Digital Commons Network^™

Re-Examining Rotavirus Innate Immune Evasion: Potential Applications Of The Reverse Genetics System, Avan Antia, Amanda N Pinski, Siyuan Ding

2020-Current year OA Pubs

Rotaviruses represent one of the most successful pathogens in the world, with high infectivity and efficient transmission between the young of many animal species, including humans. To overcome host defenses, rotaviruses have evolved a plethora of strategies to effectively evade the innate immune response, establish initial infection in the small intestine, produce progeny, and shed into the environment. Previously, studying the roles and relative contributions of specific rotaviral factors in innate immune evasion had been challenging without a plasmid-only reverse genetics system. Although still in its infancy, current reverse genetics technology will help address important research questions regarding rotavirus innate …

Blocking Chop-Dependent Txnip Shuttling To Mitochondria Attenuates Albuminuria And Mitigates Kidney Injury In Nephrotic Syndrome, Sun-Ji Park, Yeawon Kim, Chuang Li, Junwoo Suh, Jothilingam Sivapackiam, Tassia M Goncalves, George Jarad, Guoyan Zhao, Fumihiko Urano, Vijay Sharma, Ying Maggie Chen

2020-Current year OA Pubs

Albuminuria is a hallmark of glomerular disease of various etiologies. It is not only a symptom of glomerular disease but also a cause leading to glomerulosclerosis, interstitial fibrosis, and eventually, a decline in kidney function. The molecular mechanism underlying albuminuria-induced kidney injury remains poorly defined. In our genetic model of nephrotic syndrome (NS), we have identified CHOP (C/EBP homologous protein)-TXNIP (thioredoxin-interacting protein) as critical molecular linkers between albuminuria-induced ER dysfunction and mitochondria dyshomeostasis. TXNIP is a ubiquitously expressed redox protein that binds to and inhibits antioxidant enzyme, cytosolic thioredoxin 1 (Trx1), and mitochondrial Trx2. However, very little is known about …

Increased Anxiety From Fear Of Omicron In China As Compared To North America And Western Europe: A Cross-Sectional Kendall's Tau-B Analysis Using The Generalized Anxiety Disorder 7-Item Questionnaire, Dan Shan, Chang Liu, Shaoyang Li, Yuandian Zheng

Student Publications

Background: Policies dealing with the Coronavirus Disease 2019 (COVID-19) pandemic vary across the globe, the different governmental responses then affect the public perception of COVID-19. Many unofficial Chinese media outlets frequently spread misinformation about COVID-19 and exaggerated reports of rare sequelae of Omicron for monetization and attention seeking, leading to panics in the Chinese public. In comparison the attitudes toward Omicron in other countries around the world, especially in North America and Western Europe have shifted to a more relaxed stance.

Objective: This article primarily aims to investigate the association between Chinese people’s attitudes toward the potential after-effects of Omicron …

Discovery Of Sars-Cov-2 Rna-Dependent-Rna-Polymerase (Rdrp) Inhibitor From Sambiloto (Andrographis Paniculata) Based On Molecular Docking And Admet Prediction Approach, Dina Ahsana, Rizki Rahmadi Pratama, Alfisyahriatunnida Meily, Andika Andika

Pharmaceutical Sciences and Research

The rapid spread of the coronavirus disease 2019 (COVID-19) has led to the development of therapeutic inhibitor drug of SARS-CoV-2, which can inhibit the viral enzyme RNA-dependent-RNA-polymerase (RdRp), thereby preventing the replication, transcription, and synthesis of RNA virus in the host cells. Previous in-vitro studies revealed that Andrographis paniculata has the potential to inhibit the virus. Therefore, this study aims to isolate the specific compounds of Andrographis paniculata, which play a role in inhibiting SARS-CoV-2 RdRp using molecular docking. A total of 19 compounds were identified in previous literature studies, while remdesivir and favipiravir were used as the positive …

The Association Between Adherence To Oral Antihyperglycemic Agent And Hba1c Level, Indana Ayu Soraya, Rani Sauriasari, Pukovisa Prawiroharjo, Hindun Wilda Risni

Pharmaceutical Sciences and Research

Adherence to taking medication is essential for patients with chronic diseases such as Type 2 Diabetes Mellitus (T2DM). There have been many studies about the association between medication adherence and HbA1c levels, but few have used Adherence Refills and Medications Scale (ARMS) questionnaire and Proportion of Days Covered (PDC) method to measure adherence in Indonesian population. The aim of this study were to assess the association of medication adherence to HbA1c levels and compare two methods of adherence measurements. This research was conducted at Pasar Minggu Public Health Center, Jakarta using a cross-sectional design. The adherence assessment was conducted using …

Sustaining Indigenous Knowledge Through The Digitization Of Information On Herbal Medicine In Medical Libraries In Nigeria: Problems And Prospects., Emmanuel Chukwudi Ihekwoaba, Roseline Ngozi Okwor, Caroline Uchenna Nnadi, Uzoamaka Uzuoma Jidere, Ify Evangel Obim

Library Philosophy and Practice (e-journal)

This study examined the concept of herbal medicine and the need for supporting Indigenous knowledge through the digitalization of information on the accumulation and transmission of herbal healing practices from generation to generation. It examined the relevance of digitizing herbal medicine information in order to sustain and conserve this unique information. The digitalization of library health information also raises readers' attention. In addition, the organization is responsible for permanent storage and documentation of information resources, in particular health information. This research examined the strategic importance of medical libraries. It described how medical libraries could be crucial in digitizing indigenous herbal …

Spatiotemporal Correlation Analysis Of Hydraulic Fracturing And Stroke In The United States, Chuanbo Hu, Bin Liu, Shuo Wang, Zhenduo Zhu, Amelia Adcock, James Simpkins, Xin Li

2020-Current year OA Pubs

Hydraulic fracturing or fracking has led to a rapid growth of oil and gas production in the United States, but the impact of fracking on public health is an important but underresearched topic. We designed a methodology to study spatiotemporal correlations between the risk of fracking and stroke mortality. An annualized loss expectancy (ALE) model is applied to quantify the risk of fracking. The geographically and temporally weighted regression (GTWR) model is used to analyze spatiotemporal correlations of stroke mortality, fracking ALE, and nine other socioeconomic- and health-related factors. The analysis shows that fracking ALE is moderately correlated with stroke …

Contrasting Effects Of Sleep Fragmentation And Angiotensin-Ii Treatment Upon Pro-Inflammatory Responses Of Mice, David C. Ensminger, Nicholas D. Wheeler, Reem Al Makki, Kristen N. Eads, Noah T. Ashley

Faculty Research, Scholarly, and Creative Activity

Disordered sleep promotes inflammation in brain and peripheral tissues, but the mechanisms that regulate these responses are poorly understood. One hypothesis is that activation of the sympathetic nervous system (SNS) from sleep loss elevates blood pressure to promote vascular sheer stress leading to inflammation. As catecholamines produced from SNS activation can directly regulate inflammation, we pharmacologically altered blood pressure using an alternative approach-manipulation of the renin-angiotensin system (RAS). Male C57BL6/J mice were treated with angiotensin or captopril to elevate and reduce blood pressure, respectively and then exposed to 24-h of sleep fragmentation (SF) or allowed to sleep (control). Pro- and …

Association Between Fall History And Gait, Balance, Physical Activity, Depression, Fear Of Falling, And Motor Capacity: A 6-Month Follow-Up Study, Catherine Park, Md Moin Uddin Atique, Ramkinker Mishra, Bijan Najafi

Center on Aging Staff Publications

Maintaining function in older adults is key to the quality of life and longevity. This study examined the potential impact of falls on accelerating further deterioration over time in gait, balance, physical activity, depression, fear of falling, and motor capacity in older adults. 163 ambulatory older adults (age = 76.5 ± 7.7 years) participated and were followed for 6 months. They were classified into fallers or non-fallers based on a history of falling within the past year. At baseline and 6 months, all participants were objectively assessed for gait, balance, and physical activity using wearable sensors. Additional assessments included psychosocial …

Integrated Relationship Of Nasopharyngeal Airway Host Response And Microbiome Associates With Bronchiolitis Severity, Michimasa Fujiogi, Yoshihiko Raita, Marcos Pérez-Losada, Robert J Freishtat, Juan C Celedón, Jonathan M Mansbach, Pedro A Piedra, Zhaozhong Zhu, Carlos A Camargo, Kohei Hasegawa

Faculty, Staff and Students Publications

Bronchiolitis is a leading cause of infant hospitalizations but its immunopathology remains poorly understood. Here we present data from 244 infants hospitalized with bronchiolitis in a multicenter prospective study, assessing the host response (transcriptome), microbial composition, and microbial function (metatranscriptome) in the nasopharyngeal airway, and associate them with disease severity. We investigate individual associations with disease severity identify host response, microbial taxonomical, and microbial functional modules by network analyses. We also determine the integrated relationship of these modules with severity. Several modules are significantly associated with risks of positive pressure ventilation use, including the host-type I interferon, neutrophil/interleukin-1, T cell …

Polymer Chemistry Of Dental Adhesives, Alia J. Rubaie, Karen A. Schulze

Pacific Journal of Health

Dental adhesives are water soluble, non-toxic materials that bind composite resins to dentin and enamel. Adhesive systems are dependent on a polymerization process at the interface and require different moieties to prepare the substrate to effectively interact with the tooth surface. Due to their critical role in restorative procedures, many chemists are interested in strengthening the adhesive bond strength at the interface. This review paper covers the evolution of dental adhesive systems over time and provides an extensive overview of what components make up a dental adhesive system. Additionally, this article explores the common issues found in adhesive systems, and …

Transformation Based Digital Technology: The Effectivity Of Psychosocial Intervention Method, I Kadek Agus Hendriawan Putra, Pande Putu Narisya Ardhaneswari, Ni Wayan Devi Ariasih, I Komang Krisnata Kanaya

Smart City

A multitude of patterns resulting from technological change have an influence on people's mental health. People in the digital era need strong mental health in order to prevent mental disease. Coupled with the pandemic condition that happened around two years ago, it also took a part of the economic chain stability in the public, which is really important for everyday daily life. From the literature studies that have been read, showed that approximately 20% of the Indonesian population has the potential to have a mental disorder. Based on the various mental health problems that occur, the approach using the psychosocial …

Towards Public Vaccination Data Resilience During Natural Disaster Using Blockchain-Based Decentralized Application, Riri Fitri Sari, Mokhammad Rizqi Herdiawan, Muhammad Hamzah, Muhammad Aljundi, Jauzak Hussaini Windiatmaja

Smart City

This paper presents a platform development plan for a public vaccination decentralized data base based on Blockchain technology. Vaccination is a medical practice that allows a human body to produce a specific antibody as a means of developing a preventive measure and reducing the risk of contracting a particular disease. Systematic vaccination data recording is an utmost important system that is required particularly during the Covid-19 pandemic. The recording mechanism should utilize the state-of-the-art information and communication technology (ICT). For faster vaccination data recording, it is common to use digital technology, making the health care process faster thus decreasing time …

Traditional Knowledge And Twail, Gunjan Deshpande

Indonesian Journal of International Law

Traditional Knowledge (TK) is a deep-rooted notion in the Indian culture, it is the knowledge that has been passed on for centuries and is governed by the traditional customary laws. It applies to everything from food storage, agriculture to medicine to the preservation of the environment. TK are protected by national or regional laws that provide limited protection. There have been various instances where Indian TK was patented outside India some of the examples are Turmeric, Amla, and Neem. TK is the base of modern science and technology, as it is derived from a strong cultural heritage that is vital …

What’S In Your Glass? Whether Milk Labels Should Be Based On Creation Process Or End Product (Part Iii Of Iii), Samantha Masters

Law Review Blog Posts

Part III of this blog series proposes a three-part solution to the debate over labeling cultured milk that promotes consumer clarity, marketability, and judicial efficiency.

Lanthorn, Vol. 57, No. 02, August 29, 2022, Grand Valley State University

Volume 57, August 1, 2022 - April 10, 2023

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Lgbtq+ In The Cowl: The Good, The Bad, The Ugly - Tracing Coverage Of Lgbtq+ Topics From 1935 To 2022, Nicole Patano

Sociology & Anthropology Student Scholarship

In their very first issue published on November 16, 1935, The Cowl staff explained the purpose of the novel student newspaper: “Primarily, the COWL exists to serve the student body, not simply as a news organ, but more fundamentally as a means to foster and intensify an enthusiatic Providence College spirit and loyalty.” Since its founding, The Cowl has attempted to be just that, reporting news and welcoming discussion and debate from members of its staff and members of the larger Providence College community.

Unfortunately, however, the mission of the College can, and often has, run contrary to the mission …

20220829_Meet Our Students Monday, Amy Weig-Pickering

HSLIC Blog Post

No abstract provided.

The Rider (2022-08-29), Verilu Infante

The Rider Archives

Vol.8 No.1

Faculty, Student Interest Drives Expansion Of Sustainability Curriculum, Matt Windsor

Browse All News

No abstract provided.

Antioxidant Activity And Total Phenolic Content Of The Aqueous Extracts Of A Thai Blood Tonic (Bhamrung-Lohit) Remedy And Its Plant Components, Chitralada Panchakul, Pakakrong Thongdeeying, Arunporn Itharat, Weerachai Pipatrattanaseree

Asian Medical Journal and Alternative Medicine

Introduction: In the Mahachotarata scripture, there was a blood tonic remedy known as Bhamrung-Lohit remedy in Thai which has been used in female adult to treat menstrual irregularities, abnormal menstruation, and for nourishing blood and body. The aims of this study were to determine the amount of total phenolics and antioxidant activities of Bhamrung-Lohit remedy and its plant components.
Methods: All tested extracts were prepared by decoction as practiced in traditional medicine. All extracts were analyzed for their phenolic content by Folin-Ciocalteu assay and their antioxidant activities by using DPPH radical scavenging assay, ABTS radical scavenging and ferric reducing antioxidant …

Telomere Length In Various Age Groups Of Normal-Body Weight Thais And Obese Thais, Thamonwan Nantanawut, Preeya Leelahagul, Aruchalean Taweewongsounton, Wutarak Puengputtho, Somchai Bovornkitti

Asian Medical Journal and Alternative Medicine

Introduction: Telomere is non-coding nucleoprotein at the terminal of chromosomes that shortens during DNA replication as a cause of aging. In obese people, excess body fat is a key role in inducing chronic inflammation which accelerates telomere shortening. This study aimed to determine the difference in telomere length between normal body weight and obese Thais males aged 21-82 years.
Methods: This study was a cross-sectional design including 39 normal body weight and 41 obese subjects. Nutritional status was assessed using body composition and blood biochemistry. General information and health information were obtained by using questionnaires. Telomere length was measured using …

More Work, Less Reward: The Minority Tax On Us Medical Students, Marija Kamceva, Baffour Kyerematen, Sabina Spigner, Samuel Bunting, Simiao Li-Sauerwine, Jane Yee, Michael Gisondi

Journal of Wellness

Introduction: Minority tax is defined as the burden of time and resources placed on minority persons to represent and advocate for their communities. We determined whether medical students underrepresented in medicine (URM) or from historically excluded (HE) populations experience a minority tax and characterized its effects.

Methods: This cross-sectional survey of US medical students occurred November 2020 - June 2021. We used Mann-Whitney U tests to compare metrics between URM and HE participants and their peers. The primary outcome was time invested in activism/diversity initiatives versus other work. Secondary outcomes included measures of microaggressions, discrimination, institutional culture, anxiety/depression, …

Study On Pollution Management And Pollution Emergency Of Offshore Oil Drilling Platform, Jun Shi

World Maritime University Dissertations

No abstract provided.

Evaluation Of Vicinity-Based Hidden Markov Models For Genotype Imputation, Su Wang, Miran Kim, Xiaoqian Jiang, Arif Ozgun Harmanci

Faculty, Staff and Student Publications

BACKGROUND: The decreasing cost of DNA sequencing has led to a great increase in our knowledge about genetic variation. While population-scale projects bring important insight into genotype-phenotype relationships, the cost of performing whole-genome sequencing on large samples is still prohibitive. In-silico genotype imputation coupled with genotyping-by-arrays is a cost-effective and accurate alternative for genotyping of common and uncommon variants. Imputation methods compare the genotypes of the typed variants with the large population-specific reference panels and estimate the genotypes of untyped variants by making use of the linkage disequilibrium patterns. Most accurate imputation methods are based on the Li-Stephens hidden Markov …

Optimasi Hubungan Kuantitatif Struktur Senyawa Turunan Quercetin Yang Berpotensi Terhadap Aktivitas Antivirus Dengue Dengan Metode Austin Model 1, Ika Diana Evita, Charles Banon, Salprima Yudha, Morina Adfa

Chimica et Natura Acta

Antivirus dengue merupakan suatu senyawa yang memiliki kemampuan dalam menghambat aktivitas dari virus DENV. Salah satu senyawa yang memiliki aktivitas antivirus dengue yaitu quercetin. Telah dilakukan analisis Hubungan Kuantitatif Struktur Aktivitas (HKSA) secara teoritik dengan memprediksi turunan senyawa quercetin yang dioptimasi dengan menggantikan atom H dan gugus –OH dengan substituen NO2 dan/atau F (flour) pada posisi 3, 5, 7, 8, 2’, 3’, 4’ dan 5’, sehingga didapatkan 16 senyawa turunan quercetin. Metode yang digunakan adalah semiempiris AM1 dengan aplikasi Hyperchem 8.0.8 untuk pengoptimasi struktur dan metode backward untuk analisis regresi multilinier dengan aplikasi SPSS v24.0. Analisis regresi multilinier menunjukkan bahwa …

Herbaceous Production Lost To Tree Encroachment In United States Rangelands, Scott L. Morford, Brady W. Allred, Dirac L. Twidwell Jr, Matthew O. Jones, Jeremy D. Maestas, Caleb P. Roberts, David E. Naugle

Department of Agronomy and Horticulture: Faculty Publications

1. Rangelands of the United States provide ecosystem services that benefit society and rural economies. Native tree encroachment is often overlooked as a primary threat to rangelands due to the slow pace of tree cover expansion and the positive public perception of trees. Still, tree encroachment fragments these landscapes and reduces herbaceous production, thereby threatening habitat quality for grassland wildlife and the economic sustainability of animal agriculture.

2. Recent innovations in satellite remote sensing permit the tracking of tree encroachment and the corresponding impact on herbaceous production. We analysed tree cover change and herbaceous production across the western United States …

Mutant P53 Depletion By Novel Inhibitors For Hsp40/J-Domain Proteins Derived From The Natural Compound Plumbagin., Mohamed A.A. Alalem, Mrinalini Bhosale, Atul Ranjan, Satomi Yamamoto, Atsushi Kaida, Shigeto Nishikawa, Alejandro Parrales, Sana Farooki, Shrikant Anant, Subhash Padhye, Tomoo Iwakuma

Manuscripts, Articles, Book Chapters and Other Papers

Accumulation of missense mutant p53 (mutp53) in cancers promotes malignant progression. DNAJA1, a member of HSP40 (also known as J-domain proteins: JDPs), is shown to prevent misfolded or conformational mutp53 from proteasomal degradation. Given frequent addiction of cancers to oncogenic mutp53, depleting mutp53 by DNAJA1 inhibition is a promising approach for cancer therapy. However, there is no clinically available inhibitor for DNAJA1. Our in silico molecular docking study with a natural compound-derived small molecule library identified a plumbagin derivative, PLIHZ (plumbagin-isoniazid analog), as a potential compound binding to the J domain of DNAJA1. PLIHZ efficiently reduced the levels of DNAJA1 …

Current Landscape Of Uveitis Specialists In The United States, Edmund Tsui, Eric L. Crowell, Sapna Gangaputra, Kareem Moussa, Jessica G. Shantha, Alexander J. Shusko, Ian A. Thompson, Derek C. Pham, Nicholas J. Jackson, Arthi G. Venkat

Journal of Academic Ophthalmology

Abstract

Purpose This study characterizes the current landscape of uveitis specialists and their practice settings in the United States.

Methods An anonymous Internet-based survey with questions pertaining to training history and practice characteristics was distributed via REDCap to the American Uveitis Society and Young Uveitis Specialists listservs.

Results Forty-eight uveitis specialists in the United States responded to the survey out of 174 uveitis specialists that identify as practicing in the United States. Twenty-five of 48 respondents (52%) completed an additional fellowship. These additional fellowships ranged from surgical retina (12/25, 48%), cornea (8/25, 32%), and medical retina (4/25, 16%). Two-thirds of …

What Governs Attitudes Toward Artifcial Intelligence Adoption And Governance?, Matthew R. O’Shaughnessy, Daniel S. Schiff, Lav R. Varshney, Christopher J. Rozell, Mark A. Davenport

Department of Political Science Faculty Publications

Designing effective and inclusive governance and public communication strategies for artificial intelligence (AI) requires understanding how stakeholders reason about its use and governance. We examine underlying factors and mechanisms that drive attitudes toward the use and governance of AI across six policy-relevant applications using structural equation modeling and surveys of both US adults (N = 3,524) and tech- nology workers enrolled in an online computer science master’s degree program (N = 425). We find that the cultural values of individualism, egalitarianism, general risk aversion, and techno-skepticism are important drivers of AI attitudes. Perceived benefit drives attitudes toward AI use but …