Digital Commons Network^™

Public Health Surveillance In The Context Of Covid-19, Jennifer D. Oliva

Faculty Scholarship

No abstract provided.

Clinical Activity Of Fianlimab (Regn3767), A Human Anti-Lag-3 Monoclonal Antibody, Combined With Cemiplimab (Anti-Pd-1) In Patients (Pts) With Advanced Melanoma, Guilherme Rabinowits

All Publications

No abstract provided.

Phase 1 Trial Of Alrn-6924, A Dual Inhibitor Of Mdmx And Mdm2, In Patients With Solid Tumors And Lymphomas Bearing Wild-Type Tp53, Guilherme Rabinowits

All Publications

Abstract

Purpose: We describe the first-in-human dose-escalation trial for ALRN-6924, a stabilized, cell-permeating peptide that disrupts p53 inhibition by MDM2 and MDMX to induce cell cycle arrest or apoptosis in TP53 wild-type tumors.

Methods: Two schedules were evaluated for safety, pharmacokinetics, pharmacodynamics, and anti-tumor effects in patients with solid tumors or lymphomas: In arm A, patients received ALRN-6924 by intravenous infusion once-weekly for 3 weeks every 28 days; arm B, was twice-weekly for 2 weeks every 21 days.

Results: Seventy-one patients were enrolled: 41 in arm A (0.16-4.4 mg/kg), 30 in arm B (0.32-2.7 mg/kg). ALRN-6924 showed dose-dependent pharmacokinetics and …

Occupational Exposure To Antineoplastic Drugs: What About Hospital Sanitation Personnel?, France Labrèche, Capucine Ouellet, Brigitte Roberge, Nicolas J Caron, Ahmed Yennek, Jean-François Bussières

Études primaires

Objective

Occupational exposure to antineoplastic drugs (ANPs) occurs mainly through dermal contact. Our study was set up to assess the potential exposure of hospital sanitation (HS) personnel, for whom almost no data are available, through contamination of surfaces they regularly touch.

Methods

In the oncology departments of two hospitals around Montreal, surface wipe samples of 120–2000 cm² were taken at 10 sites cleaned by the HS personnel and five other sites frequently touched by nursing and pharmacy personnel. A few hand wipe samples were collected to explore skin contamination. Wipes were analyzed by ultra-performance liquid chromatography tandem–mass spectrometry for …

Leakage Versus Material Filtration In Barrier Facemask Efficiency, Ali Bahloul, Clothilde Brochot, Barbara Layne

Études primaires

The World Health Association and many governmental agencies recommend the wearing of facemasks by the general public to prevent the spread of COVID-19. It is believed that masks can significantly protect others and may offer some protection to the wearer. Although there are standards for FFRs, surgical masks, and recently for barrier face coverings, they all indicate the level of protection for the wearer. However, testing facial masks not at the point of inhalation, but at the source, the exhale, offers a new perspective on how to impede particle emissions. In this paper, the experimental results show that, although the …

On The Removal Of The Open Earcanal High-Pass Filter Effect Due To Its Occlusion: A Bone-Conduction Occlusion Effect Theory, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced by in-ear device wearers as an increased loudness sensation of bone-conducted low frequency sounds. A widespread theory proposed by Tonndorf and based on a simplified electro-acoustic model describes the phenomenon as the removal of the open earcanal high-pass filter effect due to a perfect or partial occlusion. However, this filter has not been clearly defined and several ambiguities remain. Revisiting the model, a second order high-pass filter effect for the volume velocity transferred between the earcanal wall and the eardrum is highlighted. This filter remains for partial occlusion but vanishes for perfect occlusion. In …

Role And Responsibilities Of Supervisors In The Sustainable Return To Work Of Workers Following A Work-Related Musculoskeletal Disorder, Iuliana Nastasia, Marie-France Coutu, Romain Rives, Jessica Dubé, Sarah Gaspard, Audrey Quilicot

Études primaires

Purpose Supervisors play an important role during the return to work (RTW) of injured workers. Yet little research has been done on the actions associated with this role or the contexts in which they are taken. The purpose of this study was to develop courses of action to promote supervisors’ involvement in the process aimed at achieving sustainable RTW for workers following a work-related musculoskeletal disorder (MSD), and to verify their pertinence, feasibility, and applicability in practice. Methods A two-phase qualitative method was used. (1) Secondary content analysis of 46 interviews of 14 workers post-MSD and 32 other actors in …

Principle Of An Acoustical Method For Estimating The Centroid Position Of The Earcanal Wall Normal Velocity Induced By Bone-Conducted Stimulation: Numerical Evaluation, Kevin Carillo, Olivier Doutres, Franck Sgard

Études primaires

The occlusion effect is commonly experienced as the altered perception of one’s own physiological noise when the earcanal entrance is blocked. Objectively, this phenomenon corresponds to an acoustic pressure increase in the occluded earcanal. The occlusion effect originates from the earcanal wall normal vibration and depends on the spatial distribution of the latter. At low frequencies, this spatial distribution can be characterized by the position of its centroid along the earcanal middle axis. This paper describes the principle of an acoustical method for estimating this centroid position at low frequencies. The proposed method consists in measuring the eardrum acoustic pressure …

The Effect Of Extensible And Non-Extensible Lumbosacral Orthoses On Anticipatory Postural Adjustments In Participants With Low Back Pain And Healthy Controls, Christian Larivière, Richard Preuss

Études primaires

Background

Wearing a lumbosacral orthosis (LSO) is known to influence spine mechanics, but less is known about how LSOs affect motor control. Whether the use of a LSO can negatively affect motor control of the lumbar spine is still under debate.

Objective

The current study examined the immediate effects of two flexible LSOs (extensible and non-extensible) on the anticipatory postural adjustments that prepare the spine for a predictable perturbation.

Design

A comparative study using a repeated measures design in a laboratory setting.

Methods

Healthy controls (n = 20) and participants with low back pain (n = 40) performed a rapid …

Structural Remodeling Of The Lumbar Multifidus, Thoracolumbar Fascia And Lateral Abdominal Wall Perimuscular Connective Tissues: A Search For Its Potential Determinants, Christian Larivière, Sharon M. Henry, Richard Preuss

Études primaires

Recently remodeling of lumbar soft tissues has received increased research attention. However, the major determinants that influence remodeling need to be elucidated in order to understand the impact of different rehabilitation modalities on tissue remodeling. The main aim of this study was to explore the between-subject variance of different measures of lumbar soft tissues quantified with rehabilitative ultrasound imaging (RUSI). RUSI measures (n = 8) were collected from 30 subjects without and 34 patients with LBP: (1) lumbar multifidus (LM) echogenicity (fatty infiltration/fibrosis) at three vertebral levels (L3/L4, L4/L5 and L5/S1) (n = 3); (2) posterior layer thickness …

Structural Remodeling Of The Lumbar Multifidus, Thoracolumbar Fascia And Lateral Abdominal Wall Perimuscular Connective Tissues: Medium-Term Test-Retest Reliability Of Ultrasound Measures, Christian Larivière, Dany H. Gagnon, Richard Preuss

Études primaires

Abstract

Introduction

Growing interest is being paid to the lumbar multifidus (LM) intramuscular fatty infiltrations and fibrosis that are secondary to low back pain as well to the remodeling of perimuscular connective tissues (fasciae) such as the thoracolumbar fascia and fascia sheets separating the abdominalwall muscles. Magnetic resonanceimaging and computed tomography have traditionally been used but rehabilitative ultrasound imaging (RUSI) is much more affordable and practical, which can accelerate research and clinical applications on this topic. The aim of this study was to test the medium-term (8 weeks) test-retest reliability of the corresponding RUSI measures.

Methods

Thirty-four participants …

New Hampshire Baseline Needs Assessment: Covid-19 Impact On Substance Use And Treatment, Center On Rural Addiction, University Of Vermont, Nh Citizens Health Initiative

All Materials

No abstract provided.

Cost And Utilization Of Treatment For Diabetes In New Hampshire: Analysis Of Medical And Pharmacy All-Payer Claims Data, Erica-Lyn Plante, Amy Costello, Josephine B. Porter, H. Chris White

All Materials

No abstract provided.

Combined Influence Of Transfer Distance, Pace, Handled Mass And Box Height On Spine Loading And Posture, Xavier Robert-Lachaine, Philippe Corbeil, Antoine Muller, Jasmin Vallée-Marcotte, Hakim Mecheri, Denys Denis, André Plamondon

Études primaires

Work-related low back disorders are commonly associated with handling tasks. The objective of this study was to determine the combined influence of distance, pace, handled mass and height, on back loading and posture during free box transfer. Kinematics and kinetics of 17 handlers were recorded during a box transfer task between two pallets. Four-way repeated measures ANOVA were conducted on four lift-deposit height conditions (from lift and deposit of 0.16 or 1.16 m), three distances between pallets (1.5, 1.0 and 0.5 m), two handled masses (10 and 20 kg) and two paces (free and faster). The interaction between distance and …

New Hampshire Baseline Needs Assessment: Practitioner Comfort Treating Substance Use Disorder, Center On Rural Addiction, University Of Vermont, Nh Citizens Health Initiative

All Materials

This data brief focuses on practitioners’ responses regarding their comfort treating patients with opioid use disorder (OUD) and other SUDs

Set It In Stone: Investing In 21st Century Broadband In New Hampshire To Secure Telehealth For All Residents, Institute For Health Policy And Practice (Ihpp), New Hampshire Telehealth Alliance, Deborah H. Fournier

All Materials

No abstract provided.

Celebrity Avatars:A Technical Approach To Creating Digital Avatars For Social Marketing Strategies, Ledis Molina

Electronic Theses and Dissertations 2020 - Present

Avatars are growing in popularity and presented in many computer-mediated communication environments like social media, virtual 3D worlds, and augmented reality applications. With its incredible success in the Asian market, followed by the latest rapid increase in popularity for digital avatars in the Western market, it is necessary to look at the avatars' roots and their newfound use as celebrities. Virtual celebrities or influencers are digital characters consumed in digital mediums, with a given personality, background story, and the first-person point of view of the world, accessible to different social media platforms. These virtual celebrities are now being used for …

Essays On Managerial Opportunism, Pension De-Risking, And Corporate Investment Policies, Brian Silverstein

Electronic Theses and Dissertations 2020 - Present

In the first essay, I examine how managerial opportunism affects corporate investment efficiency and, ultimately, firm performance. Prior research establishes corporate investment efficiency as a function of the firm’s information environment and internal governance. To measure managerial opportunism, I use an ex-ante firm level measure of managerial opportunism based on insider trading patterns and test its effects on investment efficiency and performance. Extant research associates opportunistic insider trading with opaque information environments about the firm and weak firm governance, making it an apropos proxy for opportunistic managerial behavior. Despite the clear establishment of opportunistic insider trading as an agency problem …

Food Web Modeling To Assess Interactions Between Artificial Reefs And Natural Reefs, Elizabeth A. Mcnamee

Electronic Theses and Dissertations 2020 - Present

The effect of artificial reefs on natural reefs is poorly understood. This study focused on Aquarius Reef Base (ARB), an underwater habitat offshore of Key Largo, Florida, and 14 natural reef sites spanning 4 habitats, on the surrounding Conch Reef. Food web models were created for ARB and natural reef habitats. Biomass at each habitat was quantified by fish surveys. Using Ecopath, species were organized into functional groups with supporting data from previous research for other inputs. ARB’s food web was found to have a large predator biomass with insufficient prey biomass to sustain the population, suggesting that these predators …

Monitoring Wading Bird Colonies Using Acoustic Sampling And Regional Shifts In Wading Bird Nest Abundances In A Pulsed Wetland System, Rachel C. Larson

Electronic Theses and Dissertations 2020 - Present

Wetland loss and degradation have led to the development of restoration programs worldwide, many of which monitor wading bird populations as indicators of wetland quality. Therefore, efficient, standardized monitoring is integral to restoration progress. I tested the use of passive acoustic monitoring to estimate nest abundances and provisioning rates in wading bird colonies and examined regional nesting dynamics in the Florida Everglades, where a long monitoring record enables analysis of nesting patterns relative to hydrologic changes. I found that call rates can serve as indices of colony nest abundances and begging call rate and timing are indicative of provisioning events. …

Photoreceptor Degeneration And Abnormal Retinal Vasculogenesis, Matthew Nguyen

Electronic Theses and Dissertations 2020 - Present

Abnormal vasculature in the retina, specifically tortuous blood vessels, are common to many of the most prevalent retinal degenerative diseases currently affecting millions across the world. The mechanisms of their formation and development in the context of retinal degenerative disease, however, are still poorly understood. The rd1 and rd10 mice are relatively well-studied animal models of retinal degenerative disease, however, there lacks a systematic characterization of vascular changes co-related to photoreceptor degeneration in the rd1 and rd10 retina. Here, we utilize advancements in confocal microscopy, immunohistochemistry, and image analysis software in order to systematically characterize vascular changes before and after …

Confirmation Of New Crapemyrtle Bark Scale (Acanthococcus Lagerstroemiae) Hosts (Spiraea And Callicarpa) Through Dna Barcoding, Allen Szalanski

Entomology and Plant Pathology Faculty Publications and Presentations

Crapemyrtle bark scale (CMBS; Acanthococcus lagerstroemiae Kuwana) is an invasive insect that was first discovered in the United States in 2004. The polyphagous feeding habit of CMBS has allowed it to infest a wide range of plant species beyond its primary host, Lagerstroemia. Using molecular approaches, we studied the genetic relationships between CMBS specimens and their hosts from different geographic locations. Naturally occurring CMBS infestations were confirmed on American beautyberry (Callicarpa americana L.), a native plant species in the United States, and spirea (Spiraea L.). The new infestation of CMBS found on Spiraea raises the alarm that other economically important …

Isolation Of Metarhizium Guizhouense And Metarhizium Robertsii Strains From Soil-Exposed Amblyomma Americanum (Acarina: Ixodidae) From Northwest Arkansas, Usa, Allen Szalanski

Entomology and Plant Pathology Faculty Publications and Presentations

The lone star tick, Amblyomma americanum (L.) (Acarina: Ixodidae), is the most abundant tick species found in Arkansas and is involved in the trans-mission of pathogens of medical and veterinary importance. When not feeding, most non-nidicolous tick species shelter in the soil and leaf litter where they may be exposed to and potentially infected with entomopathogenic fungi that reside naturally in the soil. Entomopathogenic fungi in the genus Metarhizium Sorokīn (Hypocreales: Clavicipitaceae) have shown promise as biological control agents of ticks. Here, the first study to isolate and identify Arkansas-derived isolates of Metarhizium from A. americanum ticks is presented. We …

Nh's Workforce: The Youth Retention Initiative Key Findings, Molly Donovan

UNH Cooperative Extension

No abstract provided.

New Hampshire Center For Freshwater Biology And Lakes Lay Monitoring Program Programmatic Qapp 2021, Robert Craycraft, Jeffrey A. Schloss

UNH Cooperative Extension

No abstract provided.

North River Lake 2021 Water Quality Full Annual Report, Amanda Mcquaid, Robert Craycraft

UNH Cooperative Extension

A Water Quality Report by UNH CE Lakes Lay Monitoring Program for North River Lake.

Belleau Lake 2021 Water Quality Highlight Report, Amanda Mcquaid, Robert Craycraft

UNH Cooperative Extension

A Water Quality Highlight Report by UNH CE Lakes Lay Monitoring Program for Belleau Lake in Wakefield, NH for 2021.

It Can’T Be A Farce: Teachers’ Perceptions Of Restorative Practices In An Urban Charter School, Ali Yehia Bazzi

Master's Theses and Doctoral Dissertations

The purpose of this research was to understand teacher perceptions of restorative practices in an urban charter school. This study sought to illustrate how teachers conceptualize restorative practices and use it in their classrooms. This research study utilized a single-case study design. The study examined teacher perceptions of restorative practices through the lenses of five urban charter school teachers. The findings suggest that restorative practices have shown promising results in terms of building a collaborative school culture that embraces staff and students for who they are, helps build lasting relationships between students and teachers, and above all, encourages a more …

The Appalachian Medical Student Experience: A Case Study, Jason Scott Hedrick

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Appalachian region is a rural swath of mountainous terrain home to a historically distinct culture. The region’s population suffers from a multitude of health issues and disparities. Notably, the region also experiences a major healthcare provider shortage despite the fact that states, like West Virginia, produce per capita, a high volume of physicians. Appalachia, and particularly West Virginia, also suffers from a number of educational disparities, which culminates into low numbers of college graduates within the population. There is a plethora of research that has explored the first-generation college student, students from rural and Appalachian backgrounds, first-generation and rural …

Interoperability Of Contact And Contactless Fingerprints Across Multiple Fingerprint Sensors, Brady M. Williams

Graduate Theses, Dissertations, and Problem Reports (ETD)

Contactless fingerprinting devices have grown in popularity in recent years due to speed and convenience of capture. Also, due to the global COID-19 pandemic, the need for safe and hygienic options for fingerprint capture are more pressing than ever. However, contactless systems face challenges in the areas of interoperability and matching performance as shown in other works. In this paper, we present a contactless vs. contact interoperability assessment of several contactless devices, including cellphone fingerphoto capture. During the interoperability assessment, the quality of the fingerprints was considered using the NBIS NFIQ software with the contact-based fingerprint performing the best overall …