Digital Commons Network^™

A Quantitative Research Study On Probability Risk Assessments In Critical Infrastructure And Homeland Security, Alfred B. Lee

Doctoral Dissertations and Projects

This dissertation encompassed quantitative research on probabilistic risk assessment (PRA) elements in homeland security and the impact on critical infrastructure and key resources. There are 16 crucial infrastructure sectors in homeland security that represent assets, system networks, virtual and physical environments, roads and bridges, transportation, and air travel. The design included the Bayes theorem, a process used in PRAs when determining potential or probable events, causes, outcomes, and risks. The goal is to mitigate the effects of domestic terrorism and natural and man-made disasters, respond to events related to critical infrastructure that can impact the United States, and help protect …

Covid-19 And Children, Carl A Pierce, Kevan C Herold, Betsy C Herold, Janet Chou, Adrienne Randolph, Binita Kane, Sammie Mcfarland, Deepti Gurdasani, Christina Pagel, Peter Hotez, Sarah Cobey, Scott E Hensley

Center for Medical Ethics and Health Policy Staff Publications

There has been substantial research on adult COVID-19 and how to treat it. But how do severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections afflict children? The COVID-19 pandemic has yielded many surprises, not least that children generally develop less severe disease than older adults, which is unusual for a respiratory disease. However, some children can develop serious complications from COVID-19, such as multisystem inflammatory syndrome in children (MIS-C) and Long Covid, even after mild or asymptomatic COVID-19. Why this occurs in some and not others is an important question. Moreover, when children do contract COVID-19, understanding their role in …

Body Size At Different Ages And Risk Of 6 Cancers: A Mendelian Randomization And Prospective Cohort Study, Daniela Mariosa, Karl Smith-Byrne, Tom G Richardson, Pietro Ferrari, Marc J Gunter, Nikos Papadimitriou, Neil Murphy, Sofia Christakoudi, Konstantinos K Tsilidis, Elio Riboli, David Muller, Mark P Purdue, Stephen J Chanock, Rayjean J Hung, Christopher I Amos, Tracy A O'Mara, Pilar Amiano, Fabrizio Pasanisi, Miguel Rodriguez-Barranco, Vittorio Krogh, Anne Tjønneland, Jytte Halkjær, Aurora Perez-Cornago, María-Dolores Chirlaque, Guri Skeie, Charlotta Rylander, Kristin Benjaminsen Borch, Dagfinn Aune, Alicia K Heath, Heather A Ward, Matthias Schulze, Catalina Bonet, Elisabete Weiderpass, George Davey Smith, Paul Brennan, Mattias Johansson

Staff and Researcher Publications

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in …

Ionic Liquid Pilocarpine Analog As An Antiglaucoma Drug Candidate, Juan Wang, Boxuan Li, Jing Tang, Li Qiu, Xin Qiao, Na Xu, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Ionic liquid pilocarpine analog [Pilo-OEG]Cl, the first-of-its-kind ionic liquid antiglaucoma drug candidate, is synthesized and reported. To synthesize [Pilo-OEG]Cl, pilocarpine was reacted with the oligo-polyethylene glycol chloride, 2-[2-(2-chloroethoxy)ethoxy] ethanol, to form an ionic liquid molecule with an imidazole cation and a chloride anion. The chemical structure of [Pilo-OEG]Cl was confirmed with 1H NMR spectroscopy. Compared with pilocarpine (Pilo) and pilocarpine hydrochloride (PiloHCl), [Pilo-OEG]Cl has improved structural stability according to pH measurements and LC-MS analysis. The corneal permeability coefficient of [Pilo-OEG]Cl is 2-fold higher than that of Pilo and 8-fold higher than that of PiloHCl. [Pilo-OEG]Cl does not show apparent toxicity …

Addressing The Disproportionate Adverse Health Effects Among Bipoc Communities As A Result Of Environmental Racism, Lindsay M. Farbent

Environmental and Earth Law Journal (EELJ)

This article examines factors that contribute to the negative health impacts on Black Americans, other minorities, and low-income communities that are living in areas with high levels of air pollution, toxic waste, and environmental hazards. First, this article assesses the role of historical residential redlining on the segregation of BIPOC neighborhoods. Furthermore, the article addresses gaps in both federal and state environmental laws that allow facilities to keep obtaining permits and polluting in BIPOC and primarily low-income neighborhoods. Moreover, the article explains the higher rates of trauma, stress, and stress-related illnesses among BIPOC communities exposed to high levels of environmental …

Water Pollution – Attempts To Decontaminate Florida Law, Frank E. Maloney, Sheldon J. Plager, Fletcher N. Baldwin

Florida Law Review

No abstract provided.

Law And Science As Rival Systems, Lee Loevinger

Florida Law Review

No abstract provided.

Public Law And The Obsolescence Of The Lawyer, Arthur S. Miller

Florida Law Review

No abstract provided.

A Working Model For Jurisprudential Investigation: On The Lawyer As An Emerging Force In Modern Jurisprudence, Thomas A. Cowan

Florida Law Review

No abstract provided.

Legal Ethics: Standards For Whose Sake?, Karl B. Block Jr., Michael Mcgillicuddy

Florida Law Review

No abstract provided.

Lsd: A Challenge To American Drug Law Philosophy, Brian Alexander Rosborough

Florida Law Review

No abstract provided.

What Is A Crime?, Vernon Fox

Florida Law Review

No abstract provided.

"After All, Doctors Are Human", Leonard S. Powers

Florida Law Review

No abstract provided.

The Territorial Sea: A Quest For Uniformity, Oscar Svarlien

Florida Law Review

No abstract provided.

Industrial Development Bonds: Judicial Construction Vs. Plant Construction, Don R. Livingstone

Florida Law Review

No abstract provided.

Equal Rights For Women, Grace W. Taylor

Florida Law Review

No abstract provided.

Statutory Regulation Of Marriage Counselors, Charles J. Cheves Jr.

Florida Law Review

No abstract provided.

Mandibular Expansion Appliances And Their Activation Protocols, Tivanani Venkata Durga Mahendra, Vyshnavi Mulakala, Manda Anoosha

Taiwanese Journal of Orthodontics

A tooth size-arch length discrepancy (TSALD) occurs when there is an imbalance between the size of the teeth and the space available in the dental arches to accommodate them. Relief of crowding through expanding the arch is the most employed non-extraction method in orthodontics. Because of the absence of a midline suture and the resistance of the mandibular body, resolving crowding in the lower arch is more complex than in the upper arch. However, numerous researchers have devised innovative techniques and methods to successfully bring about the desired and stable changes through mandibular expansion. The advantage of this procedure was …

In Silico Evaluation Of The Antimalarial Potential Of The Phytoconstituents Of The Azadirachta Indica Plant, Areh E.T., Atolani O., Kambizi L

Al-Bahir

Background and Objectives: Malaria, a parasitic protozoan disease caused primarily by Plasmodium falciparum, has killed millions of people in Africa, particularly those with meager or no access to orthodox medical facilities and therapies. Extracts from the Azadirachta indica (neem) plant is believed to possess antimalaria properties among the locals that rely on herbs. Numerous in - vivo studies have suggested the antimalarial properties of neem extract and phytochemicals. This study employs an in - silico method through molecular docking techniques to provide insight while adding credence to the antimalarial potential of phytochemicals of neem plants as claimed …

Medical School Watercooler Newsletter - September 8, 2022, Lindsey Lyle

Watercooler Newsletter

This is the September 8, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• Student-Run Free Clinic to host 5K
• USA basic medical sciences student selected for international policy fellowship network
• Meet a Ph.D. Student: Meredith Selby Gwin
• USA awarded $5.45 million to enhance Primary Care Pathway program

Vol.50 N.07 September 8th 2022, Voice Media Ventures

Black Voice News

No abstract provided.

The Chanticleer, 2022-09-08, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Single-Cell Rna Sequencing Reveals Molecular Features Of Heterogeneity In The Murine Retinal Pigment Epithelium., Ravi S Pandey, Mark P. Krebs, Mohan Bolisetty, Jeremy R. Charette, Juergen K. Naggert, Paul Robson, Patsy M. Nishina, Gregory W. Carter

Faculty Research 2022

Transcriptomic analysis of the mammalian retinal pigment epithelium (RPE) aims to identify cellular networks that influence ocular development, maintenance, function, and disease. However, available evidence points to RPE cell heterogeneity within native tissue, which adds complexity to global transcriptomic analysis. Here, to assess cell heterogeneity, we performed single-cell RNA sequencing of RPE cells from two young adult male C57BL/6J mice. Following quality control to ensure robust transcript identification limited to cell singlets, we detected 13,858 transcripts among 2667 and 2846 RPE cells. Dimensional reduction by principal component analysis and uniform manifold approximation and projection revealed six distinct cell populations. All …

Changes Of Physicochemical Properties Of Rice Glutelin Fibril Aggregates During Storage, Huang Hui, Wang Chuan-Yang, Li Shi-Chao, Yu Jian, Wang Fa-Xiang, Liu Yong-Le, Li Xiang-Hong

Food and Machinery

Objective:To explore the relationship between functional properties of rice glutelin fibril aggregates (RGFAs) solution formed by different storage and heating time.Methods:The RGFAs samples were prepared by heating rice glutelin (RG) at 85 ℃ and pH 2.0 for 2~15 h, and stored at 4 ℃ for 1 day and 4 days, respectively. The surface hydrophobicity, emulsifying property, shear viscosity of RGFAs samples as well as the gelatinization characteristics and hydrolysis rate of the mixture of RGFAs and starch were measured.Results:After storage at 4 ℃ for 4 days, the emulsifying properties were significantly improved. The surface hydrophobicity …

Austad's New Book Explores Lessons Humans Can Learn About Aging From The Long Lives Of Certain Animals, Staff

Browse All News

No abstract provided.

Stereoisomers Of An Aryl Pyrazole Glucocorticoid Receptor Agonist Scaffold Elicit Differing Anti-Inflammatory Responses, Ashley M. Lato, Susan J. Burke, Maggie P. Ducote, Brandon J. Kennedy, J. Jason Collier, Shawn R. Campagna

Division of Basic Science Faculty Publications

Glucocorticoids (GCs) are heavily prescribed to control inflammation in various human diseases; however, side effects associated with GCs are well documented and lead to serious metabolic and immunological complications with long-term use. The paradigm for GC function includes two well described modes of activity: dimer formation of the glucocorticoid receptor (GR) promotes transactivation, while monomeric interaction with co-regulators promotes transrepression. Previously, a set of aryl pyrazole-derived glucocorticoid receptor agonists (APGRAs) with potency rivaling current commercially available glucocorticoids were described. In this study, a further series of existing and novel stereopure APGRAs were thoroughly examined for biological activity and evaluated for …

Pando's Pulse: Vital Signs Signal Need For Course Correction At World-Renowned Aspen Forest, Paul C. Rogers

Aspen Bibliography

Upland aspen (Populus spp.) forests contribute significantly to biodiversity in their circumboreal role as keystone species. As aspen ecosystems flourish or diminish, myriad dependent species follow suit. The 43-hectare Pando aspen (Populus tremuloides Michx.) clone in Utah, USA, is thought to be the largest living organism on earth, but is faltering due to chronic herbivory. Long-term resilience in aspen communities, including Pando, rests on successful recruitment of vegetative suckers that are nutritiously desirable to browsing ungulates. Here, I evaluate aspen reproduction alongside numerous vital indicators of Pando's status in the first trend assessment of this embattled iconic forest. …

Pilot Examination Of Stress, Heart Rate Variability, And Alcohol Craving And Use Among Female Veterans, Cathryn Glanton Holzhauer, Elizabeth E. Epstein, Laurel Bickar, Robyn A. Ellis, Nnamdi Pole, Mehmet Sofuoglu, David A. Smelson, Kristin Mattocks

Psychology: Faculty Publications

Rates of alcohol use disorder (AUD) are increasing among civilian and veteran populations of women in the United States, and stress pathophysiology (i.e., abnormal acute and long-term change in physiological responses to stress) is central to the maintenance of alcohol misuse within this population. Heart rate variability (HRV) is one measure of stress regulation that may help to explain the association of stress with alcohol misuse among women. In the current analysis of pilot data, 20 women veterans attended an in-person laboratory session and completed 35 daily assessments of their alcohol use and craving. During the lab session, the effects …

Biomimetic, Mussel-Inspired Surface Modification Of 3d-Printed Biodegradable Polylactic Acid Scaffolds With Nano-Hydroxyapatite For Bone Tissue Engineering, Minghan Chi, Na Li, Junkui Cui, Sabrina Karlin, Nadja Rohr, Neha Sharma, Florian M. Thieringer

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Polylactic acid (PLA) has been widely used as filaments for material extrusion additive manufacturing (AM) to develop patient-specific scaffolds in bone tissue engineering. Hydroxyapatite (HA), a major component of natural bone, has been extensively recognized as an osteoconductive biomolecule. Here, inspired by the mussel-adhesive phenomenon, in this study, polydopamine (PDA) coating was applied to the surface of 3D printed PLA scaffolds (PLA@PDA), acting as a versatile adhesive platform for immobilizing HA nanoparticles (nHA). Comprehensive analyses were performed to understand the physicochemical properties of the 3D-printed PLA scaffold functionalized with nHA and PDA for their potent clinical application as a bone …

The Woman Question During The Japanese Occupation In Kikuko Kawakami’S And Tsuyako Miyake’S Philippine Diaries (1943), Julz E.; Riddle

Philippine Studies: Historical and Ethnographic Viewpoints

Realizing the value of women’s labor in the war effort, the Japanese Empire called for women all over the Greater East Asia Co-prosperity Sphere (GEACPS) to shed Western influence. In 1943 Filipino women intellectuals and two Japanese writers, Kikuko Kawakami and Tsuyako Miyake, held two roundtable meetings to discuss the woman’s role within the “New Order.” Based on Kawakami and Miyake’s hitherto unstudied accounts of these meetings, thisarticle examines the discourse between Filipino and Japanese women, particularly on the women’s position in Japan’s GEACPS. The tensions present in both accounts tell of the complex power relations that informed their dialogues. …