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2022

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Effect Of Floor Cooling On Sows Under Heat Stress, Javier Flores Aug 2022

Effect Of Floor Cooling On Sows Under Heat Stress, Javier Flores

American Journal of Rising Scholar Activities

With temperatures increasing steadily throughout the last century, the hog farrowing industry is beginning to confront an ongoing dilemma. Temperatures are now exceeding ideal conditions for optimal milk production, as well as maximum litter size. Temperatures that exceed optimal conditions can lead to significant heat stress among sows. Efficiently cooling-down sows, while keeping piglets at ideal temperatures, is the focus of this project. A cooling pad was built with copper pipes inside a high-density polyethylene board, covered by an aluminum plate. Experimental treatments included cool water flowing through the copper pipes at different levels depending on the specific sow. Intervals …


Purdue University Students' Perceptions Of Cybersecurity, Ricardo Gonzalez Aug 2022

Purdue University Students' Perceptions Of Cybersecurity, Ricardo Gonzalez

American Journal of Rising Scholar Activities

An investigation into Purdue University students’ attitudes about cybersecurity was conducted. Students were asked about their thoughts on cybersecurity, cyber-terrorism, and how they protect themselves. The data indicated that students were both aware of cyber-threats and participated in potentially unsafe internet activities. A variety of misconceptions regarding online security exposed, highlighting the need for greater education for college students regarding staying safe during online activities.


Purdue Hog Cooling Pad Experience, Marco Baez Aug 2022

Purdue Hog Cooling Pad Experience, Marco Baez

American Journal of Rising Scholar Activities

The demand for food is increasing with the growing population. The pork industry is currently thriving and will continue to prosper as long as sows continue to reproduce. However, the reproduction of pigs is currently facing the problem of heat stress. Environmental temperatures are reaching extremes, and lactating sows produce less milk for offspring when they are in hot weather. The main reason that they produce less is because of undernourishment. Sows eat less when hot, because when they do eat, it actually causes them to heat-up. The goal of the overall cooling pad effort is to reduce the heat …


Ajrsa Inaugural Launch Statement, Bob Stwalley Aug 2022

Ajrsa Inaugural Launch Statement, Bob Stwalley

American Journal of Rising Scholar Activities

No abstract provided.


The Minutes Of The Marshall University Graduate Council Meeting, August 26, 2022, Marshall University Graduate Council Aug 2022

The Minutes Of The Marshall University Graduate Council Meeting, August 26, 2022, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.


Zero Discharge Of Nutrient Solution To The Environment In A Soilless Greenhouse Cucumber Production System, Xiaotao Ding, Lizhong He, Rongguang Li, Tingting Qian, Hongmei Zhang, Haijun Jin, Jiawei Cui, Hong Wang, Qiang Zhou, Jun Zou, Dafeng Hui, Yuping Jiang, Kun He, Jizhu Yu Aug 2022

Zero Discharge Of Nutrient Solution To The Environment In A Soilless Greenhouse Cucumber Production System, Xiaotao Ding, Lizhong He, Rongguang Li, Tingting Qian, Hongmei Zhang, Haijun Jin, Jiawei Cui, Hong Wang, Qiang Zhou, Jun Zou, Dafeng Hui, Yuping Jiang, Kun He, Jizhu Yu

Biology Faculty Research

With the development of the economy and society, more attention is being paid to energy costs and the potential environmental pollution caused by vegetable cultivation. The aim of this study was to investigate the impacts of zero discharge of nutrient solutions on cucumber growth, leaf photosynthesis, and the yield and quality of cucumber under greenhouse conditions. The results show that zero discharge treatment did not change plant height, stem diameter, internode length, leaf area, net photosynthetic rate (Pn), stomatal conductance (Gs), intercellular CO2 concentration (Ci), transpiration rate (Tr), and leaf relative chlorophyll content on the most measurement days. Only Pn …


Infection Avoidance Behaviors Across Vertebrate Taxa: Patterns, Processes, And Future Directions, Patricia C. Lopes, Susannah S. French, Douglas C. Woodhams, Sandra A. Binning Aug 2022

Infection Avoidance Behaviors Across Vertebrate Taxa: Patterns, Processes, And Future Directions, Patricia C. Lopes, Susannah S. French, Douglas C. Woodhams, Sandra A. Binning

Biology, Chemistry, and Environmental Sciences Faculty Books and Book Chapters

An infected animal can behave, smell, sound, and look very different from a healthy version of itself. The same is true when comparing habitats, food, or water sources contaminated with parasite infectious stages to their uncontaminated counterparts. All these differences provide cues or indications of disease risk and thus allow uninfected animals to modify their behaviors in ways that alter disease transmission. This chapter focuses on prophylactic behaviors: host behaviors that reduce the risk of infection. It provides an overview of how infection avoidance behaviors are triggered, then summarizes the avoidance behaviors known to occur in vertebrates, giving special attention …


The Role Of Management Organizations And Local Governments In Destination Marketing: The Case Of Turkey Tourism Promotion And Development Agency (Tga), Murat Toktaş Aug 2022

The Role Of Management Organizations And Local Governments In Destination Marketing: The Case Of Turkey Tourism Promotion And Development Agency (Tga), Murat Toktaş

Journal of Global Hospitality and Tourism

The second viewpoint is industry-focused and is authored by Mr. Murat Toktaş. He is the founder/president of KATID (Black Sea Tourist Operators Association), the founder/president of SKAL Karadeniz, and the founder/vice-president of TUROYD (Tourism Hotel Managers Association) and a member of the Board of Directors of TUROFED (Turkish Hoteliers Federation). In his viewpoint, he explains how destination management organizations (DMOs) work with local governments in Turkey. He suggested a successful destination marketing strategy for the Turkish Tourism Promotion and Development Agency (TGA). Collaboration between local and DMOs is essential for destinations to be adequately promoted and become a successful brands. …


System And Method For The Prediction Of Atrial Fibrillation (Af), Calvin Apollos Perumalla, Richard Dennis Gitlin, Dilranjan Sunimal Wickramasuriya Aug 2022

System And Method For The Prediction Of Atrial Fibrillation (Af), Calvin Apollos Perumalla, Richard Dennis Gitlin, Dilranjan Sunimal Wickramasuriya

USF Patents

System and method for providing patient-specific models to distinguish between epochs of electrocardiograms (ECGs) located far away from atrial fibrillation rhythms and those located just prior to the onset of those episodes, to provide for the prediction of the onset of an occurrence of atrial fibrillation (AF) in the patient.


Why Not Both Nature And Nurture: Using Behavioral Genetic Markers As Sentencing Factors, Seely Kaufmann Aug 2022

Why Not Both Nature And Nurture: Using Behavioral Genetic Markers As Sentencing Factors, Seely Kaufmann

Richmond Journal of Law & Technology

On the evening of July 1, 2013, Amos Wells was upset that his pregnant girlfriend, Chanice Reed, would not answer his calls. He then drove to where she, her mother Annette, and ten-year-old brother Eddie, lived. After arguing with Chanice and yelling at the top of his voice in a “bone-chilling scream,” Wells retrieved a handgun from his Chevrolet Tahoe parked in front of the house, and shot Chanice in the front yard as she screamed, “No, no, no.” Her mother then tried to bat the gun away before he shot her too. Further shots were heard before Wells finally …


Coupled Oscillators: Protein And Acoustics, Angelique N. Mcfarlane Aug 2022

Coupled Oscillators: Protein And Acoustics, Angelique N. Mcfarlane

Theses

This work encompassed three different vibrational energy transfer studies of coupled resonators (metal, topological, and microtubule comparison) inspired by the lattices of microtubules from regular and cancerous cells. COMSOL Multiphysics 5.4 was utilized to design the experiment. The simulation starts with an acoustic pressure study to examine the vibrational modes present in coupled cylinders, representing α-, β-tubulin heterodimers. The Metal Study consisted of 3 models (monomer, dimer, and trimer) to choose the correct height (40 mm) and mode (Mode 1) for study. The Topological Study was run to predict and understand how the lattice structure changes over a parametric sweep …


The Feud Of Nemo Plus Iuris Ad Alium Transferre Potest Quam Ipse Habet And Nemo Dat Quad Non Habet (Nemo Dat Rule) Legal Principles Against The Legal Principle Of Good Faith (Bona Fides) In Indonesian Courts, Yonatan Yonatan, Rosa Agustina Aug 2022

The Feud Of Nemo Plus Iuris Ad Alium Transferre Potest Quam Ipse Habet And Nemo Dat Quad Non Habet (Nemo Dat Rule) Legal Principles Against The Legal Principle Of Good Faith (Bona Fides) In Indonesian Courts, Yonatan Yonatan, Rosa Agustina

Indonesia Law Review

Abstract

A dispute over ownership of land rights between the real Original Owner and a Good Faith Purchaser can be assumed as a dispute over legal principles in the field of civil law, namely: the legal principle of Nemo Plus Iuris Ad Alium Transferre Potest Quam Ipse Habet, and the legal principle of Nemo Dat Quad Non Habet (Nemo Dat Rule) against the legal principle of good faith (bona fides). The legal principle of Nemo Plus Iuris Ad Alium Transferre Potest Quam Ipse Habet and the legal principle of Nemo Dat Quad Non Habet (Nemo Dat Rule) are legal principles …


Global Variation In Nonstructural Carbohydrate Stores In Response To Climate, Meghan Blumstein, Jess T. Gersony, Jordi Martínez-Vilalta, Anna Sala Aug 2022

Global Variation In Nonstructural Carbohydrate Stores In Response To Climate, Meghan Blumstein, Jess T. Gersony, Jordi Martínez-Vilalta, Anna Sala

Biological Sciences: Faculty Publications

Woody plant species store nonstructural carbohydrates (NSCs) for many functions.While known to buffer against fluctuations in photosynthetic supply, such as at night, NSC stores are also thought to buffer against environmental extremes, such as drought or freezing temperatures by serving as either back-up energy reserves orosmolytes. However, a clear picture of how NSCs are shaped by climate is still lack-ing. Here, we update and leverage a unique global database of seasonal NSC storage measurements to examine whether maximum total NSC stores and the amount of soluble sugars are associated with clinal patterns in low temperatures or aridity, indicating they may …


Women Of The Scriptures In The Relief Society Magazine: An Analysis Of The Role Of Language In Maintaining Gender Norms, Kayla Bach Aug 2022

Women Of The Scriptures In The Relief Society Magazine: An Analysis Of The Role Of Language In Maintaining Gender Norms, Kayla Bach

Undergraduate Honors Theses

This paper explores the language used to discuss women from the scriptures in the Relief Society Magazine, an official publication of The Church of Jesus Christ of Latter-day Saints from 1914 to 1970. More specifically, this paper analyzes the usage of language in relation to the establishment and maintenance of gender norms, particularly those relating to women. This analysis reveals that the following core themes are frequently present throughout discussions of scriptural women in the magazine: the nature of womanhood, motherhood, wifehood, women’s roles in religion, the interaction between patriarchy and equality, and gender-neutral spiritual traits. By exploring these …


Neonicotinoid Pesticide And Nitrate Mixture Removal And Persistence In Floating Treatment Wetlands, Julia K. Lindgren, Tiffany L. Messer, Daniel N. Miller, Daniel D. Snow, Thomas G. Franti Aug 2022

Neonicotinoid Pesticide And Nitrate Mixture Removal And Persistence In Floating Treatment Wetlands, Julia K. Lindgren, Tiffany L. Messer, Daniel N. Miller, Daniel D. Snow, Thomas G. Franti

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Mesocosm and microcosm experiments were conducted to explore the applicability of floating treatment wetlands (FTWs), an ecologically based management technology, to remove neonicotinoid insecticides and nitrate from surface water. The mesocosm experiment evaluated three treatments in triplicate over a 21-d period. Floating treatment wetland mesocosms completely removed nitrate-N over the course of the experiment even when neonicotinoid insecticides were present. At the completion of the experiment, 79.6% of imidacloprid and degradation byproducts and 68.3% of thiamethoxam and degradation byproducts were accounted for in the water column. Approximately 3% of imidacloprid and degradation byproducts and 5.0% of thiamethoxam and degradation byproducts …


Ai Protein Structure Prediction-Based Modeling And Mutagenesis Of A Protostome Receptor And Peptide Ligands Reveal Key Residues For Their Interaction, Shi-Qi Guo, Ya-Dong Li, Ping Chen, Guo Zhang, Hui-Ying Wang, Hui-Min Jiang, Wei-Jia Liu, Ju-Ping Xu, Xue-Ying Ding, Ping Fu, Ke Yu, Hai-Bo Zhou, James W. Checco, Jian Jing Aug 2022

Ai Protein Structure Prediction-Based Modeling And Mutagenesis Of A Protostome Receptor And Peptide Ligands Reveal Key Residues For Their Interaction, Shi-Qi Guo, Ya-Dong Li, Ping Chen, Guo Zhang, Hui-Ying Wang, Hui-Min Jiang, Wei-Jia Liu, Ju-Ping Xu, Xue-Ying Ding, Ping Fu, Ke Yu, Hai-Bo Zhou, James W. Checco, Jian Jing

Department of Chemistry: Faculty Publications

The protostome leucokinin (LK) signaling system, including LK peptides and their G protein-coupled receptors, has been characterized in several species. Despite the progress, molecular mechanisms governing LK peptide–receptor interactions remain to be elucidated. Previously, we identified a precursor protein for Aplysia leucokinin-like peptides (ALKs) that contains the greatest number of amidated peptides among LK precursors in all species identified so far. Here, we identified the first ALK receptor from Aplysia, ALKR. We used cell-based IP1 activation assays to demonstrate that two ALK peptides with the most copies, ALK1 and ALK2, activated ALKR with high potencies. Other endogenous ALK-derived peptides …


Polymorphism & Parasites: Structure, Diversity And Selection Of The Mhcii Genes In A Weakly Electric Fish, Brachyhypopomus Occidentalis, Bruna L. Silva Aug 2022

Polymorphism & Parasites: Structure, Diversity And Selection Of The Mhcii Genes In A Weakly Electric Fish, Brachyhypopomus Occidentalis, Bruna L. Silva

Graduate Masters Theses

The major histocompatibility complex (MHC) class II molecules play a key role in inducing an immune response, by presenting foreign peptides to T-lymphocytes. They are considered one of the most polymorphic genes in the vertebrate genome and diversity has been associated with species diversification mediated by parasite, viral and bacterial infections. While MHC genes are well documented in teleost fish, none thus far have been described in the Gymnotiform order – a highly diverse group of neotropical electric fishes. Using a combination of a recently annotated genome and whole genome resequencing data, I identified and characterized both the classical MHCII …


Associations Between The Content And Level Of Parent Concerns Pre-Diagnosis And Timeliness Of Autism Screening And Diagnostic Evaluation Among A Diverse Sample Of Children In Part C Early Intervention, Kohrissa Joseph Aug 2022

Associations Between The Content And Level Of Parent Concerns Pre-Diagnosis And Timeliness Of Autism Screening And Diagnostic Evaluation Among A Diverse Sample Of Children In Part C Early Intervention, Kohrissa Joseph

Graduate Masters Theses

Though autism can be diagnosed as early as 18 months for many children, the current average age of diagnosis is between 3 and 4 years old. Children of color are diagnosed even later. Several studies have examined this disparity and have found that one significant contributor is pediatric providers’ screening practices. Though the American Academy of Pediatrics (AAP) recommends autism specific screening at 18- and 24-month well-child visits, many pediatricians report only screening if they are concerned or if the parent mentions a concern. In light of recent findings that Black and Latinx parents may have fewer autism-related concerns than …


The Role Of Emotion Regulation In Long-Term Weight Loss Maintenance: A Cross-Sectional Study, Karyn M. Aiello Aug 2022

The Role Of Emotion Regulation In Long-Term Weight Loss Maintenance: A Cross-Sectional Study, Karyn M. Aiello

Graduate Masters Theses

While many weight loss interventions have resulted in significant weight loss, maintaining that weight loss long-term continues to be challenging for most, with long-term weight loss maintenance (LTWLM) rates as low as 20% among participants of clinical weight loss studies. Those who struggle with LTWLM exhibit many shared characteristics, including lower mental health composite scores; high levels of perceived stress; and lower rates of adherence to WLM behaviors. One explanation for this might be that emotion regulation (ER) skills are stronger among those who are successful at LTWLM, and therefore more successful at self-regulating for the goal of LTWLM.

The …


Interactive Software-Based Modeling For Gait Analysis Of Musculoskeletal Structures, Nada Masood Mirza, Adnan Ali, Mohamad Khairi Ishak Aug 2022

Interactive Software-Based Modeling For Gait Analysis Of Musculoskeletal Structures, Nada Masood Mirza, Adnan Ali, Mohamad Khairi Ishak

Makara Journal of Technology

Software for interactive musculoskeletal modeling applies diverse scientific and technological concepts to stimulate the movement of musculoskeletal figures. Several tools are available for biomechanical analysis in studying motion and capturing the musculoskeletal representation data to facilitate further evaluation for muscle activation. Musculoskeletal software, such as the OpenSim model, animates, and measures in 3D the structural movement of bones, muscles, joints, ligaments, and such structures in the human body. Users apply graphical interfaces to manipulate the movement science for fast and accurate analysis. OpenSim simulation software features a user-friendly interface to allow the proper clinical application in biomechanics and rehabilitation research. …


Endophenotype Effect Sizes Support Variant Pathogenicity In Monogenic Disease Susceptibility Genes, Jennifer L Halford, Valerie N Morrill, Seung Hoan Choi, Sean J Jurgens, Giorgio Melloni, Nicholas A Marston, Lu-Chen Weng, Victor Nauffal, Amelia W Hall, Sophia Gunn, Christina A Austin-Tse, James P Pirruccello, Shaan Khurshid, Heidi L Rehm, Emelia J Benjamin, Eric Boerwinkle, Jennifer A Brody, Adolfo Correa, Brandon K Fornwalt, Namrata Gupta, Christopher M Haggerty, Stephanie Harris, Susan R Heckbert, Charles C Hong, Charles Kooperberg, Henry J Lin, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Wendy Post, Bruce M Psaty, Susan Redline, Kenneth M Rice, Stephen S Rich, Jerome I Rotter, Peter F Schnatz, Elsayed Z Soliman, Nona Sotoodehnia, Eugene K Wong, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Marc S Sabatine, Christian T Ruff, Kathryn L Lunetta, Patrick T Ellinor, Steven A Lubitz Aug 2022

Endophenotype Effect Sizes Support Variant Pathogenicity In Monogenic Disease Susceptibility Genes, Jennifer L Halford, Valerie N Morrill, Seung Hoan Choi, Sean J Jurgens, Giorgio Melloni, Nicholas A Marston, Lu-Chen Weng, Victor Nauffal, Amelia W Hall, Sophia Gunn, Christina A Austin-Tse, James P Pirruccello, Shaan Khurshid, Heidi L Rehm, Emelia J Benjamin, Eric Boerwinkle, Jennifer A Brody, Adolfo Correa, Brandon K Fornwalt, Namrata Gupta, Christopher M Haggerty, Stephanie Harris, Susan R Heckbert, Charles C Hong, Charles Kooperberg, Henry J Lin, Ruth J F Loos, Braxton D Mitchell, Alanna C Morrison, Wendy Post, Bruce M Psaty, Susan Redline, Kenneth M Rice, Stephen S Rich, Jerome I Rotter, Peter F Schnatz, Elsayed Z Soliman, Nona Sotoodehnia, Eugene K Wong, Nhlbi Trans-Omics For Precision Medicine (Topmed) Consortium, Marc S Sabatine, Christian T Ruff, Kathryn L Lunetta, Patrick T Ellinor, Steven A Lubitz

Faculty, Staff and Student Publications

Accurate and efficient classification of variant pathogenicity is critical for research and clinical care. Using data from three large studies, we demonstrate that population-based associations between rare variants and quantitative endophenotypes for three monogenic diseases (low-density-lipoprotein cholesterol for familial hypercholesterolemia, electrocardiographic QTc interval for long QT syndrome, and glycosylated hemoglobin for maturity-onset diabetes of the young) provide evidence for variant pathogenicity. Effect sizes are associated with pathogenic ClinVar assertions (P < 0.001 for each trait) and discriminate pathogenic from non-pathogenic variants (area under the curve 0.82-0.84 across endophenotypes). An effect size threshold of ≥ 0.5 times the endophenotype standard deviation nominates up to 35% of rare variants of uncertain significance or not in ClinVar in disease susceptibility genes with pathogenic potential. We propose that variant associations with quantitative endophenotypes for monogenic diseases can provide evidence supporting pathogenicity.


“The Circle Of Your Acquaintance”: Early 19th Century Ceramic Symbolism And Constructions Of Black Womanhood At The Boston-Higginbotham House, Nantucket, Ma, Lissa J. Herzing Aug 2022

“The Circle Of Your Acquaintance”: Early 19th Century Ceramic Symbolism And Constructions Of Black Womanhood At The Boston-Higginbotham House, Nantucket, Ma, Lissa J. Herzing

Graduate Masters Theses

During the early 19th century, ideologies of womanhood were beginning to solidify in the national discourse of the United States. The concept of domesticity, the process of homemaking through material and spiritual means, was a key aspect of womanhood during this time, the transition from the Early Republic to the Victorian period. These ideals were prescribed to white middle- and upper-class women but were altered by Black women to serve their needs and adopted to combat negative stereotypes of Black people in a society permeated with racism. This was evident in the work of Maria W. Stewart, the first Black …


Contributions Of Circulating Micrornas For Early Detection Of Lung Cancer, Jody Vykoukal, Johannes F Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J Ostrin, Jennifer B Dennison, Cristina Ivan, Gary E Goodman, Mark D Thornquist, Matt J Barnett, Ziding Feng, George A Calin, Samir M Hanash Aug 2022

Contributions Of Circulating Micrornas For Early Detection Of Lung Cancer, Jody Vykoukal, Johannes F Fahrmann, Nikul Patel, Masayoshi Shimizu, Edwin J Ostrin, Jennifer B Dennison, Cristina Ivan, Gary E Goodman, Mark D Thornquist, Matt J Barnett, Ziding Feng, George A Calin, Samir M Hanash

Faculty, Staff and Student Publications

There is unmet need to develop circulating biomarkers that would enable earlier interception of lung cancer when more effective treatment options are available. Here, a set of 30 miRNAs, selected from a review of the published literature were assessed for their predictive performance in identifying lung cancer cases in the pre-diagnostic setting. The 30 miRNAs were assayed using sera collected from 102 individuals diagnosed with lung cancer within one year following blood draw and 212 controls matched for age, sex, and smoking status. The additive performance of top-performing miRNA candidates in combination with a previously validated four-protein marker panel (4MP) …


Molecular Analysis Of Short- Versus Long-Term Survivors Of High-Grade Serous Ovarian Carcinoma, Elaine Stur, Emine Bayraktar, Graziela Zibetti Dal Molin, Sherry Y Wu, Lingegowda S Mangala, Hui Yao, Ying Wang, Prahlad T Ram, Sara Corvigno, Hu Chen, Han Liang, Shelley S Tworoger, Douglas A Levine, Susan K Lutgendorf, Jinsong Liu, Kathleen N Moore, Keith A Baggerly, Beth Y Karlan, Anil K Sood Aug 2022

Molecular Analysis Of Short- Versus Long-Term Survivors Of High-Grade Serous Ovarian Carcinoma, Elaine Stur, Emine Bayraktar, Graziela Zibetti Dal Molin, Sherry Y Wu, Lingegowda S Mangala, Hui Yao, Ying Wang, Prahlad T Ram, Sara Corvigno, Hu Chen, Han Liang, Shelley S Tworoger, Douglas A Levine, Susan K Lutgendorf, Jinsong Liu, Kathleen N Moore, Keith A Baggerly, Beth Y Karlan, Anil K Sood

Faculty, Staff and Student Publications

Despite having similar histologic features, patients with high-grade serous ovarian carcinoma (HGSC) often experience highly variable outcomes. The underlying determinants for long-term survival (LTS, ≥10 years) versus short-term survival (STS, < 3 years) are largely unknown. The present study sought to identify molecular predictors of LTS for women with HGSC. A cohort of 24 frozen HGSC samples was collected (12 LTS and 12 STS) and analyzed at DNA, RNA, and protein levels. OVCAR5 and OVCAR8 cell lines were used for in vitro validation studies. For in vivo studies, we injected OVCAR8 cells into the peritoneal cavity of female athymic nude mice. From RNAseq analysis, 11 genes were found to be differentially expressed between the STS and LTS groups (fold change > 2; false discovery rate < 0.01). In the subsequent validation cohort, transmembrane protein 62 (TMEM62) was found to be related to LTS. CIBERSORT analysis showed that T cells (follicular helper) were found at higher levels in tumors from LTS than STS groups. In vitro data using OVCAR5 and OVCAR8 cells showed decreased proliferation with TMEM62 overexpression and positive correlation with a longevity-regulating pathway (KEGG HSA04213) at the RNA level. In vivo analysis using the OVCAR8-TMEM62-TetON model showed decreased tumor burden in mice with high- vs. low-expressing TMEM62 tumors. Our results demonstrate that restoring TMEM62 may be a novel approach for treatment of HGSC. These findings may have implications for biomarker and intervention strategies to help improve patient outcomes


New Entry Proposal In A Dictionary: A Case Study For The Entry Lotus, Hermina Sutami, Su Xinchun, Fransiska Wiratikusuma Aug 2022

New Entry Proposal In A Dictionary: A Case Study For The Entry Lotus, Hermina Sutami, Su Xinchun, Fransiska Wiratikusuma

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

The object of this study is the word lotus. In the Comprehensive Indonesian Dictionary (KBBI), the lotus entry has only one meaning within the botanical domain. However, the word lotus is also present and used in the context of Buddhism in Indonesia. Based on this fact, it is suggested to add a new meaning to the entry. The problem is to decide whether the new meaning is a polysemy or a homonym, and the criteria used to determine this. The purpose of this research is to provide input to the Language Development and Fostering Agency to add new word entries …


Assist Conservation With Microbiome? An Investigation Using Native Amphibian Species In Hong Kong, Pui Yin Lam Aug 2022

Assist Conservation With Microbiome? An Investigation Using Native Amphibian Species In Hong Kong, Pui Yin Lam

Lingnan Theses (MPhil & PhD)

Microorganisms often have a negative connotation of disease, especially during the recent COVID-19 pandemic. However, many microorganisms are essential to health, from assisting nutrient acquisition to providing insights in advanced medicine. The diverse microorganisms (including bacteria, viruses, fungi, archaea, and protozoans) inhabiting a host are collectively known as the “microbiota”. The importance of microbiota is not limited to humans, but also applies to wildlife. Recent research highlighted the tremendous potential of applying microbiota research to wildlife conservation, such as understanding host’s health in relation to anthropogenic effects. Amphibians, being one of the most diverse but threatened groups of vertebrates, are …


Effect Of Alloying Elements On The Compressive Mechanical Properties Of Biomedical Titanium Alloys: A Systematic Review, Syed Faraz Jawed, Chirag Dhirajlal Rabadia, Muhammad Ahmed Khan, Saad Jawaid Khan Aug 2022

Effect Of Alloying Elements On The Compressive Mechanical Properties Of Biomedical Titanium Alloys: A Systematic Review, Syed Faraz Jawed, Chirag Dhirajlal Rabadia, Muhammad Ahmed Khan, Saad Jawaid Khan

Research outputs 2022 to 2026

Due to problems such as the stress-shielding effect, strength-ductility trade-off dilemma, and use of rare-earth, expensive elements with high melting points in Ti alloys, the need for the design of new Ti alloys for biomedical applications has emerged. This article reports the effect of various alloying elements on the compressive mechanical performance of Ti alloys for biomedical applications for the first time as a systematic review following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines on this subject. The search strategy in this systematic review used Scopus, Web of Science, and PubMed databases and searched the articles …


Quantifying The Ecological Impacts Of Alien Aquatic Macrophytes: A Global Meta-Analysis Of Effects On Fish, Macroinvertebrate And Macrophyte Assemblages, Samuel J.L. Tasker, Andrew Foggo, David T. Bilton Aug 2022

Quantifying The Ecological Impacts Of Alien Aquatic Macrophytes: A Global Meta-Analysis Of Effects On Fish, Macroinvertebrate And Macrophyte Assemblages, Samuel J.L. Tasker, Andrew Foggo, David T. Bilton

School of Biological and Marine Sciences

1. Biological invasions constitute a pervasive and growing threat to the biodiversity and functioning of freshwater ecosystems. Macrophytes are key primary producers and ecosystem engineers in freshwaters, meaning that alien macrophyte invasions have the capacity to alter the structure and function of recipient aquatic ecosystems profoundly. Although prevailing wisdom holds that alien macrophyte invasions tend to compromise freshwater ecosystem structure and function, the ecological impacts of alien macrophyte invasion have not been quantitatively reviewed to date. 2. Here we present a global meta-analysis of 202 cases from 53 research articles, exploring the impacts of alien macrophyte invasion on the abundance …


Thermodynamic And Structural Quantification Of Metal Ions Binding To The Antimicrobial Peptide Calcitermin, Sohee Choi Aug 2022

Thermodynamic And Structural Quantification Of Metal Ions Binding To The Antimicrobial Peptide Calcitermin, Sohee Choi

Master's Theses

Over the past several decades the number of antibiotic resistant bacteria has grown dramatically, in part due to the over-prescription of antibiotics. This rise in antibiotic resistance has led to development of novel antibiotics. An attractive alternative to treat bacterial infections may be the use of antimicrobial peptides due their little-known resistance from bacteria. One such peptide is calcitermin (VAIALKAAHYHTHKE), a 15-residue peptide found in human airways. Calcitermin has antimicrobial properties that target Gram-positive bacteria and is most active in acidic buffer (pH 5.4) due to protonation of its three histidine residues, which allows it to interact with the negatively …


College Of Education News, Georgia Southern University Aug 2022

College Of Education News, Georgia Southern University

College of Education: News & Publications (2003-2023)

  • Meet the Call Me MiSTER cohort
  • Williams-Johnson selected as Governor’s Teaching Fellow
  • COE to Host Educator Wellness Day