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Violencia, Memoria Y Empatía Reflexiva En El Ruido De Las Cosas Al Caer De Juan Gabriel Vásquez, Carlos Gardeazábal Bravo

Global Languages and Cultures Faculty Publications and Presentations

In this article, I show how Juan Gabriel Vásquez’s novel El ruido de las cosas al caer (The Sound of Things Falling, 2011) proposes an articulation of the works of memory and affects that can be ethically relevant within the context of the war on drugs in Colombia. I link this analysis with an interpretation of the novel that discusses the role of literature in debates about systemic violence in the global war on drugs. I propose that The noise of things falling, thanks to its affirmation of what I call reflexive empathy, questions the geopolitical designs that articulate that …

Inhibiting Glutamine Utilization Creates A Synthetic Lethality For Suppression Of Atp Citrate Lyase In Kras-Driven Cancer Cells, Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A. Frias, David A. Foster

Publications and Research

Metabolic reprogramming is now considered a hallmark of cancer cells. KRas-driven cancer cells use glutaminolysis to generate the tricarboxylic acid cycle intermediate α -ketoglutarate via a transamination reaction between glutamate and oxaloacetate. We reported previously that exogenously supplied unsaturated fatty acids could be used to synthesize phosphatidic acid–a lipid second messenger that activates both mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and mTOR complex 2 (mTORC2). A key target of mTORC2 is Akt–a kinase that promotes survival and regulates cell metabolism. We report here that mono- unsaturated oleic acid stimulates the phosphoryla tion of ATP citrate lyase (ACLY) at …

A Comprehensive Update On Cido: The Community-Based Coronavirus Infectious Disease Ontology, Yongqun He, Hong Yu, Anthony Huffman, Asiyah Yu Lin, Darren A Natale, John Beverley, Ling Zheng, Yehoshua Perl, Zhigang Wang, Yingtong Liu, Edison Ong, Yang Wang, Philip Huang, Long Tran, Jinyang Du, Zalan Shah, Easheta Shah, Roshan Desai, Hsin-Hui Huang, Yujia Tian, Eric Merrell, William D Duncan, Sivaram Arabandi, Lynn M Schriml, Jie Zheng, Anna Maria Masci, Liwei Wang, Hongfang Liu, Fatima Zohra Smaili, Robert Hoehndorf, Zoë May Pendlington, Paola Roncaglia, Xianwei Ye, Jiangan Xie, Yi-Wei Tang, Xiaolin Yang, Suyuan Peng, Luxia Zhang, Luonan Chen, Junguk Hur, Gilbert S Omenn, Brian Athey, Barry Smith

Faculty, Staff and Student Publications

BACKGROUND: The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the development of the community-based Coronavirus Infectious Disease Ontology (CIDO) in early 2020.

RESULTS: As an Open Biomedical Ontology …

Diversity In Children's Books, Hala Qarini

Dissertations, Theses, and Projects

Abstract

This project aimed to determine whether Leveled Literacy Intervention (LLI) curriculum represents diversity in the books in a way that reflects the diversity of students in Fargo Public Schools (FPS). I used the green system in LLI curriculum level B-level I, which represents first grade. For this study, I analyzed eighty books total (lesson 21-lesson 100) based on the Fargo Public Schools definition of diversity. This method was a good match for my research question because it included gender/age, race/ethnicity, socioeconomic, religion, disability, and culture which Fargo Public School includes in its description.

After reviewing and completing a content …

Prevalence Of Smoking (Cigarette And Waterpipe) And Its Association With Obesity/Overweight In Uae And Palestine, Haleama Al Sabbah, Enas A. Assaf, Elias Dabeet

All Works

This study aimed to assess the prevalence rate of smoking behavior (cigarette and waterpipe) and its association with obesity/ overweight among university students in the United Arab Emirates (UAE) and Palestine. A cross-sectional study was conducted at a convenient sample of 10 largest universities in the West Bank- Palestine and Dubai- UAE. In total, 3800 students were randomly selected from the universities, with an 87.6% response rate. A self-administered questionnaire was used to collect the data. The key measures were: waterpipe smoking, weight, height, cigarette smoking, dieting to reduce weight, and perception and knowledge related to tobacco waterpipe smoking (TWP). …

Biological Networks And Complexity In Early-Onset Motor Neuron Diseases, Matthew E. R. Butchbach, Rod C. Scott

Department of Pediatrics Faculty Papers

Motor neuron diseases (MNDs) are neuromuscular disorders where the spinal motor neurons–either the cell bodies themselves or their axons–are the primary cells affected. To date, there are 120 different genes that are lost or mutated in pediatric-onset MNDs. Most of these childhood-onset disorders, aside from spinal muscular atrophy (SMA), lack viable therapeutic options. Previous research on MNDs has focused on understanding the pathobiology of a single, specific gene mutation and targeting therapies to that pathobiology. This reductionist approach has yielded therapeutic options for a specific disorder, in this case SMA. Unfortunately, therapies specific for SMA have not been effective against …

Whole Genome Sequencing Of Moraxella Bovis Strains From North America Reveals Two Genotypes With Different Genetic Determinants, Emily L. Wynn, Matthew M. Hille, John Dustin Loy, Gennie Schuller, Kristen L. Kuhn, Aaron M. Dickey, James L. Bono, Michael L. Clawson

School of Veterinary and Biomedical Sciences: Faculty Publications

Background: Moraxella bovis and Moraxella bovoculi both associate with infectious bovine keratoconjunctivitis (IBK), an economically significant and painful ocular disease that affects cattle worldwide. There are two genotypes of M. bovoculi (genotypes 1 and 2) that differ in their gene content and potential virulence factors, although neither have been experimentally shown to cause IBK. M. bovis is a causative IBK agent, however, not all strains carry a complete assortment of known virulence factors. The goals of this study were to determine the population structure and depth of M. bovis genomic diversity, and to compare core and accessory genes and …

Maternal Prenatal Cortisol Trajectories Predict Accelerated Growth In Infancy, Jennifer Hahn-Holbrook, Elysia Poggi Davis, Curt A. Sandman, Laura M. Glynn

Psychology Faculty Articles and Research

Higher maternal cortisol in pregnancy has been linked to childhood obesity. Much of the previous research has been limited in that cortisol in pregnancy is only measured at one time-point, precluding the ability to examine critical timing effects of prenatal maternal cortisol. To fill this gap, this longitudinal study measured maternal plasma cortisol at 15, 19, 25, and 31 weeks of pregnancy, and assessed infant body mass index percentile (BMIP)1 at birth, 3, 6, 12, and 24 months in 189 mother-infant pairs. Three distinct patterns of maternal cortisol in pregnancy (typical, steep, and flat trajectories) were identified using general growth …

After Abrupt Shutdown Of Triplet Therapeutics, Huntington’S Disease Community Regroups In The Fight For Therapies, Kenneth P. Serbin Phd

At Risk for Huntington's Disease

No abstract provided.

Board Of Trustees Agenda, Oct. 21 2022, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Cgas-Sting Activation Contributes To Podocyte Injury In Diabetic Kidney Disease, Nan Zang, Chen Cui, Xinghong Guo, Jia Song, Huiqing Hu, Mengmeng Yang, Mingyue Xu, Lingshu Wang, Xinguo Hou, Qin He, Zheng Sun, Chuan Wang, Li Chen

Faculty, Staff and Students Publications

Diabetic kidney disease (DKD) is the leading cause of end-stage renal diseases. DKD does not have efficacious treatment. The cGAS-STING pathway is activated in podocytes at the early stage of kidney dysfunction, which is associated with the activation of STING downstream effectors TBK1 and NF-κB but not IRF3. Lipotoxicity induces mitochondrial damage and mtDNA leakage to the cytosol through Bcl-2 associated X protein (BAX) in podocytes. BAX-mediated mtDNA cytosolic leakage can activate the cGAS-STING pathway in the absence of lipotoxicity and is sufficient to cause podocyte injury. Depletion of cytosolic mtDNA, genetic STING knockdown, or pharmacological inhibition of STING or …

Genetic Inhibition Of Nuclear Factor Of Activated T-Cell C2 Prevents Atrial Fibrillation In Crem Transgenic Mice, Li Ni, Satadru K Lahiri, Jiali Nie, Xiaolu Pan, Issam Abu-Taha, Julia O Reynolds, Hannah M Campbell, Haihao Wang, Markus Kamler, Wilhelm Schmitz, Frank Ulrich Müller, Na Li, Xiang Wei, Dao Wen Wang, Dobromir Dobrev, Xander H T Wehrens

Faculty, Staff and Students Publications

AIMS: Abnormal intracellular calcium (Ca2+) handling contributes to the progressive nature of atrial fibrillation (AF), the most common sustained cardiac arrhythmia. Evidence in mouse models suggests that activation of the nuclear factor of activated T-cell (NFAT) signalling pathway contributes to atrial remodelling. Our aim was to determine the role of NFATc2 in AF in humans and mouse models.

METHODS AND RESULTS: Expression levels of NFATc1-c4 isoforms were assessed by quantitative reverse transcription-polymerase chain reaction in right atrial appendages from patients with chronic AF (cAF). NFATc1 and NFATc2 mRNA levels were elevated in cAF patients compared with those in normal sinus …

Unraveling The Pathways Involved In Intestinal Repair After Ionizing Radiation Damage, Blaine Pattavina

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Exposure to genotoxic environmental agents has detrimental effects on health span and aging. Macromolecular damage caused by these factors is also known to lead to diseases like cancer. Radiation therapy is the treatment of choice for malignant tumors and several non-malignant diseases. Despite its effectiveness, it often leads to unintended complications. Radio-sensitivity of healthy ‘bystander’ cells is an important factor in mediating these complications, which often result in several long-term and debilitating side effects. This incurs huge costs in patient care to maintain the well-being of survivors. Current efforts to understand the underlying molecular patho-physiology of radiation damage involve the …

The Effect Of Species Diversity And Shade On Milkweed Growth And Cardenolide Concentration, Estrella V. Silva, Rylee Mattson, Katherine Klassen, Laurie Dizney

RURALS: Review of Undergraduate Research in Agricultural and Life Sciences

Monarch butterflies (Danaus plexippus) rely upon milkweed plants for survival, as it is the only plant upon which female monarchs oviposit and it is the sole food supply for monarch larvae. Additionally, cardenolide, a defense toxin within milkweed tissue, is sequestered by monarchs, making them unpalatable to most predators. Eastern and Western monarch populations in the United States are in sharp decline, in part due to the growing scarcity of milkweed, and reestablishing milkweed habitat is crucial to the monarch’s long-term survival. This study aimed to study the effects of plant species diversity and shade on the growth …

Issue 405: October 20-November 3, 2022, The Local Voice

The Local Voice

No abstract provided.

Spartan Daily, October 20, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 159, Issue 26

The Immune Signatures Data Resource, A Compendium Of Systems Vaccinology Datasets., Joann Diray-Arce, Helen E R Miller, Evan Henrich, Bram Gerritsen, Matthew P Mulè, Slim Fourati, Jeremy Gygi, Thomas Hagan, Lewis Tomalin, Dmitry Rychkov, Dmitri Kazmin, Daniel G Chawla, Hailong Meng, Patrick Dunn, John Campbell, The Human Immunology Project Consortium (Hipc), Minnie Sarwal, John S Tsang, Ofer Levy, Bali Pulendran, Rafick Sekaly, Aris Floratos, Raphael Gottardo, Steven H Kleinstein, Mayte Suárez-Fariñas

Faculty Research 2022

Vaccines are among the most cost-effective public health interventions for preventing infection-induced morbidity and mortality, yet much remains to be learned regarding the mechanisms by which vaccines protect. Systems immunology combines traditional immunology with modern 'omic profiling techniques and computational modeling to promote rapid and transformative advances in vaccinology and vaccine discovery. The NIH/NIAID Human Immunology Project Consortium (HIPC) has leveraged systems immunology approaches to identify molecular signatures associated with the immunogenicity of many vaccines. However, comparative analyses have been limited by the distributed nature of some data, potential batch effects across studies, and the absence of multiple relevant studies …

Hyperexcitable And Immature-Like Neuronal Activity In The Auditory Cortex Of Adult Rats Lacking The Language-Linked Cntnap2 Gene., Kaela E Scott, Rajkamalpreet S Mann, Ashley L Schormans, Susanne Schmid, Brian L Allman

Anatomy and Cell Biology Publications

The contactin-associated protein-like 2 gene, CNTNAP2, is a highly penetrant risk gene thought to play a role in the genetic etiology of language-related disorders, such as autism spectrum disorder and developmental language disorder. Despite its candidacy for influencing language development, few preclinical studies have examined the role of CNTNAP2 in auditory processing. Using in vivo and in vitro electrophysiological recordings in a rat model with translational validity, we report that a loss of the Cntnap2 gene function caused immature-like cortical evoked potentials, delayed multiunit response latencies to acoustic stimuli, impaired temporal processing, and led to a pattern of hyperexcitability in …

The Deep End: A Journey Of Faith, Janet M. Henderson

Masters Theses

This paper is an expansion of papers written in my MFA program’s creative non-fiction writing class and workshop. In English 600: Editing, Layout, and Publishing, the class wrote a paper to document our faith journey and our approach to understanding ourselves and our worldview based on our religious indoctrination. This paper was 10-15 pages long and had a title page, a table of contents, an acknowledgment page, and a dedication page. After writing this paper, I began to consider the possibility of writing a longer work that would dig deeper into the real essence of my faith walk. It would …

2022 Erma Bombeck Writers' Workshop Program, Teri Rizvi, University Of Dayton

Documents from the Erma Bombeck Writers' Workshop

• Conference schedule
• Feature on the Erma Bombeck Collection at the University of Dayton
• Session descriptions
• Keynote speaker biographies
• Featured talent biographies
• Presenter biographies
• Winning entries in the 2022 Erma Bombeck Writing Competition
• Winners of the inaugural DC Stanfa Memorial Writers’ Award

The Comment, October 20, 2022, Bridgewater State University

The Comment

No abstract provided.

The Relationship Between Game Art Students’ Achievement And Their Perceived Quality Of Assessment, Nicole R. Lesher

Doctoral Dissertations and Projects

The purpose of this quantitative, non-experimental, predictive correlational study is to analyze the relationship between Game Art students’ perceptions of quality of assessment practices in higher education and their achievement of learning. Assessment in higher education has become increasingly significant due to accreditation and regulatory requirements around accountability of student outcomes. Institutions must commit a high level of resources toward appropriate assessment practices in order to answer tough questions about the value of higher education. This work has been met with adversity by students and educators, often resulting in overextended departments and poor-quality assessment practices. Questions pertaining to the benefits …

Adaptive Multi-Scale Place Cell Representations And Replay For Spatial Navigation And Learning In Autonomous Robots, Pablo Scleidorovich

USF Tampa Graduate Theses and Dissertations

Place cells are one of the most widely studied neurons thought to play a vital role in spatial cognition. Extensive studies show that their activity in the rodent hippocampus is highly correlated with the animal’s spatial location, forming “place fields” of smaller sizes near the dorsal pole and larger sizes near the ventral pole. Despite advances, it is yet unclear how this multi-scale representation enables navigation in complex environments.

In this dissertation, we analyze the place cell representation from a computational point of view, evaluating how multi-scale place fields impact navigation in large and cluttered environments. The objectives are to …

Clemson Board Of Trustee Minutes, Finance And Facilities Committee, 2022 October 20, Clemson University Board Of Trustees

Minutes

No abstract provided.

Clemson Board Of Trustee Minutes, Full Board Minutes, 2022 October 20, Clemson University Board Of Trustees

Minutes

No abstract provided.

On The Avenue Of The Mystery: The Postwar Counterculture In Novels And Film, Gary Hentzi

Publications and Research

This volume is a study of eight major novels from the postwar period (1945–65) in conjunction with the films made from them during a later period of a little less than three decades straddling the millennium (1985–2012). The comparison of these novels (by Ken Kesey, Paul Bowles, Carson McCullers, Jack Kerouac, James Baldwin, Alexander Trocchi, William Burroughs, and Peter Matthiessen) with their film adaptations offers the opportunity for a historical reassessment not only of the novelsthemselves but also of the global counterculture of the years 1965–75, which they prefigure in a variety of ways. Appearing more than a decade after …

Smart Drumlines Ineffective In Catching White Sharks In The High Energy Capes Region Of Western Australia: Acoustic Detections Confirm That Sharks Are Not Always Amenable To Capture, Stephen M. Taylor, Jason How, Michael J. Travers, Stephen J. Newman, Silas Mountford, Daniela Waltrick, Christopher E. Dowling, Ainslie M. Denham, Daniel J. Gaughan

Fisheries Research Articles

The management of human-shark interactions can benefit from the implementation of effective shark hazard mitigation measures. A Shark-Management-Alert-in-Real-Time (SMART) drumline trial in the Capes region of Western Australia was instigated after several serious incidents involving surfers and white sharks (Carcharodon carcharias). The project aimed to determine whether white sharks (target species), which were relocated after capture, remained offshore using satellite and acoustic tagging. Over a 27-month period, 352 fish were caught, 55% of which comprised tiger sharks (Galeocerdo cuvier). Ninety-one percent of animals were released alive in good condition. Only two white sharks were caught; both were relocated ≥ 1 …

The Cowl - V. 87 N. 5 - October 20, 2022

The Cowl

The Cowl - student newspaper of Providence College. Vol. 87 No. 5 - October 20, 2022. 24 pages.

Interactions Between Environmental Factors And Glutathione S-Transferase (Gst) Genes With Respect To Detectable Blood Aluminum Concentrations In Jamaican Children, Mohammad H Rahbar, Maureen Samms-Vaughan, Yuansong Zhao, Sepideh Saroukhani, Jan Bressler, Manouchehr Hessabi, Megan L Grove, Sydonnie Shakespeare-Pellington, Katherine A Loveland

Faculty, Staff and Student Publications

Aluminum (Al) is a metallic toxicant at high concentrations following natural or unnatural exposures. Dietary intake is considered as the main source of aluminum exposure in children. We used data from 366 typically developing (TD) children (ages 2−8 years) who participated as controls in an age- and sex-matched case−control study in Jamaica. We investigated additive and interactive associations among environmental factors and children’s genotypes for glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1), in relation to having a detectable blood aluminum concentration (BAlC) of >5.0 μg/L, using multivariable logistic regression models. Findings from interactive models revealed that the odds of having …