Digital Commons Network^™

Co-Creating Visual Representations Of Safe Spaces With Mental Health Service Users Using Photovoice And Zoom, Julie Dare, Helen Seiver, Lesley Andrew, David A. Coall, Shantha Karthigesu, Moira Sim, Kathy Boxall

Research outputs 2014 to 2021

This paper examines methodological issues related to an innovative online qualitative research project that explored ‘safe spaces’ with mental health service users. The project used photovoice and focus groups conducted via Zoom videoconferencing software. Eleven participants shared photographs, discussing their meaning and significance in relation to ‘safe spaces’. The photographs were then synthesised into an artist's impression of a safe space and transcripts of the online photovoice discussion analysed thematically and triangulated with the artist's impression. The paper provides a reflexive discussion of the research process and explores methodological and ethical implications of conducting sensitive qualitative research in online spaces.

Observations Of Children With Disability During Arts-Based Multisensory Story And Rhyme Activities: Is It All Just Chimes And Perfumes?, John O'Rourke, Susan Main, Christina Gray, Christine Lovering

Research outputs 2014 to 2021

It is generally acknowledged that alternative strategies are required to enable children with disability to access storytelling activities. In this study, we sought to analyse the benefits of one such strategy: an arts-based multisensory story and rhyme program delivered to children with Down syndrome and autism spectrum disorder. In order to determine the engagement and impact of the program on the participants, data were collected through a series of multisensory session observations, focus group interviews with parents of participants, and interviews with performing artists delivering the program. The findings of this study revealed multiple benefits of using sensory stimuli to …

Libraries As Wellbeing Supportive Spaces In Contemporary Schools, Margaret K. Merga

Research outputs 2014 to 2021

Schools are increasingly concerned with the promotion of student wellbeing, and relatively little is known about school libraries as wellbeing supportive spaces in contemporary schools. This article draws on qualitative interview data from students and library managers to explore how students make use of the school library, and how this relates to the library as a safe space. It finds that school libraries can be highly valued for their capacity to foster belonging and sanctuary and allow exposure to books and opportunities for reading. Students also appreciated how libraries provided a space for relaxing and recharging, supporting lively and social …

Questionnaires To Measure Process And Structure Of Quality Indicators For Pediatric Nursing, Maria Forsner, Evalotte Mörelius, Lena Hanberger

Research outputs 2014 to 2021

Introduction The quality of nursing care has a significant impact on the outcomes of care. The specific needs of children requiring hospital care make it essential to monitor and compare data not only on the medically oriented outcome measure but also on nursing care, structure, and process, requiring perspectives from registered nurses (RNs) and nurse managers (NMs). Thus, this project aimed to evaluate the structure and process of nursing quality indicators in pediatric hospital care with questionnaires distributed to RN and NM. Methods We developed separate questionnaires for NMs and RNs to assess the process and structure of the quality …

The Role Of Leadership In Aviation Safety And Aircraft Airworthiness, Ayiei Ayiei, Luke Pollock, Fatima Najeeb Khan, John Murray, Glenn Baxter, Graham Wild

Research outputs 2014 to 2021

Ensuring aircraft are technically safe to operate is the realm of airworthiness, literally worthy of being in the air. This is achieved not only with technological tools and techniques, or with just personnel and manpower, it is guided and supervised by managers and leaders. As such, the objective of this paper is to understand the role leadership plays in maintaining aviation safety and aircraft airworthiness. To this end, a case study of the Hawker Sidley Nimrod XV230 accident that occured on September 2, 2006 near Kandahar in Afghanistan, was utilized. The study concluded that leadership is a key aspect, specifically …

Extending Micro-Credentials To Micro-Apprenticeships For The Fourth Industrial Revolution: Enhancing Vocational Education And Training In The Post-Pandemic’S ‘New Normal’, Pi-Shen Seet, Janice Jones

Research outputs 2014 to 2021

As noted in the foreword of this Special Issue, COVID-19 has accelerated the Fourth Industrial Revolution’s or Industry 4.0’s disruption to the labour market (Sally, 2021). Beyond Industry 4.0 (I4.0), the COVID-19 pandemic has accelerated the adoption of digital technologies by enterprises, underscoring the need for workers to continuously upskill their digital competencies in order to remain relevant (Heinonen & Strandvik, 2021). Besides digitisation, organisations have had to innovate and adopt new business models to adapt to the ‘new normal’ of surviving and growing beyond the COVID-19 pandemic (Heinonen & Strandvik, 2021). In countries that largely relied on skilled migration …

Irf7-Associated Immunophenotypes Have Dichotomous Responses To Virus/Allergen Co-Exposure And Om-85-Induced Reprogramming, Emma De Jong, Jean-Francois Lauzon-Joset, Jonatan Leffler, Michael Serralha, Alexander N. Larcombe, Claus T. Christophersen, Patrick G. Holt, Deborah H. Strickland, Anthony Bosco

Research outputs 2014 to 2021

High risk for virus-induced asthma exacerbations in children is associated with an IRF7loimmunophenotype, but the underlying mechanisms are unclear. Here, we applied aSystems Biology approach to an animal model comprising rat strains manifesting high(BN)versuslow susceptibility (PVG) to experimental asthma, induced by virus/allergencoexposure, to elucidate the mechanism(s)-of-action of the high-risk asthmaimmunophenotype. We also investigated potential risk mitigationviapretreatment withthe immune training agent OM-85. Virus/allergen coexposure in low-risk PVG rats resultedin rapid and transient airways inflammation alongside IRF7 gene network formation. Incontrast, responses in high-risk BN rats were characterized by severe airways eosinophiliaand exaggerated proinflammatory responses that failed to resolve, and complete absenceof …

Perennial Ryegrass Contains Gluten-Like Proteins That Could Contaminate Cereal Crops, Sophia Escobar Correas, James A. Broadbent, Alicja Andraszek, Sally Stockwell, Crispin A. Howitt, Angela Juhasz, Michael Colgrave

Research outputs 2014 to 2021

Background: To ensure safe consumption of gluten-free products, there is a need to understand all sources of unintentional contamination with gluten in the food chain. In this study, ryegrass (Lolium perenne), a common weed infesting cereal crop, is analysed as a potential source of gluten-like peptide contamination. Materials and Methods: Ten ryegrass cultivars were analysed using shot gun proteomics for the presence of proteins from the prolamin superfamily. A relative quantitative assay was developed to detect ryegrass gluten-like peptides in comparison with those found in 10 common wheat cultivars. Results: A total of 19 protein accessions were found across 10 …

Subjective Knowledge, Perceived Risk, And Information Search When Purchasing A Franchise: A Comparative Exploration From Australia, Peter Balsarini, Claire Lambert, Maria M. Ryan, Martin Maccarthy

Research outputs 2014 to 2021

Franchising has long been a method by which organizations seek to expand and facilitate local market development. However, franchising as a growth strategy can often be hampered by lack of suitable franchisees. To mitigate this shortage, some franchisors have engaged in recruiting franchisees internally from the ranks of their employees in addition to the traditional approach of recruiting franchisees externally. Predominantly franchisees are individuals rather than corporations and thus purchasing a franchise should most commonly be characterized as a consumer acquisition. To explore the relationship between subjective knowledge, perceived risk, and information search behaviors when purchasing a franchise qualitative interviews …

Vitamin K Intake And Atherosclerotic Cardiovascular Disease In The Danish Diet Cancer And Health Study, Jamie W. Bellenge, Frederik Dalgaard, Kevin Murray, Emma Connolly, Lauren C. Blekkenhorst, Catherine P. Bondonno, Joshua R. Lewis, Marc Sim, Kevin D. Croft, Gunnar Gislason, Christian Torp-Pedersen, Anne Tjønneland, Kim Overvad, Jonathan M. Hodgson, Carl Schultz, Nicola P. Bondonno

Research outputs 2014 to 2021

Background Dietary vitamin K (K1 and K2) may reduce atherosclerotic cardiovascular disease (ASCVD) risk via several mechanisms. However, studies linking vitamin K intake with incident ASCVD are limited. We aimed to determine the relationship between dietary vitamin K intake and ASCVD hospitalizations. Methods and Results In this prospective cohort study, participants from the Danish Diet, Cancer, and Health Study, with no prior ASCVD, completed a food‐frequency questionnaire at baseline and were followed up for hospital admissions of ASCVD; ischemic heart disease, ischemic stroke, or peripheral artery disease. Intakes of vitamin K1 and vitamin K2 were estimated from the food‐frequency questionnaire, …

Intake Of Products Containing Anthocyanins, Flavanols, And Flavanones, And Cognitive Function: A Narrative Review, Samantha L. Gardener, Stephanie R. Rainey-Smith, Michael Weinborn, Catherine P. Bondonno, Ralph N. Martins

Research outputs 2014 to 2021

The purpose of this review is to examine human research studies published within the past 6 years which evaluate the role of anthocyanin, flavanol, and flavanone consumption in cognitive function, and to discuss potential mechanisms of action underlying any observed benefits. Evidence to date suggests the consumption of flavonoid-rich foods, such as berries and cocoa, may have the potential to limit, or even reverse, age-related declines in cognition. Over the last 6 years, the flavonoid subgroups of anthocyanins, flavanols, and flavanones have been shown to be beneficial in terms of conferring neuroprotection. The mechanisms by which flavonoids positively modulate cognitive …

Potential Role Of Exercise Induced Extracellular Vesicles In Prostate Cancer Suppression, Ying Zhang, Jin-Soo Kim, Tain-Zhen Wang, Robert U. Newton, Daniel A. Galvao, Robert A. Gardiner, Michelle M. Hill, Dennis Taaffe

Research outputs 2014 to 2021

Physical exercise is increasingly recognized as a valuable treatment strategy in managing prostate cancer, not only enhancing supportive care but potentially influencing disease outcomes. However, there are limited studies investigating mechanisms of the tumor-suppressive effect of exercise. Recently, extracellular vesicles (EVs) have been recognized as a therapeutic target for cancer as tumor-derived EVs have the potential to promote metastatic capacity by transferring oncogenic proteins, integrins, and microRNAs to other cells and EVs are also involved in developing drug resistance. Skeletal muscle has been identified as an endocrine organ, releasing EVs into the circulation, and levels of EV-containing factors have been …

Charging Infrastructure For Commercial Electric Vehicles: Challenges And Future Works, Bassam Al-Hanahi, Iftekhar Ahmad, Daryoush Habibi, Mohammad A. S. Masoum

Research outputs 2014 to 2021

The journey towards transportation electrification started with small electric vehicles (i.e., electric cars), which have enjoyed an increasing level of global interest in recent years. Electrification of commercial vehicles (e.g., trucks) seems to be a natural progression of this journey, and many commercial vehicle manufacturers have shifted their focus on medium- and heavy-duty vehicle electrification over the last few years. In this paper, we present a comprehensive review and analysis of the existing works presented in the literature on commercial vehicle charging. The paper starts with a brief discussion on the significance of commercial vehicle electrification, especially heavy- and medium-duty …

“Just Like Breathing”: A Portrait Of An 85-Year-Old Veteran Teacher, Christina C. Gray, Geoffrey M. Lowe Dr, Peter F. Prout, Sarah Jefferson

Research outputs 2014 to 2021

Through a phenomenological lens of portraiture methodology, this article explores the career experiences of a veteran acting teacher who, at the age of 85 years, remains highly passionate and dedicated to his work with younger aspiring actors. The article reveals how for this veteran teacher, his strong teacher identity characterised by a quest for challenge and a commitment to career-long professional development are significant to maintaining relevance and passion for teaching. As many countries grapple with issues surrounding the retention of veteran teachers, understanding the ways in which he maintains his passion and commitment over succumbing to stress and burn …

Evaluating The Energetics Of Entrainment In A Human–Machine Coupled Oscillator System, Ryan T. Schroeder, James L. Croft, John E. A. Bertram

Research outputs 2014 to 2021

During locomotion, humans sometimes entrain (i.e. synchronize) their steps to external oscillations: e.g. swaying bridges, tandem walking, bouncy harnesses, vibrating treadmills, exoskeletons. Previous studies have discussed the role of nonlinear oscillators (e.g. central pattern generators) in facilitating entrainment. However, the energetics of such interactions are unknown. Given substantial evidence that humans prioritize economy during locomotion, we tested whether reduced metabolic expenditure is associated with human entrainment to vertical force oscillations, where frequency and amplitude were prescribed via a custom mechatronics system during walking. Although metabolic cost was not significantly reduced during entrainment, individuals expended less energy when the oscillation forces …

Prevalence And Patterns Of Multimorbidity In Australian Baby Boomers: The Busselton Healthy Ageing Study, Michael L. Hunter, Matthew W. Knuiman, Bill A. W. Musk, Jennie Hui, Kevin Murray, John P. Beilby, David R. Hillman, Joseph Hung, Robert U. Newton, Romola S. Bucks, Leon Straker, John P. Walsh, Kun Zhu, David G. Bruce, Robert H. Eikelboom, Timothy M. E. Davis, David A. Mackey, Alan L. James

Research outputs 2014 to 2021

Background and objective: Chronic medical conditions accumulate within individuals with age. However, knowledge concerning the trends, patterns and determinants of multimorbidity remains limited. This study assessed the prevalence and patterns of multimorbidity using extensive individual phenotyping in a general population of Australian middle-aged adults. Methods: Participants (n = 5029, 55% female), born between 1946 and 1964 and attending the cross-sectional phase of the Busselton Healthy Ageing Study (BHAS) between 2010 and 2015, were studied. Prevalence of 21 chronic conditions was estimated using clinical measurement, validated instrument scores and/or self-reported doctor-diagnosis. Non-random patterns of multimorbidity were explored using observed/expected (O/E) prevalence …

The Supportive Care Needs Of Regional And Remote Cancer Caregivers, Anna Stiller, Belinda C. Goodwin, Fiona Crawford-Williams, Sonja March, Michael Ireland, Joanne F. Aitken, Jeff Dunn, Suzanne K. Chambers

Research outputs 2014 to 2021

Objective: As cancer survival rates continue to increase, so will the demand for care from family and friends, particularly in more isolated settings. This study aims to examine the needs of cancer caregivers in regional and remote Australia. Methods: A total of 239 informal (i.e., non-professional) cancer caregivers (e.g., family/friends) from regional and remote Queensland, Australia, completed the Comprehensive Needs Assessment Tool for Cancer Caregivers (CNAT-C). The frequencies of individuals reporting specific needs were calculated. Logistic regression analyses assessed the association between unmet needs and demographic characteristics and cancer type. Results: The most frequently endorsed needs were lodging near hospital …

The Role Of Acceptance And Commitment Therapy In Cardiovascular And Diabetes Healthcare: A Scoping Review, Amineh Rashidi, Lisa Whitehead, Lisa Newson, Felicity Astin, Paramjit Gill, Deirdre A. Lane, Gregory Y. H. Lip, Lis Neubeck, Chantal F. Ski, David R. Thompson, Helen Walthall, Ian D. Jones

Research outputs 2014 to 2021

Acceptance and commitment therapy (ACT) is an adapted form of cognitive behavioural therapy. ACT focuses on how thinking affects behaviour and promotes psychological flexibility. The prevalence of psychological distress among people living with cardiovascular disease (CVD) and/or type 2 diabetes mellitus (T2DM) is high, and ACT may offer an alternative treatment approach. This scoping review explored the use of ACT as an intervention to support adults living with CVD and/or T2DM. A systematic search of the literature resulted in the inclusion of 15 studies. Studies were reviewed using the Joanna Briggs Institute approach to conducting scoping reviews. Most studies (n …

Oat Intake And Risk Of Type 2 Diabetes, Cardiovascular Disease And All-Cause Mortality: A Systematic Review And Meta-Analysis, Faina Wehrli, Petek E. Taneri, Arjola Bano, Lia Bally, Lauren C. Blekkenhorst, Weston Bussler, Brandon Metzger, Beatrice Minder, Marija Glisic, Taulant Muka, Hua Kern

Research outputs 2014 to 2021

Cardiovascular disease (CVD) and type 2 diabetes (T2D) remain the top disease and mortality burdens worldwide. Oats have been shown to benefit cardiovascular health and improve insulin resistance. However, the evidence linking oat consumption with CVD, T2D and all-cause mortality remains inconclusive. We conducted a comprehensive systematic review and meta-analysis of prospective cohort studies to evaluate the associations between oat consumption and risks of T2D, CVD and all-cause mortality in the general population. Five electronic databases were searched until September, 2020. Study specific relative risks (RR) were meta-analyzed using random effect models. Of 4686 relevant references, we included 9 articles, …

An Outbreak Of Highly Pathogenic Avian Influenza (H7n7) In Australia And The Potential For Novel Influenza A Viruses To Emerge, Andrew T. Bisset, Gerard F. Hoyne

Research outputs 2014 to 2021

In 2020, several geographically isolated farms in Victoria, Australia, experienced an outbreak of highly pathogenic avian influenza (HPAI) virus H7N7 and low pathogenic avian influenza (LPAI) viruses H5N2 and H7N6. Effective containment and control measures ensured the eradication of these viruses but the event culminated in substantial loss of livestock and significant economic impact. The avian HPAI H7N7 virus generally does not infect humans; however, evidence shows the ocular pathway presents a favourable tissue tropism for human infection. Through antigenic drift, mutations in the H7N7 viral genome may increase virulence and pathogenicity in humans. The Victorian outbreak also detected LPAI …

Impact Of Modern Antiviral Therapy Of Chronic Hepatitis B And C On Clinical Outcomes Of Liver Disease, Tiffany Khoo, Danielle Lam, John K. Olynyk

Research outputs 2014 to 2021

Chronic infections with the hepatitis B and C viruses have significant worldwide health and economic impacts. Previous treatments for hepatitis C such as interferon and ribavirin therapy were ineffective and poorly tolerated by patients. The introduction of directly acting curative antiviral therapy for hepatitis C and the wider use of nucleos(t)ide analogues for suppression of chronic Hepatitis B infection have resulted in many positive developments. Decreasing the prevalence of hepatitis B and C have concurrently reduced transmission rates and hence, the number of new infections. Antiviral treatments have decreased the rates of liver decompensation and as a result, lowered hospitalisation …

Enhancing Adaptions To Neuromuscular Electrical Stimulation Training Interventions, Anthony J. Blazevich, David F. Collins, Guillaume Y. Millet, Marco A. Vaz, Nicola A. Maffiuletti

Research outputs 2014 to 2021

Neuromuscular electrical stimulation (NMES) applied to skeletal muscles is an effective rehabilitation and exercise training modality. However, the relatively low muscle force and rapid muscle fatigue induced by NMES limit the stimulus provided to the neuromuscular system and subsequent adaptations. We hypothesize that adaptations to NMES will be enhanced by the use of specific stimulation protocols and adjuvant interventions.

Effects Of Exercise During Radiotherapy On Physical Function And Treatment-Related Side Effects In Men With Prostate Cancer: A Systematic Review And Meta-Analysis, Oliver Schumacher, Hao Luo, Dennis Taaffe, Daniel A. Galvao, Colin Tang, Raphael Chee, Nigel Spry, Robert Newton

Research outputs 2014 to 2021

Purpose

Radiation therapy is a commonly used treatment for prostate cancer; however, the side effects may negatively affect quality of life and cause patients to be less physically active. Although exercise has been shown to mitigate radiation therapy–related fatigue in men with prostate cancer during radiation therapy, other adverse effects of treatment such as physical deconditioning, urinary symptoms, or sexual dysfunction have not been systematically reviewed in this patient population. Thus, the purpose of this review was to investigate the effect of exercise on physical function and treatment-related side effects in men with prostate cancer undergoing radiation therapy.

Methods

A …

Content Analysis Of Patent Applications For Strength Training Equipment Filed In The United States Before 1980, James L. Nuzzo

Research outputs 2014 to 2021

Nuzzo, JL. Content analysis of patent applications for strength training equipment filed in the United States before 1980. J Strength Cond Res 35(10): 2952–2962, 2021—Strength training history is an emerging academic area. The aim of the current study was to describe quantitively the history of inventions for strength training equipment. Content analysis was conducted of patent applications for strength training equipment filed with the U.S. Patent and Trademark Office before 1980. Applications were identified using relevant keyword searches in Google Patents. A total of 551 patent applications were analyzed. The earliest application identified was filed in 1860. Applications never exceed …

Healing Right Way: Study Protocol For A Stepped Wedge Cluster Randomised Controlled Trial To Enhance Rehabilitation Services And Improve Quality Of Life In Aboriginal Australians After Brain Injury, Elizabeth Armstrong, Juli Coffin, Deborah J. Hersh, Judith M. Katzenellenbogen, Sandra Thompson, Leon Flicker, Meaghan Mcallister, Dominique A. Cadilhac, Tapan Rai, Erin Godecke, Colleen Hayward, Graeme J. Hankey, Neil M. Drew, Ivan Lin, Deborah Woods, Natalie Ciccone

Research outputs 2014 to 2021

Introduction: Despite higher incidence of brain injury among Aboriginal compared with non-Aboriginal Australians, suboptimal engagement exists between rehabilitation services and Aboriginal brain injury survivors. Aboriginal patients often feel culturally insecure in hospital and navigation of services post discharge is complex. Health professionals report feeling ill-equipped working with Aboriginal patients. This study will test the impact of a research-informed culturally secure intervention model for Aboriginal people with brain injury.

Methods and Analysis: Design: Stepped wedge cluster randomised control trial design; intervention sequentially introduced at four pairs of healthcare sites across Western Australia at 26-week intervals.

Recruitment: Aboriginal participants aged ≥18 years …

An Integrated Multicomponent Care Model For Men Affected By Prostate Cancer: A Feasibility Study Of Truenth Australia, Patsy Yates, Rob Carter, Robyn Cockerell, Donna Cowan, Cyril Dixon, Anne Magnus, Robert U. Newton, Nicolas H. Hart, Daniel A. Galvão, Brenton Baguley, Nicholas Denniston, Tina Skinner, Jeremy Couper, Jon Emery, Mark Frydenberg, Wei-Hong Liu

Research outputs 2014 to 2021

Objective: To evaluate the feasibility of implementing an integrated multicomponent survivorship care model for men affected by prostate cancer. Methods: Using a single arm prospective cohort study design, men with prostate cancer were recruited from two regional public hospitals in Australia for a 6-months program that provided information and decision support, exercise and nutrition management, specialised clinical support, and practical support through localised and central care coordination. Carers of the men were also invited to the program. Data were collected from multiple sources to evaluate: (1) recruitment capability and participant characteristics; (2) appropriateness and feasibility of delivering the specific intervention …

The Tumor Suppressor Mir-642a-5p Targets Wilms Tumor 1 Gene And Cell-Cycle Progression In Prostate Cancer, Dianne J. Beveridge, Kirsty L. Richardson, Michael R. Epis, Rikki A. M. Brown, Lisa M. Stuart, Andrew J. Woo, Peter J. Leedman

Research outputs 2014 to 2021

RNA-based therapeutics are emerging as innovative options for cancer treatment, with microRNAs being attractive targets for therapy development. We previously implicated microRNA-642a-5p (miR-642a-5p) as a tumor suppressor in prostate cancer (PCa), and here we characterize its mode of action, using 22Rv1 PCa cells. In an in vivo xenograft tumor model, miR-642a-5p induced a significant decrease in tumor growth, compared to negative control. Using RNA-Sequencing, we identified gene targets of miR-642a-5p which were enriched for gene sets controlling cell cycle; downregulated genes included Wilms Tumor 1 gene (WT1), NUAK1, RASSF3 and SKP2; and upregulated genes included IGFBP3 and GPS2. Analysis of …

Emotional Labor And The Hospitality And Tourism Curriculum: The Development And Integration Of Emotion Skills, Julie Nyanjom, Hugh Wilkins

Research outputs 2014 to 2021

Emotional labor is integral to guest-host interactions. Given that this is a competency that is desired by industry in graduates, it is important to understand how the concept presents in the Hospitality and Tourism curriculum. This exploratory qualitative study sets out to investigate how hospitality and tourism educators perceive the development of emotion skills in Hospitality and Tourism education curriculum. Data was collected through in-depth interviews with higher education hospitality and tourism educators in Australia. Findings reveal that the development of emotion skills is a taken for granted concept that is not explicitly addressed within the curriculum. Implications for practice …

A Review Of Security Standards And Frameworks For Iot-Based Smart Environments, Nickson M. Karie, Nor Masri Sahri, Wencheng Yang, Craig Valli, Victor R. Kebande

Research outputs 2014 to 2021

Assessing the security of IoT-based smart environments such as smart homes and smart cities is becoming fundamentally essential to implementing the correct control measures and effectively reducing security threats and risks brought about by deploying IoT-based smart technologies. The problem, however, is in finding security standards and assessment frameworks that best meets the security requirements as well as comprehensively assesses and exposes the security posture of IoT-based smart environments. To explore this gap, this paper presents a review of existing security standards and assessment frameworks which also includes several NIST special publications on security techniques highlighting their primary areas of …

Searching For A Technology-Driven Acute Rheumatic Fever Test: The Start Study Protocol, Anna P. Ralph, Rachel Webb, Nicole J. Moreland, Reuben Mcgregor, Anthony Bosco, David Broadhurst, Timo Lassmann, Timothy C. Barnett, Rym Benothman, Jennifer Yan, Bo Remenyi, Julie Bennett, Nigel Wilson, Mark Mayo, Glenn Pearson, Tobias Kollmann, Jonathan R. Carapetis

Research outputs 2014 to 2021

Introduction:

The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. It is the precursor to rheumatic heart disease (RHD), a leading cause of health inequity and premature mortality for Indigenous peoples of Australia, New Zealand and internationally.

Methods and analysis:

Searching for a Technology-Driven Acute Rheumatic Fever Test' (START) is a biomarker discovery study that aims to detect and test a biomarker signature that distinguishes ARF cases from non-ARF, and use systems biology and serology to …