Digital Commons Network^™

Use Of By‐Products Derived From Neem Tree (Azadirachta Indica) In Livestock Production, W. Z. Yang, B. N. Ametaj

IGC Proceedings (1977-2023)

No abstract provided.

Fodder Availability And Nutritive Value Of Two Sahelian Browse Plants: Acacia Senegal And Pterocarpus Lucens, H. O. Sanon, F. Ouattara, I. Ledin

IGC Proceedings (1977-2023)

No abstract provided.

Phenomenological Study On The Lived Experience Of Black Women In Positions Of Leadership In California State Government, Tonia Burgess

Dissertations

Purpose: The purpose of this phenomenological study was to explore the lived experiences of Black women in their roles as leaders in the California state government with respect to support received and barriers encountered.

Methodology: The phenomenological qualitative study involved exploring the lived experiences of 12 Black women in positions of leadership in northern California state government with regard to the supports they received and the barriers they encountered during their careers in California state government. Patton (2015) asserted that phenomenology's philosophical interpretation occurs when individuals only know what they experience. Additionally, "to fully understand the phenomenon, it must be …

February 9, 2021, University Of Mississippi. Faculty Senate

Meeting Minutes

Minutes for the February 2021 meeting of the University of Mississippi Faculty Senate.

Governors State Alumni Help Create Covid Vaccine, Office Of Marketing And Communications

Newsroom

As the world eagerly watches the historic COVID-19 vaccine roll out, at least two scientists say they are grateful to Governors State University for preparing them for work on the vaccine frontlines.

Alumni News | Lance Mcbrayer Featured In Smithsonian Magazine For Tegu Lizard Project, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Gwu Distinguished Artist Series Presents Trombonist John Ilika And Pianist Polina Khatsko, Office Of University Communications

Gardner-Webb NewsCenter Archive

The Gardner-Webb University Distinguished Artist Series will feature trombonist John Ilika with pianist Polina Khatsko in the first concert of the spring semester. Presented by the GWU School of Performing and Visual Arts in collaboration with the Alfred and Shirley Wampler Caudill Fund, the program will be on Feb. 21 at 3 p.m. in Hamrick Hall’s Blanton Auditorium. Because of COVID-19 social distancing guidelines, seating is limited and available on a first come, first served basis.

Historical Contingency In Microbial Resilience To Hydrologic Perturbations, Hyun-Seob Song, James C. Stegen, Emily B. Graham, Timothy D. Scheibe

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Development of reliable biogeochemical models requires a mechanistic consideration of microbial interactions with hydrology. Microbial response to and its recovery after hydrologic perturbations (i.e., resilience) is a critical component to understand in this regard, but generally difficult to predict because the impacts of future events can be dependent on the history of perturbations (i.e., historical contingency). Fundamental issues underlying this phenomenon include how microbial resilience to hydrologic perturbations is influenced by historical contingency and how their relationships vary depending on the characteristics of microbial functions. To answer these questions, we considered a simple microbial community composed of two species that …

Modalities, Challenges, And Possibilities: An Introduction To The Pharmaceutical Innovation Symposium, Peter K. Yu

Texas A&M Journal of Property Law

On October 25, 2019, the Texas A&M Journal of Property Lawand the Center for Law and Intellectual Property at Texas A&M University School of Law jointly organized the “Pharmaceutical Innovation, Patent Protection, and Regulatory Exclusivities” Symposium. Although none of the organizers and participants could predict what was to come in the next few months, there was a wide consensus that the rapid changes in the pharmaceutical landscape and our continuous struggle to strike a proper balance between proprietary protection and public access in the public health arena deserves scholarly, policy, and regulatory attention.

To help contextualize the articles included in …

The Biologics Price Competition And Innovation Act 10--A Stocktaking, Yaniv Heled

Texas A&M Journal of Property Law

On March 23, 2010, President Obama signed into law the Biologics Price Competition and Innovation Act (BPCIA) as part of the Patient Protection and Affordable Care Act (“Obamacare”). The purpose of BPCIA was to create for biologics a regime similar to that of the Drug Price Competition and Patent Term Restoration Act (Hatch–Waxman Act) and, in so doing, to open biologics markets to competition and, subsequently, lower the price of these expensive and increasingly important pharmaceuticals. Using original data, this Essay takes stock of the decade that has passed since the enactment of BPCIA. This Essay surveys the state of …

Spartan Daily, February 9, 2021, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2021

Volume 156, Issue 5

Academic Senate - Agenda, 02/09/2021, Academic Senate

Academic Senate Agendas

No abstract provided.

Is Biopharma Ready For The Standard Wars?, Jorge L. Contreras

Texas A&M Journal of Property Law

This symposium contribution sheds new light on Momenta v. Amphastar, a case in which issues relating to standardization and patent disclosure that have previously been observed in the semiconductor, computing, and telecommunications sectors found their way into a dispute between two biosimilar manufacturers. One such manufacturer, Momenta, participated in the development of a standard for testing the purity of generic enoxaparin under the auspices of the United States Pharmacopeial Convention but failed to disclose that it had applied for a patent on the testing method. When Momenta later sued Amphastar for patent infringement by using the method in accordance with …

Deep Learning-Based Breast Cancer Detection And Classification Using Histopathology Images, Ghulam Murtaza

Student Works (2020-2029)

Cancer disease is drastically increasing worldwide over the past few years. Among all types of cancers in women, breast cancer (BrC) is the main cause of abnormal deaths. For a confident diagnosis of BrC, histopathology (Hp) images are usually suggested by the doctors. BrC detection is a diagnostic test for benign (non-cancerous) and malignant (cancerous) breast tumors (BrT). Once the BrT is diagnosed, then it needs to be classified for subtypes of benign and malignant to start specific treatment. Several studies developed BrC detection and classification models using Hp images. However, the existing models required high computational resources, long training …

Picking Up Where The Tmdl Leaves Off: Using The Partnership Wild And Scenic River Framework For Collaborative River Restoration, Alan R. Hunt, Meiyin Wu, Tsung-Ta David Hsu, Nancy Roberts-Lawler, Jessica T. Miller, Alessandra Rossi, Lee Lee

Department of Biology Faculty Scholarship and Creative Works

The National Wild and Scenic Rivers Act protects less than ¼ of a percent of the United States’ river miles, focusing on free-flowing rivers of good water quality with outstandingly remarkable values for recreation, scenery, and other unique river attributes. It predates the enactment of the Clean Water Act, yet includes a clear anti-degradation principle, that pollution should be reduced and eliminated on designated rivers, in cooperation with the federal Environmental Protection Agency and state pollution control agencies. However, the federal Clean Water Act lacks a clear management framework for implementing restoration activities to reduce non-point source pollution, of which …

The Roles Of Identity Formation And Moral Identity In College Student Mental Health, Health-Risk Behaviors, And Psychological Well-Being, Sam A. Hardy, Stephen W. Francis, Byron L. Zamboanga, Su Yeong Kim, Spencer G. Anderson, Larry F. Forthun

Faculty Publications

Objectives: This study examined the roles of identity formation and moral identity in predicting college student mental health (anxiety and depressive symptoms), health-risk behaviors (hazardous alcohol use and sexual risk taking), and psychological well-being (self-esteem and meaning).

Method: The sample comprised 9,500 college students (aged 18–25 years, mean = 19.78, standard deviation = 1.61: 73% female; 62% European American), from 31 different universities, who completed an online self-report survey. Results: Structural equation models found that identity maturity (commitment making and identity synthesis) predicted 5 of the health outcomes (except sexual risk taking), and moral identity predicted ail of the health …

Student Senate Meeting Minutes February 9, 2021, Student Senate-Winona State University

Student Senate Meeting Minutes

This document is the official Winona State University Student Senate Meeting Minutes for February 9, 2021.

Machine Intelligence Identifies Soluble Tnfa As A Therapeutic Target For Spinal Cord Injury, J. R. Huie, A. R. Ferguson, N. Kyritsis, J. Z. Pan, K.-A. Irvine, J. L. Nielson, P. G. Schupp, M. C. Oldham, John C. Gensel, A. Lin, M. R. Segal, R. R. Ratan, J. C. Bresnahan, M. S. Beattie

Spinal Cord and Brain Injury Research Center Faculty Publications

Traumatic spinal cord injury (SCI) produces a complex syndrome that is expressed across multiple endpoints ranging from molecular and cellular changes to functional behavioral deficits. Effective therapeutic strategies for CNS injury are therefore likely to manifest multi-factorial effects across a broad range of biological and functional outcome measures. Thus, multivariate analytic approaches are needed to capture the linkage between biological and neurobehavioral outcomes. Injury-induced neuroinflammation (NI) presents a particularly challenging therapeutic target, since NI is involved in both degeneration and repair. Here, we used big-data integration and large-scale analytics to examine a large dataset of preclinical efficacy tests combining five …

Methylation Of The D2 Dopamine Receptor Affects Binding With The Human Regulatory Proteins Par-4 And Calmodulin, Alexander Bowitch, Ansuman Sahoo, Andrea M. Clark, Christiana Ntangka, Krishna K. Raut, Paul Gollnick, Michael C. Yu, Steven M. Pascal, Sarah E. Walker, Denise M. Ferkey

Chemistry & Biochemistry Faculty Publications

No abstract provided.

Natural Genetic Variation Determines Microglia Heterogeneity In Wild-Derived Mouse Models Of Alzheimer's Disease., Hongtian Stanley Yang, Kristen D. Onos, Kwangbom Choi, Kelly J Keezer, Daniel A Skelly, Gregory W. Carter, Gareth R Howell

Faculty Research 2021

Genetic and genome-wide association studies suggest a central role for microglia in Alzheimer's disease (AD). However, single-cell RNA sequencing (scRNA-seq) of microglia in mice, a key preclinical model, has shown mixed results regarding translatability to human studies. To address this, scRNA-seq of microglia from C57BL/6J (B6) and wild-derived strains (WSB/EiJ, CAST/EiJ, and PWK/PhJ) with and without APP/PS1 demonstrates that genetic diversity significantly alters features and dynamics of microglia in baseline neuroimmune functions and in response to amyloidosis. Results show significant variation in the abundance of microglial subtypes or states, including numbers of previously identified disease-associated and interferon-responding microglia, across the …

Dna Mismatch Repair And Its Role In Huntington's Disease, Ravi R Iyer, Anna Pluciennik

Department of Biochemistry and Molecular Biology Faculty Papers

DNA mismatch repair (MMR) is a highly conserved genome stabilizing pathway that corrects DNA replication errors, limits chromosomal rearrangements, and mediates the cellular response to many types of DNA damage. Counterintuitively, MMR is also involved in the generation of mutations, as evidenced by its role in causing somatic triplet repeat expansion in Huntington's disease (HD) and other neurodegenerative disorders. In this review, we discuss the current state of mechanistic knowledge of MMR and review the roles of key enzymes in this pathway. We also present the evidence for mutagenic function of MMR in CAG repeat expansion and consider mechanistic hypotheses …

Copper Oxide Nanoparticle Diameter Mediates Serum-Sensitive Toxicity In Beas-2b Cells, Angie S. Morris, Brittany E. Givens, Aaron Silva, Aliasger K. Salem

Chemical and Materials Engineering Faculty Publications

Copper oxide (CuO) nanoparticles (NPs) are abundant in manufacturing processes, but they are an airway irritant. In vitro pulmonary toxicity of CuO NPs has been modeled using cell lines such as human bronchial epithelial cell line BEAS-2B. In 2D in vitro culture, BEAS-2B undergoes squamous differentiation due to the presence of serum. Differentiation is part of the repair process of lung cells in vivo that helps to preserve the epithelial lining of the respiratory tract. Herein, the effects of serum on the hydrodynamic diameter, cellular viability, cellular differentiation, and cellular uptake of 5 and 35 nm CuO NPs are investigated, …

Mean Square Displacement For A Discrete Centroid Model Of Cell Motion And A Mathematical Analysis Of Focal Adhesion Lifetimes And Their Effect On Cell Motility, Mary Ellen Furner Rosen

Theses and Dissertations

One of the characteristics that distinguishes living things from non-living things is motility. On the cellular level, the motility or non-motility of different types of cells can be life building, life-saving or life-threatening. A thorough study of cell motion is needed to help understand the underlying mechanisms that enhance or prohibit cell motion. We introduce a discrete centroid model of cell motion in the context of a generalized random walk. We find an approximation for the theoretical mean square displacement (MSD) that uses a subset of the state space to estimate the MSD for the entire space. We give some …

Covid-19 Newsletter (Vol. 58), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Rates Of Gene Conversions Between Escherichia Coli Ribosomal Operons, Isaac Gifford, Aurko Dasgupta, Jeffrey E Barrick

Open Access Publications

Due to their universal presence and high sequence conservation, ribosomal RNA (rRNA) sequences are used widely in phylogenetics for inferring evolutionary relationships between microbes and in metagenomics for analyzing the composition of microbial communities. Most microbial genomes encode multiple copies of rRNA genes to supply cells with sufficient capacity for protein synthesis. These copies typically undergo concerted evolution that keeps their sequences identical, or nearly so, due to gene conversion, a type of intragenomic recombination that changes one copy of a homologous sequence to exactly match another. Widely varying rates of rRNA gene conversion have previously been estimated by comparative …

Virucidal Activity Of Chlorine Dioxide Gas For Reduction Of Coronavirus On Surfaces And Ppe, Jeffrey Driver, George Lukasik, Marie Bourgeois, Patricia Tam, Raymond Harbison

School of Pharmacy Faculty Articles

A coronavirus (SARS-CoV-2) has caused a global pandemic and associated morbidity and mortality resultant from COVID-19. As a result of efforts to control direct (person to person) and indirect (contaminated objects, surfaces, indoor air) transmission of the virus, various interventions have been evaluated. Studies were conducted to evaluate the efficacy of commercially available chlorine dioxide (CD) products to reduce viral loads on PPE (face masks) and surfaces using a novel dry gas release intervention. The efficacy of CD slow release 30-day sachets was tested on N95 face masks inoculated with human coronavirus OC43 in suspension. One sachet was placed with …

Academic Senate - Minutes, 02/09/2021, Academic Senate, Academic Senate

Academic Senate Minutes

No abstract provided.

Phenytoin Inhibits Cell Proliferation Through Microrna-196a-5p In Mouse Lip Mesenchymal Cells, Hiroki Yoshioka, Sai Shankar Ramakrishnan, Akiko Suzuki, Junichi Iwata

Faculty, Staff and Student Publications

Cleft lip (CL) is one of the most common birth defects. It is caused by either genetic mutations or environmental factors. Recent studies suggest that environmental factors influence the expression of noncoding RNAs [e.g., microRNA (miRNA)], which can regulate the expression of genes crucial for cellular functions. In this study, we examined which miRNAs are associated with CL. Among 10 candidate miRNAs (miR-98-3p, miR-101a-3p, miR-101b-3p, miR-141-3p, miR-144-3p, miR-181a-5p, miR-196a-5p, miR-196b-5p, miR-200a-3p, and miR-710) identified through our bioinformatic analysis of CL-associated genes, overexpression of miR-181a-5p, miR-196a-5p, miR-196b-5p, and miR-710 inhibited cell proliferation through suppression of genes associated with CL in cultured …

Cross-Sectional Age Differences In 24 Character Strengths: Five Meta-Analyses From Early Adolescence To Late Adulthood, Sonja Heintz, Willibald Ruch

School of Psychology

No abstract provided.

49 Update: Final Spr21 Certificate Application Gerc, University Of Northern Iowa. General Education Re-Envisioning Committee.

General Education Re-envisioning Committee Documents

The proposal packet for submitting multi-disciplinary certificates for consideration for inclusion in the general education program.