Digital Commons Network^™

Patterns And Determinants Of Treatment Completion And Default Among Newly Diagnosed Multibacillary Leprosy Patients: A Retrospective Cohort Study, Veincent Christian F. Pepito, Arianna Maever L. Amit, Rae Erica D. Samontina, Sarah Jane A. Abdon, David Norman L. Fuentes, Ofelia P. Saniel

Ateneo School of Medicine and Public Health Publications

Background

Poor treatment adherence among leprosy patients contribute to relapse, development of antimicrobial resistance, and the eventual plateauing of the prevalence and incidence of leprosy not just in the Philippines, but also worldwide. For this reason, we aimed to identify the patterns and determinants affecting treatment completion and default among multibacillary leprosy patients.

Methods

We conducted a retrospective cohort study involving three large hospitals in Metro Manila, Philippines. Patients who started the World Health Organization - Multiple Drug Therapy for multibacillary leprosy between January 1, 2007 and December 31, 2013 were included in the study. Selected socio-demographic and clinical data …

Four Positive Lessons Learned During The 2020–2021 Covid-19 Global Pandemic: Implications For Spirituality In Clinical Practice, Thomas G. Plante

Psychology

While the COVID-19 global pandemic has wrecked havoc for over a year in ways that we have not seen in our lifetimes, many important positive lessons have been learned during these tumultuous and what has felt like apocalyptic times. Upon close reflection, four critical and positive lessons were learned by this author that have implications for how we productively move forward in our efforts to provide spiritually and religiously informed psychotherapy services both now and in the future. These important lessons include the benefits of telehealth and “telespirit” services as well as highlighting the advantages of reflection, discernment, and resetting …

Package Insert Conversions Using Topic-Based Writing, Emily M. Debusschere

Liberal Arts and Engineering Studies

Traditional word processing programs, at least for large companies managing controlled documents, are becoming obsolete. The next leap in the field of Technical Writing is employing Content Management Systems (CMSs). Each concept or topic created in a CMS can be referenced by multiple publications and allows for global changes.

At Cal Poly, through the Liberal Arts & Engineering Studies program, I specialized in Industrial Engineering and Technical Writing. For this senior project, I applied interdisciplinary skills to transfer four of Cepheid’s FrameMaker package inserts into an Extensible Markup Language Content Management System (XML CMS) called Vasont Inspire. The end objective …

Coronavirus Disease (Covid-19): The Value Of Chest Radiography For Patients Greater Than Age 50 Years At An Earlier Timepoint Of Symptoms Compared With Younger Patients, Mae Igi, Molly Lieux, Joe Park, Catherine Batte, Bradley Spieler

Faculty Publications

Background: A relative paucity of data exists regarding chest radiography (CXR) in diagnosis of coronavirus disease (COVID-19) compared to computed tomography. We address the use of a strict pattern of CXR findings for COVID-19 diagnosis, specifically during early onset of symptoms with respect to patient age.

Methods: We performed a retrospective study of patients under investigation for COVID-19 who presented to the emergency department during the COVID-19 outbreak of 2020 and had CXR within 1 week of symptoms. Only reverse transcription polymerase chain reaction (RT-PCR)-positive patients were included. Two board-certified radiologists, blinded to RT-PCR results, assessed 60 CXRs in consensus …

Inspire : Vol 4, Issue 6, Department Of Medicine

INSPIRE – Department of Medicine Archives

Content

• Message from the Chair
• Medicine at National and International Forums
• In-depth- feature Visiting Faculty Dr Ghazala Sadiq
• Featured Faculty: Dr. Talha Shahzad “...Be empathetic to your patients, work hard with honesty and maintain appropriate balance between your professional and family life…”
• Publications

Utilization Of Media Managerial Tools And Electronic Library In Adult Literacy Centres As A Strategy For Curbing Covid-19 Pandemic In Enugu State, Nigeria, Justina Ngozi Igwe Ph.D, Uzoamaka Ogwo Ph.D, Chinedu John. Ayolugbe

Library Philosophy and Practice (e-journal)

The study investigated the utilization of media managerial tools and electronic library in adult literacy centres as a strategy for curbing COVID-19 pandemic in Enugu State, Nigeria. Descriptive survey design was adopted for the study. The population of the study was four hundred and sixty-five (465) adult literacy facilitators in Enugu State while the sample size of 325 facilitators in Enugu State, was adopted as the respondents. The study was guided with three (3) research Questions and (1) hypothesis. The instrument for data collection was a questionnaire with 18 items titled “Utilization of media managerial tools and electronic library in …

Needles In A Haystack: How Pooling Can Control Error Rates In Noisy Tests, Arockia David Roy Kulandai, J. Stella, John Rose, Thomas Schwarz

Computer Science Faculty Research and Publications

Testing many individuals for a reasonably rare condition using imperfect, time consuming, and expensive tests can be facilitated by pooling. Pooling groups samples from different individuals that are then tested for the existence of a pathogen. An individual is diagnosed as a carrier if a threshold of the tests to which the individual contributed samples is positive. Our assumptions dictate a testing strategy that is not adaptive, with the exception of retesting positively diagnosed persons individually. Pooling is a standard proposal to stretch the supply of test kits. We show that it can also be used to control the false …

Evolutionary Generation Of Diversity In Embedded Binary Executables For Cyber Resiliency, Mitchell D. I. Hirschfeld

Theses and Dissertations

Hardening avionics systems against cyber attack is difficult and expensive. Attackers benefit from a "break one, break all" advantage due to the dominant mono-culture of automated systems. Also, undecidability of behavioral equivalence for arbitrary algorithms prevents the provable absence of undesired behaviors within the original specification. This research presents results of computational experiments using bio-inspired genetic programming to generate diverse implementations of executable software and thereby disrupt the mono-culture. Diversity is measured using the SSDeep context triggered piecewise hashing algorithm. Experiments are divided into two phases. Phase I explores the use of semantically-equivalent alterations that retain the specified behavior of …

Virus And Bacteria Inactivation Using Ultraviolet Light-Emitting Diodes, Vincent Martino, Kyra Oschsner, Paige Elyse Peters, Daniel Zitomer, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

The control of infectious diseases is a critical challenge in developing and developed nations alike. Humans can be exposed to pathogenic microorganisms such as viruses and bacteria through numerous routes of transmission, including waterborne transmission. Accordingly, effective water disinfection processes are paramount for public health protection. In this study, the inactivation efficacy of P22 virus and Escherichia coli bacteria was tested using ultraviolet light-emitting diodes (UV LEDs), which provided effective disinfection of both waterborne microorganisms. Using a peak wavelength emission of 255, 265, or 285 nm, the batch-test, UV LED collimated beam system demonstrated high inactivation potential for both microorganisms …

The Azithromycin To Prevent Wheezing Following Severe Rsv Bronchiolitis-Ii Clinical Trial: Rationale, Study Design, Methods, And Characteristics Of Study Population, Mythili Srinivasan, Leonard B Bacharier, Charles W Goss, Yanjiao Zhou, Jonathan Boomer, Sarah Bram, Dana Burgdorf, Carey-Ann Burnham, Timothy Casper, Mario Castro, Andrea Coverstone, Matthew Haslam, Watcharoot Kanchongkittiphon, Cadence Kuklinski, Qinghua Lian, Kenneth Schechtman, Gregory A Storch, Kelly True, Meghan A Wallace, Huiqing Yin-Declue, Elizabeth Ahrens, Jinli Wang, Avraham Beigelman

2020-Current year OA Pubs

Severe respiratory syncytial virus (RSV) bronchiolitis in early life is a significant risk factor for future recurrent wheeze (RW) and asthma. The goal of the Azithromycin to Prevent Wheezing following severe RSV bronchiolitis II (APW-RSV II) clinical trial is to evaluate if azithromycin treatment in infants hospitalized with RSV bronchiolitis reduces the occurrence of RW during the preschool years. The APW-RSV II clinical trial is a double-blind, placebo-controlled, parallel-group, randomized trial, including otherwise healthy participants, ages 30 days-18 months, who are hospitalized due to RSV bronchiolitis. The study includes an active randomized treatment phase with azithromycin or placebo for 2 …

A Peptide-Based Checkpoint Immunomodulator Alleviates Immune Dysfunction In Murine Polymicrobial Sepsis, Timothy W Phares, Vinayaka Kotraiah, Chun-Shiang Chung, Jacqueline Unsinger, Monty Mazer, Kenneth E. Remy, Cecille D. Browne, Peter Buontempo, Marc Mansour, James Pannucci, Alfred Ayala, Richard S. Hotchkiss, Gabriel M. Gutierrez

2020-Current year OA Pubs

Sepsis-induced immunosuppression involves both innate and adaptive immunity and is associated with the increased expression of checkpoint inhibitors, such as programmed cell-death protein 1 (PD-1). The expression of PD-1 is associated with poor outcomes in septic patients, and in models of sepsis, blocking PD-1 or its ligands with antibodies increased survival and alleviated immune suppression. While inhibitory antibodies are effective, they can lead to immune-related adverse events (irAEs), in part due to continual blockade of the PD-1 pathway, resulting in hyperactivation of the immune response. Peptide-based therapeutics are an alternative drug modality that provide a rapid pharmacokinetic profile, reducing the …

Covid-19 In Children-Not Just Little Adults., Jennifer E. Schuster, Annabelle De St Maurice

Manuscripts, Articles, Book Chapters and Other Papers

Comment on

• Underlying Medical Conditions Associated With Severe COVID-19 Illness Among Children. Kompaniyets L, Agathis NT, Nelson JM, Preston LE, Ko JY, Belay B, Pennington AF, Danielson ML, DeSisto CL, Chevinsky JR, Schieber LZ, Yusuf H, Baggs J, Mac Kenzie WR, Wong KK, Boehmer TK, Gundlapalli AV, Goodman AB.JAMA Netw Open. 2021 Jun 1;4(6):e2111182. doi: 10.1001/jamanetworkopen.2021.11182.PMID: 34097050 Free PMC article.

Augmented City, Xing Huan

Masters Theses

Racial hatred, diplomatic conflicts, financial wars, environmental destruction, Covid-19 raging. In this imperfect world that doesn't run in the way we want, we may grow numb, weary, and look for alternate realities that act as a relief from these increasingly bizarre events. And due to the current pandemic, ordinary individuals forced into isolation in a strange foreign city risk losing their psychological identity as well as their connection with the society. The city becomes a metaphor of this alienation as, in some cases, it lacks a sense of belonging by already built urban structures that disenfranchise both the individual and …

Governing By Executive Order During The Covid-19 Pandemic: Preliminary Observations Concerning The Proper Balance Between Executive Orders And More Formal Rule Making, Kelly J. Deere

Missouri Law Review

As the United States entered 2021, almost all fifty states were still operating under a state of emergency due to COVID-19 more than nine months later. Governors using emergency powers provided to them under their respective emergency disaster statutes and state constitutions continued to govern their state by executive order. These executive orders have had significant impacts on citizens’ everyday lives including stay-at-home orders, limits on non-essential gatherings, non-essential business closures and moratoriums on evictions. And these emergency orders have been opposed at almost every turn from citizens gathering in public protest shouting “Liberate Michigan,” to constitutional legal challenges to …

Exposure Characterization And Assessment Of Airborne Chemicals And Sars-Cov-2 Transmission In New York City Nail Salons, Amelia P. H. Watkins

Dissertations and Theses

Background: Currently, there are 156,000 people employed as manicurists or pedicurists in the United States. Employment in this sector is expected to grow by 10% over the next decade. Exposure assessments have revealed that salon workers are chronically exposed to a variety of substances that cause respiratory sensitization, developmental problems, contact dermatitis, blood, liver, and kidney issues, as well as nervous system impacts. Most recently, the SARS-Cov-2 pandemic has raised the issue of the vulnerability of nail salon workers to airborne infectious diseases as well. This dissertation aims to characterize and assess the chemical exposures that nail salon workers …

Disinhibition And Persistent Maladaptive Behavior, Angela T. West

Student Theses

Objective: There is an urgent need to reduce overpopulation in U.S. prisons, which are inundated with individuals needing substance use treatment. Research on both substance use and antisocial behaviors highlight maladaptive beliefs and behaviors, while also implicating disinhibition as an important factor. Disinhibition is a dynamic trait that can be targeted with therapeutic interventions. The current study explored the relationships between neurocognitive disinhibition, substance use, and recidivism among incarcerated men. The study hypothesized that disinhibition would be associated with history of substance use, history of antisocial behavior, and institutional misconduct, as well as predicting recidivism over and above history of …

Assessing Hiv Risk, Syndemics, Resilience And Engagement In Care In A Large National Cohort Of Gay, Bisexual And Other Men Who Have Sex With Men In The United States, Javier Lopez-Rios

Dissertations and Theses

Background: HIV continues to be a pervasive public health issue in the United States with more than 1.2 million people living with HIV (PLWHIV) across the nation. Gay, bisexual and other men who have sex with men (GBM) account for over two-thirds of all new HIV diagnoses with racial and ethnic minorities shouldering a large proportion of the burden of disease. Although HIV transmission is predominantly driven by sexual behaviors, there are underlying complex individual, behavioral, and structural factors that contribute to high rates of sexual behavior and subsequent HIV acquisition. Moreover, difficulties remain in maximizing linkage to care …

Nursing And Midwifery Links [June 2021 Issue], Secretariat At Johns Hopkins University School Of Nursing Global Network Of Who Collaborating Centers For Nursing And Midwifery

Nursing and Midwifery Links (LINKS)

In this June edition, all regions of the Collaborating Centers are represented with insight into the global health experience as Nurses, Midwives, Students, and Educators over the past six months. Progressive programs for better supporting the dedicated Nurse are explored. Our international colleagues are celebrated and honored; as well as mourned. In honor of those who lost their lives during the Covid Pandemic, and those who continue to forge on in the face of loss, we offer a heartfelt representation of solidarity in the form of voices from Collaborating Centers across the globe, from our community to yours.

The Utility Of An Initial Point-Of-Care Lactate In Predicting In-Hospital Mortality Among Adult Patients With Sepsis And Septic Shock At The Emergency Department Of A Tertiary Hospital In Nairobi, Gicheru B. Nyachira

Master of Medicine in Clinical Pathology

Background: Sepsis is a leading cause of death and now a global health priority. Rapid identification, diagnosis and intervention can result in reduced in-hospital mortality. Elevated lactate has been shown to be a strong predictor of in-hospital mortality. However, the optimal cut-off has not been well defined. Identification of the optimal Point-of-Care (POC) lactate cut off that best predicts in-hospital mortality can therefore be used to rapidly risk stratify patients with suspected sepsis and septic shock presenting to the emergency department allowing for immediate intervention. Objective: To determine the lactate cutoff from an initial Point-of-Care lactate result from a GEM …

The Saudi Critical Care Society Extracorporeal Life Support Chapter Guidance On Utilization Of Veno-Venous Extracorporeal Membrane Oxygenation In Adults With Acute Respiratory Distress Syndrome And Special Considerations In The Era Of Coronavirus Disease 2019, Hani N. Mufti, Ahmed A. Rabie, Alyaa M. Elhazmi, Husam A. Bahaudden, Mostafa A. Rajab, Ayed Y. Assiri, Khalid A. Maghrabi, Abdullah M. Abudayah, Adel A. Tash, Awad A. Al-Omari, Mohamed H. Azzam

Saudi Medical Journal

Extracorporeal membrane oxygenation (ECMO) is considered as a supportive treatment that provides circulatory and ventilatory support and can be thought off as a bridge to organ recovery. Since 2009, it has been applied as a rescue treatment for patients with severe adult respiratory distress syndrome (ARDS) mainly due to viral causes. In December 2019, several patients presented with a constellation of symptoms of viral pneumonia in China. A new strain of the corona virus family, called COVID-19, has been discovered to be the cause of this severe mysterious illness that was named severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). This …

Work Attitudes Of Filipino Employees During The Covid-19 Crisis, Jaimee Felice Caringal-Go, Reniel B. Tiu, Mendiola Teng-Calleja

Psychology Department Faculty Publications

The purpose of this study is to explore attitudes of Filipino employees toward work during the COVID-19 crisis. Data was collected through an online survey distributed to workers in the Philippines, and qualitative responses from 106 participants were subjected to thematic analysis. Several themes that reflect favorable and unfavorable attitudes toward job and work tasks, work arrangements, employers, as well as work-life balance, health, and sustainability emerged from the data. These themes were described using the tripartite (or affect-behavior-cognition) model of attitudes. Results of the study emphasize the importance of context in shaping employee attitudes, and suggest different ways organizations …

Covid-19 Newsletter (Vol. 74), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Social Intervention By The Numbers: Evidence Behind The Specific Public Health Guidelines In The Covid-19 Pandemic., Michael P. Savage, David L. Fischman, Mamas A. Mamas

Department of Medicine Faculty Papers

Coronavirus disease 2019 (COVID-19) has rapidly become a worldwide pandemic ushering in a global health and economic crisis. In the absence of vaccines or definitive drug therapies, current strategies against COVID-19 rely on preventing the transmission of disease through nonpharmaceutical interventions such as social distancing and proper hand hygiene. For practical and perhaps ethical reasons, the clinical efficacy of these public health measures for managing pandemics has not been demonstrated in randomized controlled clinical trials. Accordingly, guideline recommendations for using nonpharmaceutical interventions are based primarily on observational and modeling studies and on expert opinion. A recent position paper from the …

Mealtimes In Early Childhood Education Centers During Covid-19: A Mixed-Methods Assessment Of Responsibilities, Interactions, And Best Practices, Joanna Mackie

USF Tampa Graduate Theses and Dissertations

Background: Childhood obesity is a public health problem associated with many co-morbidities. The majority of young children in the United States (U.S.) attend formal early childhood education (ECE) programs, often consuming the majority of daily calories and engaging with teachers during mealtimes. Mealtime best practices support children’s development of healthy eating habits. This dissertation aimed to understand how COVID-19 has influenced mealtimes in ECE centers, including (1) the division of responsibility between adults and children during mealtimes, (2) the child feeding dynamic, and (3) how mealtime best practices have been included during COVID-19.

Methods: This dissertation used a concurrent mixed-methods …

Anti-Nmda Receptor Encephalitis, Zaid Waqar, Haris Majid Rajput, Muhammad Hassan, Iqra Athar, Neelma Naz Khattak, Mazhar Badshah

Pakistan Journal of Neurological Sciences (PJNS)

Anti N-methyl-D-aspartate receptor (NMDA)receptor encephalitis is one of the most common type of auto immune encephalitis. Its diagnosis is often delayed due to initial clinical presentation with psychiatric clinical features. Initial clinical features resemble those of acute psychosis or depression which later evolve into frank neurological dysfunction. This was first described in association with ovarian teratoma, but it was later also found to exist without neoplastic association and in men as well. It occurs more frequently in younger age group, mostly below 50 years of age. Diagnosis is established with the help of cerebrospinal fluid (CSF) analysis for oligo clonal …

Light At The End Of The Tunnel: Visitors' Virtual Reality (Versus In-Person) Attraction Site Tour-Related Behavioral Intentions During And Post-Covid-19, Omar S. Itani, Linda D. Hollebeek

Marketing Faculty Publications

Consumer behavior is changing as a result of the COVID-19 pandemic, thus compelling attraction sites to find new ways of offering safe tours to visitors. Based on protection motivation theory, we develop and test a model that examines key drivers of visitors' COVID-19-induced social distancing behavior and its effect on their intent to use virtual reality-based (vs. in-person) attraction site tours during and post-COVID-19. Our analyses demonstrate that visitor-perceived threat severity, response efficacy, and self-efficacy raise social distancing behavior. In turn, social distancing increases (decreases) visitors' intent to use virtual reality (in-person) tours during the pandemic. We find social …

Week Of June 1, 2021, New York Medical College

InTouch

• NYMC Celebrates 162nd Commencement Virtually
• Golf Tournament and Reception Set for June 28
• Rare Benjamin Rush Textbook Donated to HSL by Peter Bentivegna, M.D. '85
• NYMC Hosts Celebrating Diversity: Then and Now Event
• Twelfth COVID-19 Symposium Set for June 3
• HSL Offers Endnote 20 Training
• SHSP Students Volunteer for COVID-19 Data Collection Project

Immunological And Hematological Outcomes Following Protracted Low Dose/Low Dose Rate Ionizing Radiation And Simulated Microgravity, Amber M. Paul, Eliah G. Overbey, Willian A. Da Silveira, Nathaniel Szewczyk, Nina C. Nishiyama, Michael J. Pecaut, Sulekha Anand, Jonathan M. Galazka, Xiao Wen Mao

Publications

Using a ground-based model to simulate spaceflight [21-days of single-housed, hindlimb unloading (HLU) combined with continuous low-dose gamma irradiation (LDR, total dose of 0.04 Gy)], an in-depth survey of the immune and hematological systems of mice at 7-days post-exposure was performed. Collected blood was profiled with a hematology analyzer and spleens were analyzed by whole transcriptome shotgun sequencing (RNA-sequencing). The results revealed negligible differences in immune differentials. However, hematological system analyses of whole blood indicated large disparities in red blood cell differentials and morphology, suggestive of anemia. Murine Reactome networks indicated majority of spleen cells displayed differentially expressed genes (DEG) …

Impact Of Dietary Spirulina (Arthrospira) Platensis On Growth Performance, Gene Expression And Antioxidant Status Of Quail Challenged With Salmonella Enteritidis., Ghada Abd El-Dayem, Gehan Saleh, Reham Abd El- Elwahab

Mansoura Veterinary Medical Journal

Abstract Objective: To investigate the effect of dietary Spirulina platensis supplementation on growth performance, organ colonization, expression of inflammatory-related genes, and antioxidant status in quail challenged with Salmonella enteritidis. Design: Randomized controlled experimental study. Animals: hundred eighty-seven-day-old Japanese quail. Procedures: birds were randomly allocated into 6 equal groups. G1, G2, and G3: non challenged and fed abasal diet supplemented with Spirulina at 0, 1, and 2 g/kg diet, respectively. G4, G5, and G6: challenged and fed a basal diet supplemented with Spirulina at 0, 1, and 2 g/kg diet, respectively. At 21 days of age, all challenged groups were orally …

The Antimicrobial Effect Of Fresh Garlic And Garlic Oil Supplemented With Ground Beef, Mahmoud Mahros, Asmaa Eltanahy, Samir Abd-Elghany, Khalid Sallam

Mansoura Veterinary Medical Journal

Objective: The study was designed to investigate the antibacterial effect of fresh garlic and garlic oil against the aerobic bacteria in beef meatballs during their cold storage at 4°C. Design: Observational study Procedures: Three concentrations of fresh garlic (FG) (2%, 3%, and 5%) and garlic oil (GO) (250 mg/kg, 360 mg/kg, and 600 mg/g) were added to ground beef samples then treated meat and untreated (control) were kept in refrigeration at 4 °C for 15 days and their aerobic bacteria were determined. Results: The addition of garlic to ground beef significantly reduced (more than 3 log10 CFU/g) their aerobic bacteria …