Digital Commons Network^™

Pleomorphic Dermal Sarcoma Of The Scalp: Review Of Management And Distinguishing Features From Atypical Fibroxanthoma, Alexa J Cohen, Sahithi Talasila, Bojan Lazarevic, Laura Gleason, Viral Patel, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

No abstract provided.

Ag-Iot For Crop And Environment Monitoring: Past, Present, And Future, Nipuna Chamara, Md Didarul Islam, Geng Bai, Yeyin Shi, Yufeng Ge

Department of Agricultural and Biological Systems Engineering: Faculty Publications

CONTEXT: Automated monitoring of the soil-plant-atmospheric continuum at a high spatiotemporal resolution is a key to transform the labor-intensive, experience-based decision making to an automatic, data-driven approach in agricultural production. Growers could make better management decisions by leveraging the real-time field data while researchers could utilize these data to answer key scientific questions. Traditionally, data collection in agricultural fields, which largely relies on human labor, can only generate limited numbers of data points with low resolution and accuracy. During the last two decades, crop monitoring has drastically evolved with the advancement of modern sensing technologies. Most importantly, the introduction …

Carbohydrate Utilization By The Gut Microbiome Determines Host Health Responsiveness To Whole Grain Type And Processing Methods, Caroline Smith, Mallory J. Suhr Van Haute, Yibo Xian, Rafael R. Segura Munoz, Sujun Liu, Robert J. Schmaltz, Amanda E. Ramer-Tait, Devin J. Rose

Department of Food Science and Technology: Faculty Publications

Little is known about how interactions among grain processing, grain type, and carbohydrate utilization (CU) by the microbiome influence the health benefits of whole grains. Therefore, two whole grains – brown rice and whole wheat – and two processing methods – boiling (porridge) and extrusion – were studied for their effects on host metabolic outcomes in mice harboring human microbiomes previously shown in vitro to have high or low CU. Mice carrying either microbiome experienced increases in body weight and glycemia when consuming Western diets supplemented with extruded grains versus porridge. However, mice with the high but not low CU …

Climate Change Alters Aging Patterns Of Reservoir Aquatic Habitats, Leandro E. Miranda, Nicky M. Faucheux

United States Geological Survey: Staff Publications

Two slow-moving developments are threatening reservoir aquatic habitats globally: aging and climate change. These events are projected to transform reservoir aquatic habitats in various and often unpredictable ways. Aging affects in-lake habitats directly, whereas climate change affects both in-lake and off-lake conditions. Climate change is expected to accelerate and, in some instances, possibly decelerate aging. Aging can be indexed as functional age, an index that signals the position of a reservoir along its lifespan relying on inlake descriptors of aquatic habitat. Using existing habitat datasets and climate projections, we developed semi-quantitative predictions about the effect of climate change on reservoir …

Innexin Function Dictates The Spatial Relationship Between Distal Somatic Cells In The Caenorhabditis Elegans Gonad Without Impacting The Germline Stem Cell Pool, Theadora Tolkin, Ariz Mohammad, Todd A Starich, Ken C Q Nguyen, David H Hall, Tim Schedl, E Jane Albert Hubbard, David Greenstein

2020-Current year OA Pubs

Gap-junctional signaling mediates myriad cellular interactions in metazoans. Yet, how gap junctions control the positioning of cells in organs is not well understood. Innexins compose gap junctions in invertebrates and affect organ architecture. Here, we investigate the roles of gap-junctions in controlling distal somatic gonad architecture and its relationship to underlying germline stem cells in

Complete Issue: Volume 4 Issue 1

Maya America: Journal of Essays, Commentary, and Analysis

Maya America presents this special issue as a stand-alone primary document to further an understanding of the life experiences of Guatemalan adoptees and to encourage the inclusion of irregular adoption as part of the Maya diaspora and as an integral part of the migration of peoples from Central America. Indeed, it is striking to see Maya heritage adoptees, raised in various parts of the world, add to the concept of "Maya America.”

Analysis Of The Cytopathogenic Effect Of Different Hiv-1 Vpr Isoforms On Primary Human Cd4+ T Cells And A Model Cell Line, Jonatan Josue Fierro Nieves

Theses and Dissertations

Human Immunodeficiency Virus (HIV) is the causal agent of acquired immunodeficiency syndrome (AIDS), a disease characterized by the depletion of CD4+ T cells which impairs immune response. Analysis of HIV-1 infected patients has identified two distinctive phenotypes that differ in length of time towards the development of AIDS, Rapid Progressor (RP) and Long-Term Non-Progressor (LTNP) patients. The cause of the differences between these two groups is a process that is still under investigation. Hints about a possible cause have been attributed to the discovery of mutations in the viral protein R (Vpr) that have been associated with these phenotypes: mutations …

Bet Inhibition Induces Vulnerability To Mcl1 Targeting Through Upregulation Of Fatty Acid Synthesis Pathway In Breast Cancer, Gonghong Yan, Augustin Luna, Heping Wang, Behnaz Bozorgui, Xubin Li, Maga Sanchez, Zeynep Dereli, Nermin Kahraman, Goknur Kara, Xiaohua Chen, Caishang Zheng, Daniel Mcgrail, Nidhi Sahni, Yiling Lu, Ozgun Babur, Murat Cokol, Bora Lim, Bulent Ozpolat, Chris Sander, Gordon B Mills, Anil Korkut

Faculty, Staff and Student Publications

Therapeutic options for treatment of basal-like breast cancers remain limited. Here, we demonstrate that bromodomain and extra-terminal (BET) inhibition induces an adaptive response leading to MCL1 protein-driven evasion of apoptosis in breast cancer cells. Consequently, co-targeting MCL1 and BET is highly synergistic in breast cancer models. The mechanism of adaptive response to BET inhibition involves the upregulation of lipid synthesis enzymes including the rate-limiting stearoyl-coenzyme A (CoA) desaturase. Changes in lipid synthesis pathway are associated with increases in cell motility and membrane fluidity as well as re-localization and activation of HER2/EGFR. In turn, the HER2/EGFR signaling results in the accumulation …

Parasitisation Of Weaver Ants By A Species Of Smicromorpha Girault (Hymenoptera: Chalcididae: Smicromorphinae) And Unequivocal Evidence Of Its Presence In The Afrotropical Region, Robert S. Copeland, Bethelihem Mekonnen, Gerard Delvare

All Peer-Reviewed Publications

Smicromorpha Girault (Hymenoptera: Chalcididae) is distributed in the old world tropics and subtropics from Australia through New Guinea, Southeast and South Asia. Since its original description in 1913 conclusive evidence of its host has been lacking although it has been collected in association with weaver ants (Oecophylla spp.; Formicidae: Formicinae) either in proximity to ant nests or, on one occasion, reared from one. In this paper we report the presence of Smicromorpha pupae within the gaster of Oecophylla longinoda workers from a nest collected in coastal Kenya. This discovery extends the distribution of Smicromorpha to the Afrotropical Region and demonstrates …

Food-Borne Chemical Carcinogens And The Evidence For Human Cancer Risk, Tetyana Kobets, Benjamin P C Smith, Gary M Williams

NYMC Faculty Publications

Commonly consumed foods and beverages can contain chemicals with reported carcinogenic activity in rodent models. Moreover, exposures to some of these substances have been associated with increased cancer risks in humans. Food-borne carcinogens span a range of chemical classes and can arise from natural or anthropogenic sources, as well as form endogenously. Important considerations include the mechanism(s) of action (MoA), their relevance to human biology, and the level of exposure in diet. The MoAs of carcinogens have been classified as either DNA-reactive (genotoxic), involving covalent reaction with nuclear DNA, or epigenetic, involving molecular and cellular effects other than DNA reactivity. …

Serpinb3 Drives Cancer Stem Cell Survival In Glioblastoma, Manmeet Ahluwalia

All Publications

Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive recurrence. The precise mechanisms underlying CSC resistance, namely inhibition of cell death, are unclear. We built on previous observations that the high cell surface expression of junctional adhesion molecule-A drives CSC maintenance and identified downstream signaling networks, including the cysteine protease inhibitor SerpinB3. Using genetic depletion approaches, we found that SerpinB3 is necessary for CSC maintenance, survival, and tumor growth, as well as CSC pathway activation. Knockdown of SerpinB3 also increased apoptosis and susceptibility to radiation therapy. SerpinB3 was essential to buffer cathepsin L-mediated cell death, which was enhanced …

Full-Length Transcriptomic Sequencing And Temporal Transcriptome Expression Profiling Analyses Offer Insights Into Terpenoid Biosynthesis In Artemisia Argyi, Ran Xu, Yue Ming, Yongchang Li, Shaoting Li, Wenjun Zhu, Hongxun Wang, Jie Guo, Shaohua Shu, Chao Xiong, Xiang Cheng, Limei Wang, Jingmao You, Dingrong Wan

Student Publications

Artemisiae argyi Folium is a traditional herbal medicine used for moxibustion heat therapy in China. The volatile oils in A.argyi leaves are closely related to its medicinal value. Records suggest that the levels of these terpenoids components within the leaves vary as a function of harvest time, with June being the optimal time for A. argyi harvesting, owing to the high levels of active ingredients during this month. However, the molecular mechanisms governing terpenoid biosynthesis and the time-dependent changes in this activity remain unclear. In this study, GC-MS analysis revealed that volatile oil levels varied across four different harvest …

Reduction Of Protein Levels In Broiler Feed For Commercial Application – A German Case, Andreas Lemme, Kilian Fenske, Heiner Westendarp, Mathias Guhe, Elmar Rother

Proceedings of the Arkansas Nutrition Conference

A project was initiated to apply dietary CP reduction under commercial conditions. The main objective was to demonstrate and validate that dietary CP can be reduced without compromising broiler performance in a production system which is already rather efficient. In addition, we wanted to demonstrate the potential of dietary CP reduction on reducing N-excretions especially in the context of German revised regulations and monitoring attempts. Finally, as previous research suggested, few further aspects such as impact of dietary CP reduction on litter quality and quantity, footpad health, change of ingredient inclusion levels and related impact on sustainability impact factors were …

State Of The Art Pullet And Breeder Nutrition, Rick Van Emous

Proceedings of the Arkansas Nutrition Conference

During the last six to seven decades, broilers have been successfully selected for maximum growth and feed efficiency (Zuidhof et al., 2014). Modern fast-growing broilers reach a body weight of 2.0 to 2.5 kg in 35 to 45 days with an average daily growth of 55 or more gram a day (Augère-Granier, 2019). In a study with different broiler strains representative of broilers in 1957 or 1978 were compared with a broiler strain from 2005 (Zuidhof et al., 2014). The 2005 strain showed, over a 56-day growth period, a 4.6 times higher growth rate and a 50% lower feed conversion …

Amino Acids Were Not All Created Equal, Peter H. Selle, Shemil P. Macelline, Peter V. Chrystal, Sonia Y. Liu

Proceedings of the Arkansas Nutrition Conference

The contention that amino acids were not all created equal is based on the simple premise that intestinal uptakes of non-bound (synthetic, crystalline, feed-grade) amino acids are more rapid than their protein-bound counterparts. The post-enteral ramifications of this difference in bioequivalence are amplified in broiler chickens given their express growth rates and just one complication is the post-prandial oxidation of amino acids. The lack of bioequivalence between non-bound and protein-bound amino acids is a real obstacle to the development and adoption of reduced-crude protein diets that have the potential to promote sustainable chicken-meat production Thus, the purpose of this paper …

Recent Advancements On Calcium And Phosphorus Recommendations In Broilers, Justina Caldas, Marcelo Silva

Proceedings of the Arkansas Nutrition Conference

Calcium and phosphorus have been recognized essential nutrients in chickens since 1950’s (Lesson & Summers, 2001) playing important roles in bone development, among other functions. Calcium is assumed an inexpensive nutrient in animal least cost formulation while phosphorus is considered expensive and scant. The actual economic impact comes from the influence of calcium on phosphorus requirements, changes in phosphorus digestibility, buffer capacity, gut health, trace mineral absorption, fat digestibility, welfare traits, etc. Both minerals have important interactions to be considered during formulation. Few changes have been made over the past 20 years to calcium and phosphorus recommendations because these values …

Decoding The Gut Microbiome; Providing Solutions For Poultry Production, Nichoals Evans, Peter Karnezos, Curtis Novak, Diana Ayala, Emily Kimminau, Kay Russo

Proceedings of the Arkansas Nutrition Conference

The term “microbiome” refers to all the micro-organisms within a particular environment. In poultry, the microbiome is influenced by the barn, diet, and age of the birds and is believed to modulate immunity and inflammation. In the past, culture methods were primarily used to evaluate the presence of the various micro-organisms present in the microbiome; however, recent technological advances in genomic sequencing have revolutionized sample analysis. This technology has opened new avenues of research in poultry production and our understanding of the associated health challenges. Turkey cellulitis has been a major economic and health concern for many years. Traditional bacterial …

Application Of Nutritional Immunology In The Mitigation Of Economic And Production Losses In The Poultry Industry Associated With Food-Borne Pathogens, Coccidiosis, And Necrotic Enteritis., Shahna Fathima, Ramesh K. Selvaraj

Proceedings of the Arkansas Nutrition Conference

Sub-therapeutic doses of antibiotics were used in poultry production since the 1950s for improved production, prophylaxis, and animal welfare. Extensive and indiscriminatory use of antibiotics led to the emergence of antibiotic resistance in food-borne pathogens of public health significance (Jones & Ricke, 2003). As per the United States Centre for Disease Control, more than 2.8 million infections in 2019 were caused by multidrug resistant bacteria. Due to public health concerns, the use of antibiotic growth promoters in livestock production was prohibited by Sweden and Denmark in 1986 and 1998 respectively (Hammerum et al., 2007). The European Union banned the use …

Visualizing Hormonal Effects On Cardiomyocyte Hypertrophic Growth Dynamics Using Digital Holographic Microscopy: Does Size Matter?, Jacquelyn Simmons

McNair Research Journal SJSU

Heart disease continues to be the leading cause of death in the United States. Humans are unable to regenerate their heart tissue following an injury. However, neonatal mice are able to regenerate their heart tissue when cardiomyocytes (CMs) proliferate. This regenerative ability is lost approximately one week after birth when proliferating mononucleated CMs become binucleated and can no longer complete the cell-cycle. Recent studies have shown the combined inhibition of thyroid hormone (T3) and norepinephrine (NE) increases CM proliferation, promotes heart regeneration, and reduces cell size in vivo. Using digital holographic microscopy, the aim of this study was to (1) …

Front Matter, Maria Cruz

McNair Research Journal SJSU

No abstract provided.

Full Issue

McNair Research Journal SJSU

No abstract provided.

The Effect Of Habitat Fragmentation On Plant Communities In A Spatially-Implicit Grassland Model, Mika T. Cooney, Benjamin R. Hafner, Shelby E. Johnson, Sean Lee

Rose-Hulman Undergraduate Mathematics Journal

The spatially implicit Tilman-Levins ODE model helps to explain why so many plant species can coexist in grassland communities. This now-classic modeling framework assumes a trade-off between colonization and competition traits and predicts that habitat destruction can lead to long transient declines called ``extinction debts.'' Despite its strengths, the Tilman-Levins model does not explicitly account for landscape scale or the spatial configuration of viable habitat, two factors that may be decisive for population viability. We propose modifications to the model that explicitly capture habitat geometry and the spatial pattern of seed dispersal. The modified model retains implicit space and is …

Dampak Stress Kerja Tenaga Pelayanan Sosial Terhadap Pelayanan Bagi Warga Binaan Sosial (Studi Kasus Pada Psaa Putra Utama 3 Tebet Jakarta), Fitriyah Fitriyah, Agata Terra Febriana

Jurnal Pembangunan Manusia

Social service workers have an important role in the process of the delivery of services to the children who lived in social institutions. However, an excessive workload implicates work stress which causes an impact on service delivery. This study aims to describe the stress faced by social service workers concurrently with social workers and the impact on services at PSAA Putra Utama 3 Tebet. This study used qualitative descriptive research from October 2019 until January 2020. The data is being collected using in-depth interviews and observations method. The subject of this research is social service officers, WBS, and the leader …

Evaluation Of Hydrograph Separation Techniques With Uncertain End-Member Composition, Eileen Page Lukens, Bethany T. Neilson, Kenneth H. Williams, Janice Brahney

Watershed Sciences Faculty Publications

Hydrograph separation is one of many approaches used to analyse shifts in source water contributions to stream flow resulting from climate change in remote watersheds. Understanding these shifts is vital, as shifts in source water contributions to a stream can shape water management decisions. Because remote watersheds are often inaccessible and have poorly characterized contributing water sources, or end-members, it is critical to understand the implications of using different hydrograph separation techniques in these data-limited environments. To explore the uncertainty associated with different techniques, results from two hydrograph separation techniques, mass balance and principle component analysis, were compared using 3 …

Smokejumper Biographies For 1950 Rookie Class, A-H, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1950.

Authenticity And Psychological Safety: Building And Encouraging Talent Among Underrepresented Students In Stem, Daphne E. Pedersen, Alena Kubatova, Rebecca Simmons

Biology Faculty Publications

The Undergraduate Scholarships with Mathematics and Science Training, Exploration, and Research Program (US MASTER) is a STEM scholarship program funded by the United States National Science Foundation. It was implemented at an upper-Midwest institution to target and provide structured support to low-income, academically talented undergraduates in biology, chemistry, geography and geographic information science (GISc), environmental sciences, and physics and astrophysics. In addition to providing financial support, the program features an integrated approach to mentorship and advising consisting of an ongoing seminar course in which students engage in collaborative projects, research experiences with a faculty mentor, and targeted academic advising. As …

Optimization Of Microwave-Assisted Extraction Of Total Flavonoids From Leaves Of Moringa Oleifera Lam. By Response Surface Methodology And Its Antibacterial And Antioxidant Activities, Yang Li-Hua, Dong Xiao-Qing, Dong Qi-Lu, Li Xiao-Jiao

Food and Machinery

Objective:The purpose of this study is to improve the extraction rate of total flavonoids from the leaves of Moringa oleifera Lam. and evaluate their in vitro antibacterial and antioxidant capacity. Methods:The extraction of total flavonoids from the leaves of M. oleifera Lam. from Baoshan city was optimized by Box-Behnken response surface methodology, and its antibacterial and antioxidant activities were evaluated. Results: The optimal conditions for microwave-assisted extraction of total flavonoids from leaves of M. oleifera Lam. were solid-liquid ratio1∶29 (g/mL), microwave power 567 W, microwave time3.6 min and ethanol fraction 50%, and the highest extraction rate of total …

Pulse-Quality Metric For Nonstationary Partially Coherent Fields, Milo W. Hyde Iv, Olga Korotkova, Mark F. Spencer

Faculty Publications

This paper generalizes a pulse-quality metric referred to as P², i.e., the time analogue of Siegman’s beam quality factor M², to include pulsed (nonstationary) random fields of any state of coherence. The analysis begins with the derivation of a general P² relation, which we then specialize to the important cases of coherent and Schell-model pulsed beams. As examples, we derive the P² for two stochastic sources: (1) a cosine Gaussian-correlated Schell-model pulsed beam and (2) a nonuniformly correlated pulsed beam. For both of these sources, we generate (in simulation) random instances of each and …

Examination Of The Time Delayed Induction Between Prior Encapsulation Of Catalytic Enzymes In P22 Virus-Like Particles, Andrea Hernandez Irias

Chemistry Theses

Protein cages found in nature have the ability to protect and develop new nanomaterials in order to enhance catalytic reactions. This is due to the ability of these organelle structures to mimic protein-based organelles such as Virus-Like Particles (VLPs). VLPs have the ability to not only resemble virus protein structures but to encapsulate enzymes while retaining their activity. This research examines the in vitro encapsulation withing the bacteriophage P22 derived VLP, and show that some enzymes may require a delay in encapsulation to allowed proper folding

and maturation before they can be encapsulated inside P22 as fully active enzymes. Exploring …

Thirteen-Lined Ground Squirrel (Ictidomys Tridecemlineatus) Morphology And Burrow Placement Across A Latitudinal Range, Emma Solis, Emily Davis, Hallie Dickerson, Veronqiue Tessier, Taqwa Armstrong, Jessica Healy-La Price

Western North American Naturalist

Thirteen-lined ground squirrels (TLGS; Ictidomys tridecemlineatus) are burrowing obligate hibernators whose species range extends over 20 degrees latitude in North America from Texas to Canada. Despite their ubiquity as laboratory animals for hibernation research, relatively little is known about their life history across their range in the wild. We live-trapped TLGS in parks or cemeteries from Texas to Minnesota, took morphological measurements, and conducted a survey of burrowing locations in 5 states across the latitudinal gradient. We found that soil texture and percent soil organic matter differed at field sites in different states, with Minnesota soil high in sand …