Digital Commons Network^™

Left Atrial Thrombus In Rheumatic Mitral Stenosis: A Case Of Therapeutic International Normalized Ratio Failure, Muhammad Salman Sabri, Carly Weber, Yanis Belkadi, Donald C. Haas, Yasotha Rajeswaran

Division of Internal Medicine Faculty Papers & Presentations

BACKGROUND: Atrial fibrillation or flutter in rheumatic mitral stenosis (MS) increases left atrial appendage (LAA) thrombus risk despite therapeutic anticoagulation.

CASE SUMMARY: A 72-year-old woman on warfarin with moderate MS and atrial flutter presented with dyspnea. Transesophageal echocardiogram (TEE) showed a large LAA thrombus despite an international normalized ratio >2.5. Cardioversion was deferred, and the international normalized ratio target was raised to a range of 2.5 to 3.5.

TAKE-HOME MESSAGES: While cardioversion can be considered in patients with uninterrupted anticoagulation without TEE, those with rheumatic MS are at high risk of LAA and LA thrombus and should undergo TEE before …

Genome-Wide Association Study And Genomic Prediction Of Leaf Spot (Stemphylium Vesicarium) Resistance In Spinach Diversity Panel, Gehendra Bhattarai, Bo Liu, James Cor, Ainong Shi

Horticulture Faculty Publications and Presentations

Stemphylium leaf spot (SLP), caused by Stemphylium vesicarium, has emerged as an increasing threat to spinach production in the United States, with widespread outbreaks reported across major spinach-growing regions over the past two decades. The objectives of this study were to: (1) evaluate global USDA spinach germplasm collections and commercial cultivars for resistance to S. vesicarium; (2) perform genome-wide association studies (GWAS) to identify genomic regions associated with resistance; and (3) conduct genomic prediction (GP) to enhance selection accuracy. A total of 311 diverse spinach genotypes, including USDA germplasm accessions and commercial cultivars, were evaluated under greenhouse conditions at the …

Nebulization Of An Mrna-Encoded Monoclonal Antibody For Passive Immunization Of Foals Against Rhodococcus Equi, Rebecca M Legere, Jeannine A Ott, Cristina Poveda, Daryll Vanover, Karin E R Borba, Jae Yeon Joo, Cameron L Martin, Bibiana P Da Silveira, Jocelyne M Bray, Kerstin Landrock, Gus A Wright, J Chistensen Blazier, Andrew E Hillhouse, Ashley L Benham-Duret, Brandon Mistretta, Rafaela L Klein, Sarah M Thompson, Amelia R Woolums, Michael F Criscitiello, Luc R Berghman, Angela I Bordin, Philip J Santangelo, Jeroen Pollet, Noah D Cohen

Faculty, Staff and Students Publications

Inhalation of Rhodococcus equi causes severe pneumonia in humans and animals worldwide, most commonly affecting horse foals. The standard for preventing R. equi pneumonia in foals is transfusion of hyperimmune plasma, which is expensive and carries the risk of adverse effects. Our goal was to passively immunize foals against R. equi by nebulizing mRNA encoding an equine monoclonal antibody (mAb) against the virulence-associated protein A (VapA) directly into the lungs. VapA-specific memory B cells from an immunized horse were used to identify and select the sequence for an equine immunoglobulin (Ig)G1 mAb. In vitro-transcribed mRNA encoding this sequence expressed …

Persistent Na+ Current Couples Spreading Depolarization To Seizures In Scn8a Gain-Of-Function Mice, Isamu Aiba, Yao Ning, Jeffrey L Noebels

Faculty, Staff and Students Publications

Spreading depolarization (SD) is a slowly propagating wave of massive cellular depolarization that transiently impairs the function of affected brain regions. Although SD typically arises as an isolated hemispheric event, we previously reported that reducing M-type potassium current (IKM) by ablation of Kcnq2 in forebrain excitatory neurons results in tightly coupled spontaneous bilateral seizure–SD complexes in the awake mouse cortex.

Here we find that enhanced persistent Na+ current attributable to gain-of-function mutations in Scn8a (N1768D/+, hereafter D/+) produces a similar compound cortical excitability phenotype. Chronic direct-current (DC)-band EEG recording detected spontaneous bilateral seizure–SD complexes accompanied by seizures with …

The Sea Ice For Walrus Outlook—A Network For Weather And Sea-Ice Information Sharing In The Bering Strait, Alaska, Lisa Sheffield Guy

Benefits of Ocean Observing Catalog (BOOC)

The Sea Ice for Walrus Outlook (SIWO) is a collaborative information-sharing network that delivers weekly springtime updates on sea ice and weather conditions relevant to walrus habitat in the Bering Strait region of Alaska. Launched in 2010, SIWO shares Indigenous Knowledge from Alaska Native sea-ice experts alongside custom forecasts and imagery from the National Weather Service Alaska, the University of Alaska Fairbanks, and the Alaska Ocean Observing System. Weekly reports incorporate community-based observations, satellite imagery, 7-day forecasts, and animated current and ice movement models to inform subsistence hunters and support maritime safety. This hybrid approach facilitates real-time communication and mutual …

Use Of Eagala Model–Based Psychotherapy For Youth Psychological Disorders, Kimberley D. Ryan, Tammy L.B. Mckenzie

People and Animals: The International Journal of Research and Practice

Global youth psychological disorder prevalence has increased exponentially. Therefore, a drastic increase in mental health care utilization is expected. Since traditional approaches to the treatment of adult psychological disorders are ineffective with youth, alternative approaches to treatment of youth psychological disorders must be considered. One such approach is equine assisted psychotherapy (EAP), a person-centered, experiential approach using horses during the treatment of psychological disorders and the basis of the Equine Assisted Growth and Learning Association (Eagala) model–based programming. This article presents the quantitative research findings of a study investigating the effectiveness of the Eagala model–based EAP programming in the treatment …

Introducing Therapy Dog Programs Within Organizational Settings: A Scoping Review Of Implementation Processes And Practices, Laura Mundy, Carlie Driscoll, Janette Young

People and Animals: The International Journal of Research and Practice

Organizations are introducing therapy dog programs at a growing rate. Standards and guidelines for including therapy dogs in programs with people are also being developed and made available to those implementing such programs. How organizations are implementing programs, how they are aligning with available standards, and the presence of any barriers and facilitators to their implementation has been largely unexplored. Therefore, the aim of our review was to summarize the literature available on the implementation of therapy dog programs within organizational settings. Furthermore, we aimed to summarize available descriptions of program practices and their alignment with best practice guidelines, and …

Comparison Of Hepcidin-25 And Angiogenin (Rnase-5) Levels In Healthy Children And Children With Brucellosis, Ümmü Seleme Mumcu, Özge Metin Akcan, Mehmet Özdemir, Gökçe Kader Arslan, Mustafa Gençeli

Journal of Pediatric Infectious Diseases

Objective: The aim of this study is to determine whether there is a change in serum levels of the anti-microbial peptides Hepcidin-25 and angiogenin, in pediatric patients with Brucellosis compared to healthy controls. In addition, to evaluate their role in brucellosis and relationship with complications of brucellosis. Methods: In our study, children aged 3 to 18 years were included. There were 50 patients in the brucellosis group and 40 healthy children in the control group. Serum hepcidin-25 and angiogenin levels were studied, as well as complete blood count, alanine aminotransferase, aspartate aminotransferas, C-reactive protein, erythrocyte sedimentation rate. The relationship between …

Complete Issue - Volume 87, No. 1 And 2, Jere Nash, Jim Gulley, J. Janice Coleman, Terry Beckenbaugh, Megan Bodily, William S. Critchfield, Nathan Drake, Charles E. Jones, William Harrison Taylor, Emma L. Waldie

Journal of Mississippi History

No abstract provided.

Book Reviews, Terry Beckenbaugh, Megan Bodily, William S. Critchfield, Nathan Drake, Charles E. Jones, William Harrison Taylor, Emma L. Waldie

Journal of Mississippi History

No abstract provided.

Greenfield Farm: Faulkner, Mules, And Time, Jim Gulley

Journal of Mississippi History

No abstract provided.

Predation Of Aegaeobuthus Nigrocinctus (Ehrenberg, 1828) (Scorpiones: Buthidae) By A Middle East Black Tarantula, Chaetopelma Olivaceum (C. L. Koch, 1841) (Araneae: Theraphosidae) In Lebanon, Rami Khashab

Euscorpius

I report the first documented case of the buthid scorpion Aegaeobuthus nigrocinctus (Ehrenberg, 1828) serving as prey for the tarantula Chaetopelma olivaceum (C. L. Koch, 1841) in Lebanon. The observation was made during a nocturnal survey in the Mount Lebanon region. The case contributes to the limited records of tarantula predation on scorpions and underscores the role of prey-predator size asymmetry in facilitating high-risk predation among arachnids.

The Italian Colony Of São Paulo: Race, Class, And Cultural Capital In Brazil, Giulia Riccò

Race & Ethnic Studies

WINNER, 2024 ALDO AND JEANNE SCAGLIONE PUBLICATION AWARD FOR A MANUSCRIPT IN ITALIAN LITERARY STUDIES, MODERN LANGUAGES ASSOCIATION

Introduces a way to study migration that privileges literary analysis over and against sociological data and insists on the importance of culture in the production of political identities

This book argues that Italians first became racialized as white in São Paulo, Brazil, at the turn of the twentieth century. Whereas Italians in the United States struggled with xenophobia and were often not fully acknowledged as white, in São Paulo, due to a series of social, economic, and cultural fac­tors, Italians became closely …

Theology And Practice Of Christian Leadership, Osias Segura

Syllabi

No abstract provided.

Can Corporate Law Wake Up Disney After Biting The Enchanted Apple Of Wokeness: The Politicization Of Disney And Corporate Law’S Weak Response, Brian M. Mccall

The Business, Entrepreneurship & Tax Law Review

Corporations that are household names for American consumers have been in the news for alienating their customers and segments of the public by embroiling their companies in controversial political issues. Target, Anheuser-Busch, and Disney are three prominent examples of companies in the news for putting their foot on politically sensitive issues. As Ryan Newman has explained, the issues raised by these events demonstrate an extensive political activism by American corporations that not only spend billions of dollars on political causes unrelated to their business, but also take actions and political stances on matters wholly unrelated to their products or markets, …

Absence Of Glaucoma In Tg-Myocy437h Mice Of Diverse Genetic Backgrounds., Nicholas G Tolman, Marina Simón, Felicia A Juarez, Chi Zhang, Zhivka I Hristova, Tionna Ouellette, Michael A Sellarole, Wilhelmine N Devries, Christa Montgomery, Simon W M John

Faculty Research 2025

PURPOSE: Mutations in the myocilin (MYOC) gene cause elevated intraocular pressure and glaucoma. To better understand the factors influencing susceptibility to glaucoma, we studied the MYOC mutation (MYOCY437H).

METHODS: We characterized ocular phenotypes in Tg-MYOCY437H mice on nine different mouse strain backgrounds.

RESULTS: No glaucoma-related phenotypes were observed. We detected neither elevated intraocular pressure (daytime readings) nor optic nerve degeneration differences between wild type (WT) and Tg-MYOCY437H mice. This included an absence of Tg-MYOCY437H-induced phenotypes on a mixed B6SJL background that best reflected the original publications with this strain. We confirmed that this result was not due to an absence …

Seminar Two: Coaching In Complex Systems, Mark Dunwoody

Syllabi

No abstract provided.

C.S. Lewis And Christian Faith, Michael Peterson

Syllabi

No abstract provided.

Basic Christian Doctrine, Joel Chopp

Syllabi

No abstract provided.

Crow's Nest, September 2, 2025, Crow's Nest Staff

Crow's Nest

The September 2, 2025, issue of Crow's Nest.

Good Newsletter September 2, 2025, Seattle University School Of Law Dean

GOOD NEWSletter

No abstract provided.

Wine Unwelcome: The Constitutional Contours Of Wine Regulation, Alexander Fallone

Brooklyn Journal of Corporate, Financial & Commercial Law

Wine retail shops face a dizzying labyrinth of state laws that severely restrict their ability to ship wine to out-of-state consumers. While the dormant Commerce Clause would normally strike down laws that impose restrictions on interstate commerce, wine (and alcoholic beverages) must contend with Section Two of the Twenty-first Amendment, which gives the states control over the importation and distribution of wine intending to be consumed within their borders. Court of Appeals cases interpreting Supreme Court precedent on the tension between the dormant Commerce Clause and Section Two have practically stripped the dormant Commerce Clause of any power. This Note …

A Pilot Study On Tissue Deformation Using An Integrated Sensor–Actuator Blood Collection Setup In Aquaculture (Salmo Salar), Ishrak Siddiquee, Md Ebne Al Ashad, Ahmed Hasnain Jalal

Electrical and Computer Engineering Faculty Publications

This pilot study presents a sensor–actuator setup designed to evaluate tissue deformation in Atlantic Salmon (Salmo salar) during needle insertion. The system integrates three types of low-cost, commercially available force sensors to capture force profiles and identify biomechanical events associated with tissue layer transitions. Controlled insertions were performed on a deceased specimen, and the resulting force data were analyzed to quantify insertion dynamics and estimate tissue deformation. A simulation model based on the recorded force values was developed to calculate stress distribution and deformation, which ranged from 0.001 µm to 8.4 µm and from 0.3 N/m2 to 4.9 N/m2, respectively. …

Independent Study In Historical-Theological Studies - The Idea Of God In Vietnamese Cultural Context, Stephen Bailey

Syllabi

No abstract provided.

Theology And Practice Of Christian Leadership, Osias Segura

Syllabi

No abstract provided.

Cardiomyocyte Regeneration Therapy And Its Effect On Lvef And Scar Size- A Systematic Review And Meta-Analysis, Mahnoor Mahnoor, Syed Irtaza Hassan, Muhammad Bakhtiar, Salal Sharjeel, Roha Daneyal, Muhammad Ibrahim, Raheel Iftikhar

Kimmel Cancer Center Faculty Papers

BACKGROUND: Myocardial infarction (MI) results in loss of cardiomyocytes leading to heart failure. Despite advancements in pharmacotherapy and interventions such as revascularization, ischemic heart failure remains a challenge. Recent advancements in stem cell therapies, genetic engineering and bioengineering have shown to improve cardiac function and quality of life.

METHODOLOGY: Following PRISMA guidelines, randomized controlled trials clinical trials from last 12 years were systematically reviewed. All the patients included in these studies had ischemic heart failure and were subjected to different types of stem cell therapies. Protocol for this meta-analysis is registered on PROSPERO (Registration no: CRD42023399263). Data extraction and Quality …

The Malditas, The Filipinas, And The Azkals: A Socio-Onomastic Examination Of Nicknames Used For The Philippine Women’S And Men’S National Football Teams, Satwinder Rehal, Inez Z. Ponce De Leon

Department of Communication Faculty Publications

Nicknames in sports can serve a wide range of social and semantic functions. Assigning nicknames to athletes and teams can allow fans to identify with them. Such names can also become symbolic resources that fans and teams turn to when asserting their identity. Nicknames in sports come to convey varied meanings and interpretations understood within a set of contextual properties. This paper fills an empirical gap and investigates nicknames of national sports teams used in Southeast Asia. The investigative focus is on the nicknames of the Philippines men’s and women’s national football teams. Employing Leslie and Skipper’s socio-onomastic framework, this …

Basic Christian Doctrine, Joel Chopp

Syllabi

No abstract provided.

Chp1 Promotes Lipid Droplet Growth And Regulates The Localization Of Key Enzymes For Triacylglycerol Synthesis, Guang Yang, Ximing Du, Dougall Norris, Armella Zadoorian, Yuyuan Zheng, Mingming Gao, Andrew J Brown, Shane T Grey, Chun Zhou, Hongyuan Yang

Faculty, Staff and Student Publications

The glycerol-3-phosphate (G-3-P) pathway is central to the synthesis of triacylglycerols (TAGs) and glycerophospholipids, essential for membrane biogenesis and lipid storage. The first and rate-limiting step in this pathway is catalyzed by glycerol-3-phosphate acyltransferases (GPATs), with microsomal GPAT3 and GPAT4 being evolutionarily conserved and predominant in most tissues. While previous studies have implicated Calcineurin B homologous protein 1 (CHP1) as a cofactor for GPAT4, the broader role of CHP1 in regulating microsomal GPATs and TAG biosynthesis remains unclear. Here, we demonstrate that CHP1 is a critical regulator of both GPAT3 and GPAT4, essential for their stability, enzymatic activity, and lipid …

Targeting Aldh16a1 Mediated Thioredoxin Lysosomal Degradation To Enhance Ferroptosis Susceptibility In Smarca4-Deficient Nsclc, Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Shencheng Ren, Haochun Shi, Xiaolong Huang, Junkan Zhu, Qun Wang, Wei Jiang, Boyi Gan, Cheng Zhan

Faculty, Staff and Student Publications

Ferroptosis, an iron-dependent form of cell death, holds promise for cancer therapy. However, the intricate link between ferroptosis and oncogenic mutations remains unclear. Here we show that SMARCA4, a well-established tumour suppressor whose deficiency is associated with poor prognosis and resistance to treatments, sensitizes non-small cell lung cancer (NSCLC) cells to ferroptosis. Mechanistically, SMARCA4 promotes chromatin accessibility and expression of ALDH16A1. Surprisingly, ALDH16A1 lacks ALDH enzymatic activity, but binds to the anti-ferroptotic oxidoreductase thioredoxin (TXN), facilitating its translocation to the lysosome and subsequent degradation. Meanwhile, ALDH16A1 directly inhibits TXN's oxidoreductase function by occluding its active site. We also show that …