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2022 October 26 - Undergraduate Curriculum Council Minutes, Undergraduate Curriculum Council, East Tennessee State University

Undergraduate Curriculum Council Minutes

No abstract provided.

Research That Makes A Difference For New Hampshire, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Guanylyl Cyclase C As A Diagnostic And Therapeutic Target In Colorectal Cancer, Adi Caspi, Ariana A. Entezari, Madison Crutcher, Adam E. Snook, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Colorectal cancer remains a major cause of mortality in the USA, despite advances in prevention and screening. Existing therapies focus primarily on generic treatment such as surgical intervention and chemotherapy, depending on disease severity. As personalized medicine and targeted molecular oncology continue to develop as promising treatment avenues, there has emerged a need for effective targets and biomarkers of colorectal cancer. The transmembrane receptor guanylyl cyclase C (GUCY2C) regulates intestinal homeostasis and has emerged as a tumor suppressor. Further, it is universally expressed in advanced metastatic colorectal tumors, as well as other cancer types that arise through intestinal metaplasia. In …

October 26, 2022 (Vol. 107, No. 10), Daily Eastern News

Daily Eastern News: 2022-2023

No abstract provided.

Daily Eastern News: October 26, 2022, Eastern Illinois University

October

No abstract provided.

A Case Study On The Consolidation Of Two Schools In The Arkansas Mississippi River Delta, Chad Williams Martin

Student Theses and Dissertations

As schools have been required to provide more and more services and as more and more people have left rural areas, school consolidation has become the answer. During the 1990s, it was ruled that the state of public school funding was unconstitutional. To solve this problem the state legislature passed Act 60 of 2003. Act 60 set the minimum enrollment for a school district at 350. This has led to the consolidation of many school districts. These consolidations have been prevalent in the Arkansas Mississippi River Delta. After dropping below 350 students in 2015, the Cookville School District was ordered …

Cftr Deletion In Mouse Epithelial And Immune Cells Differentially Influence The Intestinal Microbiota, Callie E. Scull, Meng Luo, Scott Jennings, Christopher M. Taylor, Guoshun Wang

School of Medicine Faculty Publications

Cystic fibrosis (CF) is a life-threatening genetic disorder, caused by mutations in the CF transmembrane-conductance regulator gene (cftr) that encodes CFTR, a cAMP-activated chloride and bicarbonate channel. Clinically, CF lung disease dominates the adult patient population. However, its gastrointestinal illness claims the early morbidity and mortality, manifesting as intestinal dysbiosis, inflammation and obstruction. As CF is widely accepted as a disease of epithelial dysfunction, it is unknown whether CFTR loss-of-function in immune cells contributes to these clinical outcomes. Using cftr genetic knockout and bone marrow transplantation mouse models, we performed 16S rRNA gene sequencing of the intestinal microbes. Here we …

Undergraduate Perceptions Of Warmth And Competence Across Academic Professions, Porsha Nichole Neal Mcgregor

Student Theses and Dissertations

The Stereotype Content Model (SCM; Fiske et al., 2002) is utilized to make sense of how individuals and groups assess others. The SCM consist of to two basic dimensions: perceived warmth and competence. Little research has been conducted to analyze how people perceive individuals in relation to their professional roles. To better understand potential stereotypes of professions, participants were asked to rate general professions on the two dimensions of warmth and competence. Results from the study supported some patterns found in previous research by Brambillia et al. (2010) in regards to two professions and indicated similarities in newly studied professions.

Reproductive Biology Of Gazella Arabica: Predictors Of Offspring Weight And Short- And Long-Term Offspring Survival, Ryan A. Martin

Faculty Scholarship

Reproductive traits are central to organismal fitness, and so the factors influencing patterns of reproduction and offspring survival are at the heart of biology. Making use of breeding data collected over 16 years at the King Khalid Wildlife Research Centre in Saudi Arabia, we investigated the reproductive biology of Arabian gazelles Gazella arabica. Offspring survival was mainly a function of birth weight, with heavier offspring having higher survival rates than lighter offspring. However, while sons were heavier than daughters, daughters had higher survival rates. We could not find evidence that giving birth to sons negatively impacts offspring weight in the …

The Bg News October 26, 2022, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. October 26, 2022. Volume 102-Issue 9.

Rescue Of Deficits By Brwd1 Copy Number Restoration In The Ts65dn Mouse Model Of Down Syndrome, Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze

Publications and Research

With an incidence of ~1 in 800 births, Down syndrome (DS) is the most com- mon chromosomal condition linked to intellectual disability worldwide. While the genetic basis of DS has been identified as a triplication of chromosome 21 (HSA21), the genes encoded from HSA 21 that directly contribute to cognitive de fi cits remain incompletely understood. Here, we found that the HSA21- encoded chromatin effector, BRWD1, was upregulated in neurons derived from iPS cells from an individual with Down syndrome and brain of trisomic mice. We showed that selective copy number restoration of Brwd1 in trisomic animals rescued de fi …

Dysfunctional Glymphatic System With Disrupted Aquaporin 4 Expression Pattern On Astrocytes Causes Bacterial Product Accumulation In The Csf During Pneumococcal Meningitis, Jaqueline S Generoso, Sigrun Thorsdottir, Allan Collodel, Diogo Dominguini, Roberta R E Santo, Fabricia Petronilho, Tatiana Barichello, Federico Iovino

Faculty, Staff and Student Publications

Pneumococcal meningitis, inflammation of the meninges due to an infection of the Central Nervous System caused by Streptococcus pneumoniae (the pneumococcus), is the most common form of community-acquired bacterial meningitis globally. Aquaporin 4 (AQP4) water channels on astrocytic end feet regulate the solute transport of the glymphatic system, facilitating the exchange of compounds between the brain parenchyma and the cerebrospinal fluid (CSF), which is important for the clearance of waste away from the brain. Wistar rats, subjected to either pneumococcal meningitis or artificial CSF (sham control), received Evans blue-albumin (EBA) intracisternally. Overall, the meningitis group presented a significant impairment of …

Who Fears Strangers And Spiders: Political Ideology And Feeling Threatened, Thomas Lukaszewicz

Honors Program: Senior Projects (Public)

In this study, I evaluated the correlations between threat sensitivities and political ideology. Two hypotheses were tested. First, I hypothesized that conservatives would have higher social threat sensitivity than liberals, with social threat defined as a threat dependent on outgroup or social actions (Barclay & Benard, 2020). Second, I hypothesized that conservatives would have higher disgust sensitivity than liberals. To test these and related hypotheses I used a 2018 Qualtrics national demographically representative sample that included 1031 participants. To operationalize threat sensitivity, I used items asking participants to rate how threatened they felt by various fears. These individual items were …

Lanthorn, Vol. 57, No. 10, October 26, 2022, Grand Valley State University

Volume 57, August 1, 2022 - April 10, 2023

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Rapid Reconstruction Of Neural Circuits Using Tissue Expansion And Light Sheet Microscopy, Joshua L Lillvis, Hideo Otsuna, Xiaoyu Ding, Igor Pisarev, Takashi Kawase, Jennifer Colonell, Konrad Rokicki, Cristian Goina, Ruixuan Gao, Amy Hu, Kaiyu Wang, John Bogovic, Daniel E Milkie, Linus Meienberg, Brett D Mensh, Edward S Boyden, Stephan Saalfeld, Paul W Tillberg, Barry J Dickson

Faculty, Staff and Student Publications

Brain function is mediated by the physiological coordination of a vast, intricately connected network of molecular and cellular components. The physiological properties of neural network components can be quantified with high throughput. The ability to assess many animals per study has been critical in relating physiological properties to behavior. By contrast, the synaptic structure of neural circuits is presently quantifiable only with low throughput. This low throughput hampers efforts to understand how variations in network structure relate to variations in behavior. For neuroanatomical reconstruction, there is a methodological gulf between electron microscopic (EM) methods, which yield dense connectomes at considerable …

Spectrum, Volume 49, Issue 6, Sacred Heart University

Newspapers (Obelisk & Spectrum)

Highlights include: Accreditation for Computer Science and Engineering -- Erin Harrison Spotlight -- Funeral for 2 Ambushed Officers draws peers from around the U.S. -- The Wild Wild Fall Fest! -- Family Weekend Under the Fireworks -- (Green) Thumbs Up for Clean Up! -- Halloween Classics Revisted

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Eagles Gather for ‘Celebrate Together’ on the Armstrong Campus

The Burren Smokehouse, Aileen Kennedy Dr, Tara Rooney Dr

Case Studies

The Burren Smokehouse is one of Ireland’s best known artisan producers of organic Smoked Salmon, Mackerel, Trout and Gauda Cheese using 100% Irish quality raw materials for its products. This case explores the role of the Brand and brand experiences in the artisan food market. The role of place in the brand story and values is central to The Burren Smokehouse and the expansion of the operation to include a visitor centre has ensured that these values are embedded.

The case explores the role of visitor experiences and asks the student to Identify and discuss the strategic and tactical business …

What Makes A Great Strategy? Gea Farm Technologies Road To Smart Farming, Jan-Philipp BüChler Prof. Dr.

Case Studies

GEA Farm Technologies is a mid-sized world market leader of mechanical equipment and service solutions for milk production and livestock farming. Senior management of the hidden champion gets approval for an accelerated acquisition strategy to boost growth and innovate the business model vis-á-vis strong competitors in order to lead and develop the market. However, the existing strategic management of internal technology development would be altered and a significant part of management attention would be shifted towards M&A as well as post-merger integration efforts. The case study invites students to explore the benefits and limits of this business model innovation and …

Viruses In Astrobiology, Ignacio De La Higuera, Ester Lázaro

Biology Faculty Publications and Presentations

Viruses are the most abundant biological entities on Earth, and yet, they have not received enough consideration in astrobiology. Viruses are also extraordinarily diverse, which is evident in the types of relationships they establish with their host, their strategies to store and replicate their genetic information and the enormous diversity of genes they contain. A viral population, especially if it corresponds to a virus with an RNA genome, can contain an array of sequence variants that greatly exceeds what is present in most cell populations. The fact that viruses always need cellular resources to multiply means that they establish very …

Ambient Athleticism: Politicizing Akira’S Accelerationist Olympiad, Thomas G. Chaplin

USF Tampa Graduate Theses and Dissertations

This thesis politicizes Katsuhiro Otomo’s 1988 animated cyberpunk film, Akira, specifically through how it stages its myriad neoliberal crises as opportunities for accelerationist solutions mediated by the Tokyo Olympics. Akira’s display of fully animated and intense action physics produces an aesthetic relation to its own athletes that contracts around their bodies in an attempt to transgress classical and oppressive compositions. Akira’s vague utopic promise receives broad acceptance and affirmation by extant scholarship, often relying on the accelerative impulses found in the works of Gilles Deleuze to substantiate Akira’s hopeful ending. Invoking Gilles Deleuze’s notion of athleticism, this thesis critically rereads …

Self-Renewal Of Macrophages: Tumor-Released Factors And Signaling Pathways, Serena Filiberti, Mariapia Russo, Silvia Lonardi, Mattia Bugatti, William Vermi, Cathy Tournier, Emanuele Giurisato

2020-Current year OA Pubs

Macrophages are the most abundant immune cells of the tumor microenvironment (TME) and have multiple important functions in cancer. During tumor growth, both tissue-resident macrophages and newly recruited monocyte-derived macrophages can give rise to tumor-associated macrophages (TAMs), which have been associated with poor prognosis in most cancers. Compelling evidence indicate that the high degree of plasticity of macrophages and their ability to self-renew majorly impact tumor progression and resistance to therapy. In addition, the microenvironmental factors largely affect the metabolism of macrophages and may have a major influence on TAMs proliferation and subsets functions. Thus, understanding the signaling pathways regulating …

Epidemiology Of Plasmid Lineages Mediating The Spread Of Extended-Spectrum Beta-Lactamases Among Clinical Escherichia Coli, Bejan Mahmud, Meghan A Wallace, Kimberly A Reske, Kelly Alvarado, Carol E Muenks, David A Rasmussen, Carey-Ann D Burnham, Cristina Lanzas, Erik R Dubberke, Gautam Dantas

2020-Current year OA Pubs

The prevalence of extended-spectrum beta-lactamases (ESBLs) among clinical isolates of Escherichia coli has been increasing, with this spread driven by ESBL-encoding plasmids. However, the epidemiology of ESBL-disseminating plasmids remains understudied, obscuring the roles of individual plasmid lineages in ESBL spread. To address this, we performed an in-depth genomic investigation of 149 clinical ESBL-like E. coli isolates from a tertiary care hospital. We obtained high-quality assemblies for 446 plasmids, revealing an extensive map of plasmid sharing that crosses time, space, and bacterial sequence type boundaries. Through a sequence-based network, we identified specific plasmid lineages that are responsible for the dissemination of …

Addressing Specific Safety And Occupational Health Challenges For The Canadian Mines Located In Remote Areas Where Extreme Weather Conditions Dominate, Rachid Halabi, Mustafa Kumral

Journal of Sustainable Mining

The number of mining operations is increasing in the Canadian North, where extreme weather conditions govern. Currently, many mine development projects are also in progress in this region. These mines’ working atmosphere and employment circumstances are highly different from regular mines. One of the main differences is the special safety issues of the Canadian North. The primary sources of these special issues are: the difficulty of finding skilled employees; high employee turnover rate; insufficient training and certification requirements; delicate employment circumstances affecting the psychological well-being of employees; permafrost; mine inspection challenges; inventory and logistic hardship; and the legislative and regulative …

Diaphragmatic Function In Cardiovascular Disease: Jacc Review Topic Of The Week., Husam M Salah, Lee R Goldberg, Jeroen Molinger, G Michael Felker, Willard Applefeld, Tienush Rassaf, Ryan J Tedford, Michael Mirro Md, Facc, Fhrs, Faha, John G F Cleland, Marat Fudim

Parkview Heart Institute

In addition to the diaphragm's role as the primary respiratory muscle, it also plays an under-recognized role in cardiac function. It serves as a pump facilitating venous and lymph return, modulating left ventricular afterload hemodynamics and pericardial pressures, as well as regulating autonomic tone. Heart failure (HF) is associated with diaphragmatic changes (ie, muscle fiber atrophy and weakness, increased ratio of type I to type II muscle fibers, and altered muscle metaboreflex) that lead to diaphragmatic dysfunction with subsequent symptomatic manifestations of HF. Herein, it is proposed that targeting the diaphragm in patients with HF via inspiratory muscle training or …

Successful Buprenorphine Transition While Overlapping With A Full Opioid Agonist To Treat Chronic Pain: A Case Report, Kishan V. Patel, Sidharth Sahni, Lanvin F. Taylor

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Buprenorphine is a partial mu opioid agonist that has been increasingly utilized to treat patients with chronic pain and opioid use disorder (OUD). The drug has proven to provide significant chronic pain relief at low doses ranging from 75 to 1800 mcg. The conventional buprenorphine transitional process delays its introduction until patients begin withdrawal. However, this process can pose a barrier to both patients and providers due to some patients' inability to tolerate traditional prerequisite withdrawal. To our knowledge, this is a rare reported case to describe a transitional process utilizing buccal buprenorphine in which a patient with chronic pain …

Insights From Nursing Students About Factors Affecting And Strategies Supporting Their Mental Health, Saima Hirani, Ambreen Tharani, Zohra Jetha, Shehla Khan

Journal of Wellness

Introduction: Nursing students experience high stress and mental health issues. It is essential to pay adequate attention to students’ mental health so they are trained to deliver quality patient care in complex settings. In order to provide a healthy environment to student nurses, it is essential that nursing students’ voices are heard. This study aims to explore nursing students’ perceptions about factors that influence their mental health and understand strategies that support mental health during nursing education.

Methods: The study used an exploratory descriptive qualitative design to achieve the objective. Purposive sampling was used to recruit nursing students from a …

Factors Motivating Individuals With No School-Based Agricultural Education Background To Enter The Profession, Jenna Kay Offerman

Theses and Dissertations

Teacher recruitment and retention have been deemed a national issue across all disciplines and grade-levels in education. School-based agricultural education (SBAE) has been no exception as it has also seen a substantial decline in individuals majoring in agricultural education, entering the teaching profession, and then choosing to remain a SBAE teacher until eligible for retirement. This has resulted in a shortage of qualified SBAE teachers across the country. While alternative licensure routes have existed to help fill these teaching vacancies, it has done little to solve the long-term problem of acquiring qualified, career SBAE teachers. Agricultural education stakeholder groups have …

An Unforgettable Weekend, Erma Bombeck Writers' Workshop

Erma Bombeck Writers' Workshop Blog

Fond of reading Erma Bombeck’s columns in the paper while growing up, I was overjoyed to attend a virtual Erma Bombeck Writers’ Workshop.

The Impact Of Covid-19 On Employment Characteristics, Eliana Shatkin

Theses and Dissertations

The following study examines ways in which COVID-19 has disrupted the United States labor market. My findings present disproportionately negative effects of COVID-19 on employment, labor force participation, worker absence, and weekly working hours for the female population in my sample, as well as veterans, disabled persons, and racial minorities.