Digital Commons Network^™

A Transgenerational Analysis Of Factors Influencing Fertility Among Jamaican Men, Shanique Deniellia Essuman

Walden Dissertations and Doctoral Studies

No abstract provided.

Short-Term Bayesian Influenza Forecasting In A Hospital Environment Using A Linear Kalman Filter., Shankar Kaleeswaran Mani, Grzegorz A Rempala, Eben Kenah, Fernanda L Schumacher

Ambulatory and Primary Care Articles

Accurately forecasting the weekly number of influenza (flu) lab tests and positive cases is important for hospitals as they work to plan staffing, manage supplies, and provide timely patient care. In this paper, we describe a practical use of a Bayesian Kalman filter to forecast weekly flu tests and positives in a hospital setting. Using data from a large hospital system in Ohio, we show that this approach, which blends real-time hospital information with historical patterns, offers a dependable way to anticipate flu-related patient volume as far as four weeks ahead.

Uncovering Cytoskeletal Length Control From Growth Trajectories Using Sparse Dynamical Modeling, Carson Hearn

Theses

Understanding the governing equations of biological filament dynamics is essential for predicting cellular behavior, yet these equations are often difficult or impossible to derive directly from first principles. This thesis investigates the use of Sparse Identification of Nonlinear Dynamics (SINDy) as a unified, data-driven framework for discovering, validating, and refining governing equations from both simulated and experimental data. Focusing on biological filament processes, including growth, disassembly, and severing, this work is designed not only to apply SINDy, but to systematically demonstrate that it is a reliable and generalizable tool for modeling complex biophysical systems. To establish this, SINDy is first …

Skeletal Muscle Characteristics Long-Living Dwarf Mice In Response To High Fat Diet, Landon Schumacher, Matthew Johnston, Jaspreet Osan, Holly Brown-Borg

Arts & Sciences Undergraduate Showcase

Introduction: The effects of high fat diet (HFD; 60% kcal: fat) on skeletal muscle in mice with postnatal growth hormone deficiency is relatively unknown. We compared the tibialis anterior (TA) muscle from middle aged female Ames Dwarf and Wildtype mice fed HFD for 16 weeks and standard diet (STD; 10%: fat) to see the impacts of a HFD on inflammation and fibrotic formation in the musculature.   Methodology: Mice were euthanized after diet duration (age 10-12 months), and TAs were collected and frozen in OCT for cross-sectional cryosection. Ten um thick muscle was fixed to slides and stained with Oil Red-O …

From Sunshine To Sight Lost: Amd In North Dakota, Sidney J. Leciejewski, Diane Darland

Arts & Sciences Undergraduate Showcase

Age-related macular degeneration (AMD) is a progressive eye disease that directly harms the macula, which could eventually cause vision loss. The macula is an area on the back of the eye that contains cone cells, which allow for our color vision. Its location also allows us to have our central vision. There are two kinds: the dry and wet form, where the wet form is more extreme. The disease, itself, is highly prevalent in North Dakota, which is why it is important to note its causes and prevention methods. Some causes of AMD include genetic risks,  health risks, and metabolic …

Monotone Traveling Waves In A General Discrete Model For Populations With K-Generation Long-Term Memory, Austin Kernel Sanders

Theses and Dissertations

We investigate the spatial dynamics of a population modeled by a general discrete integrodifference equation incorporating k-generation long-term memory. While classical models rely solely on the im- mediately preceding state to determine population growth and dispersal, introducing multiple past states causes the associated evolution operator to lose compactness. Consequently, standard fixed- point theorems are insufficient to prove the existence of traveling wave solutions. We overcome this difficulty by constructing a time-independent moving frame operator and employing the monotone iteration method. By assuming the fecundity function is locally Lipschitz, bounded, and nondecreasing on a specified interval, and by relaxing continuity requirements …

Cloud-Deployed Rna-Seq Analytics For Identifying Imaging And Therapeutic Targets In Chemotherapy-Induced Toxicities, Zhimu Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Chemotherapy has significantly improved cancer survival rates; however, many anticancer agents induce severe acute and chronic side effects that substantially reduce patient quality of life and limit therapeutic efficacy. Despite their clinical importance, the molecular mechanisms underlying chemotherapy-induced toxicities across different organs remain incompletely understood, in part due to the lack of integrated, scalable, and accessible analytical platforms capable of synthesizing large transcriptomic datasets across tissues and experimental models.

This thesis describes the development of a cloud-deployed RNA-seq analytics platform designed to identify candidate imaging biomarkers and therapeutic targets associated with chemotherapy induced toxicities. The platform integrates large-scale transcriptomic datasets …

Listen To Your Parents: An Exploration Into Why Mississippi Foster Parents Enter, Stay In, And Exit The System, Howell D. Jenkins Iii

Honors Theses

Like many states across the country, Mississippi’s foster care system has faced a shrinking pool of foster parents to care for the state’s most vulnerable children. When states do not have adequate numbers of foster parents, children are susceptible to negative outcomes such as developmental delays, broken attachments with adults, and extended stays in the system. This thesis seeks to understand what motivates individuals to become foster parents, how they experience the system, and what pressures influence their decision to remain fostering or close their doors. To place this research within the appropriate contexts, the thesis draws on literature from …

Community Composition Of Antibiotic-Resistant Bacteria On The Mississippi Gulf Coast, Marisa Martin, Colin Jackson

Honors Theses

The Mississippi Gulf Coast is an important resource for transportation, economic development, and recreation. Given its economic and cultural importance, it is crucial to maintain clean and safe conditions along the coast for public health, but other than routine beach monitoring, few studies have examined microbial contamination of coastal waters in this region. This study aimed to determine the quantity, composition, and distribution of bacteria resistant to six different antibiotics (Vancomycin, Kanamycin, Tetracycline, Ciprofloxacin, Erythromycin, or Amoxicillin) in seawater at seven public beaches along the Mississippi Gulf Coast. No bacteria resistant to Ciprofloxacin were detected, and bacteria resistant to Kanamycin …

Current Options And Future Trends In Green Fuels Storage, Muhammad Anas Maqbool, Md Jahir Rizvi, Yeaw Chu Lee, Pablo Borja Rosales

School of Engineering, Computing and Mathematics

The global transition to renewable energy underscores the urgent need for safe, efficient, and cost-effective storage solutions for green hydrogen and green ammonia. This review critically examines their fundamental characteristics and unique behaviours, emphasising storage, handling, and integration engineering challenges. To identify the influential studies, knowledge gaps and future trends in the research area, a systematic Scopus-based bibliometric and data analysis is conducted. A novel approach is adopted to identify the better green energy storage option between green hydrogen storage and green ammonia storage, combining a risk-mitigation assessment framework, strengths, weaknesses, opportunities, threats (SWOT) analysis, and a multicriteria taxonomy based …

Clemson Commencement Program, May 2026, Clemson University

Clemson Commencement Programs

No abstract provided.

Systemic Α₂-Agonist Use And Lower Hazard Of Glaucoma Compared With Β-Blockers: A Cohort Study, Ibrahim Abboud, Amin Z. Khudari, Abdelaziz Abdelaal, Amr Almobayed, Subhi J. Al'aref, Jonathan S. Myers, Richard K. Lee, Abdelrahman M. Elhusseiny

Wills Eye Hospital Papers

OBJECTIVE: Systemic antihypertensive medications may influence glaucoma-related outcomes through intraocular pressure-dependent and vascular mechanisms. While topical α₂-agonists are established glaucoma therapies, the association between systemic α₂-agonists and glaucoma hazard remains unexamined; we compared their hazard with systemic β-blockers in adults with hypertension.

METHODS AND ANALYSIS: We conducted a multicentre retrospective cohort study using deidentified electronic health records. Adults aged ≥40 years with hypertension and chronic exposure to systemic α₂-agonists or β-blockers were included. Patients with pre-existing ocular hypertension (OHT), primary open-angle glaucoma (POAG), concomitant comparator use, or inadequate ophthalmic follow-up were excluded. We balanced cohorts using propensity score matching (PSM) …

Illness Perception, Depression, And Anxiety Among Middle-Aged Adults With End-Stage Chronic Kidney Disease, Zioleyda Soto

Walden Dissertations and Doctoral Studies

No abstract provided.

Exploring North Carolina’S Teen Pregnancy Prevention Initiative In Rural Communities, Annie Belle Perry

Walden Dissertations and Doctoral Studies

No abstract provided.

Pharmacogenomic-Guided Prescribing And Polypharmacy Across Age Groups In Obsessive-Compulsive Disorder: A Retrospective Study, Sheldon R Garrison, Matthew W Boyer, Anthony W Zoghbi, Rachel A Schwartz, Nicolette Weisensel, Martin E Franklin, Madeline M Hartig, Maharaj Singh, Sreya Vadapalli

Faculty, Staff and Students Publications

Background: This study evaluated medication utilization in children, adolescents, and adults with obsessive-compulsive disorder (OCD), a chronic psychiatric condition characterized by intrusive thoughts and repetitive behaviors. Although first-line treatments include selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT), the heterogeneous biological underpinnings contribute to suboptimal outcomes, with 40-60% of individuals not responding to SSRIs. This complex phenotype often leads to psychotropic polypharmacy, which may be mitigated by incorporating combinatorial pharmacogenomic (PGx) testing into protocol-based care to identify potential gene-drug interactions.

Methods: A retrospective review was conducted of individuals with OCD aged 8 to 65 years who received either …

Exploring The Skills Gap And Implications Of Science Technology Engineering And Mathematics Graduates And Professional Laboratory Staff, Indrajee Wewaliyadda

Dissertations, Theses, and Projects

The noticeable expansion of the biotech and research industries, fueled by increased funding due to the 2019 pandemic (Wallace et al., 2022), which increased the existing skills gap among fresh STEM graduates entering professional laboratories. This study aims to evaluate whether bachelor’s degree holders in biological sciences possess the necessary laboratory competencies to meet professional demands. Utilizing survey methods and Kolb’s experiential learning model (Kolb, 1984), the research examines the extent and implications of the skill deficiencies observed. The study helps to understand the gap in practical laboratory skills among new graduates. Further, results from this work will show the …

Exploring The Impact Of Ungrading On Student Engagement And Motivation In A First-Year Composition Class, Mary B. Gruis

Dissertations, Theses, and Projects

This study investigated the association between student engagement, motivation, and self-efficacy in college-level writing-intensive courses using an ungraded approach. Motivated by disillusionment with traditional grading methods and inspired by texts on equitable grading and culturally responsive teaching, the researcher explored how ungrading could foster deeper learning and equitable educational practices. Grounded in Bandura’s (1997) self-efficacy framework, this qualitative case study examined the lived experiences of first-year composition students at a two-year institution. Data collection included student interviews, student reflections, and an instructor interview. The analysis revealed themes aligned with self-efficacy, engagement, and motivation, suggesting that ungrading positively impacted students' perceptions …

Comparative Behavioral Impacts Of Neuroactive Pharmaceuticals On Crayfish Locomotion, Grace Elizabeth Smith

Masters Theses

Pharmaceuticals are increasingly recognized as contaminants of concern in aquatic ecosystems, often entering waterways due to incomplete removal by wastewater treatment plants. Despite frequent detection, the effects of these compounds on non-target, neurochemically sensitive organisms such as crayfish remains underexplored. Gabapentin, an anticonvulsant that binds to presynaptic voltage-gated calcium channels and reduces excitatory neurotransmitter release, is one such emerging contaminant. Given crayfish’s ecological importance and sensitivity to neuroactive substances, exposure to gabapentin may disrupt key behaviors such as locomotion. To place gabapentin’s effects in context, we also examined escitalopram (Lexapro), a selective serotonin reuptake inhibitor that elevates synaptic 5-HT, and …

Inside The World Of Probation Officers: Challenges, Perspectives, And Purpose, Achilles A.C. Beumel

Honors Theses

In the United States, probation is the most commonly imposed criminal sentence, necessitating an abundance of probation officers (POs) to serve the system. Given high rates of failed reentry in tandem with high rates of recidivism, there have been calls for a reevaluation of post-conviction supervision systems and strategies, including the PO. The PO is the final form of assistance provided by the criminal justice system to those facing reentry and can heavily impact a client’s likelihood of recidivism. Despite years of research and attempted reform, more studies are still needed to determine strategies for successful reentry outcomes. This study …

An Integrated Artificial Intelligence–Circular Economy Framework For Sustainable Industrial Waste Management System: Case Study From The Carpet Industry Supply Chain, Noha Mostafa

Mechanical Engineering

Waste management has become a critical issue in industry due to its environmental and  economic impact. This urges societies to move towards circular economy and sustainability in managing wastes to achieve economic, social and environmental benefits that cannot be achieved by using traditional disposal methods. Artificial intelligence technologies can play an effective role in developing systems and applications that help in realizing circular economy approaches. This research explores using circular economy in the carpet industry with a focus on being eco-friendly and achieving operational excellence. Circular economy aims to use resources efficiently within a reduce, reuse, recycle paradigm. Critical literature …

Celiac Plexus Radiosurgery For Retroperitoneal Pain In Advanced Cancer: A Pre-Specified Secondary Analysis Of Health-Related Quality Of Life In A Phase Ii Single-Arm Trial, Aisling Barry, Ronen Fluss, Laura Dawson, David Hausner, Michael Buckstein, Talia Golin, Laurence Freedman, Marcin Miszczyk, Dayssy Diazpardo, Artur Aguiar, Dror Limon, Raphael Pfeffer, Moaz Ben-Ayun, Liat Hammer, Ziv Symon, Ofir Morag, Gali Jacobson, Adam Dicker, Jerzy Wydmanski, Camilla Zimmermann, Yaacov Lawrence

Department of Radiation Oncology Faculty Papers

BACKGROUND: Retroperitoneal pain syndrome seen in pancreatic cancer is a major clinical challenge. Celiac plexus radiosurgery, a new palliative technique for retroperitoneal pain syndrome, decreased pain levels in a phase II study. Here Health-Related Quality of Life (HRQOL) outcomes are reported.

METHODS: Evaluable patients, who were enrolled between January 2018 and December 2021, in an international single-arm Phase II ethics-approved study (NCT03323489), were included. The pre-specified secondary endpoint-change in HRQOL from baseline to 3- and 6-weeks post-treatment, was measured by the Functional Assessment of Cancer Therapy - Hepatobiliary (FACT-Hep) version 4 questionnaire. Mean change was deemed clinically significant (CS) if …

The Ethical Imperative Of Public Health Institutions To Protect The Reproductive Autonomy Of Vulnerable Populations, Kennethea Wilson

Electronic Theses and Dissertations

This dissertation establishes the ethical responsibility of public health institutions to safeguard reproductive autonomy, especially among vulnerable populations. While reproductive decision-making is traditionally framed within individual clinical encounters, this work contends that reproductive autonomy is fundamentally a matter of public health ethics. Socioecological determinants, including social, legal, environmental, and structural factors, often constrain individuals’ ability to make meaningful reproductive choices, leading to preventable harm.

Reproductive autonomy is defined as the capacity to make informed decisions about whether and when to conceive, as well as how to parent. The dissertation critiques the sufficiency of clinical ethics frameworks, such as informed consent …

Beyond The Bug: How The Covid-19 Pandemic Exposed Longstanding Systemic Failures In The United States Workforce And Economy, Abbey M. Markley

Honors Theses

The purpose of this thesis is to investigate and discuss how longstanding systemic failures in the United States exacerbated the effects the COVID-19 pandemic had on the American economy, essential healthcare workers, and overall public trust in institutions. A review of the existing literature surrounding this topic and the subsequent results of various studies were used to compose this thesis. The United States has a painful lack of worker protections and tends to view members of its workforce as expendable, even in times such as pandemic when they are deemed essential. Healthcare workers in particular faced increasing threats to their …

Genetic Analysis Of The X-Linked Adrenoleukodystrophy Gene Abcd1 In Drosophila Uncovers A Conserved Phenotype, Joshua Manor, Sharayu V Jangam, Hyung-Lok Chung, Pranjali Bhagwat, Jonathan C Andrews, Hillary Chester, Shu Kondo, Saurabh Srivastav, Juan Botas, Ann B Moser, Suzette M Huguenin, Michael F Wangler

Duncan NRI Faculty and Staff Publications

X-linked adrenoleukodystrophy (X-ALD) is a progressive neurodegenerative disorder caused by a loss-of-function (LOF) mutation in the ATP-binding cassette subfamily D member 1 (ABCD1) gene, leading to the accumulation of very long-chain fatty acids (VLCFAs). This disorder exhibits striking heterogeneity; some male patients develop an early childhood neuroinflammatory demyelination disorder, while other patients, including adult males and most affected female carriers, experience a chronic progressive myelopathy. Adrenocortical failure is observed in almost all male patients, with the age of onset varying, sometimes being the first diagnostic finding. The gene underlying this spectrum of disease encodes an ATP-binding cassette (ABC) transporter that …

Machine Learning-Based Prediction Of Proximal Junctional Pathology After Adult Spinal Deformity Surgery: A Systematic Review And Diagnostic Test Accuracy Meta-Analysis, Shaan Patel, Shiva A. Nischal, Yi Hein Chai, Kush M. Kale, Kevin Hines, Joshua Pelta-Heller, Jack Jallo, James S. Harrop, Srinivas K. Prasad

Department of Neurosurgery Faculty Papers

BACKGROUND: Proximal junctional kyphosis (PJK) and failure (PJF) remain challenging and incompletely predictable adverse event following adult spinal deformity (ASD) surgery. Machine learning (ML) models have been proposed to improve risk stratification, but performance varies and clinical applicability remains uncertain. A systematic review and diagnostic test accuracy meta-analysis was performed to synthesize the predictive performance of ML-based models for proximal junctional pathology after ASD surgery.

METHODS: PubMed, Embase, and CENTRAL were searched from inception to February 2026. Studies developing or validating ML models predicting PJK or PJF following ASD surgery were included. Diagnostic performance was synthesized using random-effects models, pooling …

Prinsip Military Necessity Dalam Hukum Internasional Humaniter, Hersapta Mulyono

Jurnal Hukum & Pembangunan

Abstract

Establishing Sustainable Vegetation On A Challenging Legacy Ccr Site, Derek Oosterhouse, Blake Arthur

World of Coal Ash Proceedings

American Electric Power (AEP) is closing and restoring a legacy Coal Combustion Residuals (CCR) site in Ohio that once held a power plant that pioneered innovative steam generation technology. The plant was closed in 1975. Today, the legacy CCR site is being transformed back to natural, sustainable vegetation. To comply with and close the Stormwater Pollution Prevention Plan (SWPPP) permit, permanent stabilization is required on the site. AEP, one of the largest electric companies in the country, holds a core principle to respect the environment through creative sustainable solutions. AEP connected with Profile Products, the world’s largest manufacturer and supplier …

A Cost-Effective, Low-Impact Remedial Approach For Metals: Utilizing Phyto-Enhancement To Accelerate Ph Adjustment Of Shallow Groundwater, Jerry Wylie, Thomas Colton

World of Coal Ash Proceedings

SynTerra will present a unique, low-cost, low-impact approach to metals remediation in shallow groundwater at a former industrial site located in the Atlantic Coastal Plain. The approach employs pH adjustment of groundwater using agricultural lime coupled with the use of daikon radish to augment lime contact time and to increase depth of soil augmentation. This method is designed to be a more sustainable, less resource-intensive, and less technically challenging remedial alternative with lower estimated overall costs. The primary corrective action—source removal—has been completed. However, the oxidation of residual sulfide-bearing minerals has resulted in persistent low-pH groundwater, which increases the solubility …

Life History, Stock Status, And Movement Ecology Of Narrow-Barred Spanish Mackerel, Scomberomorus Commerson (Lacépède, 1800) In The Southern Arabian Gulf, Mohamed Abdulla Almusallami

Thesis/ Dissertation Defenses

The narrow-barred Spanish mackerel, Scomberomorus commerson, is the most commercially valuable pelagic fish species in the Arabian Gulf. This thesis integrated three studies to comprehensively assess the life history, stock status, and movement ecology of this species in Abu Dhabi waters. Life history traits were characterized from data collected during a 15-month monitoring program (January 2019–May 2020). Fork length ranged from 30.5 to 132 cm. Growth parameters were k = 0.14–0.15 year⁻¹ and L∞ = 128.9–135.4 cm for males and females, respectively. Size-at-maturity (Lm₅₀) was 78.7 cm FL for females and 69.7 cm FL for males. The spawning season occurred …

Dictionary Of A Vietnamese-American* Borderland, Ngọc Hải Nguyễn '26

Senior Scholarly and Creative Symposium

This project, composed of a contextualising research paper and an autoethnographical writing creative component, explores the conceptualisation of Anzaldúa's (2021) borderlands by applying to the author's own experience as a Vietnamese-native student growing up along multiple cultural points of inquiry (primarily the American culture). The core research question of this paper is What does it mean to be at the crossroads of many cultures? In the research paper, the author first contextualises the current discourse on borderlands, along with a justification for their usage of storytelling as a mode of inquiry. The author implements a framework theorised through Loveless (2019) …