Hidden Workload In Emergency Medicine: Examining The Role Of Outside-Of-Shift Duties In Emergency Physician Fatigue, Sarah Meyer

All Theses

Emergency physicians (EPs) face high rates of burnout. In addition to well-known stressors, such as fatiguing shift work schedules and intense emotional and cognitive demands faced during clinical shifts, many EPs must also attend to certain outside-of-shift duties (OSDs)–extra-clinical role responsibilities that are expected but not always formally tracked or compensated. These duties often occur during times when EPs are expected to rest and recover from shift work. Despite concerns surrounding burnout in emergency medicine and beliefs among EPs that OSDs contribute to burnout, the effects of OSDs have rarely been studied. Using daily and weekly surveys across 28 days, …

Confronting The Darkness: Nightmare Distress, Fear, And Avoidance Through The Lens Of Courage, Casidee Gonzales

All Theses

Nightmares are an infamous phenomenon where subjective meaning and objective implications meet. This thesis examined nightmare distress’ impact on fear of sleep and nightmare processing avoidance, a novel construct measured with a pilot survey; it also investigated the moderating roles of courage and neuroticism, with PTSD included as a covariate. The research was rooted in the dual-process model of courage and a phenomenology to assess approach and avoidance through goals and risks.

Participants were primarily recruited through Clemson’s SONA system, were mainly White, women, and young adults (N = 351); measures were administered via Qualtrics. Four hypotheses were tested, …

Quantifying Macrophyte Ecosystem Services And Improving Environmental Nonprofit Messaging, Peyton R. Hughey

All Theses

Environmental nonprofits are essential to the management and restoration of our natural spaces. They are also tasked with engaging the public via outreach, education, and advocacy. As natural spaces are degraded, the ability of environmental nonprofits to deliver on their missions will become increasingly important. This study aimed to improve two approaches to environmental nonprofits’ missions: ecological restoration and social media communication.

Environmental nonprofits operate with limited resources, and ecological restoration can be an exhaustive task; therefore, we explore functional restoration as a tool. In this study, we focus on the use of functional, trait-based restoration to restore ecological function …

Mining The Usda Snap Bean Association Panel For Resilience: Genetic Dissection Of Heat And Disease Tolerance In Snap Bean, Atiya F. Khan

All Theses

Snap bean (Phaseolus vulgaris L.) is an economically and nutritionally important vegetable crop whose production is increasingly threatened by rising temperatures and emerging bacterial diseases, particularly in the southeastern United States. Heat stress during reproductive development can significantly reduce yield, while newly emerging pathogens such as Pseudomonas capsici present additional risks to crop productivity. This study leveraged the USDA Snap Bean Association Panel (SnAP) to investigate the genetic basis of heat tolerance and disease resistance and to identify germplasm and genomic regions useful for breeding resilient cultivars.

To evaluate heat tolerance, a subset of the SnAP panel was …

Estimation Of The Mechanical Properties Of South Carolina Timber Piles Using Non-Destructive Evaluation Methods And Experimentally-Informed Models, Aashish Sapkota

All Theses

South Carolina has about 2,600 bridges that are supported by nearly 75,000 timber piles. They are increasingly vulnerable to biological decay, cracking and impact damages after decades of service. Current inspection methods used by the South Carolina Department of Transportation (SCDOT), such as hammer sounding and awl probing, are labor-intensive and expensive. This study investigated non-destructive evaluation (NDE) methods, including micro-resistance drilling and stress wave timing, as alternatives for assessing timber pile condition.

Ten timber piles were collected from two South Carolina bridges, and their above-grade portions were cut into 40 specimens approximately 13 to 15 inches long. Specimens were …

Identity, Party, And Politics: A Discourse Analysis Of Democratic Elites In Pod Save America, Geneva Lei P. Luteria

All Theses

The rise of popular podcasts has shaped public discourse and influenced millions worldwide on how they ought to think, imagine, and act about controversial subjects. Podcasts create an avenue for stories about power and technology to co-create a narrative that viewers buy into. This thesis analyzes one of these essential podcasts, Pod Save America, in how Democratic elite guests approach identity politics, a phenomenon best described as advocacy based on one position’s in society. I begin the thesis by considering the differences in scholarly interpretation of how identity politics functions conceptually and practically. Then, I integrate ideas about how …

Between Home And Hallway: Does School Discipline And Parental Incarceration Moderate Academic Outcomes Among Justice Involved Youth?, Morgan M. Hamer

All Theses

This study examines the relationship between parental justice contact, school disciplinary action, and academic performance of juvenile justice involved youth. Prior research has found youth with parents with justice system contact and juvenile justice involved youth to be vulnerable populations. Specifically, this study examines how a youthful offender with at least one parent with justice system contact performs academically, and if this relationship is moderated by school disciplinary action. Using quantitative data from the baseline wave of the Pathways to Desistance Study (Mulvey et. al, 2004), an ordered logistic regression analysis was employed to assess whether parental justice contact predicts …

Taking A Deeper Look: Attributing Tonal Values Of Photolumens To Their Emulsions Using Scanning Electron Microscopy, Anna M. Moore

All Theses

This thesis examines whether tonal variation in photolumens made with historic silver gelatin photographic papers can be linked to differences in elemental composition. Photolumens are cameraless photographic images created by placing objects directly on light-sensitive paper and exposing them to ultraviolet light. Because expired and historic darkroom papers often produce unpredictable colors and tones, this study asks whether visually defined tonal groups also show measurable chemical differences.

Twenty historic paper samples were exposed, documented, and sorted into five tonal groups based on visible image characteristics. Each sample was then analyzed using scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) …

The Impact Of Dipeptides On Product Quality In Chinese Hamster Ovary Cells, Louise C. Herman

All Theses

Biopharmaceuticals are medicines produced in cells which are used to treat diseases such as cancer. Monoclonal antibodies (mAbs) represent the majority of approved biotherapeutics. MAbs are mostly produce using Chinese hamster ovary (CHO) cells. CHO cells are favored for resiliency, scalability, and established safety, and are considered the “workhorse” organism for biopharmaceuticals.  Amino acids are a key component of cell culture media, however several amino acids have solubility limits, such as cysteine, cystine, and tyrosine.  At neutral pH, these amino acids are poorly soluble.  However, dipeptides, such as N,N'-di-L-Alanyl-L-Cystine (ACCA) have been reported to increase cysteine and cystine availability. Further, …

How Mindfulness Influences The Frequency Of Flow In Collegiate Athletes, Kelly Torres

All Theses

Flow is defined as a state of optimal experience characterized by deep focus and total absorption that has been consistently linked to enhanced performance (Csikszentmihalyi, 1990; Jackson and Csikszentmihalyi, 1999). Mindfulness, defined as present-moment awareness with acceptance and nonjudgement, has been widely used in sport psychology interventions to improve both performance and well-being (Harris et al., 2023; Kabat-Zinn, 2015; Reive, 2019). However, less is known about how and why mindfulness contributes to performance outcomes and what role flow plays. This study examined the relationship between trait mindfulness and dispositional flow among Clemson University collegiate athletes (N=144), while exploring …

Fluorescence-Based Quantification Of Hepatic Ldl Uptake And Donor Hepatocyte Engraftment Using Atto 700–Labeled Ldl, Victor Agustin Cortes Flores

All Theses

Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated low-density lipoprotein cholesterol (LDL-C) that increases the risk of premature atherosclerotic cardiovascular disease. In severe FH, including low-density lipoprotein receptor (LDLR), hepatic LDL clearance is profoundly impaired and many lipid lowering treatment strategies have limited effectiveness. Current advances in ex vivo CRISPR–Cas9 hepatocyte gene editing in vivo and ex vivo approaches for treatment of FH are under development.

However, a central barrier to translation is the ability to quantitatively measure the percentage of healthy gen edited hepatocytes in the liver while simultaneously assessing functional hepatic LDL handling. This thesis establishes …

Forest Overstory Mortality & Recruitment Patterns Eight Years Following Wildfire In The Southern Appalachians, Ruth Cumberland

All Theses

In this study, we investigated patterns of forest overstory mortality and recruitment eight years after wildfire in a large wildfire site the Southern Appalachians, a topic that has not been thoroughly investigated to date. With evidence that pre-fire drought promotes post-fire mortality through impaired physiological function and increased fuel consumption, unknown patterns following wildfire are important to study under shifting climate and land-use conditions. In Chapter 1, three areas of interest were investigated: (a) functional group mortality response to wildfire effects, (b) temporal differences in early (1-3 years) and late (5-8 years) periods of delayed forest overstory mortality patterns following …

Exercise-Induced Muscle Damage As A Model For Exploring The Effects Of Pain On Gait, Sydney Savage

All Theses

Persistent gait asymmetry following anterior cruciate ligament reconstruction (ACLR) is a recognized contributor to post-traumatic knee osteoarthritis, yet the independent role of pain in driving altered movement patterns remains poorly understood due to confounding factors inherent to clinical populations. This study used exercise-induced muscle damage (EIMD) as a controlled experimental model to isolate the effects of musculoskeletal pain on gait, independent of kinesiophobia, structural damage, and proprioceptive disruption. Eighteen healthy adults underwent unilateral eccentric calf-raise protocols to induce delayed onset muscle soreness (DOMS), with gait assessed at baseline, 48 hours, and 168 hours post-exercise using bilateral inertial measurement units. Outcomes …

Portrayals Of Miscarriage In Film And Television: A Qualitative Analysis, Geovana Leonetti Saraiva

All Theses

Entertainment media may serve as a primary source through which individuals learn about miscarriage; however, little research has examined how miscarriage is portrayed in film and television. This study addresses this gap by conducting a textual analysis of five films and five television shows using a constructivist grounded theory approach. Guided by the model of stigma communication (MSC), communication privacy management theory (CPM), and social support frameworks, the analysis explores how miscarriage is represented in entertainment media.

Findings indicate that the analyzed content frequently includes stigma-related cues—such as marks, labels, responsibility, and peril—that may contribute to the formation and reinforcement …

Modeling Repeated Evolution Of Polygenic Traits, Marshall N. Hoskins

All Theses

Understanding the genetic composition of adaptive evolution is a longstanding and primary goal of evolutionary genetics. Despite many advances in our knowledge of trait adaptation, it remains unclear how demographic changes and repeated selection might alter the expected genetic architecture of adaptation. We used forward-in-time genetic simulations to test and observe the effects of opposing, repeated selection regimes on a polygenic trait in populations with and without changes in demography to better understand the genetic alleles that underlie polygenic adaptation. To further illuminate how natural populations might evolve, we investigated the impact of mutation effect size, the role of dominant/recessive …

The Invisible Toll: Black College Women And The Intersection Of Academic Stress, Rest Deficiency And Exhaustion At Clemson University, Jomya Ford

All Theses

Leisure has been an under-explored aspect of Black women’s lives in higher education, particularly within predominantly white institutions (PWIs), where limited culturally relevant opportunities and racialized isolation shape daily experiences. Constraints around rest, rooted in racism and gendered expectations, continue to influence how Black college women navigate academic pressure, deficiency narratives, and exhaustion. Guided by intersectionality, this qualitative study draws on semi‑structured interviews with Black undergraduate and graduate women at a PWI to explore how cultural upbringing, institutional climates, and internalized expectations shape their definitions and practices of rest. Findings show that while participants recognize rest as necessary, they rarely …

Design And Development Of A Perfusable Hydrogel Platform With Bioprinted Human-Endothelialized Microvascular Channels, Calvin A. Chernyatinskiy

All Theses

We developed an integrated bioprinting and perfusion platform to generate vascularized hydrogel constructs that support perfusable microchannel networks. Multiple hydrogel formulations, sacrificial ink systems, device geometries, and perfusion conditions were systematically evaluated to optimize print fidelity, mechanical stability, and cellular compatibility. Internally gelling alginate–calcium carbonate hydrogels were identified as a robust matrix, providing tunable gelation kinetics and structural stability during embedded printing. In parallel, Pluronic F-127 fugitive ink enabled reliable fabrication of continuous hollow channels due to its shear-thinning behavior and efficient post-print removal.

The finalized platform integrates stereolithographically fabricated perfusion chambers with extrusion-based bioprinting to produce three-dimensional, perfusable vascular …

Biology, Ecology And Control Of Eye Gnats In An Open Pine Ecosystem, Leela Hospach

All Theses

Eye gnats of the genus Liohippelates are bothersome flies of the family Chloropidae. They breed in moist, disturbed, sandy soils that contain organic matter, and have been implicated as vectors of conjunctivitis, bovine mastitis, and yaws. We conducted research into some basic biological and ecological characteristics. Using wild-caught gnats in a temperature-controlled incubator, we found that their activity peaks between 27°C and 41°C. Trapping at different heights above the forest floor in an open-pine savannah, we captured most gnats at 7.5 m off the ground. This may have to do with the attractiveness of the rotten egg lures we used, …

Characterizing The Molecular Response Of Embryonic Zebra Finch To Acute Sound Playback, Saidat O. Adeniran-Obey Miss

All Theses

Auditory stimuli are important cues that influence developmental plasticity in animals and are important for development and adaptation to an ever-changing environment. In the zebra finch (Taeniopygia guttata), there is evidence of adaptive developmental reprogramming in response to a prenatal ‘heat call’. Embryos exposed to this heat call exhibit changes in growth rate post-hatch, increased heat resistance, and enhanced reproductive success at maturity. However, it has long been assumed that embryonic zebra finches cannot respond to sound due to the immaturity of their auditory system. These findings raise the critical question of whether late-stage zebra finch embryos can, …

Comparative Biomechanics: Blattodea Antennal Morphology And Physiology, Lucas W. Marsh

All Theses

Equipped with muscle-free antennae, many insects can twist and bend their antennae on demand. We hypothesized that hemolymph circulating through the antennae provides pressure that facilitates twisting and bending and provides a feedback control channel for tactile sensing in insects. To test this hypothesis, we conducted a thorough morphological and physiological analysis of antennae in three Clades of Blattodea. We studied morphology by evaluating the distinguishable features of the body and antenna, as well as the internal structure of the antennal lumen. Then, in a series of experiments on live cockroaches, we measured blood pressure along the antenna. This was …

Scrolling For Support: Social Media Use, Health Information Seeking, And Social Support In Individuals With Type 1 Diabetes, Loren Myers

All Theses

Type 1 diabetes (T1D) is a lifelong chronic illness that is rapidly increasing in prevalence. Continuous treatment is necessary for proper management, but barriers to care can cause some to turn to other sources for health-related information, like social media. Given the limited research on social media use and health information seeking behaviors in people with T1D, this study aims to gain an understanding of how people with T1D use social media, where they get their health information, and how social support is related to social media behaviors among people with T1D. Adult T1D participants completed an online survey that …

Anxiety And Intuitive Eating: Examining Dispositional Mindfulness As A Protective Factor, Jordan Signorelli

All Theses

Intuitive eating (IE) is an anti-diet approach focused on listening to internal hunger and fullness cues and is associated with reduced disordered eating patterns and improved dietary intake. However, anxiety negatively impacts IE. Dispositional mindfulness (DM) – one’s innate, present-centered, nonjudgmental awareness of thoughts, emotions, and bodily sensations – is associated with lower anxiety and greater IE. Yet, whether DM mitigates the negative impact of anxiety on IE remains underexplored. Grounded in the Cognitive Behavioral Therapy Framework, this study aimed to: 1) examine the relationship between anxiety and IE, 2) examine the relationship between DM and IE, 3) examine whether …

I Am The Perfect Wife: The Bildungsroman And The Disruption Of The System In Jane Eyre And The Hunger Games, Carolyn Carpenter

All Theses

None.

Stochastic Universal Differential Equations For Epidemiological Modeling: Uncertainty Quantification In Disease Transmission Dynamics, Alice Menaya Armah-Bonney

Electronic Theses and Dissertations

Epidemic forecasting requires not only predictions of expected case counts, but also quantification of uncertainty, although existing surrogate modeling frameworks for agent-based models remain fundamentally deterministic. In this thesis a Stochastic Universal Differential Equation framework is presented that extends the deterministic Universal Differential Equation approach by incorporating a learnable stochastic diffusion term, enabling calibrated probabilistic forecasts while preserving the mechanistic interpretability and computational efficiency of the deterministic baseline. In doing so, a two-phase training algorithm is introduced to ensure stable convergence and the framework is validated against the ensemble output from ExaEpi, an exascale agent-based model of a COVID-19 outbreak …

University Student Mental Health: Service Utilization, Equity Gaps, And Strategies To Improve Access, Richard Mutua Kilonzo

Electronic Theses and Dissertations

Student mental health and access to care are pressing concerns in higher education. This study assesses mental health outcomes and access to campus mental health services at East Tennessee State University. Survey data from the 2023–2024 Healthy Minds Study were analyzed to report the prevalence of depression, anxiety, and suicidal ideation across the student population. The study evaluates disparities in these outcomes and barriers to care across student groups, with particular attention to equity-impacted students, especially sexual and gender minority students.

Findings indicate widespread psychological distress alongside persistent barriers, including long wait times, limited-service availability, and stigma-related concerns. These barriers …

Bergsonian Blend: Subjective Temporality Within Modernist Aesthetics Of Mental Illness, Lydia Victoria Gervais

Electronic Theses and Dissertations

Henri Bergson was a modernist French philosopher who wrote extensively on the topic of the lived experience of time, which he called durée, or duration. His contemporary, Sigmund Freud, was developing psychoanalytic theory in a growing field of psychological study, which serves as a prominent ancestor to modern psychiatry and current psychoanalytical literary studies. Fiction writers of the 1900s absorbed the zeitgeist of melded chronology and consciousness, interweaving themes of time and trauma in their works. Utilizing Henri Bergson’s durée as a philosophical framework, I examine the moralization of time-consciousness in connection with mental illness and investigate representations of …

Malnutrition And Frailty Risk Among Community Dwelling Older Adults In Northeast Tennessee, Shreeyesha Pradhan

Electronic Theses and Dissertations

Frailty and malnutrition are prevalent conditions among community-dwelling older adults, affecting approximately 10% and 25% of this population, respectively. Despite overlapping symptoms such as functional decline, their relationship remains underexplored in community dwelling older adults. This cross-sectional feasibility study examined the association between frailty and nutritional status among 47 older adults in the East Tennessee Tri-Cities area using the Fried’s Frailty Phenotype (FFP) and the Mini Nutritional Assessment-Long Form (MNA-LF®). Results indicated 13% were pre-frail, 24% were frail, 21% were at risk for malnutrition, and 2% were malnourished. Regression analyses revealed that self-perceived nutritional status (37.6%), daily meal frequency (29.0%), …

Addressing Substance Use Disorder In Rural Appalachia: Improving Access And Treatment Outcomes For Justice-Involved Individuals, Jessica Muldowney

Electronic Theses and Dissertations

Background: Opioid use disorder (OUD) represents a critical public health crisis disproportionately affecting justice-involved (JI) populations, with approximately 65% of incarcerated individuals having substance use disorders (James & Beatty, 2006). Rural Appalachian communities face compounded challenges due to limited healthcare access, provider shortages, and cultural stigma surrounding addiction treatment. Despite evidence demonstrating that medication-assisted treatment (MAT) reduces recidivism and overdose deaths, only 20% of correctional facilities offer these services (Klein & Seppala, 2019).

Objective: This mixed-methods study evaluated organizational readiness and infrastructure capacity for implementing evidence-based OUD interventions, specifically MAT programs across three rural counties in northwestern North Carolina.

Methods: …

Feasibility Of Assessing Dietary Patterns And Anxiety In College Students: A Pilot Study Using Nutrition Questionnaires, Gad-7, And Asq, Kylie Ford

Electronic Theses and Dissertations

Anxiety is highly prevalent among college students representing a significant public health concern. Research indicates that dietary patterns may influence mental health outcomes; however, the practicality of collecting comprehensive dietary and psychological data in college populations remains unclear. This pilot study assessed the feasibility of evaluating dietary patterns and anxiety using self-report instruments. Participants completed the Nutrition and Eating Habit questionnaire, the Generalized Anxiety Disorder-7 (GAD-7), and the Anxiety Sensitivity Questionnaire (ASQ). Although twenty-one students were recruited, survey completion rates were low, with only seven participants completing the nutrition questionnaire necessary to calculate the Dietary Inflammatory Index (DII). Descriptive analyses …

Ontogeny And The Effects Of Perinatal Stress In The First Immature Skeleton Of Teleoceras Aepysoma (Perissodactyla, Rhinocerotidae), Joe Gajewski

Electronic Theses and Dissertations

Recovery of an immature fossil rhinoceros (Teleoceras aepysoma) skeleton (ETMNH 32999) from the Gray Fossil Site in Tennessee offers the first insights into the ontogeny of the species. ETMNH 32999 is interpreted to be a subadult male in an age class equivalent to ~17-20% of potential lifespan. Comparative analyses support the hypothesis that subadults of related taxa are typically ~91% of average adult size in most dimensions. However, certain cranial dimensions are substantially lower than expected in ETMNH 32999, averaging only ~74% of the average conspecific adult. Such departure from typical growth rates is suggested to be attributable …