Digital Commons Network^™

Anxiety And Mood Disorders Impacting Physician Opioid Prescribing In The Pediatric Hospital Setting, Candice D. Donaldson, Zeev N. Kain, Louis Ehwerhemuepha, Michelle A. Fortier, Michael T. Phan, Daniel M. Tomaszewski, Sun Yang, William Feaster, Brooke N. Jenkins

Psychology Faculty Articles and Research

This research examined whether pediatric inpatients without an anxiety/mood disorder are more likely to receive opioids in response to pain compared to patients diagnosed with a mental health condition. Research questions were tested using cross-sectional inpatient electronic medical record data. Propensity score matching was used to match patients with a disorder with patients without the disorder (anxiety analyses: N = 2892; mood analyses: N = 1042). Although patients with anxiety and mood disorders experienced greater pain, physicians were less likely to order opioids for these patients. Analyses also disclosed an interaction of anxiety with pain—the pain-opioid relation was stronger for …

Assessment Of Major Depressive Disorders Through Neuroimaging Studies And Their Treatment Methods, Jevetha Vijayadasan, Diksha Raghunathan, Sivakumar Rajagopal, Rahul Soangra

Physical Therapy Faculty Articles and Research

Many mental disorders are caused due to improper regulation of the brain and depression is one such. It affects both children and adults and is very common among teenagers. There are many challenges clinicians face regarding the management of this disease. These challenges have prompted the development of various neuroimaging techniques that effectively diagnose the condition. The main techniques are Magnetic resonance imaging (MRI) and Positron emission tomography (PET) which have gained momentum over the years. Advanced MRI techniques help study certain regions of the brain such as hippocampus and amygdala. Effective treatments for depression include antidepressant medications and brain …

Content Analysis Of Library Websites Of National Institutes In West Bengal, India: An Evaluative Study, Santosh Kumar Tunga

Library Philosophy and Practice (e-journal)

Institute libraries as resource centers and disseminators of information occupy primary place in Institute setup. Library websites integrate it resources and services and has to be taken in designing and developing from perspective of users needs. The present study is concerned with web based content analysis of library websites of Institute of National Importance in West Bengal, India. The required content information has been collected through searching, browsing and analyzing the selected library websites of said Institutes during October to December, 2020. The library websites of studied Institutes were identified from Google, Wikipedia and other E-Resources. Only five Institute libraries …

Vertical Sleeve Gastrectomy Confers Metabolic Improvements By Reducing Intestinal Bile Acids And Lipid Absorption In Mice, Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D Moore, Li Yang, Wendong Huang

Faculty, Staff and Students Publications

Vertical sleeve gastrectomy (VSG) is a highly effective bariatric surgery that sustainably treats obesity and type 2 diabetes (T2D). However, the underlying mechanisms governing its metabolic benefits remain unclear. In this study, we have used four different genetically modified mouse lines to understand the link between bile acid circulation and metabolic effects of VSG. Instead of directly activating the nuclear bile acid receptor farnesoid X receptor (Fxr) in the liver or intestine, VSG reduces intestinal levels of bile acids, thereby decreasing fat absorption in the intestine. Given the rising popularity of bariatric surgeries to treat obesity and associated T2D, the …

Shikata Ga Nai: Statelessness And Sacrifice For Japanese-American Volunteers During The Second World War, Kenzo E. Okazaki

Swarthmore Undergraduate History Journal

Through a Philosophical analysis of the nature of Internment Camps as well as oral histories of veterans who volunteered to serve in the US military from the camps, this paper will argue that the internment of Japanese Americans during WWII was an event that the Supreme Court and surrounding legal discourse placed outside of legal jurisdiction. Those within the camps were thus condemned to a life lacking political qualification and juridical personhood. Faced with the dangers of this condition, interned Japanese Americans who served in the U.S. Army consciously laid claim to the American political community through the sacrifice of …

Distribution, Status, And Life History Aspects Of Two Rare Logperches, Percina Burtoni And Percina Apina, Jeffrey W. Simmons

Southeastern Fishes Council Proceedings

The Blotchside Logperch, Percina burtoni, and Tennessee Logperch, Percina apina, are Tennessee-Cumberland River drainage endemics that have experienced range reductions due to anthropogenic influences. All known collection records were gathered to fully describe the historical distribution of these species for comparison to their currently inhabited range. Discussion of major impacts to rivers that contain or contained these species is included for an understanding of factors that may have influenced contemporary distributions. Extensive field surveys were conducted during 2014 to 2017 to aid in determination of the current status and distribution of populations. New information of previously unreported or …

Personality Patterns In Psychopathology: An Examination Of Lower-Order Personality Facets, Depression, And Anxiety, Tori Jansen

The Pegasus Review: UCF Undergraduate Research Journal

Past research concerning personality and psychological disorders have focused predominantly on higher- order personality traits. However, investigating the lower order facets of personality traits may reveal unique aspects of psychological disorders. Participants were asked to complete a survey evaluating the relationships between symptoms of Major Depressive Disorder, Generalized Anxiety Disorder, and Social Anxiety Disorder. Associations between these disorders and positive and negative affect were also investigated. This study revealed numerous associations between each of the disorders and various facets compiling each trait. Of particular interest are the links found between facets of Agreeableness and Openness to Experience and all three …

Front Matter, Human Biology Editors

Human Biology

Front cover and editorial credits

The 100 Most-Cited Articles In Library Philosophy And Practice (E-Journal): A Bibliometric Analysis, Ikram Ul Haq, Zia Ahmed, Yasir Abbasi

Library Philosophy and Practice (e-journal)

Aim: The study aimed to evaluate the characteristics of the 100 most-cited articles published in the electronic journal Library Philosophy and Practice (LPP). Bibliometric studies to determine the attributes of the most-cited articles in the field of Library and Information Science (LIS) journals are deficient. The current study was conducted to fill this gap.

Methodology: We conducted a retrospective bibliometric analysis of the 100 most-cited articles of the LPP retrieved from Elsevier’s Scopus database on 31st December 2020. The data was downloaded on Microsoft Excel Sheet for analysis. For comparison, the citations of data these articles were taken …

Decline Of Novel Ecosystems Used By Endangered Species: The Case Of Piping Plovers, Least Terns, And Aggregate Mines, Joel G. Jorgensen, Stephen J. Brenner, Lauren R. Greenwalt, Mark P. Vrtiska

School of Natural Resources: Faculty Publications

Sand and gravel mining creates novel ecosystems along the Platte, Loup, and Elkhorn rivers in Nebraska, USA. Piping plovers and least terns are state and/or federally threatened and endangered species, respectively, that nest and raise young at these sites and their derivatives. Despite hosting relatively large numbers of piping plovers and least terns for decades, an important question that has largely gone unaddressed is whether the industry that has produced these novel ecosystems is stable and will continue to produce habitat consistently in the future. We evaluated how the number, size, and spatial distribution of different site types hosting different …

The Utah Statesman, February 8, 2021, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Corporate Boardrooms And The National Football League: A Gender Diversity Marriage Made In Corporate Governance Heaven, Danielle Hartley

Denver Law Review

No abstract provided.

The Challenges Of Forensic Genealogy: Dirty Data, Electronic Evidence, And Privacy Concerns, Divya Ramjee, Katelyn Ringrose

Denver Law Review

No abstract provided.

Dna Repair Pathways In Cancer Therapy And Resistance, Lan-Ya Li, Yi-Di Guan, Xi-Sha Chen, Jin-Ming Yang, Yan Cheng

Toxicology and Cancer Biology Faculty Publications

DNA repair pathways are triggered to maintain genetic stability and integrity when mammalian cells are exposed to endogenous or exogenous DNA-damaging agents. The deregulation of DNA repair pathways is associated with the initiation and progression of cancer. As the primary anti-cancer therapies, ionizing radiation and chemotherapeutic agents induce cell death by directly or indirectly causing DNA damage, dysregulation of the DNA damage response may contribute to hypersensitivity or resistance of cancer cells to genotoxic agents and targeting DNA repair pathway can increase the tumor sensitivity to cancer therapies. Therefore, targeting DNA repair pathways may be a potential therapeutic approach for …

2020-2021 Faculty Senate Xxv - February 8, 2021 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Crow's Nest, February 8, 2021, Crow's Nest Staff

Crow's Nest

The February 8, 2021, issue of the Crow's Nest.

Response Of Biological Productivity To North Atlantic Marine Front Migration During The Holocene, David J. Harning, Anne E. Jennings, D Köseoğlu, Simon T. Belt, Áslaug Geirsdóttir, Julio Sepúlveda

School of Geography, Earth and Environmental Sciences

Abstract. Marine fronts delineate the boundary between distinct water masses and, through the advection of nutrients, are important facilitators of regional productivity and biodiversity. As the modern climate continues to change, the migration of frontal zones is evident, but a lack of information about their status prior to instrumental records hinders future projections. Here, we combine data from lipid biomarkers (archaeal isoprenoid glycerol dibiphytanyl glycerol tetraethers and algal highly branched isoprenoids) with planktic and benthic foraminifera assemblages to detail the biological response of the marine Arctic and polar front migrations on the North Iceland Shelf (NIS) over the last 8 …

The Guardian, Week Of February 8, 2021, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the week of February 8, 2021. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

February 8, 2021 - Sense Of The Senate Resolution On The Yusuf Kalyango De-Tenuring Hearing, Ohio University Faculty Senate

Faculty Senate Resolutions

No abstract provided.

Contribution Of Bimstec (Bay Of Bengal Initiative For Multi-Sectional Technical Economic Co-Operation) Country Through Opendoar As On: 01.10.2020, Sheuli Hazra

Library Philosophy and Practice (e-journal)

This paper study open access repositories in the contribution of BIMSTEC country through OpenDOAR to demonstrate country wise no of repositories, ccategory wise, language wise, software wise, subject wise, software wise, content wise distribution of these repositories. These BIMSTEC (Bay of Bengal Initiative for Multi-Sectional Technical Economic Co-operation) country which is include Bhutan, India, Myanmar, Sri Lanka, Thailand, Bangladesh, Nepal. This paper includes only one conceptual part – i) analysis of these countries through OpenDOAR set a parameter like software in use, country of origin, language wise distribution, document types etc.; and ii) growth of these countries using these OpenDOAR. …

Wjmsc-Derived Small Extracellular Vesicle Enhance T Cell Suppression Through Pd-L1, Meizhang Li, Rupal Soder, Sunil Abhyankar, Haitham Abdelhakim, Mitchell W. Braun, Camille V. Trinidad, Harsh B. Pathak, Ziyan Pessetto, Clayton Deighan, Siddhartha Ganguly, Buddhadeb Dawn, Joseph Mcguirk, Neil Dunavin, Andrew K. Godwin

School of Medicine Faculty Research

© 2021 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles Both mesenchymal stem cells (MSCs) and their corresponding small extracellular vesicles (sEVs, commonly referred to as exosomes) share similar immunomodulatory properties that are potentially beneficial for the treatment of acute graft versus host disease (aGvHD). We report that clinical grade Wharton's Jelly-derived MSCs (WJMSCs) secrete sEVs enriched in programmed death-ligand 1 (PD-L1), an essential ligand for an inhibitory immune checkpoint. A rapid increase in circulating sEV-associated PD-L1 was observed in patients with aGvHD and was directly associated with …

Treatment Of Patients With Chronic Pruritus Of Unknown Origin With Dupilumab, Jiehyun Jeon, Fang Wang, Asima Badic, Brian S Kim

Open Access Publications

BACKGROUND: Chronic pruritus of unknown origin (CPUO) is a highly debilitating disease that lacks effective treatments. This study explores a new therapeutic strategy with dupilumab.

OBJECTIVES: To examine whether patients with CPUO demonstrate clinical response to dupilumab.

PATIENTS AND METHODS: This is a retrospective case series examining all patients with CPUO who were treated with dupilumab from March 2017 to December 2019 at a tertiary referral clinic at Washington University School of Medicine in St. Louis, MO. Numerical rating scale (NRS) itch score changes over time were recorded and analyzed.

RESULTS: Fifteen patients (67% women; mean [SD] age, 68.7 [12.6] …

Controlling Opioid Receptor Functional Selectivity By Targeting Distinct Subpockets Of The Orthosteric Site, Rajendra Uprety, Tao Che, Balázs R. Varga, Abdelfattah Faouzi, Sarah M. Bernhard, Susruta Majumdar, Et Al

Open Access Publications

Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal structures of opioid receptors, including the recently solved active state kappa opioid complex with

Impact Of Scholarly Articles On Social Media: An Altmetric Mapping Of University Of Calicut, Kerala-India., Haseena V K K M, Abdul Azeez T A

Library Philosophy and Practice (e-journal)

Article level metrics (Altmetrics) is a source of a wide range of metrics regarding the scholarly impact of articles by generating the statistics of usage, citations, bookmarks, social shares, attentions, and online comments on various social media and other platforms. The paper is an attempt to showcase the state of the art of the most viewed fifteen scholarly articles of the University of Calicut through various social media platforms and which were selected and ranked based on altmetric attention score in the Dimension database during January 2021. The study intends to explore the most viewable social media platforms to disseminate …

Observations On The Distribution And Status Of Selected Nebraska Mammals, Zachary P. Roehrs, Russell A. Benedict, Thomas E. Labedz, Hugh H. Genoways

Transactions of the Nebraska Academy of Sciences and Affiliated Societies

Information on the distribution and current status of 25 species or subspecies of mammals occurring in Nebraska are presented. The species covered include one shrew, an armadillo, eight bats, 10 rodents (including two subspecies of one species), three carnivores, and one artiodactyl. Distributional information reported includes the first state record for one species (Sorex nanus) and new county records for 18 species. In Nebraska, we know that mammals are shifting their geographic ranges with some extending populations into the state, whereas others are expanding their geographic ranges within the state. The current status of six additional mammalian taxa …

Bacterium-Enabled Transient Gene Activation By Artificial Transcription Factor For Resolving Gene Regulation In Maize, Mingxia Zhao, Zhao Peng, Yang Qin, Ling Zhang, Bin Tian, Yueying Chen, Hairong Wei, Et. Al.

Michigan Tech Publications, Part 1

Cellular functions are diversified through intricate transcription regulations, and an understanding gene regulation networks is essential to elucidating many developmental processes and environmental responses. Here, we employed the Transcriptional-Activator Like effectors (TALes), which represent a family of transcription factors that are synthesized by members of the γ-proteobacterium genus Xanthomonas and secreted to host cells for activation of targeted host genes. Through delivery by the maize pathogen, Xanthomonas vasicola pv. vasculorum, designer TALes (dTALes), which are synthetic TALes, were used to induce the expression of the maize gene glossy3 (gl3), a MYB transcription factor gene involved in the …

Mind-Body Interventions To Reduce Coronavirus Pandemic Stress And Support Long-Term Recovery, Patricia L. Gerbarg, Richard P. Brown

NYMC Faculty Publications

The COVID-19 pandemic is causing global stress, trauma and mental illness that has already outpaced current healthcare resources. Inequalities in the burden of illness, death, and economic loss are exacerbated by inequalities in the provision of mental health care. Minority populations and indigenous peoples bear the brunt of both inequities. Ancient healing systems, such as Yoga, Qigong, and tribal practices, are a rich source of group healing methods that can be studied and optimized for prevention and recovery during current and future disasters. Modern research is shedding light on a myriad of mechanisms that underly the healing properties of voluntarily …

Repurposing Of Omarigliptin As A Neuroprotective Agent Based On Docking With A2a Adenosine And Ache Receptors, Brain Glp-1 Response And Its Brain/Plasma Concentration Ratio After 28 Days Multiple Doses In Rats Using Lc-Ms/Ms, Bassam Ayoub, Haidy Michel, Shereen Mowaka, Moataz S. Hendy, Mariam M. Tadros

Pharmacy

Abstract: The authors in the current work suggested the potential repurposing of omarigliptin (OMR) for neurodegenerative diseases based on three new findings that support the preliminary finding of crossing BBB after a single dose study in the literature. The first finding is the positive results of the docking study with the crystal structures of A2A adenosine (A2AAR) and acetylcholine esterase (AChE) receptors. A2AAR is a member of non-dopaminergic GPCR superfamily receptor proteins and has essential role in regulation of glutamate and dopamine release in Parkinson’s disease while AChE plays a major role in Alzheimer’s disease as the primary enzyme responsible …

Hermansky-Pudlak Syndrome-2 Alters Mitochondrial Homeostasis In The Alveolar Epithelium Of The Lung, Karina Cuevas-Mora, Willy Roque, Hoora Shaghaghi, Bernadette R Gochuico, Ivan O Rosas, Ross Summer, Freddy Romero

Faculty, Staff and Students Publications

BACKGROUND: Mitochondrial dysfunction has emerged as an important player in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a common cause of idiopathic interstitial lung disease in adults. Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that causes a similar type of pulmonary fibrosis in younger adults, although the role of mitochondrial dysfunction in this condition is not understood.

METHODS: We performed a detailed characterization of mitochondrial structure and function in lung tissues and alveolar epithelial cells deficient in the adaptor protein complex 3 beta 1 (Ap3b1) subunit, the gene responsible for causing subtype 2 of HPS (HPS-2).

RESULTS: We …

A Concise Review Of The Multimodality Imaging Features Of Renal Cell Carcinoma, Ali Morshid, Elif S. Duran, Woongsoon J. Choi, Cihan Duran

School of Medicine Publications

The evaluation of renal cell carcinoma (RCC) is routinely performed using the multimodality imaging approach, including ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET). Ultrasonography is the most frequently used imaging modality for the initial diagnosis of renal masses. The modality of choice for the characterization of the renal mass is multiphasic CT. Recent advances in CT technology have led to its widespread use as a powerful tool for preoperative planning, reducing the need for catheter angiography for the evaluation of vascular invasion. CT is also the standard imaging modality for staging and follow-up. MRI …