteristics, or preferences, results in negative patient outcomes. UCV detection is performed to compare healthcare outcomes across regions or organizations and reduce UCV incidences. However, the lack of standardized UCV concepts and the local context factors hinder the interoperability of UCV analyses between organizations. Currently, UCV analysis relies on centralized analysis, posing challenges due to the proprietary nature of an organization's healthcare and operational data. Standardizing analysis factors enables interoperable analyses by establishing a common context between organizations. This …

Growth Hormone Pathway As A Prognostic And Therapeutic Biomarker In Patients With Unresectable Hepatocellular Carcinoma Treated With Radiation Therapy, Joe R Eid, Safa Kaseb, Lianchun Xiao, Ryan Sun, Mahesh Kumar Kannan, Manal Hassan, Asif Rashid, Hop S Tran Cao, Hesham M Amin, Eugene J Koay

Faculty, Staff and Student Publications

Purpose: Radiation therapy (RT) has emerged as an effective local therapy option for patients with unresectable hepatocellular carcinoma (HCC) and is associated with improved overall survival (OS). However, some patients still have poor outcomes after RT, and biomarkers are needed to stratify prognostic groups. High circulating growth hormone (GH) levels promote HCC proliferation and survival and are associated with aggressive disease. In this study, we evaluated whether pretreatment GH levels are associated with OS and progression-free survival (PFS) in patients who underwent RT for unresectable HCC.

Methods and materials: Patients undergoing RT for HCC during 2017-2023 were identified from a …

Computational Modeling Meets 3d Bioprinting: Emerging Synergies In Cardiovascular Disease Modeling, Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L Tomov, Emilio A Mendiola, Vahid Serpooshan, Reza Avazmohammadi

Faculty, Staff and Student Publications

Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, underscoring the need for improved strategies in diagnosis, treatment, and disease modeling. Traditional in vitro models often fall short in replicating human CV physiology, prompting efforts to advance cardiac tissue engineering and computational modeling. Among these, three-dimensional (3D) bioprinting has emerged as a transformative tool, enabling the creation of biomimetic CV constructs that more faithfully replicate native tissue structure and function. However, challenges persist in achieving appropriate mechanical properties and long-term performance of engineered CV constructs. Computational modeling offers powerful solutions to assist with these challenges, providing predictive insights into …

Low Methane Emissions From Nutrient-Rich Former River Channels In A Hydrologically Managed Dryland Delta, Siena Stassi, Jude A. Benavides, Chu-Lin Cheng, Marcelo Gomes Da Silva, Nicholas E. Ray, Nathan O. Barros, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Anthropogenic stresses in dryland regions can alter hydrology, salinization, and biogeochemical processes. How these pressures influence methane (CH4) cycling and emissions from aquatic ecosystems remains poorly understood. Over the course of 1 year, we measured diffusive and ebullitive CH4 emissions from resacas—shallow, hydrologically managed distributary channels prevalent throughout the Lower Rio Grande Valley along the US–Mexico border. Despite warm, nutrient-rich waters, CH4 emissions from resacas were low, and more comparable to rates observed in estuarine systems. CH4 fluxes were positively related to temperature but negatively related to salinity and rainfall. Elevated salinity, driven by evaporation and source water from the …

Landscape Connectivity And Wildlife Access To Water Across An International Border: Barriers And Opportunities For Facilitating Transboundary Movement, Bogdan Chivoiu, Erin L. Koen, Michael J. Osland, Christopher A. Gabler, Jerald T. Garrett, Ernesto Reyes, Stephanie A. Bilodeau, Mitch A. Sternberg, Jude A. Benavides, James Martinez

School of Earth, Environmental, & Marine Sciences Faculty Publications

Rapid global acceleration in the construction of physical barriers along international borders has greatly influenced biodiversity and animal movement. Physical barriers can fragment landscapes, hinder access to essential resources, impact long-distance migrations, and inhibit dispersal and gene flow. The effects of physical barriers on animal movement and landscape connectivity can be exacerbated in dryland environments where access to water is a limiting factor. In recent decades, the construction of border barrier infrastructure has accelerated along the international boundary between the United States and Mexico. Here, we used a landscape connectivity model to investigate the effects of barriers on wildlife access …

Ecological Insights And Management Implications Of The Global Migratory Connectivity Of Green Turtles, Jaime Restrepo, Dina Nisthar, Harris Wei-Khang Heng, Lily K. Bentley, Corrie Curtice, Sarah Deland, Ei Fujioka, Patrick N. Halpin, Sarah K. Poulin, Roldán A. Valverde

School of Earth, Environmental, & Marine Sciences Faculty Publications

Aim

Green turtles are a widely distributed and highly migratory species; despite extensive data on their movement, there is no species-specific global synthesis on the subject. Based on three decades of published literature and building on previous global analyses, we developed a global network model of migratory connectivity for green turtles to better understand their spatial biology.

Location

Global.

Time Period

1990–2022.

Major Taxa Studied

Green Sea Turtle (Chelonia mydas).

Methods

We conducted a structured literature review extracting georeferenced information on the movement of green turtles from 1990 to 2022, aggregating this information into a single connectivity model, …

Estrogen As A Therapeutic Agent: Targeting Endotheliopathy And Coagulopathy In Trauma, Niruktha Raghavan, Mira Patel, Bryan A Cotton, Julia Coleman, Donald Jenkins

Faculty, Staff and Student Publications

Background: Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma-induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need for new precision resuscitation strategies that acknowledge factors like biological sex.

Design: The central hypothesis is that estrogen confers a survival advantage in hormonally active females through a dual action: endothelial cell stabilization (halting glycocalyx shedding) and its inherent procoagulant effect. The analysis assesses the therapeutic potential of both exogenous estrogen and female-derived blood products …

Arkansas Soybean Research Studies 2024, Jeremy Ross

Arkansas Agricultural Experiment Station Research Series

The 2024 Arkansas Soybean Research Studies includes research reports on topics pertaining to soybean across several disciplines from breeding to post-harvest processing. Research reports contained in this publication may represent preliminary or only data from a single year or limited results; therefore, these results should not be used as a basis for long-term recommendations. Several research reports in this publication will appear in other University of Arkansas Division of Agriculture’s Arkansas Agricultural Experiment Station publications. This duplication is the result of the overlap in research coverage between disciplines and our effort to inform Arkansas soybean producers of the research being …

Promises, Pitfalls, And Paths Forward For The Pediatric Research Equity Act., Alexa L. Pagano, Danielle J. Green, Jennifer Goldman, Anjali Deshmukh

Manuscripts, Articles, Book Chapters and Other Papers

IMPORTANCE: Since its enactment in 2003, the Pediatric Research Equity Act (PREA) has significantly increased the number of pediatric drug studies performed and expanded pediatric drug labeling. Despite these advancements, many drugs used in children still lack pediatric-specific US Food and Drug Administration (FDA) labeling, even when pediatric studies are required by law. Recent legislative changes strengthened the FDA's enforcement authority over PREA. As these changes are implemented, persistent gaps in pediatric drug development warrant examination. Addressing these gaps may help ensure that children are systematically included in clinical research and that medications used in children are supported by rigorous …

An Investigation Of Data Granularity In Rag Pipelines For Personalized Medicine, Paritosh Pandey

Master's Theses

Generative AI, exemplified by large language models like the OpenAI GPT and Meta LLaMA families, can produce diverse content in response to prompts. This capability offers a promising solution to challenges in precision medicine, which seeks to tailor treatments to individual clinical profiles but often struggles with data collection, cost, and privacy concerns. By generating realistic, privacy-preserving patient data, generative AI has the potential to transform patient-centric healthcare. With such motivation, this research develops a comprehensive Generative AI pipeline emphasizing data granularity for accurate prediction of personalized treatments. The pipeline features a central Large Language Model interacting with a Machine …

Simulation Of A Buried Hydrogen Pipeline In Kansas State Soil, Sidney Hines

Master's Theses

Underground pipelines can be used to transport large amounts of pressurized hydrogen gas over several hundred kilometers. The design will be sensitive to the pipe material, diameter, and trench construction, and traffic loads above the pipe. The purpose of this paper is to conduct various geotechnical engineering analyses (seepage, stress, and slope stability) using the software program GeoStudio (version 2025.2.0) on a buried steel or FRP pipe section in a specific soil type, Harney Soil. Harney soil is of particular interest, because it is the Kansas State Soil and the analysis is for a buried gas pipe to run through …

A Phenomenological Study Of Teachers Who Use Oral Reading To Foster Student Reading Fluency And Engagement, Donyetta Grimes

Dissertations

The National Reading Panel (2000) recommends oral reading instruction as a means to improve overall reading fluency and reading comprehension. Oral reading fluency is a necessary foundational skill, and students who have not mastered it by the end of third grade, when students transition from learning to read to reading to learn, become struggling adolescent readers (Ming, 2018). Furthermore, there is a lack of research on reading fluency past the primary grades (Makebo et al., 2022). Additionally, research gaps exist when considering teachers’ actual practices during reading instruction (O’Sullivan et al., 2009). This gap is particularly concerning considering that teachers …