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Primary Mediastinal B-Cell Lymphoma Presenting As Chest Pain In A Young Woman And Treated With Epoch-R, Chloe Weidenbaum, Akanksha Kushwah, Ariana Geromes, Jonathan A. Abbas

Journal of Community Hospital Internal Medicine Perspectives

Primary mediastinal B-cell lymphoma (PMBCL) is a rare type of diffuse large B-cell lymphoma, constituting 2-4% of non-Hodgkin lymphomas. Here we present a case of PMBCL initially presenting as pleuritic chest pain in an otherwise healthy 33-year-old woman. PMBCL typically presents as a large, fast-growing tumor limited to the mediastinum, making the iliosacral involvement in this case unusual. R-CHOP is the most commonly used chemotherapy regimen, although more aggressive therapies like EPOCH-R can spare the need for consolidative radiation therapy. PMBCL represents one of the greatest diagnostic and therapeutic challenges in malignant hematology.

Curricular Changes Proposed For 2023-2025 Morris Catalog Division Of Science And Mathematics,, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

Curricular Changes Proposed For 2023-2025 Morris Catalog Philosophy, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

College Faculty In The News: Sept. 9, 2022, University Of Dayton

College of Arts and Sciences Newsroom

News agencies across the region, the nation and throughout the world often reach out to our faculty experts for their perspectives on today's issues.

2022 Proceedings Of The 28th Annual Summer Research Symposium, College Of The Holy Cross

Summer Research Program

The 2022 Dr. Charles S. Weiss Summer Research Symposium, now in its 28th year, the symposium is a college-wide event that brings together faculty and students from all disciplines at Holy Cross and provides an opportunity to celebrate their accomplishments over the summer of 2022. It also affords an occasion for students to witness the breadth of research possibilities both on and off campus, and to open a dialogue with members of the faculty about conducting research during the upcoming academic year and summer. This program lists participating students, the faculty with whom they worked, abstracts and funding sources of …

Reshaping The Path Of Mild Cognitive Impairment By Refining Exercise Prescription: A Study Protocol Of A Randomized Controlled Trial To Understand The "What," "For Whom," And "How" Of Exercise To Promote Cognitive Function, Cindy K. Barha, Ryan S. Falck, John R. Best, Lindsay S. Nagamatsu, Ging Yuek Robin Hsiung, A. William Sheel, Chun Liang Hsu, Arthur F. Kramer, Michelle W. Voss, Kirk I. Erickson, Jennifer C. Davis, J. Kevin Shoemaker, Lara Boyd, Rachel A. Crockett, Lisanne Ten Brinke, Louis Bherer, Joel Singer, Liisa A.M. Galea, Claudia Jacova, Alexis Bullock, Sofia Grant, Teresa Liu-Ambrose

Neuroscience Institute Publications

BACKGROUND: Targeted exercise training is a promising strategy for promoting cognitive function and preventing dementia in older age. Despite the utility of exercise as an intervention, variation still exists in exercise-induced cognitive gains and questions remain regarding the type of training (i.e., what), as well as moderators (i.e., for whom) and mechanisms (i.e., how) of benefit. Both aerobic training (AT) and resistance training (RT) enhance cognitive function in older adults without cognitive impairment; however, the vast majority of trials have focused exclusively on AT. Thus, more research is needed on RT, as well as on the combination of AT and …

Ucc Minutes Sept 9, 2022, Undergraduate Curriculum Committee

Undergraduate Currirculum Committee Minutes

No abstract provided.

Editorial: Mammalian Responses To Climate Change: From Organisms To Communities, Johan T. Du Toit, Robyn S. Hetem, M. Denise Dearing

Wildland Resources Faculty Publications

Mammals have displayed spectacular evolutionary success ever since an asteroid impact caused the Cretaceous-Tertiary extinction event ~66 million years ago, when the non-avian dinosaurs disappeared. Now another mass extinction event is underway because of another major planetary disturbance, but this time it is directly caused by just one over-achieving species among all those mammals: Homo sapiens.

Evaluation Of The Effects Of Wood-Sourced Biochar As A Feedlot Pen Surface Amendment On Manure Nutrient Capture, Jessica L. Sperber, Galen E. Erickson, Andrea K. Watson

Department of Animal Science: Faculty Publications

Feedstuffs utilized in U.S. feedlot finishing rations incorporate high concentrations of N and P, with less than 15% of fed N and P retained by the animal. The remaining N and P are excreted in the manure, where the opportunity for manure N loss via ammonia (NH3) volatilization from the feedlot pen surface is a risk to the environment and lowers the value of manure as a fertilizer. Two nutrient mass balance experiments were conducted during the winter and summer seasons to evaluate the effects of spreading unprocessed Eastern red cedar biochar onto the feedlot pen surface on manure nutrient …

Effect Of Ethephon Ripening And Peeling On Quality Of Fresh Walnut During Freezing Storage, Wu Xiao-Hua, Chen Bai, Li Ming-Ze, Zhang Rui, Feng Ji-Hu

Food and Machinery

Objective:To evaluate the feasibility of the production of ethephon in the freezing thawing and fresh keeping of fresh walnut, and to provide theoretical basis and technical support for fresh walnut freezing thawing and fresh keeping technology system. Methods:The late fruiting walnut variety 'Qingxiang' from Longnan county of Gansu province was used as the experimental material, and then the green walnut was picked by hand and then peeled by Ethephon. Meanwhile, the artificial peeling was used as the control (CK). The fresh walnut was peeled and stored in a constant temperature freezer with temperature of -7~-5 ℃ and humidity …

Uab Students Selected For Prestigious Gilman International Scholarship And Freeman-Asia Award, Staff

Browse All News

No abstract provided.

Covid-19 Newsletter (Vol. 135), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

September 9, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Ud In The News Sept. 3-9, University Of Dayton

News Releases

The Conversation, Inside Higher Ed and radio stations in Columbus, Ohio, and central Massachusetts tapped UD faculty expertise. Dayton TV station WDTN highlighted a UD student awarded a grant for a childhood cancer research project.

Variation In Morpho‑Physiological And Metabolic Responses To Low Nitrogen Stress Across The Sorghum Association Panel, Marcin Grzybowski, Mackenzie Zwiener, Mackenzie Zwiener, Hongyu Jin, Nuwan K. Wijewardane, Abbas Atefi, Michael J. Naldrett, Sophie Alvarez, Yufeng Ge, James C. Schnable

Center for Plant Science Innovation: Faculty Publications

Background: Access to biologically available nitrogen is a key constraint on plant growth in both natural and agricultural settings. Variation in tolerance to nitrogen deficit stress and productivity in nitrogen limited conditions exists both within and between plant species. However, our understanding of changes in different phenotypes under long term low nitrogen stress and their impact on important agronomic traits, such as yield, is still limited.

Results: Here we quantified variation in the metabolic, physiological, and morphological responses of a sorghum association panel assembled to represent global genetic diversity to long term, nitrogen deficit stress and the relationship …

Exploring The Attitudes And Perceptions Of Hispanics As Caregivers For Children In Foster Care: A Phenomenological Study, Erica M. Ortiz-Pellicer

Doctoral Dissertations and Projects

The purpose of this phenomenological study is to understand the attitudes and perceptions of Hispanics living in Tampa Bay, Florida regarding foster parent roles. The theory guiding this study is the researcher’s axiological philosophical assumption. The philosophical assumption is applied within the social constructivist interpretive framework. The researcher seeks to understand the study participants' world and develop meaning to their lived experiences, as discussed during the interviews. The participants’ views are the primary source of reliance for the research (Creswell & Poth, 2018). The researcher’s position in this study is relative to their social position, personal, political, and professional beliefs …

A Correlational Study Of Noncognitive Variables And Student Success In Dental Education, Jennifer Lynn Keim Wibbeler

Doctoral Dissertations and Projects

In 1995, the Institute of Medicine (IOM) published Dental Education at the Crossroads: Challenges and Change, advocating for a revolution in dental education. Notably, it recommended that course content, structure, and delivery be modernized in response to graduating clinicians lacking the critical thinking and problem-solving skills required in a patient care setting. To help determine if current dental education trends are promoting these skills, the purpose of this cross-sectional, correlational study is to investigate the relationship between students' noncognitive variables (self-regulation, intrinsic motivation, autonomous functioning, learning strategies, and grit), as predictor variables, and self-directed academic performance (as measured by end-of-term …

Surface Translocation Of Ace2 And Tmprss2 Upon Tlr4/7/8 Activation Is Required For Sars-Cov-2 Infection In Circulating Monocytes, Yi Yao, Kalpana Subedi, Tingting Liu, Namir Khalasawi, Carla D. Pretto-Kernahan, Jesse W. Wotring, Jie Wang, Congcong Yin, Aimin Jiang, Chunmei Fu, Peter Dimitrion, Jia Li, Jesse Veenstra, Qijun Yi, Kathleen Maksimowicz-Mckinnon, John E. Mckinnon, Jonathan Z. Sexton, Li Zhou, Qing-Sheng Mi

Dermatology Articles

Infection of human peripheral blood cells by SARS-CoV-2 has been debated because immune cells lack mRNA expression of both angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease type 2 (TMPRSS2). Herein we demonstrate that resting primary monocytes harbor abundant cytoplasmic ACE2 and TMPRSS2 protein and that circulating exosomes contain significant ACE2 protein. Upon ex vivo TLR4/7/8 stimulation, cytoplasmic ACE2 was quickly translocated to the monocyte cell surface independently of ACE2 transcription, while TMPRSS2 surface translocation occurred in conjunction with elevated mRNA expression. The rapid translocation of ACE2 to the monocyte cell surface was blocked by the endosomal trafficking inhibitor endosidin …

Mutations In Bcor, A Co-Repressor Of Crx/Otx2, Are Associated With Early-Onset Retinal Degeneration, Maéva Langouët, Christine Jolicoeur, Awais Javed, Pierre Mattar, Micah D Gearhart, Stephen P Daiger, Mette Bertelsen, Lisbeth Tranebjærg, Nanna D Rendtorff, Karen Grønskov, Catherine Jespersgaard, Rui Chen, Zixi Sun, Hui Li, Najmeh Alirezaie, Jacek Majewski, Vivian J Bardwell, Ruifang Sui, Robert K Koenekoop, Michel Cayouette

Faculty, Staff and Student Publications

Many transcription factors regulating the production, survival, and function of photoreceptor cells have been identified, but little is known about transcriptional co-regulators in retinal health and disease. Here, we show that BCL6 co-repressor (BCOR), a Polycomb repressive complex 1 factor mutated in various cancers, is involved in photoreceptor degenerative diseases. Using proteomics and transcription assays, we report that BCOR interacts with the transcription factors CRX and OTX2 and reduces their ability to activate the promoters of photoreceptor-specific genes. CUT&RUN sequencing further shows that BCOR shares genome-wide binding profiles with CRX/OTX2, consistent with a general co-repression activity. We also identify missense …

Social Predictors Of Doctoral Student Mental Health And Well-Being, Feng Zhang, Kaylee Litson, David F. Feldon

Instructional Technology and Learning Sciences Faculty Publications

Graduate students' mental health and well-being is a prominent concern across various disciplines. However, early predictors of mental health and well-being in graduate education, specifically doctoral education, have rarely been studied. The present study evaluated both the underlying latent classification of individuals' mental well-being and predictors of those classifications. Results estimated two latent classes of students' mental health and well-being: one class with generally high levels of mental well-being and one with lower levels of mental well-being. Regression analyses showed that mentoring in the second year of doctoral study, certainty of choice in the thrid year, and both academic development …

Atherogenic Potential Of Microgravity Hemodynamics In The Carotid Bifurcation: A Numerical Investigation, Philippe Sucosky, Varun Vinayak Kalaiarasan, Graham B. Quasebarth, Patricia Strack, Jason A. Shar

Open Access Publishing Fund Collection

Long-duration spaceflight poses multiple hazards to human health, including physiological changes associated with microgravity. The hemodynamic adaptations occurring upon entry into weightlessness have been associated with retrograde stagnant flow conditions and thromboembolic events in the venous vasculature but the impact of microgravity on cerebral arterial hemodynamics and function remains poorly understood. The objective of this study was to quantify the effects of microgravity on hemodynamics and wall shear stress (WSS) characteristics in 16 carotid bifurcation geometries reconstructed from ultrasonography images using computational fluid dynamics modeling. Microgravity resulted in a significant 21% increase in flow stasis index, a 22–23% decrease in …

Predictors Of Early Childhood Development: A Machine Learning Approach, Andrea Bizzego, Giulio Gabrieli, Mengyu Lim, W. Andrew Rothenberg, Marc H. Bornstein, Gianluca Esposito

Research Outputs: 2025-Present

No abstract provided.

The Pioneer Advantage: Filling The Blank Spots On The Map Of Genome Diversity In Europe, Taras K. Oleksyk, Walter Wolfsberger, Khrystyna Schubelka, Serghei Mangul, Stephen James O'Brien

Biology Faculty Articles

Documenting genome diversity is important for the local biomedical communities and instrumental in developing precision and personalized medicine. Currently, tens of thousands of whole-genome sequences from Europe are publicly available, but most of these represent populations of developed countries of Europe. The uneven distribution of the available data is further impaired by the lack of data sharing. Recent whole-genome studies in Eastern Europe, one in Ukraine and one in Russia, demonstrated that local genome diversity and population structure from Eastern Europe historically had not been fully represented. An unexpected wealth of genomic variation uncovered in these studies was not so …

2022-09-09 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

Institutional Animal Care and Use Committee meeting minutes from September 9, 2022.

Interplay: The Essential Role Between Insm1 And N-Myc In Aggressive Neuroblastoma, Chiachen Chen, Michael S. Lan

School of Medicine Faculty Publications

An aggressive form of neuroblastoma (NB), a malignant childhood cancer derived from granule neuron precursors and sympathoadrenal lineage, frequently comprises MYCN amplification/elevated N-Myc expression, which contributes to the development of neural crest-derived embryonal malignancy. N-Myc is an oncogenic driver in NB. Persistent N-Myc expression during the maturation of SA precursor cells can cause blockage of the apoptosis and induce abnormal proliferation, resulting in NB development. An insulinoma-associated-1 (INSM1) zinc-finger transcription factor has emerged as an NB biomarker that plays a critical role in facilitating tumor cell growth and transformation. INSM1 plays an essential role in sympathoadrenal cell differentiation. N-Myc activates …

Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcal Infection (Pandas): A Qualitative Study Of Parental Perceptions Of Factors In Remission, Janice Diane Weddle

Doctoral Dissertations and Projects

Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS) starts as the child’s body has an inappropriate reaction to the immune response for streptococcal infection. PANDAS is characterized by the sudden onset of neuropsychiatric disorders, including obsessive-compulsive disorder (OCD), anxiety, chorea movements, and tics. Previous research has drawn conflicting conclusions on PANDAS treatment efficacy and long-term treatment outcomes leaving remission rates unclear. The purpose of this qualitative phenomenological case study was to explore parents’ perceptions of factors related to PANDAS remission. Parents of children diagnosed with PANDAS were recruited through Facebook PANDAS support groups and the National Institute of Mental …

Minimal Covid-19 Quieting Measured In The Deep, Offshore Waters Of The U.S. Outer Continental Shelf, Jennifer L. Miksis-Olds, S. Bruce Martin, Kim Lowell, Christopher Verlinden

Center for Coastal and Ocean Mapping

Using a 2-year time series (2019–2020) of 1-min sound pressure level averages from seven sites, the extension of COVID-related quieting documented in coastal soundscapes to deep (approximately 200–900 m) waters off the southeastern United States was assessed. Sites ranged in distance to the continental shelf break and shipping lanes. Sound level decreases in 2020 were observed at sites closest to the shelf break and shipping lanes but were inconsistent with the timing of shipping changes related to a COVID-19 slowdown. These observations are consistent with increased numbers of vessel tracks in 2020 compared to 2019 at a majority of sites.

Drosophila Melanogaster As A Model For Male Reproductive System Ethanol Toxicity, Gbemisola Ilelaboye

Seton Hall University Dissertations and Theses (ETDs)

Drosophila melanogaster has been extensively used in different types of research as a model organism due to its high reproductivity, short life span, and easy maintenance. In this paper, we examined drosophila as a model for ethanol toxicity in the male reproductive system. We developed three assays: The DAPI assay, sperm viability assay, and tubulin staining assay. The DAPI assay is a nuclear staining assay that assesses the effects of various ethanol concentrations in late spermiogenesis in which increased detrimental effects to the sperm bundles were observed. The second assay consisted of the sperm viability assay which showed an increase …

Effective Environmental Education: The Way To A Greener, Brighter Future, Amber Leanne Bailey

Masters Theses

Green spaces provide many benefits to local communities, including improved mental and physical health and stronger, safer communities. They also provide sustainable ecosystems for wildlife. These benefits provide a better quality of life for the people in the community. However, some communities cannot experience these benefits due to a common issue among green spaces: degradation in the forms of littering and vandalism. Despite efforts in environmental education, this problem persists. The aim of this project is to contribute to keeping green spaces greener. To study potential solutions for the continued degradation, an analysis of relevant literature is conducted on the …

Improving Inattentiveness Through Asymmetric Tonic Neck Reflex Integration Exercises: A Quantitative, Quasi-Experimental Study, Arrin Christine Brummett

Doctoral Dissertations and Projects

The purpose of this quantitative, quasi-experimental study was to understand the difference in the posttest detectability scores, as measured by the Conners Kiddie Continuous Performance Test 2nd edition, among early childhood students participating in various activity types, including ATNR integration exercises, running exercises, or sedentary work, when controlling for pretest detectability scores at schools in rural north Texas using a nonequivalent control-group, pretest-posttest design. This study built on the theory of structural cognitive modifiability and helped to expand research regarding the impact of a specific type of physical activity, namely asymmetric tonic neck reflex integration exercises, on focal inattentiveness, a …