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September 12, 2022

The Gavel Gazette

No abstract provided.

Ohio University Faculty Senate Minutes September 12, 2022, Ohio University Faculty Senate

Faculty Senate Minutes

No abstract provided.

Effects Of Nutrient Level And Growth Rate On The Conjugation Process That Transfers Mobile Antibiotic Resistance Genes In Continuous Cultures, Mohammadreza Shafieifini, Yuepeng Sun, Zachery R. Staley, University Of Nebraska-Lincoln, Jean-Jack Riethoven, Xu Li

Department of Civil and Environmental Engineering: Faculty Publications

Bacteria in the effluent of wastewater treatment plants (WWTPs) can transfer antibiotic resistance genes (ARGs) to the bacteria in receiving water through conjugation; however, there is a lack of quantitative assessment of this phenomenon in continuous cultures. Our objective was to determine the effects of background nutrient levels in river water column and growth rates of bacteria on the conjugation frequency of ARGs from effluent bacteria to river bacteria, as well as on the resulting resistance level (i.e., MICs) of the river bacteria. Chemostats were employed to simulate the discharge points of WWTPs into rivers, where effluent bacteria (donor cells) …

Health-Care Seeking Behaviors Of Puerto Ricans With Diabetes Mellitus Who Live In South Florida: An Exploratory Study, Laura N. Gonzalez

Dissertations

Latinos are the fastest growing minority population in the United States (U.S.) and have the worst access to health care of any ethnic group. The chronic disease of diabetes is twice as common in adult Latinos as in non-Latino whites, and the risk of death related to diabetes is twofold. Reasons for this disparity have yet to be clearly identified. This study had two purposes: 1) to explore cultural beliefs regarding health-care seeking behaviors in Puerto Ricans with diabetes who live in South Florida; and 2) to examine Puerto Ricans' perceptions about their health-care providers. The cultural phenomena of interest …

Clonal Hematopoiesis Of Indeterminate Potential, Dna Methylation, And Risk For Coronary Artery Disease, M D Mesbah Uddin, Ngoc Quynh H Nguyen, Bing Yu, Jennifer A Brody, Akhil Pampana, Tetsushi Nakao, Myriam Fornage, Jan Bressler, Nona Sotoodehnia, Joshua S Weinstock, Michael C Honigberg, Daniel Nachun, Romit Bhattacharya, Gabriel K Griffin, Varuna Chander, Richard A Gibbs, Jerome I Rotter, Chunyu Liu, Andrea A Baccarelli, Daniel I Chasman, Eric A Whitsel, Douglas P Kiel, Joanne M Murabito, Eric Boerwinkle, Benjamin L Ebert, Siddhartha Jaiswal, James S Floyd, Alexander G Bick, Christie M Ballantyne, Bruce M Psaty, Pradeep Natarajan, Karen N Conneely

Faculty, Staff and Student Publications

Age-related changes to the genome-wide DNA methylation (DNAm) pattern observed in blood are well-documented. Clonal hematopoiesis of indeterminate potential (CHIP), characterized by the age-related acquisition and expansion of leukemogenic mutations in hematopoietic stem cells (HSCs), is associated with blood cancer and coronary artery disease (CAD). Epigenetic regulators DNMT3A and TET2 are the two most frequently mutated CHIP genes. Here, we present results from an epigenome-wide association study for CHIP in 582 Cardiovascular Health Study (CHS) participants, with replication in 2655 Atherosclerosis Risk in Communities (ARIC) Study participants. We show that DNMT3A and TET2 CHIP have distinct and directionally opposing genome-wide …

Characterizing First-Year Biology Majors’ Motivations And Perceptions Of The Discipline, Jeremy L. Hsu, Lauren Dudley

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Understanding why students choose to major in biology provides important insight into the motivations of biology majors. It is similarly important to investigate how biology majors perceive the discipline, including associated activities, such as independent research, which can influence students’ interests in the field and likelihood to persist in science, engineering, technology, and math. However, there has been little work done examining biology student motivations and perceptions, particularly at non-research-intensive universities or after the COVID-19 pandemic started. To address this gap, we surveyed the first-year cohort of biology majors at a private, comprehensive university. We found that students largely reported …

Openkbp-Opt: An International And Reproducible Evaluation Of 76 Knowledge-Based Planning Pipelines, Aaron Babier, Rafid Mahmood, Binghao Zhang, Victor G L Alves, Ana Maria Barragán-Montero, Joel Beaudry, Carlos E Cardenas, Yankui Chang, Zijie Chen, Jaehee Chun, Kelly Diaz, Harold David Eraso, Erik Faustmann, Sibaji Gaj, Skylar Gay, Mary Gronberg, Bingqi Guo, Junjun He, Gerd Heilemann, Sanchit Hira, Yuliang Huang, Fuxin Ji, Dashan Jiang, Jean Carlo Jimenez Giraldo, Hoyeon Lee, Jun Lian, Shuolin Liu, Keng-Chi Liu, José Marrugo, Kentaro Miki, Kunio Nakamura, Tucker Netherton, Dan Nguyen, Hamidreza Nourzadeh, Alexander F I Osman, Zhao Peng, José Darío Quinto Muñoz, Christian Ramsl, Dong Joo Rhee, Juan David Rodriguez, Hongming Shan, Jeffrey V Siebers, Mumtaz H Soomro, Kay Sun, Andrés Usuga Hoyos, Carlos Valderrama, Rob Verbeek, Enpei Wang, Siri Willems, Qi Wu, Xuanang Xu, Sen Yang, Lulin Yuan, Simeng Zhu, Lukas Zimmermann, Kevin L Moore, Thomas G Purdie, Andrea L Mcniven, Timothy C Y Chan

Faculty, Staff and Student Publications

Objective.To establish an open framework for developing plan optimization models for knowledge-based planning (KBP).

Approach.Our framework includes radiotherapy treatment data (i.e. reference plans) for 100 patients with head-and-neck cancer who were treated with intensity-modulated radiotherapy. That data also includes high-quality dose predictions from 19 KBP models that were developed by different research groups using out-of-sample data during the OpenKBP Grand Challenge. The dose predictions were input to four fluence-based dose mimicking models to form 76 unique KBP pipelines that generated 7600 plans (76 pipelines × 100 patients). The predictions and KBP-generated plans were compared to the reference …

Transmembrane Helices Mediate The Formation Of A Stable Ternary Complex Of B5r, Cyt B5, And Scd1, Jiemin Shen, Gang Wu, Ah-Lim Tsai, Ming Zhou

Faculty, Staff and Students Publications

Mammalian cytochrome b5 (cyt b5) and cytochrome b5 reductase (b5R) are electron carrier proteins for membrane-embedded oxidoreductases. Both b5R and cyt b5 have a cytosolic domain and a single transmembrane (TM) helix. The cytosolic domains of b5R and cyt b5 contain cofactors required for electron transfer, but it is not clear if the TM helix has function beyond being an anchor to the membrane. Here we show that b5R and cyt b5 form a stable binary complex, and so do cyt b5 and stearoyl-CoA desaturase-1 (SCD1). We also show that b5R, cyt b5 and SCD1 form a stable ternary complex. …

Neural And Cardiac Mechanisms In Friedreich's Ataxia With Patient-Derived Ipscs, Mariana Burgos Angulo

USF Tampa Graduate Theses and Dissertations

Friedreich's ataxia (FA) is an autosomal recessive disease caused, in most cases, by a GAA trinucleotide repeat expansion in the first intron of the frataxin (FXN) gene, which results in transcriptional repression of the encoded protein frataxin. FA is a progressive neurodegenerative disorder, but the primary cause of death is hypertrophic cardiomyopathy, which occurs in 60% of the patients. Several functions of frataxin have been proposed, but none of them can fully explain why its deficiency causes the FA phenotypes nor why the most affected cell types are neurons and cardiomyocytes. It is possible that frataxin affects neural and cardiac …

Word Embeddings For Automatic Equalization In Audio Mixing, Satvik Venkatesh, David Moffat, Eduardo Reck Miranda

School of Art, Design and Architecture

In recent years, machine learning has been widely adopted to automate the audio mixing process. Automatic mixing systems have been applied to various audio effects such as gain-adjustment, equalization, and reverberation. These systems can be controlled through visual interfaces, providing audio examples, using knobs, and semantic descriptors. Using semantic descriptors or textual information to control these systems is an effective way for artists to communicate their creative goals. In this paper, we explore the novel idea of using word embeddings to represent semantic descriptors. Word embeddings are generally obtained by training neural networks on large corpora of written text. These …

Uk Perspective Research Landscape For Offshore Renewable Energy And Its Role In Delivering Net Zero, Deborah Greaves, Siya Jin, Puiwah Wong, Dave White, Henry Jeffrey, Beth Scott, Ross Wigg

School of Engineering, Computing and Mathematics

Abstract This paper sets out the role of offshore renewable energy (ORE) in UK targets for Net Zero greenhouse gas emissions by 2050 and provides a review of the research challenges that face the sector as it grows to meet these targets. The research challenges are set out in a Research Landscape that was established by the ORE Supergen Hub following extensive consultation with the ORE community. The challenges are divided into eight themes, each challenge is described, and current progress is summarised. The progress of the ORE sector in recent years has seen huge cost reductions, which have encouraged …

Study On Optimization Of Extraction Technology And Antibacterial Activity Of Total Flavonoids From The Root Of Clausena, Xu Dan-Ni, Su Xiu-Fang, Huang Li-Juan

Food and Machinery

Objective:This study aimed to optimize the optimal extraction process of total flavonoids from the root of Clausena anisum-olens and determine the yield and antibacterial effect of total flavonoids from different producing areas. Methods:The total flavonoids were extracted by ultrasonic method from the roots of C. anisum-olens. Through single factor and orthogonal test, the effect of ultrasonic assisted extraction conditions on the extraction rate of total flavonoids from the root of C. anisum-olens was investigated, and the extraction and antibacterial test of total flavonoids from various producing areas were carried out. Results: The optimum extraction process of total flavonoids …

9/11, Culture War, And The Pitfalls Of History, David Horowitz

History Faculty Publications and Presentations

9/11 marks one of the traumatic events of modern U. S. history. Yet its occurrence and aftermath must be placed in the context of social movements and global developments. This presentation focuses on getting past political and social divisiveness. Professor Horowitz has taught at Portland State since 1968, where he won a prize for outstanding achievement in 2007. He is co-author of a U.S. history textbook and has a number of publications to his credit. He is the author of a personal, professional, and political memoir with the title “Getting There: An American Cultural Odyssey.”

Convergence Of #Metoo Movement Into #Sayajuga?: How Social Activists In Malaysia Leverage Social Media In Empowering Women, Yong Le Goh

Makara Human Behavior Studies in Asia

This research primarily aims to highlight the interconnections among social activists, social media, and ordinary public in the actor-network encompassing women empowerment in Malaysia. The secondary aim is to expand the knowledge gap on active social activists’ perspective toward the development of the country’s women empowerment. Qualitative interview was used to create a holistic research on interviewee’s personal involvement toward women empowerment in Malaysia. The following themes were derived from the data analysis: an association exists between women empowerment and #MeToo movement; communication barriers to popularizing women empowerment; vulnerable groups in search of gender equality; and opinions toward policymakers’ attitudes …

Beauty Premium Of Working Women In Urban Indonesia, Tri Putri Octafia, Diahhadi Setyonaluri

Makara Human Behavior Studies in Asia

Being attractive is believed to give many benefits in life. Economic studies have observed that physical attractiveness is associated with a higher wage. The benefits of being attractive have been perceived from early age, to the labor market, and to the marriage market. Despite all the advantages that beauty brings, efforts are being made to achieve or maintain attractiveness. People spend substantial resources,such as time and money, to enhance appearance. Using Ordinary Least Square (OLS) regression, this study examines the correlation between perceived attractiveness and earnings among urban working women in Indonesia. Findings show that the income of women who …

Understanding The Chemical, Biological, Radiological, Nuclear And Explosive (Cbrne) Defense Policy Making Process Through Historical And Current Event Analysis, Michaela Christine Mesiti

Theses

Understanding Chemical, Biological, Radiological, Nuclear, and Explosives (CBRNE) defense policies is critical in promoting safety to civilian and military personnel in the United States and globally. This thesis first examines a few of the most significant CBRNE policies in history, their place in the world today, and how their creation has impacted society. Utilizing two canonical policy making models– the “linear model” and the “policy stream model”– a range of case studies are analyzed to examine how decision-making behind CBRNE policy compares with other comparable policy domains, particularly non-CBRNE biotechnology innovation. The likelihood of proactivity and the potential influence of …

Chemical Investigation And Drug Discovery Potential Of Terpenoid Secondary Metabolites From Three Deep-Sea Irish Soft Corals, Joshua Thomas Welsch

USF Tampa Graduate Theses and Dissertations

Secondary metabolites produced primarily by terrestrial plants and animals have provided the basis for treatments and cures of human diseases as far back as historians have been able to probe. However, recent technological advances including the self-contained underwater breathing apparatus, and even further remotely operated vehicles, have allowed researchers a unique opportunity for targeted collection of marine organisms at depths previously thought to possess conditions unsustainable for life as was understood. This has afforded a glimpse into the potential for not only life, but the potential for new biochemical adaptations developed over billions of years that have been evolutionarily developed …

Study On Anti-Fatigue Activities Of Chick-Pea Oligopeptides, Jia Qian-Sheng, Liu Yuan-Yang, Li Dan

Food and Machinery

Objective:The purpose of this study was to explore the antioxidative activity in vitro experiments and the anti-fatigue activity of chickpea oligopeptides in mice. Methods:In this study, the antioxidant capacity of chickpea oligopeptide was detected by in vitro method, and the anti-fatigue capacity of chickpea oligopeptide was comprehensively evaluated by detecting physiological and biochemical indexes of mice. Results:The superoxide anion radical scavenging ability IC50of chickpea oligopeptide was 4.26 mg/mL, which was significantly higher than that of GSH positive control group (P＜0.05); The reducing power of chickpea oligopeptide was significantly higher than that of GSH positive control …

Exploring Bacterial Diversity Through Hand-Printing & Bacterial Art, Sudeshna Roy, Mark Abrahamson, Madhav Nepal, Nicholas Butzin

iLEARN Teaching Resources

Bacteria are present in a wide variety of environments, ranging from deep ocean floor to volcanoes. Based on their niche, bacteria can differ in their physiologies. This lesson is designed to make the students aware of the presence of bacteria in their surroundings. This lesson also aims to demonstrate the diversity in bacterial species using colorful bacteria. The bacteria used in this lesson require specific temperatures to grow and develop their color. By the end of this lesson, students will be able to visualize the different colored bacteria on the plate.

Toward Genetic Engineering: Teaching Transformation Using The Pglo Plasmid In High School Classrooms, Isaac Kovash, Tahmina Hossain, Sudeshna Roy, Michael Mitchell, Madhav P. Nepal, Nicholas Butzin

iLEARN Teaching Resources

In this lesson plan, students will learn about genetic engineering and perform the same transformation protocol used by scientists on a daily basis around the world. Genetic engineering is a technique used for direct manipulation, alteration, or modification of genes or genomes of an organism to manipulate the phenotypes. The use of genetically modified organisms (GMOs) has emerged everywhere as a mainstay from agriculture to pharmaceuticals. Through this lesson, students will transform Escherichia coli with pGLO plasmid, which give a brilliant fluorescent green glow under UV light. Students will also learn the central dogma of molecular biology: DNA à RNA …

Cell-Type-Specific Profiling Of The Arabidopsis Thaliana Membrane Protein-Encoding Genes, Sergio Alan Cervantes-Pérez, Marc Libault

Department of Agronomy and Horticulture: Faculty Publications

Membrane proteins work in large complexes to perceive and transduce external signals and to trigger a cellular response leading to the adaptation of the cells to their environment. Biochemical assays have been extensively used to reveal the interaction between membrane proteins. However, such analyses do not reveal the unique and complex composition of the membrane proteins of the different plant cell types. Here, we conducted a comprehensive analysis of the expression of Arabidopsis membrane proteins in the different cell types composing the root. Specifically, we analyzed the expression of genes encoding membrane proteins interacting in large complexes. We found that …

Cell-Type-Specific Profiling Of The Arabidopsis Thaliana Membrane Protein-Encoding Genes, Sergio Alan Cervantes-Pérez, Marc Libault

Department of Agronomy and Horticulture: Faculty Publications

Membrane proteins work in large complexes to perceive and transduce external signals and to trigger a cellular response leading to the adaptation of the cells to their environment. Biochemical assays have been extensively used to reveal the interaction between membrane proteins. However, such analyses do not reveal the unique and complex composition of the membrane proteins of the different plant cell types. Here, we conducted a comprehensive analysis of the expression of Arabidopsis membrane proteins in the different cell types composing the root. Specifically, we analyzed the expression of genes encoding membrane proteins interacting in large complexes. We found that …

Phylogenetic Diversity Of Animal Oral And Gastrointestinal Viromes Useful In Surveillance Of Zoonoses, Anthony Michael Esposito, Michelle Marie Esposito, Albert Ptashnik

Publications and Research

Great emphasis has been placed on bacterial microbiomes in human and animal systems. In recent years, advances in metagenomics have allowed for the detection and characterization of more and more native viral particles also residing in these organisms. The digestive tracts of animals and humans—from the oral cavity, to the gut, to fecal excretions—have become one such area of interest. Next-generation sequencing and bioinformatic analyses have uncovered vast phylogenetic virome diversity in companion animals, such as dogs and cats, as well as farm animals and wildlife such as bats. Zoonotic and arthropod-borne illnesses remain major causes of worldwide outbreaks, as …

Whole-Exome Sequencing Of 14 389 Individuals From The Esp And Charge Consortia Identifies Novel Rare Variation Associated With Hemostatic Factors, Nathan Pankratz, Peng Wei, Jennifer A Brody, Ming-Huei Chen, Paul S De Vries, Jennifer E Huffman, Mary Rachel Stimson, Paul L Auer, Eric Boerwinkle, Mary Cushman, Moniek P M De Maat, Aaron R Folsom, Oscar H Franco, Richard A Gibbs, Kelly K Haagenson, Albert Hofman, Jill M Johnsen, Christie L Kovar, Robert Kraaij, Barbara Mcknight, Ginger A Metcalf, Donna Muzny, Bruce M Psaty, Weihong Tang, André G Uitterlinden, Jeroen G J Van Rooij, Abbas Dehghan, Christopher J O'Donnell, Alex P Reiner, Alanna C Morrison, Nicholas L Smith

Faculty, Staff and Student Publications

Plasma levels of fibrinogen, coagulation factors VII and VIII and von Willebrand factor (vWF) are four intermediate phenotypes that are heritable and have been associated with the risk of clinical thrombotic events. To identify rare and low-frequency variants associated with these hemostatic factors, we conducted whole-exome sequencing in 10 860 individuals of European ancestry (EA) and 3529 African Americans (AAs) from the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium and the National Heart, Lung and Blood Institute's Exome Sequencing Project. Gene-based tests demonstrated significant associations with rare variation (minor allele frequency < 5%) in fibrinogen gamma chain (FGG) (with fibrinogen, P = 9.1 × 10-13), coagulation factor VII (F7) (with factor VII, P = 1.3 × 10-72; seven novel variants) and VWF (with factor VIII and vWF; P = 3.2 × 10-14; one novel variant). These eight novel rare variant associations were independent of the known common variants at these loci and tended to have much larger effect sizes. In addition, one of the rare novel variants in F7 was significantly associated with an increased risk of venous thromboembolism in AAs (Ile200Ser; rs141219108; P = 4.2 × 10-5). After restricting gene-based analyses to only loss-of-function variants, a novel significant association was detected and replicated between factor VIII levels and a stop-gain mutation exclusive to AAs (rs3211938) in CD36 molecule (CD36). This variant has previously been linked to dyslipidemia but not with the levels of a hemostatic factor. These efforts represent the largest integration of whole-exome sequence data from two national projects to identify genetic variation associated with plasma hemostatic factors.

Tissue Rotation Of The Xenopus Anterior–Posterior Neural Axis Reveals Profound But Transient Plasticity At The Mid-Gastrula Stage, Lyuba Bolkhovitinov, Bryan T Weselman, Gladys A Shaw, Chen Dong, Janhavi Giribhattanavar, Margaret S Saha

2020-Current year OA Pubs

The establishment of anterior-posterior (AP) regional identity is an essential step in the appropriate development of the vertebrate central nervous system. An important aspect of AP neural axis formation is the inherent plasticity that allows developing cells to respond to and recover from the various perturbations that embryos continually face during the course of development. While the mechanisms governing the regionalization of the nervous system have been extensively studied, relatively less is known about the nature and limits of early neural plasticity of the anterior-posterior neural axis. This study aims to characterize the degree of neural axis plasticity in

Morpho-Anatomical Characters Of The Floral Structures Of Erythrina × Neillii Mabberley And Lorence (Fabaceae) And Their Importance To Species Characterization, Salma Khaled Gabr, Riham Omar Bakr, Ahlam Mahmoud El-Fishawy, Taha Shahat El-Alfy

Bulletin of Faculty of Pharmacy Cairo University

Erythrina (Coral tree, Family Fabaceae) is a genus of flowering plant worldwide cultivated for ornamental purposes. The flower of Erythrina species was widely used as a tranquilizer, sedative, and in dysentery and syphilis. Studies on the morphology of this genus are insufficient. This study aims to provide information on the morpho-anatomical characters of the E×neillii flowers and their usefulness in distinguishing this hybrid plant from other closely related species. Erythrina×neillii flower is characterized by a racemose compound panicle inflorescence, diadelphous androecium, superior gynoecium (monocarpellary) with marginal placentation, different type of stomata, rounded to triangular pollen grains with granular exine.

Climate Change Adaptation And Mitigation In A Small Archipelago: The Role Of Ecotourism In Malta, Karl Agius

International Journal of Islands Research

The aim of this paper is to present the potential of ecotourism to develop into a niche contributing to climate change adaptation strategies whilst making the existing tourism industry more resilient. The paper provides an overview of mitigation measures adopted in Malta by the aviation, tourism and hospitality industry as well as policy makers in the archipelago to respond to major challenges that climate change poses for tourism. These changes are vital to lure ecotourists and to support ecotourism development. Six main themes emerged from the research in the context of the role ecotourism can play as an adaptation to …

Artificial Insemination—Legal And Related Problems, Thurston A. Shell

Florida Law Review

No abstract provided.

Admissibility Of Evidence Obtained By Scientific Devices And Analyses, Felver A. Rowell Jr.

Florida Law Review

No abstract provided.

Pancreatic Cancer With A Skeletal Muscle Metastasis - A Case Presentation And Literature Review, Nicholas Spetsieris, Gayatri Bobba, Priyanka Bhandari, Samir Patel, Zubin Tharayil, Ravi Gupta

Journal of Community Hospital Internal Medicine Perspectives

One-half of patients with newly diagnosed pancreatic cancer will have metastatic disease at the time of diagnosis, mainly due to its non-specific initial clinical presentation which includes abdominal pain, dyspepsia, weight loss, bowel habit changes, jaundice and pruritus. The signs, symptoms and stage of the disease at initial diagnosis depends on the origin of the primary tumor, with tumors of the head presenting earlier with obstructive symptoms while tumors of the body/tail are often diagnosed at an advanced stage due to their non-specific presentation. The most common sites of metastasis are the lymph nodes, liver, lung, and peritoneum. The presence …