Digital Commons Network^™

Slowly But Steadily, Animals Are Being Replaced In Safety Testing, Andrew N. Rowan

WellBeing News

Periodically, WellBeing News (WBN) carries a story on using animals to test the safety of chemicals (see May 2021 and December 2021). Advocacy campaigns to switch from animal tests to non-animal alternatives started over a hundred years ago. Public policy initiatives and technological advances leading to the implementation of alternatives began several decades ago. The WBN December 2021 story included an illustration of five selected countries showing animal use in laboratories increased rapidly from 1900 to the mid-1970s and then declined almost as rapidly to around 20-40% of peak laboratory animal use. It should be noted that the technical …

Rickettsia Parkeri Infection Modulates The Sialome And Ovariome Of The Gulf Coast Tick, Amblyomma Maculatum, Melina Garcia Guizzo, Khemraj Budachetri, Abdulsalam Adegoke, Jose M.C. Ribeiro, Shahid Karim

Faculty Publications

The Gulf Coast tick, Amblyomma maculatum, is a vector of several tick-borne pathogens, including Rickettsia parkeri. The ability of R. parkeri to persist within the tick population through transovarial and transstadial transmission, without apparently harming the ticks, contributes to the pathogen’s perpetuation in the tick population. Previous studies have shown that the R. parkeri load in A. maculatum is regulated by the tick tissues’ oxidant/antioxidant balance and the non-pathogenic tick microbiome. To obtain further insights into the interaction between tick and pathogen, we performed a bulk RNA-Seq for differential transcriptomic analysis of ovaries and salivary …

Sleep Disorders In Children With Prader Willi Syndrome: Current Perspectives., David G. Ingram Md, Jill M. Arganbright, Emily Paprocki, Kelsee Halpin

Manuscripts, Articles, Book Chapters and Other Papers

Children with Prader-Willi syndrome (PWS) face a multitude of potential health challenges including life-threatening obesity, endocrinopathies, behavioral and emotional dysregulation, developmental delays, and sleep disorders. In the current perspective piece, we provide a focused review of the condition's etiology and clinical findings, as well as a more in-depth discussion of sleep disorders frequently associated with PWS. In particular, we highlight and discuss difficult clinical scenarios frequently encountered by the pediatric sleep physician caring for this patient population, including diagnosis and treatment of complex sleep-related breathing disorders, considerations for sleep apnea surgery, the interplay between growth hormone and sleep apnea, diagnostic …

Marian Library Christmas Exhibit Shares Story Of Juggler, University Of Dayton

News Releases

A new, family-friendly Christmas exhibit at the University of Dayton shares the medieval story of a juggler whose humble performance as a gift to Virgin Mary brought her statue to life.

Revitalizing The Russian Of A Heritage Speaker, Aaron Jordan

Theses and Dissertations

This study presents a linguistic profile of a heritage speaker of Russian and recounts the efforts to revitalize his Russian after he had nearly stopped speaking it. The study was conducted over the course of almost two years, starting when the subject was twelve years old and ending when he was fourteen. Although this study found that the subject displayed many of the linguistic features typical of heritage speakers, the subject's Russian had suffered less attrition than is common for heritage speakers of Russian in the United States. This study presents its linguistic findings under the rubrics of phonology, morphosyntax, …

The Montclarion, November 10, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Microbiome Diversity And Metabolic Capacity Determines The Trophic Ecology Of The Holobiont In Caribbean Sponges, Michael P. Lesser, M. Sabrina Pankey, Marc Slattery, Keir J. Macartney, Deborah J. Gochfeld

School of Earth, Environmental, & Marine Sciences Faculty Publications

Sponges are increasingly recognized as an ecologically important taxon on coral reefs, representing significant biomass and biodiversity where sponges have replaced scleractinian corals. Most sponge species can be divided into two symbiotic states based on symbiont community structure and abundance (i.e., the microbiome), and are characterized as high microbial abundance (HMA) or low microbial abundance (LMA) sponges. Across the Caribbean, sponge species of the HMA or LMA symbiotic states differ in metabolic capacity, as well as their trophic ecology. A metagenetic analysis of symbiont 16 S rRNA and metagenomes showed that HMA sponge microbiomes are more functionally diverse than LMA …

Treatment Of Severe Swallowing Dysfunction In Systemic Sclerosis With Ivig: Role Of Antimuscarinic Antibodies, Fabian A Mendoza, Anthony J. Dimarino, Sidney Cohen, Christopher Adkins, Shady Abdelbaki, Satish Rattan, Christopher Cao, Susie Denuna-Rivera, Sergio A. Jimenez

Division of Gastroenterology and Hepatology Faculty Papers

Oropharyngeal and esophageal dysmotility can cause serious clinical complications such as aspiration pneumonia, cachexia, and sarcopenia, with a resulting increase in mortality and disability. The current standard of care for the treatment of SSc-associated swallowing dysfunction is mainly supportive, although severe cases are usually refractory to conventional management. Recent studies have shown that the abnormal production of functional autoantibodies such as anti-cholinergic muscarinic receptor III antibodies may participate in the pathogenesis of SSc-associated gastrointestinal dysmotility and may provide a novel target for therapeutic intervention. We describe two patients with severe and rapid onset of SSc-associated severe swallowing dysfunction and esophageal …

Effective Medical Waste Management For Sustainable Green Healthcare, Sang M. Lee, Donhee Lee

Department of Management: Faculty Publications

This study examines the importance of medical waste management activities for developing a sustainable green healthcare environment. This study applied a multiple methodological approach as follows. A thorough review of the literature was performed to delineate the factors that have been explored for reducing medical waste; hospital staff who handle medical waste were surveyed to obtain their opinions on these factors; the analytic hierarchy process (AHP) was applied to determine the priorities among the identified key factors; and experts’ opinions were consulted to assess the actual applicability of the results derived by the AHP. The study identified the following factors …

Montana Kaimin, November 10, 2022, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Editor’S Introduction, Michael D. Pante

Philippine Studies: Historical and Ethnographic Viewpoints

No abstract provided.

The Student Movement Volume 107 Issue 8: Cuffing Season, Co-Curriculars, And Ctc Telehealth: The Student Movement Highlights Important Issues On Campus, Lauren Kim, Nora Martin, Caryn Cruz, Ceiry Flores, Solana Campbell, Skyler Campbell, Neesa Richards, Nicholas C. Gunn, Gloria Oh, Andrew Francis, T Bruggemann, Alexander Navarro, Jonathon Woolford-Hunt, Scott Moncrieff, Joseph Keough, Brendan Syto, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

CTC Prevention Coordinator/Staff Counselor Interview: Nycole Goldberg, Interviewed by: Lauren Kim

Meet Ellie Dovich: Cast/Cardinal Lead Editor, Interviewed by: Nora Martin

Women in Stem: A Peek into Physics, Interviewed by: Caryn Cruz

ARTS & ENTERTAINMENT

Creatives on Campus: Art via Insta, Ceiry Flores

Currently..., Solana Campbell

Spotlight: The Parent Trap, Skyler Campbell

NEWS

AUSA Senate News Update, November 2022, Neesa Richards, AUSA Senate Public Relations Officer

Governor Whitmer Takes A Stop In Benton Harbor, Nicholas C. Gunn

Home Season Opener, Solana Campbell

Hopes and Plans Behind the Seminary Center of Community Change, Interviewed by: Gloria Oh

The Days Speak …

Targeting The Mdm2-P53 Pathway In Dedifferentiated Liposarcoma, Raymond S Traweek, Brandon M Cope, Christina L Roland, Emily Z Keung, Elise F Nassif, Derek J Erstad

Faculty, Staff and Student Publications

Dedifferentiated liposarcoma (DDLPS) is an aggressive adipogenic cancer with poor prognosis. DDLPS tumors are only modestly sensitive to chemotherapy and radiation, and there is a need for more effective therapies. Genetically, DDLPS is characterized by a low tumor mutational burden and frequent chromosomal structural abnormalities including amplification of the 12q13-15 chromosomal region and the MDM2 gene, which are defining features of DDLPS. The MDM2 protein is an E3 ubiquitin ligase that targets the tumor suppressor, p53, for proteasomal degradation. MDM2 amplification or overexpression in human malignancies is associated with cell-cycle progression and worse prognosis. The MDM2-p53 interaction has thus garnered …

Investigating The Rat Grimace Scale As A Potential Indicator Of Chronic Pain Following Forelimb Deafferentation, Nasreen Nemati

Electronic Theses and Dissertations Archive

Reorganization of the primary somatosensory cortex (S1) that follows deafferentation may play a role in phantom limb pain (PLP). An animal model of forelimb amputation and subsequent S1 reorganization, like the rat, could advance research in the underlying mechanisms of PLP. The rat grimace scale (RGS) is a method of behavioral analysis used to quantify the affective state. In this study, 8 amputee and 4 sham-operated rats were observed for a minimum of one week pre-surgery and up to 11 weeks post-surgery to score the facial behaviors using RGS. The change in overall average pre-surgery and post-surgery RGS score was …

Community Heritage: A Source Of Health/Medical Aspirational Capital For Black Males, Lafrance Clarke Jr.

USF Tampa Graduate Theses and Dissertations

There is a recognized need for more Black male healers who pursue careers in medical fields.Thus, the purpose of this study was twofold: to explore historical documents to tell the histories of men of African descent who practiced healing in Florida and, from those histories, create a virtual heritage tour to support teaching about leadership through African American history and narratives of healing. The research questions were: How does the heritage curriculum history about Black men healers of FL provide a historical counter-narrative about Black men and their leadership in connection to health/medicine?How do historical counter-narratives about Black men support …

The Effects Of Motivationally Enhanced Digital Game-Based Learning On Undergraduate Students’ Learning Motivation, Mathematics Achievement, And Learning Retention In College Algebra, Dennis Ward

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to design, develop, and test the effects of digital game-based learning on undergraduate students’ learning motivation, mathematics achievement, and learning retention in a college algebra course. Digital games utilize interactive digital media that offer rules-based challenges and react to the individual’s choices. Digital games have been used in preschool, K-12, higher education, and workplace environments in a wide range of subject areas, including language arts, secondary language acquisition, social studies, science, and math. Specifically, the effectiveness of digital game-based learning on students’ learning and motivation has been studied in college-level mathematics courses. However, previous …

Erk Inhibitor Ulixertinib Inhibits High-Risk Neuroblastoma Growth In Vitro And In Vivo, Yang Yu, Yanling Zhao, Jongmin Choi, Zhongcheng Shi, Linjie Guo, John Elizarraras, Andy Gu, Feng Cheng, Yanxin Pei, Dai Lu, Muller Fabbri, Saurabh Agarwal, Chunchao Zhang, Sung Yun Jung, Jennifer H Foster, Jianhua Yang

Faculty, Staff and Students Publications

Neuroblastoma (NB) is a pediatric tumor of the peripheral nervous system. Approximately 80% of relapsed NB show RAS-MAPK pathway mutations that activate ERK, resulting in the promotion of cell proliferation and drug resistance. Ulixertinib, a first-in-class ERK-specific inhibitor, has shown promising antitumor activity in phase 1 clinical trials for advanced solid tumors. Here, we show that ulixertinib significantly and dose-dependently inhibits cell proliferation and colony formation in different NB cell lines, including PDX cells. Transcriptomic analysis revealed that ulixertinib extensively inhibits different oncogenic and neuronal developmental pathways, including EGFR, VEGF, WNT, MAPK, NGF, and NTRK1. The proteomic analysis further revealed …

The Presidential Succession Act At 75 | The Twentieth Amendment, The Presidential Succession Act Of 1947, And Pre-Inaugural Problems, Brian C. Kalt

Fordham Law Review Online

These remarks were delivered as part of the program entitled The Presidential Succession Act at 75: Praise It or Bury It?, which was held on April 6, 2022, and hosted by the Fordham University School of Law. The Presidential Succession Act sets out the presidential line of succession and other procedures for situations in which the president and vice president have both died, resigned, been removed, or become unable to discharge the presidency’s powers and duties. The Act also addresses succession scenarios before Inauguration Day. In light of the statute’s seventy-fifth anniversary, this program explored relevant history and analyzed …

Spartan Daily, November 9, 2022, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2022

Volume 159, Issue 34

November 9, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

Educational Policies Committee, Minutes, November 3, 2022, Utah State University

Educational Policies Committee

• Approval of Minutes - October 6, 2022
• Subcommittee Reports
• Curriculum Subcommittee (Chad Simon)
• Academic Standards Subcommittee (Renee Galliher)
• General Education Subcommittee (Matt Sanders)
• Other Business
• Adjourn: 3:50 pm

Bison Influences On Composition And Diversity Of Riparian Plant Communities In Yellowstone National Park, J. Boone Kauffman, Dian Lyn Cummings, Cimarron Kauffman, Robert L. Beschta, Jeremy Brooks, Keeley Macneill, William J. Ripple

School of Natural Resources: Faculty Publications

Riparian zones are among the most biologically diverse ecosystems in the Intermountain West, USA, and provide valuable ecosystem services, including high rates of biotic productivity, nutrient processing, and carbon storage. Thus, their sustainability is a high priority for land managers. Large ungulates affect composition and structure of riparian/stream ecosystems through herbivory and physical effects, via trailing and trampling. Bison (Bison bison) in Yellowstone National Park (YNP) have been characterized as “ecosystem engineers” because of their demonstrated effects on phenology, aboveground productivity of grasses, and woody vegetation structure. Bison have greatly increased in numbers during the last two decades …

The College Voice, Vol. 57, No. 4 [November 9, 2022], Connecticut College

2022-2023

No abstract provided.

Inactivation Of Salmonella In Nonintact Beef During Low-Temperature Sous Vide Cooking, Heather B. Hunt, Samuel C. Watson, Byron D. Chaves, Gary Sullivan

Department of Animal Science: Faculty Publications

Sous vide cooking is a method of food preparation in which food is vacuum sealed and cooked in a water bath that is set to a precise temperature and circulated by a sous vide device. Due to ease of use and affordability, this cooking method has grown increasingly popular in food service kitchens and domestic settings. However, low‐temperature, long holding time sous vide cooking recommendations from manufacturers and chefs in popular press raise food safety concerns – specifically those for the preparation of nonintact beef products. The objective of this experiment was to address these concerns by validating a 5 …

Oregon State Rank Assessment For Columbia Torrent Salamander (Rhyacotriton Kezeri), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Columbia torrent salamander (Rhyacotriton kezeri) using NatureServe methodology, 2022.

Low-Pressure Plasma Surface Treatment Of Polycarbonate And Polyacrylic Plates With Different Plasmas And Their Characterization, Suleyman Gorkem Gizer

USF Tampa Graduate Theses and Dissertations

In this thesis, polycarbonate (PC) and acrylic (PMMA) surfaces were treated with carbon tetrafluoride (CF4), oxygen (O2), and air plasmas with a low-pressure plasma method in order to change their surface properties such as surface free energy and wettability. Moreover, different pattern sized, line, triangular and square shaped surface patterns were used to determine the shape and size-dependent changes. The characteristics of untreated and plasma treated surfaces were examined via contact angle (CA) measurements with distilled (DI) water, against plasma treatment number. Moreover, surface free energy (SFE) calculations of the PC and PMMA surfaces were carried out from sessile drop …

Farmer Adoption Of Advanced Technology In Agribusiness, Justin W. Belcher

USF Tampa Graduate Theses and Dissertations

Normally, family-owned farms are slow to adopt advanced technologies though these technologies can provide several benefits to the farm and have the potential to increase farm production volumes to help meet future population growth. The goal of this study was to document the factors that influence the adoption decision of advanced technologies by family-owned farms and what strategies can be used to motivate adoption. Case study research was conducted to gather data in a more structured way from family-owned farms typically excluded from past research for the purpose of comparing similarities across similar and dissimilar farms. For generalizing similarities, a …

The Innovative Patient-Centered Case Study Model: Cbv Protocol For Autologous Hematopoietic Stem Cell Transplant, Jean Coffey, Lisa Wesinger, Carissa Morton, Judi Gentes, Jennifer Holl, Ashley Prokopik, Sara Cooke, John M. Jr. Hill, Elizabeth B. Mcgrath, Thomas Lawrence Long

General Submissions: Presentations (Oral and Poster)

The purpose of this study was to explore the lived experience of individuals undergoing bone marrow transplant and to explore the lived experience of caregivers of patients undergoing bone marrow transplant.

Females Exhibit Higher Glua2 Levels And Outperform Males In Active Place Avoidance Despite Increased Amyloid Plaques In Tgf344‑Alzheimer’S Rats, Osama Chaudry, Kelechi Ndukwe, Maria Figuiredo-Perira, Peter A. Serrano, Patricia Rockwell

Publications and Research

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that is most prevalent in females. While estrogen provides neuroprotection in females, sex mediated differences in the development of AD pathology are not fully elucidated. Therefore, comparing events between sexes in early-stage AD pathology may reveal more effective therapeutic targets of intervention. To address sex differences, we analyzed early-stage 9-month male and female TgF344-AD (Tg-AD) rats, an AD model carrying the APPswe and Presenilin 1 (PS1ΔE9) mutations that develops progressive age-dependent AD pathology similar to humans. Tg-AD females significantly outperformed Tg-AD males in the active place avoidance (aPAT) test that assesses hippocampal-dependent …

Innovative Feedstocks For Optimal Mass Production Of The Edible Long-Horned Grasshopper, Ruspolia Differens, Kababu Margaret, Mweresa K. Collins, Sevgan Subramanian, James P. Egonyu, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Nyamu Faith, Sunday Ekesi, Chrysantus M. Tanga

All Peer-Reviewed Publications

The edible long-horned grasshopper Ruspolia differens Serville (Orthoptera:Tettigoniidae) is a highly nutritious food source consumed in over 20 African countries. Its occurrence is highly seasonal, and wild harvesting is carried out using locally designed and inefficient light traps, thus limiting sustainable utilization as an important food source. To ensure year-round production and availability of R. differens, we evaluated the effects of low-cost and affordable diets based on agricultural by-products on their growth performance, survival, fecundity, and longevity. A total of four diets with varying ratios of agricultural by-products were evaluated: Diet 1 [33.3% maize bran (MB) + 33.3% wheat bran …