Digital Commons Network^™

Landscape Genetics Of The Camas Pocket Gopher (Thomomys Bulbivorus), An Endemic Mammal Of Oregon’S Willamette Valley, Luke E. Painter, Matthew J. Weldy, Rachel S. Crowhurst, Leslie N. Carraway, Clinton W. Epps

Western North American Naturalist

Animal species living in small populations with small ranges may be particularly vulnerable to habitat loss and fragmentation. We investigated genetic population structure of the camas pocket gopher (Thomomys bulbivorus), a species endemic to the Willamette Valley, Oregon, an area strongly affected by human development. Pocket gophers collected across much of the range of the species were analyzed for genetic structure, diversity, and influences of landscape on gene flow using microsatellite markers identified in closely related gopher species. We used k-means clustering to group individuals into genetically similar clusters based on their locations along principal component axes, and …

Neural Implementation Of Computational Mechanisms Underlying The Continuous Trade-Off Between Cooperation And Competition, Andrea Pisauro, E. F. Fouragnan, D. H. Arabadzhiyska, M. A.J. Apps, M. G. Philiastides

School of Psychology

Social interactions evolve continuously. Sometimes we cooperate, sometimes we compete, while at other times we strategically position ourselves somewhere in between to account for the ever-changing social contexts around us. Research on social interactions often focuses on a binary dichotomy between competition and cooperation, ignoring people’s evolving shifts along a continuum. Here, we develop an economic game – the Space Dilemma – where two players change their degree of cooperativeness over time in cooperative and competitive contexts. Using computational modelling we show how social contexts bias choices and characterise how inferences about others’ intentions modulate cooperativeness. Consistent with the modelling …

G-Dam: A Distributed Data Storage With Blockchain Framework For Management Of Groundwater Quality Data, Sukrutha L. T. Vangipuram, Saraju P. Mohanty, Elias Kougianos, Chittaranjan Ray

Department of Civil and Environmental Engineering: Faculty Publications

Groundwater overuse in different domains will eventually lead to global freshwater scarcity. To meet the anticipated demands, many governments worldwide are employing innovative and traditional techniques for forecasting groundwater availability by conducting research and studies. One challenging step for this type of study is collecting groundwater data from different sites and securely sending it to the nearby edges without exposure to hacking and data tampering. In the current paper, we send raw data formats from the Internet of Things to the Distributed Data Storage (DDS) and Blockchain (BC) edges. We use a distributed and decentralized architecture to store the statistics, …

Oregon State Rank Assessment For Umatilla Megomphix (Megomphix Lutarius), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Umatilla megomphix (Megomphix lutarius) using NatureServe methodology, 2022.

Pancreatic Tumor Microenvironmental Acidosis And Hypoxia Transform Gold Nanorods Into Cell-Penetrant Particles For Potent Radiosensitization, Pradipta Ranjan Rauta, Yuri Mackeyev, Keith Sanders, Joseph B K Kim, Valeria V Gonzalez, Yasmin Zahra, Muhammad A Shohayeb, Belal Abousaida, Geraldine V Vijay, Okan Tezcan, Paul Derry, Anton V Liopo, Eugene R Zubarev, Rickey Carter, Pankaj Singh, Sunil Krishnan

Faculty, Staff and Student Publications

Coating nanoparticles with stealth epilayers increases circulation time by evading opsonization, macrophage phagocytosis, and reticuloendothelial sequestration. However, this also reduces internalization by cancer cells upon reaching the tumor. We designed gold nanorods (GNRs) with an epilayer that retains stealth properties in circulation but transforms spontaneously in the acidotic tumor microenvironment to a cell-penetrating particle. We used a customized stoichiometric ratio of l-glutamic acid and l-lysine within an amphiphilic polymer of poly(l-glutamic acid-co-l-lysine), or P(Glu-co-Lys), to effect this transformation in acidotic environments. P(Glu-co-Lys)-GNRs were internalized by cancer cells to facilitate potent in vitro radiosensitization. When administered intravenously in mice, they accumulate …

Circulating Microrna Responses To Acute Whole-Body Vibration And Resistance Exercise In Postmenopausal Women, Samuel R. Buchanan, Ryan M. Miller, Michelle Nguyen, Christopher D. Black, J. Mikhail Kellawan, Michael G. Bemben, Debra A. Bemben

Health & Human Performance Faculty Publications

Evaluating alterations in circulating microRNA (c-miRNA) expression may provide deeper insight into the role of exercise in the attenuation of the negative effects of aging on musculoskeletal health. Currently, there are sparse data on c-miRNA responses to acute exercise in postmenopausal women. The purpose of this study was to characterize the effects of acute bouts of resistance exercise and whole-body vibration on expression of selected c-miRNAs in postmenopausal women aged 65-76 years (n=10). We also examined relationships between c-miRNAs and muscle strength and bone characteristics. This randomized crossover design study compared c-miRNA responses to a bout of resistance exercise (RE) …

Pancreatic Tumor Microenvironmental Acidosis And Hypoxia Transform Gold Nanorods Into Cell-Penetrant Particles For Potent Radiosensitization, Pradipta Ranjan Rauta, Yuri Mackeyev, Keith Sanders, Joseph B K Kim, Valeria V Gonzalez, Yasmin Zahra, Muhammad A Shohayeb, Belal Abousaida, Geraldine V Vijay, Okan Tezcan, Paul Derry, Anton V Liopo, Eugene R Zubarev, Rickey Carter, Pankaj Singh, Sunil Krishnan

Faculty, Staff and Student Publications

Coating nanoparticles with stealth epilayers increases circulation time by evading opsonization, macrophage phagocytosis, and reticuloendothelial sequestration. However, this also reduces internalization by cancer cells upon reaching the tumor. We designed gold nanorods (GNRs) with an epilayer that retains stealth properties in circulation but transforms spontaneously in the acidotic tumor microenvironment to a cell-penetrating particle. We used a customized stoichiometric ratio of l-glutamic acid and l-lysine within an amphiphilic polymer of poly(l-glutamic acid-co-l-lysine), or P(Glu-co-Lys), to effect this transformation in acidotic environments. P(Glu-co-Lys)-GNRs were internalized by cancer cells to facilitate potent in vitro radiosensitization. When administered intravenously in mice, they accumulate …

Development And Use Of A Survey Tool To Prioritize And Catalyze Change Surrounding Faculty Wellness In A Department Of Pediatrics, Sarah Rhoads, Alison Riese, Mohammed Faizan, Lloyd Feit, Shuba Kamath, Albert Ross, Katherine Mason

Journal of Wellness

Introduction: Physician wellness is an important factor in the delivery of safe, effective and humanistic patient care. There is compelling data describing the widespread prevalence of physician burnout and its subsequent adverse impact on patient care, healthcare costs, and relationships. Initiatives to improve wellness are necessary to maintain the healthcare work force as well as to ensure high-quality care. This project investigated faculty physicians’ attitudes and priorities regarding physician wellness within the department of Pediatrics at a single-center academic institution.

Methods: A survey was created and distributed via e-mail to all faculty physicians employed within the Department of Pediatrics in …

Imprinted Antibody Responses Against Sars-Cov-2 Omicron Sublineages, Young-Jun Park, Zhuoming Liu, Javier Janer, Sean P J Whelan, Herbert W Virgin, Et Al.

2020-Current year OA Pubs

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages carry distinct spike mutations resulting in escape from antibodies induced by previous infection or vaccination. We show that hybrid immunity or vaccine boosters elicit plasma-neutralizing antibodies against Omicron BA.1, BA.2, BA.2.12.1, and BA.4/5, and that breakthrough infections, but not vaccination alone, induce neutralizing antibodies in the nasal mucosa. Consistent with immunological imprinting, most antibodies derived from memory B cells or plasma cells of Omicron breakthrough cases cross-react with the Wuhan-Hu-1, BA.1, BA.2, and BA.4/5 receptor-binding domains, whereas Omicron primary infections elicit B cells of narrow specificity up to 6 months after …

2022-11-11 Institutional Animal Care And Use Committee Meeting Minutes, Morehead State University. Faculty Senate., Institutional Animal Care And Use Committee.

Faculty Senate Records

Institutional Animal Care and Use Committee meeting minutes for November 11, 2022.

Sex Differences In Brain Tumor Glutamine Metabolism Reveal Sex-Specific Vulnerabilities To Treatment, Jasmin Sponagel, Jill K Jones, Cheryl Frankfater, Shanshan Zhang, Olivia Tung, Kevin Cho, Kelsey L Tinkum, Hannah Gass, Elena Nunez, Gary J Patti, Jingqin Luo, Joshua B Rubin, Joseph E Ippolito, Et Al.

2020-Current year OA Pubs

BACKGROUND: Brain cancer incidence and mortality rates are greater in males. Understanding the molecular mechanisms that underlie those sex differences could improve treatment strategies. Although sex differences in normal metabolism are well described, it is currently unknown whether they persist in cancerous tissue.

METHODS: Using positron emission tomography (PET) imaging and mass spectrometry, we assessed sex differences in glioma metabolism in samples from affected individuals. We assessed the role of glutamine metabolism in male and female murine transformed astrocytes using isotope labeling, metabolic rescue experiments, and pharmacological and genetic perturbations to modulate pathway activity.

FINDINGS: We found that male glioblastoma …

Repeated Out-Of-Africa Expansions Of Helicobacter Pylori Driven By Replacement Of Deleterious Mutations, Harry A Thorpe, Elise Tourrette, Koji Yahara, Filipa F Vale, Siqi Liu, Mónica Oleastro, Teresa Alarcon, Tsachi-Tsadok Perets, Saeid Latifi-Navid, Yoshio Yamaoka, Beatriz Martinez-Gonzalez, Ioannis Karayiannis, Timokratis Karamitros, Dionyssios N Sgouras, Wael Elamin, Ben Pascoe, Samuel K Sheppard, Jukka Ronkainen, Pertti Aro, Lars Engstrand, Lars Agreus, Sebastian Suerbaum, Kaisa Thorell, Daniel Falush

Faculty, Staff and Students Publications

Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori from East Asia, which have undergone little admixture, have accumulated many more non-synonymous mutations than African strains. European and Middle Eastern bacteria have elevated African ancestry at the sites of these mutations, implying …

Theme - Fungi Stakes A Claim In The Luxury Market

SIGNED: The Magazine of The Hong Kong Design Institute

When your company's first "alternative leather" product is released in partnership with iconic leatherware brand Hermès, it is an indication that fungi has serious credentials in the luxury fashion industry. Success has been decades in the making, but the people at MycoWorks are convinced they have developed a technology that will push the envelope of sustainable fashion.

Issue Twenty Seven Full Text

SIGNED: The Magazine of The Hong Kong Design Institute

No abstract provided.

The Interplay Between Acute Stress And Antimicrobial Peptide Modulation In The Fish Skin, Yago Santos

Shared Knowledge Conference

The fish skin is a crucial first line of defense against different external threats. Among these dangers, several sources of stress, such as overcrowding and transportation, are often associated to intensive aquaculture. Thus, fish requires efficient mechanisms to sense and respond to those danger signals. In fish, the skin produces a large amount of mucus, that covers and protects the whole body. Within the mucus layer, several molecules can directly interact and kill pathogens, one of them are beta-defensins. Beta-defensins are antimicrobial peptides present in almost all animals, including fish. As in humans, beta-defensins are highly expressed in the fish …

Chanting The Medicine Buddha Sutra: A Musical Transcription And English Translation Of The Medicine Buddha Service Of The Liberation Rite Of Water And Land At Fo Guang Shan Monastery, Jeffrey W. Cupchik

Yale Journal of Music & Religion

A book review is presented for Reed Criddle, ed., Chanting the Medicine Buddha Sutra: A Musical Transcription and English Translation of the Medicine Buddha Service of the Liberation Rite of Water and Land at Fo Guang Shan Monastery. Recent Researches in the Oral Traditions of Music 13. Philip V. Bohlman, general editor. Middleton, WI: A-R Editions, 2020. 77 pages.

Shifting Paradigms, Pandemic Realities: The Reception Of Ishay Ribo’S Music In The American Hasidic Community, Tzipora Weinberg, Gordon Dale

Yale Journal of Music & Religion

The COVID-19 pandemic has irrevocably changed the landscape of social, communal, and religious life. Within the Jewish community, reactions to the virus have taken many forms. One of the most visible and criticized populations, the Hasidic community of Brooklyn, has been the focus of attention from the media and press, and has responded in unprecedented ways, both in political and social arenas. Our close study of the evolution of a particular instance of atypical musical permissiveness in the period preceding COVID-19, and its subsequent development during the pandemic period itself, follows this metamorphosis, limning the shift in communal norms as …

From The Islands To The Motherland: Motivic Traveling In Contemporary Gospel Music, Lauren Eldridge Stewart

Yale Journal of Music & Religion

Contemporary gospel musicians frequently use ad libs that describe diasporic desires, imagined identities, and the music itself. “To the islands” and “to the motherland” are directives that call audiences to join musicians in a motivic journey that spans the Black Atlantic, and flows between North America, the Caribbean, and Africa. Though deployed throughout the genre’s history, I focus here on the motivic traveling featured in gospel music released within the past two decades. I posit that musicians engage in this symbolism for three possible reasons: to enliven gospel music, to appeal to increasingly diverse congregations both within the U.S. and …

Functional Anatomy Of The Thoracodorsal Ceiling And The Hepatic-Piston Pulmonary Apparatus In Alligator Mississippiensis, Andy Grand Pre, William Thielicke, Brandon P. Hedrick, Ruth Elsey

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.

Lymph From Alcohol-Fed Animals Alters Perilymphatic Adipose Tissue Immune Milieu, Kourtney D. Weaver, Patricia E. Molina, Flavia M. Souza-Smith

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.

Chronic Binge Alcohol-Mediated Decreased Skeletal Muscle Stem Cell Differentiation In Siv-Infected Female Macaques: Mechanisms Of Extracellular Microrna-206, Brianna Bourgeois, Peter Bergeaux, Patricia Molina, Liz Simon

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.

Novel Naphthalenyl Substituted Aminothiazoles Derived From Riluzole Prevent Acute Neural Excitotoxic Injury In A Rat Model Of Temporal Lobe Epilepsy, Thomas Kyllo, V. Singh, H. Shim, L. Singh

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.

Characterizing Frontal Cortex Function In A Mouse Model Using Touchscreen-Based Behavioral Tasks, Hernan Mejia Gomez, Faith Maxwell, Michael Salling

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.

Cholinergic Modulation Of Ca1 Place Cell Firing, Carol Upchurch, Crescent Combe, Sonia Gasparini, Carmen Canavier

Dr. Joseph M. Moerschbaecher, III Graduate Research Day

No abstract provided.

Examining The Use Of Naturally Occurring Free Radical Scavengers Against Uv Light Damage In Cancer Prevention, Tanner Justice

Honors Theses

A strong association has been found between mutated p53 tumor suppressor genes and cancers in humans. Cancers arise from a culmination of genetic and environmental factors, including exposure to ultraviolet (UV) light from the sun. Prolonged exposure to UV has proven negative effects on cell homeostasis. Much of the damage caused by UV light exposure is through generation of free radicals. Zeaxanthin and melatonin are known antioxidant/free radical scavengers which protect cells by neutralizing damage causing free radical molecules. This study was conducted to determine the effectiveness of zeaxanthin and melatonin in preventing the negative effects of UV light on …

Whistleblowing As An Anti-Corruption Strategy In Health And Pharmaceutical Organizations: A Scoping Review Protocol., Taryn Vian, Brianna Agnew Mph, Keith Mcinnes Jr

Nursing and Health Professions Faculty Research and Publications

Background

Whistleblowing can bring suspected wrongdoing to the attention of someone who is in the position to rectify the problem. Whistleblowing research can help improve effectiveness of anti-corruption efforts in the health sector.

Objective

The objective of this scoping review is to understand the extent and type of evidence on whistleblowing as an anti-corruption strategy in health and pharmaceutical organizations in low- and middle-income countries (LMICs).

Methods

This scoping review searched the PubMed, Scopus, and EMBASE databases from 2005 to 2020, limited to English language. We also searched websites of multilateral agencies or international non-governmental organizations for policy documents, guidance …

Resource Availability Affects Seasonal Trajectories Of Population-Level Learning, Matthew W. Austin, Aimee S. Dunlap

Educator Preparation & Leadership Faculty Works

Environmental effects on learning are well known, such as cognition that is mediated by nutritional consumption. Less known is how seasonally variable environments affect phenological trajectories of learning. Here, we test the hypothesis that nutritional availability affects seasonal trajectories of population-level learning in species with developmentally plastic cognition. We test this in bumble bees (Apidae: Bombus), a clade of eusocial insects that produce individuals at different time points across their reproductive season and exhibit organ developmental plasticity in response to nutritional consumption. To accomplish this, we develop a theoretical model that simulates learning development across a reproductive season for …

Law And The Moral Dynamics Of Collective Action, Aditi Bagchi

Seton Hall Law Review

No abstract provided.

The Case Against Summary Eviction Proceedings: Process As Racism And Oppression, Andrew Scherer

Seton Hall Law Review

No abstract provided.

The Nexus Between Animal Welfare, Environment, And Sustainable Development, Andrew N. Rowan

WellBeing News

The Nexus between Animal Welfare, the Environment, and Sustainable Development was the focus of a Resolution (sponsored by six African states and Pakistan) passed by consensus at the Fifth United Nations Environment Assembly (UNEA-5) in March of 2022. The Resolution requested the United Nations Environment Programme’s (UNEP) Executive Director produce a report on the Nexus between animal welfare, the environment, and sustainable development.