Digital Commons Network^™

Agrostring: Visibility And Provenance Through A Private Blockchain Platform For Agricultural Dispense Towards Consumers, Sukrutha L. T. Vangipuram, Saraju P. Mohanty, Elias Kougianos, Chittaranjan Ray

Department of Civil and Environmental Engineering: Faculty Publications

It is a known fact that large quantities of farm and meat products rot and are wasted if correct actions are not taken, which may lead to serious health issues if consumed. There is no proper system for tracking and communicating the status of the goods to their respective stakeholders in a secure way. Consumers have every right to know the quality of the products they consume. Using monitoring tools, such as the Internet of Agricultural Things (IoAT), and modern data protection techniques for storing and sharing, will help mitigate data integrity issues during the transmission of sensor records, increasing …

Antibody Prevalence And Risk Factors Associated With Rickettsia Spp. In A Pediatric Cohort: Sfgr Remains Underdiagnosed And Underreported In El Salvador, Kyndall C. Dye-Braumuller, Marvin Stanley Rodríguez Aquino, Kia Zellars, Hanna Waltz, Madeleine Meyer, Lídua Gual-Gonzalez, Stella C.W. Self, Mufaro Kanyangarara, Melissa Nolan Ph.D., Mph

Faculty Publications

Spotted fever group rickettsioses (SFGR) are caused by a group of tick-borne pathogens that are increasing in incidence globally. These diseases are typically underreported and undiagnosed in low- and middle-income countries, and thus, have been classified as neglected bacterial pathogens. Countries with high poverty, low human development index score, and limited health infrastructure—like El Salvador in Central America—lack necessary surveillance for SFGR and other tick-borne pathogens. This paucity of baseline SFGR infection prevalence leaves vulnerable populations at risk of misdiagnosis. Further, tick-borne disease burdens in El Salvador are severely limited. To lay the foundation for tick-borne disease epidemiology in El …

The Tumor Invasion Paradox In Cancer Stem Cell-Driven Solid Tumors, Alexandra Shyntar, Ashna Patel, Meghan Rhodes, Heiko Enderling, Thomas Hillen

Faculty, Staff and Student Publications

Cancer stem cells (CSCs) are key in understanding tumor growth and tumor progression. A counterintuitive effect of CSCs is the so-called tumor growth paradox: the effect where a tumor with a higher death rate may grow larger than a tumor with a lower death rate. Here we extend the modeling of the tumor growth paradox by including spatial structure and considering cancer invasion. Using agent-based modeling and a corresponding partial differential equation model, we demonstrate and prove mathematically a tumor invasion paradox: a larger cell death rate can lead to a faster invasion speed. We test this result on a …

Maternal Obesity And Gut Microbiota Are Associated With Fetal Brain Development, Sanjay Basak, Ranjit Kumar Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy

Health & Biomedical Sciences Faculty Publications

Obesity in pregnancy induces metabolic syndrome, low-grade inflammation, altered endocrine factors, placental function, and the maternal gut microbiome. All these factors impact fetal growth and development, including brain development. The lipid metabolic transporters of the maternal-fetal-placental unit are dysregulated in obesity. Consequently, the transport of essential long-chain PUFAs for fetal brain development is disturbed. The mother's gut microbiota is vital in maintaining postnatal energy homeostasis and maternal-fetal immune competence. Obesity during pregnancy changes the gut microbiota, affecting fetal brain development. Obesity in pregnancy can induce placental and intrauterine inflammation and thus influence the neurodevelopmental outcomes of the offspring. Several epidemiological …

Montana Kaimin, October 27, 2022, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The Grizzly, October 27, 2022, Layla Halterman, Chase Portaro, Sean Mcginley, Marie Sykes, Isabel Wesman, Ryan Divergilis

Ursinus College Grizzly Newspaper, 1978 to Present

Our 2022 Homecoming King and Queen! • Historic Trees Become Nasal Nuisance • Halloween Cartoon • The Film Club Satisfies Student Interests • Halloween Word Search • Opinions: President Hannigan Made Me Cry (And Frankly, I Loved It) • Golf Teams' Fall Season Brings Hope for Spring • Jack Psenicska: Smashing Ursinus Football Records

Effect Of Hyperoxia On Cardiac Pathophysiology In Female Guinea Pig Hearts, Chayapatou Chayawatto

USF Tampa Graduate Theses and Dissertations

Hyperoxia is widely implemented in critical care and ICU patients. The administration of a high concentration of inspired oxygen to the lung can unknowingly cause hyperoxia and thereby damaging the lungs and heart due to oxidative stress. Technically, hyperoxia occurs when the patient receives PaO2 > 200 mmHg. Major research focused on hyperoxia-induced lung injury, but nothing is known on its effect on heart. Our lab is the pioneer in understanding the effect of hyperoxia on cardiovascular remodeling using mice model. Previous results show that mice under 72 hours of hyperoxia present severe cardiac pathophysiology. This research uses Guinea pigs, which …

October 27, 2022, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Transcriptional Profiles In Olfactory Pathway-Associated Brain Regions Of African Green Monkeys: Associations With Age And Alzheimer’S Disease Neuropathology, Jacob D Negrey, Dorothy L Dobbins, Timothy D Howard, Karin E Borgmann-Winter, C G Hahn, Sergey Kalinin, Douglas L Feinstein, Suzanne Craft, Carol A Shively, Thomas C Register

Department of Neuroscience Faculty Papers

Introduction: Olfactory impairment in older individuals is associated with an increased risk of Alzheimer's disease (AD). Characterization of age versus neuropathology-associated changes in the brain olfactory pathway may elucidate processes underlying early AD pathogenesis. Here, we report age versus AD neuropathology-associated differential transcription in four brain regions in the olfactory pathway of 10 female African green monkeys (vervet, Chlorocebus aethiops sabaeus), a well-described model of early AD-like neuropathology.

Methods: Transcriptional profiles were determined by microarray in the olfactory bulb (OB), piriform cortex (PC), temporal lobe white matter (WM), and inferior temporal cortex (ITC). Amyloid beta (Aβ) plaque load in …

Vista: October 27, 2022, University Of San Diego

USD Vista (1965-)

No abstract provided.

Kenyon Collegian - October 27, 2022

The Kenyon Collegian

No abstract provided.

A Mini Review Of Citrus Rootstocks And Their Role In High-Density Orchards, Faisal Hayat, Juan Li, Shahid Iqbal, Yang Peng, Leming Hong, Rashad Mukhtar Balal, Muhammad Nawaz Khan, Muhammad Azher Nawaz, Ummara Khan, Muhammad Asad Farhan, Caiqing Li, Wenpei Song, Panfeng Tu, Jiezhong Chen

Michigan Tech Publications, Part 1

Dwarfing is an important agricultural trait for intensive cultivation and effective orchard management in modern fruit orchards. Commercial citrus production relies on grafting with rootstocks that reduce tree vigor to control plant height. Citrus growers all over the world have been attracted to dwarfing trees because of their potential for higher planting density, increased productivity, easy harvest, pruning, and efficient spraying. Dwarfing rootstocks can be used to achieve high density. As a result, the use and development of dwarfing rootstocks are important. Breeding programs in several countries have led to the production of citrus dwarf rootstocks. For example, the dwarfing …

Discovery And Characterization Of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors And Preclinical Safety Assessment Of Ucb7362, Martin A Lowe, Daniel E Goldberg, Et Al.

2020-Current year OA Pubs

Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking transmission to mosquitoes, making it a potential multistage drug target. We report the optimization of an aspartyl protease binding scaffold and the discovery of potent, orally active PMX inhibitors with in vivo antimalarial efficacy. Incorporation of safety evaluation early in the characterization of PMX inhibitors precluded compounds with a long human half-life (

Ec Expression Of Activated K-Ras Leads To Capillary Deficiency Due To Excessive Lumen Formation, Reduced Pericyte Recruitment, And An Increased Susceptibility To Mmp-1-Dependent Vascular Regression, Zheying Sun

USF Tampa Graduate Theses and Dissertations

Activated k-Ras mutations play a role in a variety of pathological conditions, such as arteriovenous malformations (AVMs). To study the effect of activated k-Ras mutation on lumen formation, we engineered human ECs to simultaneously express the activated k-Ras (G12V) mutation and compared their ability to form lumens with control ECs. We demonstrated that ECs with k-RasV12 lead to marked stimulation of EC lumen formation due to dramatic increases in intracellular vacuole formation and fusion, signaling changes including accelerated Src kinase activation, and MT1-MMP-dependent lumen expansion, all of which drive the process of lumen formation. The markedly accentuated lumen formation is …

Interactions Between Juvenile Estuary-Dependent Fishes And Microalgal Dynamics, Ian C. Williams

USF Tampa Graduate Theses and Dissertations

The ontogenetic movement of juvenile estuary-dependent fishes upstream in estuarine settings is a phenomenon observed around the world. These movements usually coincide with a shift in diet from smaller prey, such as calanoid copepods, to larger prey, such as mysids. However, the mechanism that drives this pattern has yet to be conclusively described. Prior to the current study, zooplankton/hyperbenthos (“zooplankton”), primary production, and water quality data were collected from the Caloosahatchee River estuary in two concurrent and coordinated studies over a two-year period. One of the products of these sampling efforts was a classification of primary-producer types at the sediment-water …

Cluster Analysis Of Short Sensory Profile Data Reveals Sensory-Based Subgroups In Autism Spectrum Disorder, Ariel M Lyons-Warren, Michael F Wangler, Ying-Wooi Wan

Duncan NRI Faculty and Staff Publications

Autism spectrum disorder is a common, heterogeneous neurodevelopmental disorder lacking targeted treatments. Additional features include restricted, repetitive patterns of behaviors and differences in sensory processing. We hypothesized that detailed sensory features including modality specific hyper- and hypo-sensitivity could be used to identify clinically recognizable subgroups with unique underlying gene variants. Participants included 378 individuals with a clinical diagnosis of autism spectrum disorder who contributed Short Sensory Profile data assessing the frequency of sensory behaviors and whole genome sequencing results to the Autism Speaks’ MSSNG database. Sensory phenotypes in this cohort were not randomly distributed with 10 patterns describing 43% (162/378) …

Distinct Organization Of Two Cortico-Cortical Feedback Pathways, Shan Shen, Xiaolong Jiang, Federico Scala, Jiakun Fu, Paul Fahey, Dmitry Kobak, Zhenghuan Tan, Na Zhou, Jacob Reimer, Fabian Sinz, Andreas S Tolias

Duncan NRI Faculty and Staff Publications

Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase–followed by a prolonged decrease–in pyramidal …

Risk Factors And Treatment Strategy For Retinal Vascular Occlusive Diseases, Ryo Terao, Ryosuke Fujino, Tazbir Ahmed

2020-Current year OA Pubs

Retinal occlusive diseases are common diseases that can lead to visual impairment. Retinal artery occlusion and retinal vein occlusion are included in the clinical entity, but they have quite different pathophysiologies. Retinal artery occlusion is an emergent eye disorder. Retinal artery occlusion is mainly caused by thromboembolism, which frequently occurs in conjunction with life-threatening stroke and cardiovascular diseases. Therefore, prompt examinations and interventions for systemic vascular diseases are often necessary for these patients. Retinal vein occlusion is characterized by retinal hemorrhage and ischemia, which may impair visual function via several complications such as macular edema, macular ischemia, vitreous hemorrhage, and …

Genetic Addiction Risk And Psychological Profiling Analyses For "Preaddiction" Severity Index, Kenneth Blum, Mark S Gold, Et Al.

2020-Current year OA Pubs

Since 1990, when our laboratory published the association of the

Empirical Study On The Acceptance Of Mobility As A Service (Maas) Based On The Utaut2 Model, Masaki Toyama

Asia Marketing Journal

To achieve the widespread use of Mobility as a Service (MaaS), a novel transportation platform, it is important to increase consumers’ intention to use MaaS. Therefore, this study clarifies the determinants of consumers’ intention to use MaaS based on the UTAUT2 model. The research model is tested using structural equation modeling based on data from a web-based questionnaire survey of Japanese consumers. The results show that performance expectancy, social influence, hedonic motivation, and price value have significant effects on the intention to use MaaS. Moreover, the relationship between the intention to use MaaS and independent variables is moderated by old …

Books Of Note

Appalachia

No abstract provided.

Research

Appalachia

No abstract provided.

Accidents

Appalachia

No abstract provided.

The Stones Of Rome: A Walk Along Hadrian's Wall, Parkman Howe

Appalachia

No abstract provided.

Art For All! Nordic Art And Cultural Democracy, 1945–1959, Marta Edling

Artl@s Bulletin

The article will by emphasizing a transnational and geopolitical approach, investigate eight exhibitions of modern art from Denmark, Finland, Iceland, Norway and Sweden presented in Nordic cities 1946–1959. The text highlights the importance of this regional context and argues that the artworks can be seen as socially interconnected signs mediated through the communicative agency of the exhibitions. By focusing on subject matter and artwork titles presented, the article suggests that the exhibitions can be viewed as part of interacting artistic, civic, and political agendas aiming to democratize culture in the postwar Nordic welfare states.

Hay Feeding Strategies To Build Fertility In Grazing Systems, Nick Roy, Fred Thomas

Kentucky Grazing Conference

No abstract provided.

Charting The Beyond. On The Two “First” International Surrealist Exhibitions In Scandinavia, Andrea Kollnitz

Artl@s Bulletin

This article examines two exhibitions introducing international surrealism in the North: Paris 1932 in Stockholm 1932 and Kubisme = Surrealisme in Copenhagen in 1935. Focusing on contents, networks and agents, the analysis shows competitive negotiations of national and local identities in interaction with the promotion of surrealism as a universal international phenomenon. Using a decentralising approach, the article reflects on the role of Paris and other cities as stations as well as elucidates national, transnational and transcultural processes and interactions in the international dissemination of surrealism.

Right Sizing Your Cows For Profit, Les Anderson

Kentucky Grazing Conference

No abstract provided.

My Soil Is Alive! Introduction To Soil Life And Its Role In Profitable Grazing Systems, Ray Archuleta

Kentucky Grazing Conference

No abstract provided.

Two To Tango Is Not Enough: How To Build Ecosystems For Smart Service Innovation?, Jan-Philipp BüChler Prof. Dr.

Case Studies

Senior managers of two German mid-sized world market leaders in sensor electronics (ifm electronic) and mechanical engineering (GEA Group) discuss the opportunities and barriers of developing smart service innovations. The case study addresses different roles and patterns in ecosystems of multiple collaborating actors in different stages of development. The open-end discussion invites learners to evaluate the opportunities from different perspectives based on industry-specific experiences.