Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2021

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 6571 - 6600 of 33735

Full-Text Articles in Entire DC Network

Preparing Nursing Students To Respond To Disasters: Faculty Perspectives, Melissa Jayne Freshwater Sep 2021

Preparing Nursing Students To Respond To Disasters: Faculty Perspectives, Melissa Jayne Freshwater

Dissertations

This mixed methods study explored emergency preparedness and disaster response in the concept-based learning curriculum adopted by the Alabama Community College System (ACCS) in 2016. The concept-based curriculum employs active learning in lieu of the traditional lecture-style teaching methods.

This study addressed the problem that educators may be unfamiliar with this content and are unsure how to present this material to students. The purpose of this study was to gain insight on teaching methodologies, to better prepare nursing students on this content.

Kolb's 1984 Experiential Learning Theory was the framework that parallels closely with this curriculum. Kolb emphasizes four stages …


Microglia Polarize In Response To Transactive Response Dna-Binding Protein-43 (Tdp-43) And Display Partial Recovery After Removal Of The Stimulus, Alicen Wilcox Sep 2021

Microglia Polarize In Response To Transactive Response Dna-Binding Protein-43 (Tdp-43) And Display Partial Recovery After Removal Of The Stimulus, Alicen Wilcox

Honors Theses

The proper response to protein signals is necessary for a healthy central nervous system (CNS), and protein dysregulation is a feature of neurodegenerative diseases. Transactive response DNA-binding protein-43 (TDP-43) is an intranuclear protein, but mislocalization is associated with amyotrophic lateral sclerosis (ALS). TDP-43 is released into the extracellular space where it is sensed by microglia, the CNS-resident immune cells. Our data and the literature suggest that microglia respond to TDP-43 dysregulation by increasing CNS inflammation. The goal of this study was to determine the impact of TDP-43 on microglial function and the extent to which microglia recovery. To study the …


Bedside Counseling For Medical Inpatients Who Misuse Alcohol, Lise Anne Cooper Sep 2021

Bedside Counseling For Medical Inpatients Who Misuse Alcohol, Lise Anne Cooper

Dissertations

This dissertation addresses the process and results of a program implemented to motivate patients that are admitted to a medical center with diagnoses of alcohol misuse to seek addiction recovery. The primary research question is: How does bedside addiction counseling reduce the patient's number of readmissions and length of stay? This is a comparative, interventional mixed methods study. This study also examines the methods used to identify the inpatients at the medical center that are admitted with alcohol misuse, and how that identification process initiates treatment.


Measuring Knowledge And Behavior After An Educational Program On Air Pollution As A Health Risk Reduction Strategy, Mary Eileen Guerin Kloster Sep 2021

Measuring Knowledge And Behavior After An Educational Program On Air Pollution As A Health Risk Reduction Strategy, Mary Eileen Guerin Kloster

Dissertations

Potential exposure to indoor and outdoor air pollution must be considered as part of an overall health risk reduction strategy. Toxicants identified in outdoor air pollution, fine particulate matter (PM2.5), and photochemical ozone cause a systemic inflammatory response to the heart and lungs after exposure. Inside the home, health issues from exposure to carbon monoxide (CO), PM2.5, nitrogen dioxide (NO2), and volatile organic compounds (VOC) are intensified when the home is sealed with the windows and doors closed. This explanatory study sought to promote health by teaching participants about strategies to reduce risks related to indoor and outdoor effects of …


Trace Element (Fe, Co, Ni And Cu) Dynamics Across The Salinity Gradient In Arctic And Antarctic Glacier Fjords, Jana Krause, Mark J. Hopwood, Juan Höfer, Stephan Krisch, Eric P. Achterberg, Emilio Alarcón, Dustin Carroll, Humberto E. González, Thomas Juul-Pedersen, Te Liu, Pablo Lodeiro, Lorenz Meire, Minik T. Rosing Sep 2021

Trace Element (Fe, Co, Ni And Cu) Dynamics Across The Salinity Gradient In Arctic And Antarctic Glacier Fjords, Jana Krause, Mark J. Hopwood, Juan Höfer, Stephan Krisch, Eric P. Achterberg, Emilio Alarcón, Dustin Carroll, Humberto E. González, Thomas Juul-Pedersen, Te Liu, Pablo Lodeiro, Lorenz Meire, Minik T. Rosing

Faculty Research, Scholarly, and Creative Activity

Around the Greenlandic and Antarctic coastlines, sediment plumes associated with glaciers are significant sources of lithogenic material to the ocean. These plumes contain elevated concentrations of a range of trace metals, especially in particle bound phases, but it is not clear how these particles affect dissolved (<0.2 µm) metal distributions in the ocean. Here we show, using transects in 8 glacier fjords, trends in the distribution of dissolved iron, cobalt, nickel and copper (dFe, dCo, dNi, dCu). Following rapid dFe loss close to glacier outflows, dFe concentrations in particular showed strong similarities between different fjords. Similar dFe concentrations were also observed between seasons/years when Nuup Kangerlua (SW Greenland) was revisited in spring, mid- and late-summer. Dissolved Cu, dCo and dNi concentrations were more variable and showed different gradients with salinity depending on the fjord, season and year. The lack of consistent trends for dCu and dNi largely reflects less pronounced differences contrasting the concentration of inflowing shelf waters with fresher glacially-modified waters. Particles also made only small contributions to total dissolvable Cu (dCu constituted 83 ± 28% of total dissolvable Cu) and Ni (dNi constituted 86 ± 28% of total dissolvable Ni) within glacier plumes. For comparison, dFe was a lower fraction of total dissolvable Fe; 3.5 ± 4.8%. High concentrations of total dissolvable Fe in some inner-fjord environments, up to 77 µM in Ameralik (SW Greenland), may drive enhanced removal of scavenged type elements, such as Co. Further variability may have been driven by local bedrock mineralogy, which could explain high concentrations of dNi (25–29 nM) and dCo (6–7 nM) in one coastal region of west Greenland (Kangaatsiaq). Our results suggest that dissolved trace element distributions in glacier fjords are influenced by a range of factors including: freshwater concentrations, local geology, drawdown by scavenging and primary production, saline inflow, and sediment dynamics. Considering the lack of apparent seasonality in dFe concentrations, we suggest that fluxes of some trace elements may scale proportionately to fjord overturning rather than directly to freshwater discharge flux.


Evaluation Of “Feeding Intelligence” In Murrah Water Buffaloes Grazing Three Different Tropical Grasses, P. B. Alcântara Sep 2021

Evaluation Of “Feeding Intelligence” In Murrah Water Buffaloes Grazing Three Different Tropical Grasses, P. B. Alcântara

IGC Proceedings (1977-2023)

Acceptability and palatability are two terms of large utilization that help to understand animal selection for feed. “Feeding intelligence” is a new theory recently introduced to replace those terms mentioned before. According to most recent research works, the feeding intelligence is acquired and remains for a long period of time in the memory of some animals. The present experiment had the purpose of showing its occurence in water buffaloes aiming, at the same time, to better understand their feeding behaviour. Three tropical grasses were tested: Brachiaria brizantha cv Marandu, Panicum maximum cv Tanzania and Setaria sphacelata var. sericeae cv Kazungula. …


Foraging Strategies On Rangeland: Effects On Intake And Animal Performance, Peter O’Reagain Sep 2021

Foraging Strategies On Rangeland: Effects On Intake And Animal Performance, Peter O’Reagain

IGC Proceedings (1977-2023)

Rangelands exhibit extreme spatial and temporal variability in forage quality and availability. The animals that utilise these rangelands have consequently evolved a range of foraging strategies in an attempt to cope with this variability and maintain nutrient intake. In general, animals respond to and exploit spatial variability at all scales by selecting those items or units which optimise the intake of digestible nutrients and hence animal production. Animals similarly employ a variety of strategies to cope with temporal variability on rangelands. These strategies may include adjusting foraging behaviour and/or exploiting critical resources or resource areas to buffer temporal variability in …


On The Scale Dependence Of Foraging In Terrestrial Herbivores, John M. Fryxell, C. B. D. Fortin, J. Wilmshurst Sep 2021

On The Scale Dependence Of Foraging In Terrestrial Herbivores, John M. Fryxell, C. B. D. Fortin, J. Wilmshurst

IGC Proceedings (1977-2023)

Meaningful modeling of the spatial and trophic dynamics of terrestrial herbivores demands understanding of the constraints and fitness objectives that presumably underlie behavior. This is complex in terrestrial herbivores, because of scale-dependent constraints on nutrient or energy gain. Mechanistic processes of forage cropping, forage mastication, movements between feeding stations, and forage digestion each have unique constraints that apply on different time, size, and spatial scales. Moreover, competing activities are rarely taken into account. Experimental testing of foraging objectives is therefore clouded by uncertainty regarding which time scale is most relevant from the animal’s perspective, leading to confusion and misrepresentation in …


Influence Of Sward Height, Concentrate Supplementation And Season On Grazing Activity Of Beef Cows, O. J. Gekara, E. C. Prigge, W. B. Bryan, M. Schettini, E. L. Nestor Sep 2021

Influence Of Sward Height, Concentrate Supplementation And Season On Grazing Activity Of Beef Cows, O. J. Gekara, E. C. Prigge, W. B. Bryan, M. Schettini, E. L. Nestor

IGC Proceedings (1977-2023)

The influence of sward height, concentrate supplementation and season on daily pattern of forage consumption of lactating beef cows grazing cool season pastures was determined. Cows (n=24; BW=535±10.8 kg) were randomly assigned to eight plots maintained at sward heights (SH) of either 4-8 cm or 8-12 cm and fed three levels of concentrate supplement: none = 0 kg/day, low = 3.12 kg/day or high = 6.24 kg/day. Cows on lower SH had greater (P < .08) forage dry matter intake and spent an additional 1.2 hours/day (P < .01) grazing compared to the higher SH. Cows on lower SH consumed 7.7 kg/day of forage dry matter and grazed 9.4 hours/day whereas those on higher SH consumed 7.1 kg/day and grazed 8.2 hours/day. Cows on lower SH grazed 0.7 hours/day (P < .06) and 0.4 hours/day (P < .08) longer at 06:00-10:00 hour and 11:00-13:00 hour, respectively, compared to the higher SH. Grazing efficiency (kg of forage consumed/hour of grazing) decreased (P < .01) as season progressed. Season influenced duration of grazing activity (P < .01). Cows grazed 0.5 hours longer (P < .01) at 06:00-10:00 hour late in summer (August) compared to spring (May) and mid summer (June/July). Cows grazed 0.3 hours longer (P < .08) at 11:00-13:00 hour during spring compared to late summer.


Safflower (Carthamus Tintorius): A Promising Forage Crop For Semi-Arid Regions, Y. Leshem, I. Bruckental, S. Y. Landau, G. Ashbell, Z. Weinberg Sep 2021

Safflower (Carthamus Tintorius): A Promising Forage Crop For Semi-Arid Regions, Y. Leshem, I. Bruckental, S. Y. Landau, G. Ashbell, Z. Weinberg

IGC Proceedings (1977-2023)

The yield, quality, preservation and intake of safflower hay were determined in two successive years - 1998 and 1999. Field experiments carried out at the Bet Dagan experimental station on the coastal plain of Israel under rain-fed conditions. A spineless variety was tested under three sowing dates. Yield decreased and quality improved as the sowing date receded from November 12 to February 3. Respective yields, IVDMD and CP content were: 22 and 8 ton DM/ha, 48.9% and 65.5% , 10.0% and 14.6%. Safflower at 290, 410 and 770 g/kg DM was ensiled in 1.5-l anaerobic glass jars with or without …


Effects Of Different Levels Of Energy On Growth Of Grazing And Drylot Fed Holstein Heifers, L. P. Novaes, C. E. Polan Sep 2021

Effects Of Different Levels Of Energy On Growth Of Grazing And Drylot Fed Holstein Heifers, L. P. Novaes, C. E. Polan

IGC Proceedings (1977-2023)

Growth of Holstein heifers were studied to evaluate the combination of a drylot phase followed by feeding energy for pasture supplementation during the grazing season of 1988. Heifers grazed a grass-legume mixture in six paddocks of 1.5 ha each. After drylot, animals were equally allotted to pasture and none or 2.0 kg/d of corn were fed in addition to grazing in a changeover design with repeated measurements. Heifers were fed a high (HE) or low energy (LE) diets in confinement and daily gains were 1190 (HE) and 990 g/day (LE) which were different. On pasture, corn supplementation did not enhance …


Leaf Fragment Identification Of Subtropical Native Grass Species, C. H. E. C. Poli, J. M. Rosito, A. G. Schirmer, P. R. Boggiano, P. C. De F. Carvalho Sep 2021

Leaf Fragment Identification Of Subtropical Native Grass Species, C. H. E. C. Poli, J. M. Rosito, A. G. Schirmer, P. R. Boggiano, P. C. De F. Carvalho

IGC Proceedings (1977-2023)

The present study was carried out to characterise leaf fragments of important plant species of a subtropical native sward in the southernmost state of Brazil. Thirteen important grass species were collected from April to May 1999. Both sides of the leaves were observed using a stereomicroscope. In addition, two approaches were tested to provide a clearer characterisation of the leaves of each species: the leaves were either dried or frozen. The kind and number of veins, the kind and number of hair, and the arrangements and number of stomates on both sides of each leaf are the most useful characteristics …


Socio-Economic And Governance Conditions Corresponding To Change In Animal Agriculture: South Dakota Case Study, Jacqueline S. Welles, Noelle Cielito T. Soriano, Freda Elikem Dorbu, G M. Pereira, Laura M. Rubeck, Erica L. Timmermans, Benjamin Ndayambaje, Alison V. Deviney, John J. Classen, Jacek A. Koziel, Erin L. Cortus Sep 2021

Socio-Economic And Governance Conditions Corresponding To Change In Animal Agriculture: South Dakota Case Study, Jacqueline S. Welles, Noelle Cielito T. Soriano, Freda Elikem Dorbu, G M. Pereira, Laura M. Rubeck, Erica L. Timmermans, Benjamin Ndayambaje, Alison V. Deviney, John J. Classen, Jacek A. Koziel, Erin L. Cortus

School of Natural Resources: Faculty Publications

Understanding sustainable livestock production requires consideration of both qualitative and quantitative factors in a temporal and/or spatial frame. This study adapted Qualitative Comparative Analysis (QCA) to relate conditions of social, economic, and governance factors to changes in livestock inventory across several counties and over time. This paper presents an approach that (1) identified factors with the potential to relate to a change in livestock inventory and (2) analyzed commonalities within these factors related to changes spatially and temporally. This paper illustrates the approach and results when applied to five counties in eastern South Dakota. The specific response variables were periods …


Artemisinin Dna Base Interaction Studies In Presence Of Fe (Ii): Lc/Tof Ms Separation Of Reaction Products, Kogila Oke, Amos Mugweru Sep 2021

Artemisinin Dna Base Interaction Studies In Presence Of Fe (Ii): Lc/Tof Ms Separation Of Reaction Products, Kogila Oke, Amos Mugweru

College of Science & Mathematics Departmental Research

Artemisinin (ART) is a sesquiterpene lactone and a popular malaria drug with potential anticancer properties. In this work, LC/TOF/MS, was used to investigate the reaction of ART with DNA bases. ART-deoxyadenosine and ART-deoxycytidine interactions, were studied in the presence of iron II ions. ART-deoxyadenosine and ART-deoxycytidine reaction mixtures gave chromatographic signatures that remained fairly unchanged at room temperature but grew after incubation at 37 °C. The change in temperature from room temperature to 37 °C was the main driver of adduct formation in these reactions. ART was found to react with Fe(II) ions as observed from several new chromatographic peaks. …


Pandemic Policing, Christian Sundquist Sep 2021

Pandemic Policing, Christian Sundquist

Georgia State University Law Review

No abstract provided.


Current Evidence On Potential Of Adipose Derived Stem Cells To Enhance Bone Regeneration And Future Projection, Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe, Quanjun Cui Sep 2021

Current Evidence On Potential Of Adipose Derived Stem Cells To Enhance Bone Regeneration And Future Projection, Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe, Quanjun Cui

Department of Orthopaedic Surgery Faculty Papers

Injuries to the postnatal skeleton are naturally repaired through successive steps involving specific cell types in a process collectively termed “bone regeneration”. Although complex, bone regeneration occurs through a series of well-orchestrated stages wherein endogenous bone stem cells play a central role. In most situations, bone regeneration is successful; however, there are instances when it fails and creates non-healing injuries or fracture nonunion requiring surgical or therapeutic interventions. Transplantation of adult or mesenchymal stem cells (MSCs) defined by the International Society for Cell and Gene Therapy (ISCT) as CD105+-CD90+CD73+CD45-CD34-CD14orCD11b-CD79αorCD19-HLA-DR-is being investigated as an attractive therapy for bone regeneration throughout the …


New Tb3+-Simvastatin Optical Biosensor For Sensitive Determination Of Folic Acid, Progesterone, Testosterone And Vitamin D3in Biological Fluids, Ekram Hany Mohamed, Mohamed S. S. Attia, Ahmed O. Youssef, Mona N. Abou-Omar,, Amal M. Ahmed,, Safwat A. Mahmoud,, Mohammed A. Amin, Tarek A. Mahmoud, Sep 2021

New Tb3+-Simvastatin Optical Biosensor For Sensitive Determination Of Folic Acid, Progesterone, Testosterone And Vitamin D3in Biological Fluids, Ekram Hany Mohamed, Mohamed S. S. Attia, Ahmed O. Youssef, Mona N. Abou-Omar,, Amal M. Ahmed,, Safwat A. Mahmoud,, Mohammed A. Amin, Tarek A. Mahmoud,

Pharmacy

An innovative, simple and cost effective Tb3+-simvastatin photo probe was designed and used as a core for a spectrofluorometric approach to sensitively determine four vital biological compounds in different matrices. A Tb3+-simvastatin complex displays a characteristic electrical band with λem at 545 nm with significant luminescence intensity, which is quenched in the presence of folic acid, progesterone, testosterone and vitamin D3 at four variant sets of pH: 5.0, 6.2, 7.5 and 9.0, respectively. The conditions were optimized and the best solvent for operation was found to be acetonitrile at λex at 340 nm. Folic acid was successfully estimated in tablet …


Effect Of Soil Ph On Emergence And Survival Of Austrodanthonia Spp., M. A. Islam, P. M. Dowling, B. C. Jacobs, P. J. Milham, D. L. Garden, M. K. Conyers, R. Van De Ven Sep 2021

Effect Of Soil Ph On Emergence And Survival Of Austrodanthonia Spp., M. A. Islam, P. M. Dowling, B. C. Jacobs, P. J. Milham, D. L. Garden, M. K. Conyers, R. Van De Ven

IGC Proceedings (1977-2023)

We evaluated the effects of soil acidity on seedling emergence and seedling persistence of several ecotypes of Austrodanthonia spp. collected from the Central, Southern and Monaro Tablelands of New South Wales (NSW) in southern temperate Australia. A pot experiment was conducted outdoors to identify the most promising material tolerant to soil acidity for domestication. In the experiment, 183 ecotypes and two commercial cultivars of Austrodanthonia were grown in pots at three levels of pHCa (3.9, 4.4 and 5.3). The pH treatments were achieved by adding either aluminium sulphate or lime to an acid earthy sandy loam soil collected from …


Effects Of Fertilizer Rates And Pasture Type On Soil Mineral Nitrogen Concentration Under Dairy Pasture, T. A. Cox, D. F. Chapman, Frank R. Mckenzie Sep 2021

Effects Of Fertilizer Rates And Pasture Type On Soil Mineral Nitrogen Concentration Under Dairy Pasture, T. A. Cox, D. F. Chapman, Frank R. Mckenzie

IGC Proceedings (1977-2023)

The effects of three rates of nitrogen (N) fertilizer applied to monocultures of perennial ryegrass (Lolium perenne L.) and white clover (Trifolium repens L.), and mixed ryegrass / clover swards, grazed by dairy cows on soil mineral nitrogen levels in the top 10cm of soil were studied on a dryland pasture in south-western, Victoria, Australia. Ammonium and nitrate were monitored for 14 months. Clover monocultures had significantly greater NO3- levels, however a similar trend was not observed for NH4+ . Increasing fertilizer application rate significantly increased both NO3- and NH4+ …


Nitrogen Fertilization In Paspalum Dilatatum, Poir: Herbage Production, Nutritive Value And Structural Characteristics, G. Acosta, V. A. Deregibus Sep 2021

Nitrogen Fertilization In Paspalum Dilatatum, Poir: Herbage Production, Nutritive Value And Structural Characteristics, G. Acosta, V. A. Deregibus

IGC Proceedings (1977-2023)

It was studied the effect of nitrogen application on structural changes and quantity and quality characteristics of a Paspalum dilatatum Poir sward, under field conditions during two growing seasons. The nitrogen (N) rates were 0 and 440 kg ha-1 applied during the first year in split applications. The nitrogen fertilization increased leaf, stem and cumulative total dry matter yield, plant height, tiller density, cover ground and leaf crude protein yield.


Growth Responses Of Acacia Angustissima To Vesicular-Arbuscular Mycorrhizal Inoculation, N. Lucena Costa, Valdinei T. Paulino, T. S. Paulino Sep 2021

Growth Responses Of Acacia Angustissima To Vesicular-Arbuscular Mycorrhizal Inoculation, N. Lucena Costa, Valdinei T. Paulino, T. S. Paulino

IGC Proceedings (1977-2023)

The response of Acacia angustissima to VAM species (Acaulospora laevis, A. muricata, Entrophosphora colombiana, Glomus mosseae, G. fasciculatum, G. macrocarpum, G. etunicatum, Gigaspora margarita, G. gigantea and Scutellospora heterogama) was evaluated under greenhouse conditions, in a P-deficient clayey Oxisol of pH 5.5. The soil was sterilized at 110oC for one hour each day for three days and reinoculated with a soil microbial suspension free of mycorrhizal fungi spores. The several VAM fungi were effective in increasing DM yield, nodulation, and N and P uptake of A. angustissima plants. The most efficient species were E. colombiana, A. …


Automatic Identification And Monitoring Of Plant Diseases Using Unmanned Aerial Vehicles: A Review, Krishna Neupane, Fulya Baysal-Gurel Sep 2021

Automatic Identification And Monitoring Of Plant Diseases Using Unmanned Aerial Vehicles: A Review, Krishna Neupane, Fulya Baysal-Gurel

Agricultural and Environmental Sciences Faculty Research

Disease diagnosis is one of the major tasks for increasing food production in agriculture. Although precision agriculture (PA) takes less time and provides a more precise application of agricultural activities, the detection of disease using an Unmanned Aerial System (UAS) is a challenging task. Several Unmanned Aerial Vehicles (UAVs) and sensors have been used for this purpose. The UAVs’ platforms and their peripherals have their own limitations in accurately diagnosing plant diseases. Several types of image processing software are available for vignetting and orthorectification. The training and validation of datasets are important characteristics of data analysis. Currently, different algorithms and …


Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna K. Arnett, H3 Africa Kidney Research Network, Adetola Daramola Sep 2021

Association Of Body Composition With Odds Of Breast Cancer By Molecular Subtype: Analysis Of The Mechanisms For Established And Novel Risk Factors For Breast Cancer In Nigerian Women (Mend) Study, Tomi Akinyemiju, Kelley Jones, Anjali Gupta, Taofik Oyekunle, Veeral Saraiya, April Deveaux, Omolola Salako, Allison Hall, Olusegun Alatise, Gabriel Ogun, Adewale Adeniyi, Omobolaji Ayandipo, Thomas Olajide, Olalekan Olasehinde, Olukayode Arowolo, Adewale Adisa, Oludolapo Afuwape, Aralola Olusanya, Aderemi Adegoke, Trygve O. Tollefsbol, Donna K. Arnett, H3 Africa Kidney Research Network, Adetola Daramola

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: The association between obesity and breast cancer (BC) has been extensively studied among US, European and Asian study populations, with often conflicting evidence. However, despite the increasing prevalence of obesity and associated conditions in Africa, the continent with the highest age-standardized BC mortality rate globally, few studies have evaluated this association, and none has examined in relation to molecular subtypes among African women. The current analysis examines the association between body composition, defined by body mass index (BMI), height, and weight, and BC by molecular subtype among African women.

METHODS: We estimated odds ratios (ORs) and 95% confidence intervals …


"Prep"Aring For A Challenge To Government-Owned Patents, Caleb Holland Sep 2021

"Prep"Aring For A Challenge To Government-Owned Patents, Caleb Holland

Catholic University Law Review

The United States Government owns one of the largest patent estates in the world, but it rarely brings suit for patent infringement. To understand why that may be, this paper looks critically at the Government as a patent holder. Specifically, the paper reviews the fundamentals of American patents and explores the intricacies unique to the Government as an entity that both grants and holds patent rights. The paper examines the historical progression of how the United States Government positions itself with regard to its patents, tracing this evolution from Constitutional origins to more recent statutory refinements. Finally, the paper looks …


Kdm6a Regulates Cell Plasticity And Pancreatic Cancer Progression By Non-Canonical Activin Pathway, Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca Di Magliano, Kai Ge, Yali Dou, Jiaqi Shi Sep 2021

Kdm6a Regulates Cell Plasticity And Pancreatic Cancer Progression By Non-Canonical Activin Pathway, Zhujun Yi, Shanqiao Wei, Lin Jin, Sivakumar Jeyarajan, Jing Yang, Yumei Gu, Hong Sun Kim, Shula Schechter, Shuang Lu, Michelle T. Paulsen, Karan Bedi, Ishwarya Venkata Narayanan, Mats Ljungman, Howard C. Crawford, Marina Pasca Di Magliano, Kai Ge, Yali Dou, Jiaqi Shi

Hematology/Oncology Articles

BACKGROUND & AIMS: Inactivating mutations of KDM6A, a histone demethylase, were frequently found in pancreatic ductal adenocarcinoma (PDAC). We investigated the role of KDM6A in PDAC development.

METHODS: We performed a pancreatic tissue microarray analysis of KDM6A protein levels. We used human PDAC cell lines for KDM6A knockout and knockdown experiments. We performed Bru-seq analysis to elucidate the effects of KDM6A loss on global transcription. We performed studies with Ptf1a(Cre); LSL-Kras(G12D); Trp53(R172H/+); Kdm6a(fl/fl or fl/Y), Ptf1a(Cre); Kdm6a(fl/fl or fl/Y), and orthotopic xenograft mice to investigate the impacts of Kdm6a deficiency on pancreatic tumorigenesis and pancreatitis.

RESULTS: Loss of KDM6A was …


Mg53 Preserves Neuromuscular Junction Integrity And Alleviates Als Disease Progression, Jianxun Yi, Ang Li, Xuejun Li, Kiho Park, Frank Yi, Yajuan Xiao, Dosuk Yoon, Tao Tan, Lyle W. Ostrow, Jianjie Ma, Jingsong Zhou Sep 2021

Mg53 Preserves Neuromuscular Junction Integrity And Alleviates Als Disease Progression, Jianxun Yi, Ang Li, Xuejun Li, Kiho Park, Frank Yi, Yajuan Xiao, Dosuk Yoon, Tao Tan, Lyle W. Ostrow, Jianjie Ma, Jingsong Zhou

Faculty and Staff Publications

Respiratory failure from progressive respiratory muscle weakness is the most common cause of death in amyotrophic lateral sclerosis (ALS). Defects in neuromuscular junctions (NMJs) and progressive NMJ loss occur at early stages, thus stabilizing and preserving NMJs represents a potential therapeutic strategy to slow ALS disease progression. Here we demonstrate that NMJ damage is repaired by MG53, an intrinsic muscle protein involved in plasma membrane repair. Compromised diaphragm muscle membrane repair and NMJ integrity are early pathological events in ALS. Diaphragm muscles from ALS mouse models show increased susceptibility to injury and intracellular MG53 aggregation, which is also a hallmark …


Genetic Characterization, Current Model Systems And Prognostic Stratification In Pax Fusion-Negative Vs. Pax Fusion-Positive Rhabdomyosarcoma, Carina A Dehner, Amy E Armstrong, Marielle Yohe, Jack F Shern, Angela C Hirbe Sep 2021

Genetic Characterization, Current Model Systems And Prognostic Stratification In Pax Fusion-Negative Vs. Pax Fusion-Positive Rhabdomyosarcoma, Carina A Dehner, Amy E Armstrong, Marielle Yohe, Jack F Shern, Angela C Hirbe

Open Access Publications

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents and accounts for approximately 2% of soft tissue sarcomas in adults. It is subcategorized into distinct subtypes based on histological features and fusion status (


Tinjauan Yuridis Terhadap Perlindungan Anak Dalam Ruang Siber Di Indonesia, Muhammad Rafifnafia Hertianto Sep 2021

Tinjauan Yuridis Terhadap Perlindungan Anak Dalam Ruang Siber Di Indonesia, Muhammad Rafifnafia Hertianto

Jurnal Hukum & Pembangunan

Indonesia high internet development and penetration rate make the child as user in a vulnerable position tocyberspace threat. Ironically Indonesia until this moment has no specific law or technical mechanism that can guarantee child security and fulfill child rights. In the current situation the number of criminal reports which utilize internet as its medium arehigh and keep on increasing over the year. This research aim to analyze the concept of child protection in cyberspace based on existing regulations on child protection. This research uses normative juridical methods and secondarydata which is then analyzedto state conclusion and recommendation. Based on the …


Comparison Of The Sensitivity Of Patient-Reported Outcomes For Detecting The Benefit Of Biologics In Severe Asthma, Michael E. Hyland, Joseph W. Lanario, Andrew Menzies-Gow, Adel H. Mansur, James W. Dodd, Stephen J. Fowler, Gemma Hayes, Rupert C. Jones, Matthew Masoli Sep 2021

Comparison Of The Sensitivity Of Patient-Reported Outcomes For Detecting The Benefit Of Biologics In Severe Asthma, Michael E. Hyland, Joseph W. Lanario, Andrew Menzies-Gow, Adel H. Mansur, James W. Dodd, Stephen J. Fowler, Gemma Hayes, Rupert C. Jones, Matthew Masoli

School of Psychology

Background The sensitivity of patient-reported outcomes (PROs) to detect the effects of treatment change depends on the match between the change in items of the PRO and the change that takes place in a sample of people. The aim of this study is to compare the sensitivity of different PROs in detecting changes following the initiation of biologic treatment in asthma. Methods: Patients starting a biologic treatment as part of clinical care completed the Asthma Control Questionnaire (ACQ-6), the Severe Asthma Questionnaire (SAQ and SAQ-global scores) and the EQ5D (EQ-5D-5L and EQ5D-VAS) at baseline. They completed the ACQ-6, SAQ, SAQ-global …


Data Analysis Of The “2021 Covid, Equity And Social Justice Showcase”, Cristo Leon, James Lipuma Sep 2021

Data Analysis Of The “2021 Covid, Equity And Social Justice Showcase”, Cristo Leon, James Lipuma

STEM Month

During the “2021 STEM for All Video Showcase” (NSF, 2021) funded by the National Science Foundation, 287 short videos showcasing federally funded projects aimed at improving STEM and CS education were presented.

The videos highlight strategies to engage students during COVID-19 and address educational inequities.