Digital Commons Network^™

Saag Details Hiv Screening, Diagnosis And Treatment In Nejm Feature, Adam Pope

Browse All News

No abstract provided.

Minority Health Disparities In A 21st-Century Pandemic: A Comprehensive Report Of Project Research Focused On New York, University At Albany, Suny, Nys Covid-19 Minority Health Disparities Team

Publications, Issue Briefs, Reports, Etc

The COVID-19 pandemic has exacted a starkly unequal toll on New Yorkers of color – both in terms of the virus itself and the accompanying social and economic impacts of the pandemic. These are not separate issues. They stem from the structural racism embedded in American society. While our work begins by establishing a statistical baseline for how the virus’s unequal toll played out in the early months of the COVID-19 pandemic in New York, any analysis of these disparities that looks solely at hospitalizations and deaths misses a tremendous piece of this tragic and preventable story. Minority health disparities …

The Effects Of Coronavirus Victimization Distress And Coronavirus Racial Bias On Mental Health Among Aian, Asian, Black, And Latinx Young Adults, Celia B. Fisher, Xiangyu Tao, Tiffany Yip

Covid-19 Digital Research

Rationale U.S. Racial/ethnic minorities have been disproportionately impacted by the COVID-19 pandemic in rates of infection and morbidity. Pre-pandemic racial discrimination has been associated with depression and general anxiety. However, the effect of Coronavirus specific forms of discrimination on mental health have not been examined. This study assessed the effect of previously identified social determinants of mental health and COVID-19 specific victimization and racial bias beliefs on depression and anxiety among young adults of color in the U.S.

Methods A national online survey of 399 AIAN, Asian, Black, and Latinx adults (18 – 25 years) included demographic variables, COVID-19 health …

Development Of A Human Health-Centered Climate Resilience/Vulnerability Framework For The Mexico City Region, Alex Stever

Sustainability and Social Justice

With climate change impacting every corner of the globe, the health and well-being of all humans is threatened, especially in heavily populated areas such as the Mexico City Region (MCR). With this threat continuously growing it is important to not only be aware of the problem and its complications but have a framework and process that will allow for rapid and well-rounded analyses of how at risk the residents of certain areas are to the threats of climate change. However, with analyzing the impacts of climate change on any sector, including human health and well-being, three conundrums arise: the socio-ecological …

Correlation Between Reported Dengue Illness History And Seropositivity In Rural Thailand, Darunee Buddhari, Kathryn B. Anderson, Gregory D. Gromowski, Richard G. Jarman, Sopon Iamsirithaworn, Butsaya Thaisomboonsuk, Taweewun Hunsawong, Anon Srikiatkhachorn, Alan L. Rothman, Anthony R. Jones, Stefan Fernandez, Stephen J. Thomas, Timothy P. Endy

Cell and Molecular Biology Faculty Publications

In the latest World Health Organization (WHO) recommendation for Dengvaxia implementation, either serological testing or a person’s history of prior dengue illness may be used as supporting evidence to identify dengue virus (DENV)-immune individuals eligible for vaccination, in areas with limited capacity for laboratory confirmation. This analysis aimed to estimate the concordance between self-reported dengue illness histories and seropositivity in a prospective cohort study for dengue virus infection in Kamphaeng Phet province, a dengue-endemic area in northern Thailand. The study enrolled 2,076 subjects from 516 multigenerational families, with a median age of 30.6 years (range 0–90 years). Individual and family …

Discrete Dynamics And Epidemiological Multi-Physics Models For Transportation Applications, Sirish Namilae, Dahai Liu

Center for Advanced Transportation Mobility

Air transportation is central to the global mobility of goods and people. Elimination or reduction of air travel during epidemic emergencies, such as during the 2014 Ebola outbreak in West Africa, carry considerable economic and human costs. This has come to the fore in the current COVID-19 crisis. Air travel has been identified as a leading factor in the spread of several epidemic diseases including influenza, SARS, as well as COVID-19. Mathematical modeling can play a crucial role in understanding this problem and devising strategies to mitigate emergency transportation disruptions. There is a strong correlation between contact rates and infection …

Reflecting On The Now: Race, Gender, Socio-Economic Status And Covid-19, Ariana Montemayor, Sydney M. Scanlon

VA Engage Journal

Early in 2020, we began a project for our Women and Technology class at Old Dominion University to highlight women working in health sciences. However, our original project idea drastically changed with the onset of the COVID-19 pandemic. COVID-19 focused our attention on issues regarding societal inequalities and health disparities. Therefore, we decided to create a new project that emphasized the societal inequalities and the disproportionate impact COVID had on People of Color, women and low-income individuals. In this paper, we critically reflect on the journey of our project from conception to completion, as well as how we, and the …

The Discrete-Event Modeling Of Administrative Claims (Demac) System: Dynamically Modeling The U.S. Healthcare Delivery System With Medicare Claims Data To Improve End-Of-Life Care, Rachael Chacko

Dartmouth College Undergraduate Theses

The shift of the U.S. healthcare delivery system from the treatment of acute conditions to chronic diseases requires a new method of healthcare system analysis to properly assess end- of-life (EOL) quality throughout the country. In this paper, we propose the Discrete-Event Modeling of Administrative Claims (DEMAC) system, which relies on a hetero-functional graph theory and discrete event-driven framework to dynamically model EOL care on multiple levels. The heat map visualizations produced by the DEMAC system enable the elucidation of not only patient-specific EOL care but also broader treatment patterns among providers and hospitals. As a whole, the DEMAC system …

2021-06-01_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Prevalence And Clinical Presentation Of Skin Affections In Donkey (Equus Asinus) In Egypt, Mohamed Sayed-Ahmed, Ahmed Ahdy, Emad Younis, Sabry El-Khodery

Mansoura Veterinary Medical Journal

Objective: To document prevalence and clinical presentation of skin diseases in donkeys as well as to investigate predilections for the most common conditions. Design: Epidemiological study Animals: A total of 1134 donkeys at northern Egypt were investigated. Procedures: A questionnaire was constructed to verify the number of infected contact animals as well as the associated factors. Physical examination was carried out and the distribution of skin lesions was recorded. Skin scraping and biopsy were obtained to perform bacteriological, mycological and histopathological examinations. Results: Thirty-five (3.09%) Out of 1134 noticed donkeys had skin affections including mange (18/35; 51.42%), dermatophytosis (6/35; 17.14%), …

Global Stability Of Generalized Within-Host Chikungunya Virus Dynamics Models, Taofeek O. Alade, Afeez Abidemi, Cemil Tunç, Shafeek A. Ghaleb

Applications and Applied Mathematics: An International Journal (AAM)

This paper proposes two models of a general nonlinear within-host Chikungunya virus (CHIKV) dynamics. The production, incidence, proliferation and removal rates of all compartments are modeled by general nonlinear functions that satisfy a set of reasonable conditions. The second model takes into consideration two forms of infected host cells: (i) latently infected cells which do not produce the CHIKV, (ii) actively infected cells which generate the CHIKV particles. We show that all the solutions of the models are nonnegative and bounded. The global stability of the steady states of the models is proven by applying Lyapunov method and LaSalle’s invariance …

Getting Back On Track With Cancer Prevention And Adolescent Immunizations, Sharon Humiston

Presentations

Objectives:

1.Explain why HPV vaccine is important enough to be routinely recommended for young people (i.e., HPV cancer prevention).

2. Give an HPV vaccination recommendation that is effective and succinct using the same way, same day approach to the introduction of HPV vaccine.

3. Answer the most frequently asked questions about HPV vaccine accurately and succinctly.

Catch And Contain Novel Pathogens Early!—Assessing U.S. Medical Isolation Laws As Applied To A Future Pandemic Detection And Prevention Model, April Xiaoyi Xu

University of Michigan Journal of Law Reform Caveat

As of July 2, 2021, there have been 196,553,009 confirmed cases of the Coronavirus Disease (COVID-19), including 4,200,412 deaths, globally. Unfortunately, infectious diseases have been an “unavoidable fact of life” throughout history. While the global community looks forward to a gradual return to normalcy from COVID-19 with an increasing number of individuals getting vaccinated on a daily basis, the COVID-19 public health crisis has exposed significant inadequacies in many countries’ pandemic responses—the United States included. Governing authorities must actively consider more effective solutions to quickly detect and prevent the spread of future pandemics.

One proposed model that offers promising potential, …

Numerical Technique For Solving Fractional-Order Of Ivgtt Glucose-Insulin Interaction, M. A. Abdelkawy

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we use a numerical technique to solve fractional nonlinear differential equations systems that arise in Bergman’s minimal model that describe blood glucose and insulin metabolism, after intravenous tolerance testing. Shifted Jacobi -Gauss-Radau collocation (SJ-GR-C) method is developed for approximating the proposed model. The principal target in our technique is to transform the proposed model to a system of algebraic equations. Finally, numerical simulation is introduced to illustrate the analytical results.

Promise And Complexity Of Lupus Mouse Models, Erica Moore, Joshua A. Reynolds, Anne Davidson, Stefania Gallucci, Laurence Morel, Deepak A. Rao, Howard A. Young, Chaim Putterman

United States Public Health Resources

As a follow up to a 2010 meeting deliberating on the benefits of studying mouse models of systemic lupus erythematosus (SLE), the virtual conference “Mouse models of lupus 10 years later” convened on 10 December 2020 to address a challenging decade that saw few new therapies approved, despite leaps in knowledge

Abnormalities in both innate and adaptive immunity characterize SLE, a systemic autoimmune disease with potentially severe consequences in patients. Treatment has traditionally been limited to broad-acting, side-effect-heavy immunosuppressants, which are also incompletely effective. Thus, the need for specific therapies targeting the pathogenic mechanisms of SLE remains unmet. Affirming the …

Clinical Presentations Associated With Adverse Outcomes Among Patients Admitted With Dengue At A Tertiary Hospital In Dar Es Salaam., Nakiganda John Mkasa

Master of Medicine in Family Medicine

Introduction Dengue is one of the most important mosquito viral borne infections caused by four viral serotypes (DENV 1-4). In 2019 WHO named dengue as among the top ten global threats due to an increase in the number of cases worldwide. Tanzania is among the countries in Africa with multiple outbreaks; 2010, 2013-2014, and 2019. Dengue has variable clinical presentations ranging from nonspecific such as fever, joint pain, and fatigue to more serious such as hemorrhage and shock. Dengue can result in adverse outcomes such as ICU admissions and prolonged hospital stays. Clinical presentations associated with adverse outcomes have been …

Is Climate Change A Threat To International Peace And Security?, Mark Nevitt

Michigan Journal of International Law

The climate-security century is here. Both the United Nations Intergovernmental Panel on Climate Change (“IPCC”) and the U.S. Fourth National Climate Assessment (“NCA”) recently sounded the alarm on climate change’s “super-wicked” and destabilizing security impacts. Scientists and security professionals alike reaffirm what we are witnessing with our own eyes: The earth is warming at a rapid rate; climate change affects international peace and security in complex ways; and the window for international climate action is slamming shut.

Contract As Emergency Law, Xuan-Thao Nguyen

Washington International Law Journal

This Article offers a new perspective of contract law as emergency law. Doctrines of impossibility, supervening events, force majeure, and good faith performance are core principles resiliently allowing parties to address contract nonperformance under state of emergency crises. Comparatively, China prefers drastic measures to confront contract nonperformance problems by issuing Certificates of Force Majeure, permitting Chinese companies to escape contract liability and forfeiting the resiliency of contract law as emergency law. The Article argues that the pandemic reaffirms the role of contract law as emergency law and urges governments to solidify the freedom to contract.

Environmental Law Disrupted By Covid-19, Katrina Fischer Kuh, Lissa Griffin, Rebecca Bratspies, Vanessa Casado Perez, Robin Kundis Craig, Keith Hirokawa, Sarah Krakoff, Jessica Owley, Melissa Powers, Shannon Roesler, Jonathan Rosenbloom, J.B. Ruhl, Erin Ryan, David Takacs

Elisabeth Haub School of Law Faculty Publications

For over a year, the COVID-19 pandemic and concerns about systemic racial injustice have highlighted the conflicts and opportunities currently faced by environmental law. Scientists uniformly predict that environmental degradation, notably climate change, will cause a rise in diseases, disproportionate suffering among communities already facing discrimination, and significant economic losses. In this Article, members of the Environmental Law Collaborative examine the legal system’s responses to these crises, with the goal of framing opportunities to reimagine environmental law. The Article is excerpted from their book Environmental Law, Disrupted, to be published by ELI Press later this year.

Serological Survey Of Leptospira Infection In Arabian Horses In Poland, Bernard Wasiński, Katarzyna Paschalis-Trela, Jan Trela, Michał Czopowicz, Jerzy Kita, Monika Żychska, Anna Cywińska, Iwona Markowska-Daniel, Craig N. Carter, Lucjan Witkowski

Veterinary Diagnostic Laboratory Faculty Publications

Leptospirosis is one of the most common zoonotic infections worldwide, including in most livestock, some companion animals, horses, wildlife, and humans. Epidemiological estimation of its prevalence in all species is difficult due to the variety of clinical presentations and challenges regarding laboratory diagnosis. The purpose of this study was to measure the seroprevalence of leptospiral infection in Arabian horses kept in the largest breeding farms in Poland, representing over 15% of the Polish Arabian horse population. Leptospira antibodies were detected by MAT (cut-off 1:100) in 33.2% of serum samples (204 of 615 animals) (CI 95%: 29.6–37.0%), most frequently reacting with …

2021-June-01-Etsu's Yaomoorman Group Publishes First Covid-19 Paper, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (June 1, 2021)  – A group of East Tennessee State University scientists recently published their first COVID-19 related paper emerging from funding awarded to Dr. Zhi Q. Yao by the American Diabetes Association (ADA).

The paper, titled “Blockage of SARS-CoV-2 spike protein-mediated cell–cell fusion using COVID-19 convalescent plasma,” was recently published in Scientific Reports. The funding Yao received from the ADA in 2020 was the university’s first major funding for COVID-19-specific research.

The ongoing COVID-19 pandemic remains a serious threat to global public health. In an effort to treat individuals suffering from severe COVID illness, …

Oral History Of Tom Jenkin, Unlv Gaming Law Journal, University Of Nevada, Las Vegas -- William S. Boyd School Of Law

UNLV Gaming Law Journal

No abstract provided.

I Just Can't Get You Out Of My Head : Frenetic Vortex, Animal As Image - Field Notes (1989-2021), Steffanie A. Padilla

Masters Theses

This essay is an attempt to describe a hypnosis induced by media through the accumulation of images in everyday life starting the day I was born. Raised by television and the internet, I go through a chronological timeline of my life selecting banal memories to showcase how violence to animals became neutralized/rendered invisible. The work is primarily concerned with mental health while focused on the youth, ecological destruction, and how sensory overload keeps us from knowing ourselves. The motivation of this paper is to better understand how our environment shapes our reality by using a psychological, media theory, and cognitive …

Identification And Localization Of Nf-Κb During The Embryonic Development Of The Schistosome-Transmitting Snail Biomphalaria Glabrata, Amanda Karin Marsh

Lawrence University Honors Projects

The freshwater snail Biomphalaria glabrata is best known as the intermediate host to Schistosoma mansoni, a parasitic worm that causes the neglected tropical disease schistosomiasis. Because of its role as a host to a parasite, the snail can be used as a model organism to study conserved, immune-related pathways and proteins that may be involved in defense of parasite infection. One complex of proteins under investigation isnuclear factor kappa-light-chain-enhancer (NF-kB), an evolutionarily conserved family of transcription factors that are primarily known for their function in vertebrate immunity and, more recently, processes related to the nervous system. While NF-kBhas been identified …

Cervical Cancer Screening Outcomes In Zambia, 2010-19: A Cohort Study, Jake M Pry, Albert Manasyan, Sharon Kapambwe, Katayoun Taghavi, Miquel Duran-Frigola, Mulindi Mwanahamuntu, Izukanji Sikazwe, Jane Matambo, Jack Mubita, Kennedy Lishimpi, Kennedy Malama, Carolyn Bolton Moore

Open Access Publications

BACKGROUND: Globally, cervical cancer is the fourth leading cause of cancer-related death among women. Poor uptake of screening services contributes to the high mortality. We aimed to examine screening frequency, predictors of screening results, and patterns of sensitisation strategies by age group in a large, programmatic cohort.

METHODS: We did a cohort study including 11 government health facilities in Lusaka, Zambia, in which we reviewed routine programmatic data collected through the Cervical Cancer Prevention Program in Zambia (CCPPZ). Participants who underwent cervical cancer screening in one of the participating study sites were considered for study inclusion if they had a …

Epidemic Preparedness: Prenatal Zika Virus Screening During The Next Epidemic, Luxi Qiao, Celina M Turchi Martelli, Amber I Raja, Nuria Sanchez Clemente, Thalia Velho Barreto De Araùjo, Ricardo Arraes De Alencar Ximenes, Demócrito De Barros Miranda-Filho, Anna Ramond, Elizabeth B Brickley

Open Access Publications

Zika virus (ZIKV) is a vectorborne infectious agent of global public health significance due to its potential to cause severe teratogenic outcomes. The question of whether health systems should consider adopting screening programmes for ZIKV infections during pregnancy warrants consideration. In this analysis, we apply the Wilson-Jungner framework to appraise the potential utility of a prenatal ZIKV screening programme, outline potential screening strategies within the case-finding pathway, and consider other epidemiological factors that may influence the planning of such a screening programme. Our evaluation of a potential prenatal ZIKV screening programme highlights factors affirming its usefulness, including the importance of …

Longitudinal Data Reveal Strong Genetic And Weak Non-Genetic Components Of Ethnicity-Dependent Blood Dna Methylation Levels, Chris Mckennan, Katherine Naughton, Catherine Stanhope, Meyer Kattan, George T O'Connor, Megan T Sandel, Cynthia M Visness, Robert A Wood, Leonard B Bacharier, Avraham Beigelman, Stephanie Lovinsky-Desir, Alkis Togias, James E Gern, Dan Nicolae, Carole Ober

Open Access Publications

Epigenetic architecture is influenced by genetic and environmental factors, but little is known about their relative contributions or longitudinal dynamics. Here, we studied DNA methylation (DNAm) at over 750,000 CpG sites in mononuclear blood cells collected at birth and age 7 from 196 children of primarily self-reported Black and Hispanic ethnicities to study race-associated DNAm patterns. We developed a novel Bayesian method for high-dimensional longitudinal data and showed that race-associated DNAm patterns at birth and age 7 are nearly identical. Additionally, we estimated that up to 51% of all self-reported race-associated CpGs had race-dependent DNAm levels that were mediated through …

Herc5 And The Isgylation Pathway: Critical Modulators Of The Antiviral Immune Response, Nicholas A. Mathieu, Ermela Paparisto, Stephen D. Barr, Donald E. Spratt

Chemistry

Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 15.2 kDa tandem ubiquitin-like protein (UBL) that is used by specific E1–E2–E3 ubiquitin cascade enzymes to interfere with the activity of viral proteins. Recent biochemical studies have demonstrated how the E3 ligase HECT and RCC1-containing protein 5 (HERC5) regulates ISG15 signaling in response to hepatitis C (HCV), influenza-A (IAV), human immunodeficiency virus (HIV), SARS-CoV-2 and other viral infections. Taken together, the potent antiviral activity displayed by HERC5 and ISG15 make them promising drug targets for the development …

Modeling Covid-19 Spread Using An Agent-Based Network, Stephen Yh Hung

Master's Theses

Beginning in 2019 and quickly spreading internationally, the Coronavirus disease Covid-19 became the first pandemic that many people have witnessed firsthand along with the severe disruption to their daily lives. A key field of research for Covid-19 that is studied by epidemiologists, biologists, and computer scientists alike is modeling the spread of Covid-19 in order to better predict future outbreaks of the pandemic and evaluate potential strategies to reduce infections, hospitalizations, and deaths.

This thesis proposes a method of modeling Covid-19 spread and interventions for local environments based on different levels of perspective. The goal for this thesis is to …

The Impact Of Climate Change On Virginia's Coastal Areas, Jonathan L. Goodall, Antonio Elias, Elizabeth Andrews, Christopher "Kit" Chope, John Cosgrove, Jason El Koubi, Jennifer Irish, Lewis L. Lawrence Iii, Robert W. Lazaro Jr., William H. Leighty, Mark W. Luckenbach, Elise Miller-Hooks, Ann C. Phillips, Henry Pollard V, Emily Steinhilber, Charles Feigenoff, Jennifer Sayegh

Faculty Publications

As part of HJ47/SJ47 (2020), the Virginia General Assembly directed the Joint Commission on Technology and Science (JCOTS) to study the “safety, quality of life, and economic consequences of weather and climate-related events on coastal areas in Virginia.” In pursuit of this goal, the commission was to “accept any scientific and technical assistance provided by the nonpartisan, volunteer Virginia Academy of Science, Engineering, and Medicine (VASEM). VASEM convened an expert study board with representation from the Office of the Governor, planning district commissions in coastal Virginia, The Port of Virginia, the Virginia Economic Development Partnership, state universities, private industry, and …