Digital Commons Network^™

Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer

All ETDs from UAB

Osteoarthritis (OA) is a debilitating, inflammatory, joint degeneration disorder, and is the most common form of arthritis. Individuals reaching end-stage OA often pursue elective total hip/knee arthroplasty (THA/TKA) to relieve pain and improve mobility and quality of life. However, approximately one third of THA/TKA patients suffer long-term mobility impairments following surgery, likely in part due to an inability to repair the damaged muscle surrounding the diseased joint. Mechanisms driving this impaired recovery remain poorly understood, therefore it is prudent to interrogate the molecular signatures in skeletal muscle at the time of surgery to provide candidate markers that may improve upon …

The Role Of Mitochondrial Genetic Background In Cellular Function, Response To Cell Stress And Disease Susceptability, Jamelle A. Brown

All ETDs from UAB

There is a differential susceptibility associated with several diseases including cardiovascular disease (CVD) and hypertension, with Blacks being more likely to develop these conditions. Blacks are also more likely to die from these diseases. To explain the genetic etiology underlying CVD pathogenesis, the primary focus has been on nuclear genetics-environmental interactions, whereas the contribution of mitochondrial genetics is less explored. Therefore, we sought to determine whether differences exist in cellular function and response to cell stress in healthy and diseased individuals with distinct mitochondrial genetic backgrounds. To determine this, we sought first to develop a technique to detect and quantify …

"The Cloak Of Social Feeling": Alfred Adler's Gemeinschaftsgefuhl In Practice And Memory, Esteban T. Arnold

All ETDs from UAB

This thesis provides a comprehensive overview of the evolution of Alfred Adler’s concept of Gemeinschaftsgefühl (community feeling), a simple yet potent idea that started in a Viennese café and expanded far beyond it. Ideas have lives beyond that of their authors, and this thesis argues that Alfred Adler’s idea of Gemeinschaftsgefühl was pressed into the service of various social and political agendas. Adler was privately a socialist, but he never wished to see Gemeinschaftsgefühl become a tool for this or any other movement. With an idealistic worldview, Adler sought to challenge and transform the pervading medical and psychotherapeutic conceptions of …

Gastroprotective Effect Of Phyllanthus Reticulatus Poir. Against Pylorus Ligation-, Ethanol-Induced, And Stress-Induced Ulcer Models In Wistar Rats, Saravanan Jayaram, G. Thamotharan, N. Senthilkumar

The Thai Journal of Pharmaceutical Sciences

Objective: The objective of the present study is to evaluate the antiulcer property of ethanolic extract of Phyllanthus reticulatus Poir. against pylorus ligation-, ethanol-induced, and stress-induced ulcer models in Wistar albino rats. Materials and Methods: Three models – pylorus ligation-induced ulcer, ethanol-induced ulcer, and swim stress-induced ulcer – were used to induce ulcer in Wistar rats. The animals were treated with 200 mg/kg and 400 mg/kg p. o of the ethanolic extract of P. reticulatus Poir, to estimate the gastroprotective potential. The effect of P. reticulatus Poir. on pH of the gastric juice, volume of acid secretion, total and free …

Phytochemical Screening And Potential Anticonvulsant Activity Of Aqueous Root Extract Of Decalepis Nervosa Wight & Arn., Kuntal Das, M. Saifulla Khan, A. Muthukumar, Sayani Bhattacharyya, M. Usha, S. Venkatesh, James Sounder

The Thai Journal of Pharmaceutical Sciences

The effect of phytochemicals in the aqueous root extracts of Decalepis nervosa Wight & Arn. (ARDN) (Family: Apocynaceae) was investigated on an anticonvulsant action in laboratory animals (mice). The DN roots were extracted using microwave extraction method with aqueous solvent using two parameters, such as temperature variation and extraction time. The phytochemical screening followed by thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC) studies was performed. The pentylenetetrazole and isoniazid models were used with two doses, 250 mg and 500 mg, for the anticonvulsant effects of the ARDN extract. The microwave extraction during 15 min at 60°C temperature revealed the …

Cell Type-Specific Diurnal Variation In Hippocampus Physiology, Lacy Kathryn Goode

All ETDs from UAB

Circadian rhythms are biological processes that cycle across 24 hours. Driven endogenously by widely expressed and highly conserved clock genes that compose the circadian molecular clock, circadian rhythms are exhibited in numerous facets of physiology across nearly every tissue throughout the body. Diurnal rhythms in cognition, long-term potentiation (LTP), and the expression of clock genes in hippocampus subfields support a role for circadian regulation of hippocampus physiology. However, little is known regarding the circadian molecular clock and diurnal rhythms in neurophysiology at the cellular level. Here, we characterized diurnal differences in spatial memory, LTP, excitability of and synaptic transmission onto …

Exploring The Influence Of Psychosocial Stress And Inflammatory Properties Of The Diet On Cardiometabolic Risk And Gut Microbiome Health Among Young Adult Women Of Birmingham, Alabama, Rachel Olivia Knight

All ETDs from UAB

Concerning trends for obesity, diabetes, heart attacks, and obesity-related cancers, or cardiometabolic disease (CMD), are developing within the emerging and young adult/adulthood (EYA) population. Evidence supports the concept that chronic stress leads to physiologic dysregulation, reduced mental health, chronic diseases, and reduced longevity; however, these are not inevitable outcomes, and resilience or vulnerability is determined by interacting environmental and biobehavioral factors. Although CMD manifests clinically in older adulthood, disease pathophysiology begins earlier, and thus, EYA is a critical time for observation and intervention. Growing evidence indicates inflammation is a major risk factor in CMD development and may be exacerbated by …

Intrinsically-Photosensitive Retinal Ganglion Cells And Their Functional Roles, Kevin Q. Chang

All ETDs from UAB

This project was conducted in Old World monkeys and focused on characterization of the intrinsically photosensitive retinal ganglion cells (ipRGCs) as they pertain to the pupillary light reflex, as well as on the neuroanatomical and electrophysiological characterization of the suprachiasmatic nucleus (SCN) of the hypothalamus as it pertains to circadian rhythms. A custom antibody was developed against the human melanopsin gene. We validated the antibody using western blot and immunohistochemistry. The functional role of ipRGCs in driving pupillary responses was investigated through immunotoxin-induced ablation in Rhesus macaques with the antibody conjugated to saporin. As hypothesized, the pupillary light reflex and …

Geographic Range Size As A Predictor Of Dispersal-Dependent Behavioral Traits In Two Clades Of A Terrestrial Salamander, Teah Evers

Masters Theses

Animal movement has the potential to affect diverse processes within ecology and evolution including range expansion, gene flow, adaptation, and speciation. Two aspects of animal personality that are germane to dispersal are exploratory and aggressive behavior. These behavioral categories may represent a trade-off such that energy invested in territorial defense leaves little energy for movement and dispersal. The Eastern Red-backed Salamander (Plethodon cinereus) is a wide ranging, dispersal limited, terrestrial salamander with well documented phylogeographic divisions. I examined dispersal-relevant behavioral traits within two clades of P. cinereus with disparate geographic ranges. The Northern Clade (NC) has a range extending from …

Early Elementary Students' Use Of Shape And Location Schemas When Embedding And Disembedding, Laura Bofferding, Lizhen Chen, Sezai Kocabas, Mahtob Aqazade

Faculty Publications – Mathematics

Elementary students’ early development of embedding and disembedding is complex and paves the way for later STEM learning. The purpose of this study was to clarify the factors that support students’ embedding (i.e., overlapping shapes to form a new shape) and disembedding (i.e., identifying discrete shapes within another shape) through the use of filled shapes as opposed to shape frames. We recruited 26 Grade 1 students (~6–7 years old) and 23 Grade 3 students (~8–9 years old), asked them to work on two layered puzzle designs from the Color Code puzzle game, and interviewed them about their thinking processes. The …

Imago Dei Interrupted : Christocentric Measures To Reintegrate American Women Into New Communities After Having Survived Commercial Sexual Exploitation, Timothy Peter Robbins

ATS Dissertations

No abstract provided.

“We Want Our Land Back”: Returning Land To First Peoples In The Land Return Era Using The Native Land Claims Commission To Reverse Centuries Of Land Dispossession., William Y. Chin

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract Forthcoming.

Blood Meal Analysis And Arbovirus Detection In A Sylvatic Aedes Chaussieri At Oloolua Forest, Kenya, Robinson Okoth Kisero Okiro

All Master’s Theses

Arboviral pathogens are a growing public health problem especially in Africa. Bridge vectors facilitate virus transmission to humans from forest or sylvatic environments although the species involved are not fully understood. In this study, we investigated the role of Aedes chaussieri in sylvatic arboviral transmission cycle. Archived samples collected from the Oloolua Forest in the outskirts of Nairobi, Kenya, were analyzed in pools for viruses by cell culture in Vero Cells followed by RT-PCR and sequencing. Blood-fed specimens were processed for host meal sources by PCR and sequencing of a portion of the mitochondrial 12S ribosomal RNA gene. Viral screening …

The Landscape Of Startup Corporate Governance In The Founder-Friendly Era, Jennifer S. Fan

Articles

In corporate governance scholarship, there is an important debate about the nature and roles of the members of the board of directors in venture capital-backed private companies. The impact of a newly emerged, founder-centric model has been underappreciated, while the role of the independent director as tiebreaker or swing vote is vastly overstated. The reality is that corporate governance in these companies is a norm-driven, consensus-building process that rarely spills out into open conflict.

This is the first empirical study of startup corporate governance post-Great Recession and during the pandemic. Using survey and interview methodologies, this Article makes four primary …

Terrified By Technology: How Systemic Bias Distorts U.S. Legal And Regulatory Responses To Emerging Technology, Steve Calandrillo, Nolan Kobuke Anderson

Articles

Americans are becoming increasingly aware of the systemic biases we possess and how those biases preclude us from collectively living out the true meaning of our national creed. But to fully understand systemic bias we must acknowledge that it is pervasive and extends beyond the contexts of race, privilege, and economic status. Understanding all forms of systemic bias helps us to better understand ourselves and our shortcomings. At first glance, a human bias against emerging technology caused by systemic risk misperception might seem uninteresting or unimportant. But this Article demonstrates how the presence of systemic bias anywhere, even in an …

Analysis Of Hematocrit Levels In Walleye Sander Vitreus From Similar Waterbodies, Alyssa Hauser

Journal of Earth and Life Science

Walleye Sander vitreus are a popular fish among anglers and hold a prominent place in Minnesotan’s identity as their state fish. Because of this, multiple management practices are used to ensure the continued health of their populations within Minnesota waters. In this study, the process of analyzing hematocrit levels was used to determine if the analysis of hematological parameters could be a useful tool in detecting differences in population health. To evaluate this, blood samples were acquired from age-0 and age-1 fish from two similar lakes and run through a hematocrit centrifuge to separate platelets from plasma to read the …

The Effects Of Diet On Yellow Perch Morphology Throughout Lake Bemidji, Quiana L. Radaich

Journal of Earth and Life Science

Morphology is very important as it looks at the arrangement of an organism’s parts to determine their functionality, development, and how they could have changed through evolution. It is also important for the identification of species as it can show how closely species are related. This study examines if the morphology of yellow perch changes throughout Lake Bemidji. Along with examining a subset of five stomachs for each group (A-F) of yellow perch collected to determine if diet was a driving force behind morphological changes. The data collected in this study suggested that morphology does change throughout Lake Bemidji and …

Brief Of Black Women Law Scholars As Amici Curiae In Support Of Respondents, Students For Fair Admissions, Inc. V. President And Fellows Of Harvard College And Univ. Of N.C., Suzette Malveaux

Scholarly Articles

Amici are Black women law scholars who, based on their professional and personal experiences, share a deeply rooted commitment to defending the legality of race-conscious admissions policies in educational institutions across the country. They submit this brief to present their unique and vital perspective on the history, constitutionality, and importance of race-conscious programs like those adopted by Harvard University and the University of North Carolina (“UNC”).

Model Definition For Genetic Evaluation Of Purebred And Crossbred Lambs Including Heterosis, Napoleón Vargas Jurado, David R. Notter, Joshua B. Taylor, Daniel J. Brown, Michelle R. Mousel, Ronald M. Lewis

Department of Animal Science: Faculty Publications

Crossbreeding is a common practice among commercial sheep producers to improve animal performance. However, genetic evaluation of U.S. sheep is performed within breed type (terminal sire, semi-prolific, and western range). While incorporating crossbred records may improve assessment of purebreds, it requires accounting for heterotic and breed effects in the evaluation. The objectives of this study were to: 1) describe the development of a paternal composite (PC) line, 2) determine the effect of direct and maternal heterosis on growth traits of crossbred lambs, 3) estimate (co)variance components for direct and maternal additive, and uncorrelated maternal environmental, effects, and 4) provide an …

Interaction Of Urea With Frequency And Amount Of Distillers Grains Supplementation For Growing Steers On A High Forage Diet, Haley F. Linder, Josh E. Sebade, Zac E. Carlson, Hannah C. Wilson, Tyler J. Spore, Mary E. Drewnoski, Jim C. Macdonald

Department of Animal Science: Faculty Publications

Two studies were conducted to determine interactions of urea inclusion to a dried distillers grains plus solubles (DDGS; 29.4% crude protein, 5.48% ether extract) supplement fed at two amounts and two frequencies to steers on a high forage diet. In Exp. 1, 120 (247 kg; SD = 20) steers were fed individually for 84 d. Steers received ad libitum grass hay (6.8% crude protein) and one of eight treatments. Treatment design was a 2 × 2 × 2 factorial. Supplement was fed daily or three times per week, amount of supplement fed was 6.36 kg dry matter (DM)/week [0.37% body …

Production Cow-Calf Responses From Perennial Forage-Based And Integrated Beef-Cropping Systems, Zac E. Carlson, Levi Mcphillips, Galen E. Erickson, Mary E. Drewnoski, Jim C. Macdonald

Department of Animal Science: Faculty Publications

An experiment was conducted to measure production responses of an alternative cow-calf production system integrated into a cropping system without access to perennial forage compared to a traditional cow-calf system utilizing perennial forage. Multiparous, cross-bred beef cows (n = 160; average age = 6.2 ± 2.8 yr) were utilized in a randomized complete block experimental design and unstructured treatment design. Upon initiation, cows were blocked by age and stratified by source, assigned randomly to one of two production systems, each with four replicates (n = 20 cows/replicate). Once allotted to their treatment groups, cows remained in their experimental units for …

Evaluation Of A Novel Computer Vision-Based Livestock Monitoring System To Identify And Track Specific Behaviors Of Individual Nursery Pigs Within A Group-Housed Environment, Ty B. Schmidt, Jessica M. Lancaster, Eric T. Psota, Benny E. Mote, Lindsey E. Hulbert, Aaron Holliday, Ruth Woiwode, Lance Perez

Department of Animal Science: Faculty Publications

Animal behavior is indicative of health status and changes in behavior can indicate health issues (i.e., illness, stress, or injury). Currently, human observation (HO) is the only method for detecting behavior changes that may indicate problems in group-housed pigs. While HO is effective, limitations exist. Limitations include HO being time consuming, HO obfuscates natural behaviors, and it is not possible to maintain continuous HO. To address these limitations, a computer vision platform (NUtrack) was developed to identify (ID) and continuously monitor specific behaviors of group-housed pigs on an individual basis. The objectives of this study were to evaluate the capabilities …

Assessing Population Structure And Genetic Diversity In Us Suffolk Sheep To Define A Framework For Genomic Selection, Carrie S. Wilson, Jessica L. Petersen, Harvey D. Blackburn, Ronald M. Lewis

Department of Animal Science: Faculty Publications

Long-term sustainability of breeds depends on having sufficient genetic diversity for adaptability to change, whether driven by climatic conditions or by priorities in breeding programs. Genetic diversity in Suffolk sheep in the United States was evaluated in four ways: 1) using genetic relationships from pedigree data [(n = 64 310 animals recorded in the US National Sheep Improvement Program (NSIP)]; 2) using molecular data (n = 304 Suffolk genotyped with the OvineHD BeadChip); 3) comparing Australian (n = 109) and Irish (n = 55) Suffolk sheep to those in the United States using molecular data; and 4) assessing genetic relationships …

Site Of Infusion Of A Commercially Available Direct-Fed Microbial On Performance And Digestibility In Lactating Holstein Cows, K. S. Thompson, A. G. Mckeith, C. R. Krehbiel

Department of Animal Science: Faculty Publications

Objective: The objective of this research was to evaluate site of infusion of a commercially available direct-fed microbial (DFM) containing 10⁹ cfu/g of Lactobacillus acidophilus and 10⁹ cfu/g Propionibacterium freudenreichii on DMI, rumen kinetics, ruminal VFA, digestibility, milk production, milk components, and blood metabolites in lactating dairy cows.

Materials and Methods: Four Holstein cows equipped with ruminal cannulas were used in a Latin square design experiment with 4 periods. Each 37-d period consisted of 14 d of no treatment to prevent crossover contamination, 14 d of adaptation to treatments, 8 d of sampling, and 1 d for …

The Natural Law Ethics Of Public Health Lockdowns, Eric C. Ip

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Communique, 2022, University Of Montana--Missoula. School Of Journalism

Communique, 1953-2020

An annual publication of the University of Montana’s School of Journalism. This is volume 66.

The Effect Of Anti-Aging Treatment On Expression Of Aging Markers In A Mouse Model Of Huntington Disease, Mary Isabelle E. Guerra

Honors Undergraduate Theses

Huntington disease (HD) is a fatal neurodegenerative disease caused by CAG tract expansion in the huntingtin (HTT) gene, which results in production of mutant huntingtin (mtHTT) protein. Although mtHTT is expressed throughout life, onset of HD symptoms typically begins in mid-life, around 35 to 50 years of age. Characteristic HD symptoms include motor, cognitive, and psychiatric abnormalities. The emergence of symptoms in adulthood suggests that aging may play a role in HD pathogenesis. Furthermore, markers of accelerated aging can be observed in HD patients, including telomere attrition, epigenetic alterations, and mitochondrial dysfunction. Our lab has previously observed that …

Characteristics Of Covid-19 Vaccine-Hesitant Ucf College Students And Potential Avenues For Increasing Vaccination Rates, Justin A. Barthel

Honors Undergraduate Theses

The COVID-19 pandemic has been an ongoing disaster that has devasted millions of lives. With the development of COVID-19 vaccines in late 2020, there was a potential for populations to gain artificial active immunity in order to prevent future outbreaks. However, despite successful clinical trials, millions of citizens have been hesitant to receive the COVID-19 vaccines (Khubchandani et al., 2021). Demographics of the most prominent US vaccine-hesitant populations consist of ethnic/racial minorities and Republicans groups (Khubchandani et al., 2021). Little information is known about COVID-19 vaccine hesitancy in colleges and universities. Colleges provide an elevated risk for infection through their …

Relationship Between Video Games And Recovery From Work: A Comparison Of Different Genres And Leisure Activities, Jessica A. Gass

Honors Undergraduate Theses

Work stress can have a negative impact for both individuals and organizations, warranting research on how to recover from it. This research analyzes how the relationship between video games and work recovery differs depending on the genre of the video game played. In addition, these relationships are compared against the relationships between the recovery experiences and other leisure activities. Participants were asked to provide information on how often they play video games and engage in other leisure activities. In addition, two different measures of the four components of work recovery (psychological detachment from work, relaxation, mastery experiences, and control) were …

A Systematic Review And Meta-Analysis Of The Relationship Between The Creb Protein's Neuroplastic Functions And The Implications In Neurodegenerative Diseases: A Possible Link Between Synaptic Plasticity And Neurodegenerative Diseases, Mani Sarmast

Honors Undergraduate Theses

In this two-part study, I investigated whether the cyclic-adenosine monophosphate response element-binding (CREB) protein has the potential to be clinically modulated as a therapeutic target for the treatment of neurodegenerative diseases. Part one consisted of a systematic review that was conducted on select articles gathered through a stepwise method to explore (1) the relationship between diseased, neurodegenerative brains and levels of active, phosphorylated CREB (pCREB), (2) increased activation of CREB as a treatment for neurodegenerative symptoms, and (3) a potential therapeutic drug for neurodegenerative diseases that can target CREB signaling. The results of the systematic review showed evidence that suggested …