The Impact Of Device-Assisted Therapies On The Gut Microbiome In Parkinson's Disease, Michal Lubomski, Xiangnan Xu, Andrew J. Holmes, Jean Y.H. Yang, Carolyn M. Sue, Ryan L. Davis

Medical Papers and Journal Articles

Background: Microbiome feedbacks are proposed to influence Parkinson’s disease (PD) pathophysiology. A number of studies have evaluated the impact of oral medication on the gut microbiome (GM) in PD. However, the influence of PD device-assisted therapies (DATs) on the GM remains to be investigated.

Objectives: To profile acute gut microbial community alterations in response to PD DAT initiation.

Methods: Clinical data and stool samples were collected from 21 PD patients initiating either deep brain stimulation (DBS) or levodopa–carbidopa intestinal gel (LCIG) and ten spousal healthy control (HC) subjects. 16S amplicon sequencing of stool DNA enabled comparison of …

Breast Density Notification: A Systematic Review Of The Impact On Primary Care Practitioners, Brooke Nickel, Tessa Copp, Meagan Brennan, Rachel Farber, Kirsten Mccaffery, Nehmat Houssami

Medical Papers and Journal Articles

Background: In the last decade, there has been an unprecedented amount of advocacy and attention surrounding the issue of breast density (BD) in relation to mammography screening. It is largely unknown what impact notifying women of their BD has had on clinical practice for PCPs. This systematic review aimed to synthesize evidence from existing studies to understand the impact of BD notification on primary care practitioners' (PCPs) knowledge, attitudes, and practice implications.

Methods: Empirical studies were identified through relevant database searches (database inception to May 2020). Two authors evaluated the eligibility of studies, extracted and crosschecked data, and assessed the …

Mental State Of Demoralisation Across Diverse Clinical Settings: A Systematic Review, Meta-Analysis And Proposal For Its Use As A ‘Specifier’ In Mental Illness, Lucy L. Gan, Susanna Gong, David W. Kissane

Medical Papers and Journal Articles

Objective: Demoralisation is a state of poor coping characterised by low morale, hopelessness, subjective incompetence, and loss of meaning and purpose in life. While studied extensively in oncology and palliative care, there has been recent exploration in broader medical and mental health settings. The aim was to investigate the prevalence of demoralisation and associated sociodemographic and psychological factors across these clinical settings.

Method: Six electronic databases were used to locate articles from January 2014 to March 2020. A pre-publication update of non-oncology populations was completed in September 2021. The review has been reported following Preferred Reporting Items for Systematic Reviews …

Endmt Regulation By Small Rnas In Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress, Roberta Giordo, Yusra M A Ahmed, Hilda Allam, Salah Abusnana, Lucia Pappalardo, Gheyath K Nasrallah, Arduino Aleksander Mangoni, Gianfranco Pintus

Faculty, Staff and Student Publications

Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts through a process known as endothelial to mesenchymal transition (EndMT). During EndMT, endothelial cells lose their typical phenotype to acquire mesenchymal features, characterized by the development of invasive and migratory abilities as well as the expression of typical mesenchymal products such as α-smooth …

Summit Avenue Studios: A Creative Hub In Scott's Addition, Elizabeth Berry

Theses and Dissertations

In this fast-paced life that seems to be moving at an even more rapid speed, we rely upon online retailers and the ability to purchase anything we need with a few taps on the phone or clicks on the computer. It can be wonderful to have this kind of exposure, but it comes at a price. We are trading convenience for craft, and risk overlooking talent in our own community. Most of these purchases are made from big box stores and online retailers selling cheap, international goods. We continue to lose the connection to our neighbors and communities, and local …

Shape Shifting: Bodies, Sound, And Queerness, Cordylia B. Vann

Theses and Dissertations

Writings in support of my visual and sonic thesis, Performing Ourselves. The paper examines the relationship between the labor of creating a queer body in how it moves and feels to the creation of choreography, sound, and graphic scores

Using Deep Learning-Based Framework For Child Speech Emotion Recognition, Gerald N. Onwujekwe

Theses and Dissertations

Biological languages of the body through which human emotion can be detected abound including heart rate, facial expressions, movement of the eyelids and dilation of the eyes, body postures, skin conductance, and even the speech we make. Speech emotion recognition research started some three decades ago, and the popular Interspeech Emotion Challenge has helped to propagate this research area. However, most speech recognition research is focused on adults and there is very little research on child speech. This dissertation is a description of the development and evaluation of a child speech emotion recognition framework. The higher-level components of the framework …

E-Cigarette Use And Perceptions Among Adolescents With Attention-Deficit/Hyperactivity Disorder: The Role Of Parental Messages About Tobacco, Mayra S. Ramos

Theses and Dissertations

Adolescents with attention-deficit/hyperactivity disorder (ADHD) are at increased risk of using e-cigarettes compared to their neurotypical peers. Parent-adolescent communication about tobacco use and number of ADHD symptoms can influence adolescents’ perceptions of e-cigarettes and their e-cigarette use. Adolescents with ADHD (n = 80) completed questionnaires assessing parental messages about tobacco use; e-cigarette harm perceptions; susceptibility to use e-cigarettes; and e-cigarette use. Parents reported on messages about tobacco use, adolescent’s ADHD symptomatology, and completed demographic questionnaires. Twenty-percent of adolescents reported e-cigarette ever use. Adolescent girls were significantly more likely to report higher e-cigarette harm perceptions than boys. Parents reported providing messages …

Rheological Analysis Of The Mechanical Properties Of Murine Lungs Over The Lifespan, Olajumoke Olufunke Harrison

Theses and Dissertations

To study the effects of aging in murine lungs, we characterized C57Bl6j mice from neonatal to 24-month-old mice. Samples were divided into two groups: Young Mice (YM) and Middle Age/Old Age Mice (MOM). The YM group included the neonatal and 6-10week. The MOM group included 7- and 22–24-month-old mice. Rheological testing was performed using a TA Instruments DHR-2 Rheometer to collect the mechanics of each mice sample. Utilizing a 20-mm parallel plate fixture, a gap of 0.8-1.0-mm, and a temperature setting of 25C, we conducted a frequency sweep. Samples were the decellularized over a four-day process then lyophilized for mass …

Impact Of Physical Activity And Cardiorespiratory Fitness On Vascular Homeostasis In Premenopausal Women Consuming A Westernized High-Fat Meal, Lauren N. Pedersen

Theses and Dissertations

A large percentage of adults in industrialized nations consume a Westernized dietary pattern, which contributes to fasting dyslipidemia and increased risk for atherosclerotic cardiovascular disease. Evidence suggests that a single Westernized meal containing high saturated fat may induce alterations in blood lipids as well as disturb multiple factors regulating peripheral vascular homeostasis, including innate immune cell function, oxidative stress, and vascular function. Conversely, participation in acute and chronic exercise may beneficially impact an individual’s postprandial response. Therefore, this dissertation contains three manuscripts seeking to describe how acute exercise, cardiorespiratory fitness, and physical activity level impact the lipemic and vascular homeostatic …

Therapeutic Modalities For Preventing Osteoarthritis Following Trauma To The Knee, Kayla M. Scott

Theses and Dissertations

Over 32.5 million adults in the United States and 300 million worldwide have osteoarthritis (OA). To date, there are no disease-modifying therapeutics, only strategies to slow OA progression through pain management, regenerative medicine approaches, and ultimately joint replacement.

On a microscale, a phenotypic shift of the normally quiescent articular chondrocytes leads to aberrant expression of pro-inflammatory and catabolic pathways, which are hypothesized to contribute to OA progression. Of note, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and WNT/β-catenin signaling are key players disrupting cartilage homeostasis and driving inflammatory pathway activation. These pathways become dysregulated and form a positive feedback loop, increasing …

A Deep Learning U-Net For Detecting And Segmenting Liver Tumors, Vidhya Cardozo

Theses and Dissertations

Visualization of liver tumors on simulation CT scans is challenging even with contrast-enhancement, due to the sensitivity of the contrast enhancement to the timing of the CT acquisition. Image registration to magnetic resonance imaging (MRI) can be helpful for delineation, but differences in patient position, liver shape and volume, and the lack of anatomical landmarks between the two image sets makes the task difficult. This study develops a U-Net based neural network for automated liver and tumor segmentation for purposes of radiotherapy treatment planning. Non-contrast simulation based abdominal CT axial scans of 52 patients with primary liver tumors were utilized. …

Development Of Unnatural Amino Acid Mutagenesis Technologies To Control Enzyme Activity And Synthesis Of Chemically Reactive Ubiquitin Probes, Jenny Cheung

Theses and Dissertations

Most of the work vital for the survival of the cell are performed by proteins. The primary sequence of proteins is composed of 20 canonical amino acids. However, these 20 amino acids do not offer the full range of functionalities needed for proteins to do their job. Often times, post-translational modifications (PTM’s) occur to add the required functional group. This interaction between all the different proteins in the proteome in addition to PTM’s create a complex system that scientists are still trying to unravel to this day. Many different tools had been developed for this purpose, and one such tool …

Examining The Impact Of Entrepreneurship Training On Entrepreneurial Mindset And Economic Well-Being, Sombo Muzata

Theses and Dissertations

This study used a mixed methods research design to examine the impact of entrepreneurship training on entrepreneurial mindset and economic well-being using the RVA Works Entrepreneurship Training Program as a case study. With human capital theory as a theoretical framework, a combination of 55 interviews and 36 surveys were used to answer the research questions. The study found that entrepreneurship training positively impacts an entrepreneurial mindset. The impact of the training on entrepreneurial mindset differed by participants age and educational level. Study participants applied their entrepreneurial mindset to their businesses, jobs, and other aspects of life. Participation in the program’s …

A General Framework For Characterizing And Evaluating Attacker Models For Cps Security Assessment, Christopher S. Deloglos, Christopher Deloglos

Theses and Dissertations

Characterizing the attacker’s perspective is essential to assessing the security posture and resilience of cyber-physical systems. The attacker’s perspective is most often achieved by cyber-security experts (e.g., red teams) who critically challenge and analyze the system from an adversarial stance. Unfortunately, the knowledge and experience of cyber-security experts can be inconsistent leading to situations where there are gaps in the security assessment of a given system. Structured security review processes (such as TAM, Mission Aware, STPA-SEC, and STPA-SafeSec) attempt to standardize the review processes to impart consistency across an organization or application domain. However, with most security review processes, the …

Inquiries In Intelligent Information Systems: New Trajectories And Paradigms, Samaa Elnagar

Theses and Dissertations

Rapid Digital transformation drives organizations to continually revitalize their business models so organizations can excel in such aggressive global competition. Intelligent Information Systems (IIS) have enabled organizations to achieve many strategic and market leverages. Despite the increasing intelligence competencies offered by IIS, they are still limited in many cognitive functions. Elevating the cognitive competencies offered by IIS would impact the organizational strategic positions.

With the advent of Deep Learning (DL), IoT, and Edge Computing, IISs has witnessed a leap in their intelligence competencies. DL has been applied to many business areas and many industries such as real estate and manufacturing. …

Behavioral And Quantitative Electroencephalogram Alterations During The Whisker Nuisance Task Following Mild Traumatic Brain Injury In Mice, David Wildman

Theses and Dissertations

Mild traumatic brain injury (mild TBI) has been shown to cause an array of symptoms in individuals lasting up to several years. Several publications have lead researchers to believe that parvalbumin axotomy and its associated changes with gamma oscillations may be the driving force for these symptoms. Several publications have demonstrated alterations in both resting gamma and evoked gamma by way of parvalbumin dysfunction. Our research analyzed resting and evoked gamma obtained by electroencephalograms (EEG) in nine mild TBI mice and six SHAM mice by utilizing a behavioral test known as the Whisker Nuisance Task (WNT). The central fluid percussion …

Associations Between Social Determinants Of Health And Chlamydia Infections Among Georgia Counties, Bre'auna K. Beasley

Theses and Dissertations

Chlamydia is a growing public health concern that disproportionately impacts southern states. While social determinants of health are not direct causes of chlamydia infections, studies have found that these determinants do influence infections by creating environments that promote or hinder health seeking behaviors, as well as exposure to risk factors. Guided by the Social Ecological Model of Public Health and the Healthy People 2030 Social Determinants of Health Conceptual Framework, this dissertation study aimed to examine the associations between social determinants of health and chlamydia infections among Georgia counties. This study employed a correlational research design. Aggregate-level secondary data for …

Black Feminist Thought, Interrupted: Dissecting The Voice Of Black Feminists In The Blogosphere And Their Engagement With Platform Affordances, Dawn G. Johnson

Theses and Dissertations

ABSTRACT

BLACK FEMINIST THOUGHT, INTERRUPTED

DISSECTING THE VOICE OF BLACK FEMINISTS IN THE BLOGOSPHERE AND THEIR ENGAGEMENT WITH PLATFORM AFFORDANCES

By Dawn G. Johnson, Ph.D

A dissertation submitted to the faculty at Virginia Commonwealth University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Media, Art, and Text Department in the College of Humanities and Sciences

Virginia Commonwealth University, 2021

Dissertation Chair: Dr. Archana Pathak, Associate Professor, Dept. of Gender, Sexuality & Women's Studies, Virginia Commonwealth University

Black women that have long searched for spaces to be creative and have voice due to their …

Examining The Effect Of Item-Writing Flaws On The Psychometric Parameters Of Pharmacy Therapeutics Examinations, Veronica P. Shuford

Theses and Dissertations

Colleges and schools of pharmacy (C/SOP) use direct measures of assessment to provide evidence of student learning, with multiple-choice questions (MCQs) being one the most common formats used in health sciences education to assess students’ knowledge, skills, and abilities (Pate & Caldwell, 2014). This study examined the occurrence of item-writing flaws (IWFs) in the Clinical Therapeutics Module (CTM) sequence of courses at a college of pharmacy at an academic health center in the southeastern United States. The goals of the study were to: (1) identify the most common item-writing flaws on examinations in the CTM sequence of courses, (2) determine …

First-Year Retention At Virginia Commonwealth University: Understanding Student Departure And The Potential Impact Of Academic Advising, Ben Plache

Theses and Dissertations

This dissertation examines first-year enrollment at Virginia Commonwealth University to determine what factors are associated with an increased likelihood of a student not being retained, and for which of these factors there is evidence that academic advising is an effective intervention. A survey of common retention models identified six factors associated with retention likelihood: student background prior to enrollment (“pre-enrollment factors”), financial support, institutional support, institutional performance, institutional engagement, and student intention. Prior research has shown that academic advising is an effective intervention for two of these factors: institutional performance and institutional support.

The significance of these factors was tested …

Antibiotic-Loaded Dendrimer Hydrogels In Periodontal Bone Regeneration: A Feasibility Study, Nicholas G. Yesbeck

Theses and Dissertations

Purpose: Prescription of a complete course of oral antibiotics following bone grafting procedures is a common clinical practice in surgical periodontics. Prophylactic administration of antibiotics reduces the risk of surgical site infection and systemic administration is preferred over local delivery because of short duration of action in the latter circumstance. The goal of this study is to demonstrate the ability of dendrimer hydrogels (DH) to prolong the release kinetics of antibiotics in-vitro. A secondary goal will be to analyze the effect of different particulate bone allografts on the release kinetics of the antibiotic.

Methods: Dendrimer hydrogels (DH) were synthesized …

Understanding Predictors Of Telemedicine Adoption Before, During, And After The Covid-19 Pandemic, Bradford S. Pierce

Theses and Dissertations

This study examined change in physicians’ use of telemedicine before, during, and expectations after the COVID-19 pandemic. It also examined the ability of personal and environmental variables to predict telemedicine adoption, and applied the theory of reasoned action and technology acceptance model to physicians’ adoption of telemedicine during the pandemic. A total of 230 licensed physicians currently practicing in the United States were recruited. Telemedicine accounted for 3.72% of physicians’ clinical work prior to the pandemic, 46.03% during the pandemic, and predicted 25.44% after the pandemic ends. Physicians within hospitals reported less telemedicine use during the pandemic (M = …

The Impact Of Postmodernism On 21st Century Higher Education, Lia B. Wheatley

Liberal Studies (MA) Final Essays

The American undergraduate higher educational institution was organized and developed well over 100 years ago, and for the most part, it was designed around Eurocentric ideals, experiences, and values—ones that hardly reflect the population and principles of a 21^st century America. The higher education system is undoubtedly a product of modernism; however, as postmodernism has become more widespread through mainstream society, universities must reevaluate their means and their ends in order to meet transitioning standards and expectations especially if academe hopes to remain a pillar of our ever-progressing society.

The three majorly impacted areas of higher education include enrollment …

Nursing, Physical Therapy, And Cytotechnology Graduate And Undergraduate Students' Attitudes Toward Teamwork Before And After Participation In An Interprofessional Education Experience, Shelley C. Mishoe, Muge Akpinar Elci, Rebecca Poston, Kimberly Adams Tufts, Beth Thompson

Community & Environmental Health Faculty Publications

BACKGROUND Educating health professional (HP) students in environments wherein they can learn about, from, and with each other can prepare them for interprofessional collaborative practice (IPCP), which may positively impact patient safety and satisfaction (Brashers et al., 2015; Health Professions Accreditors Collaborative [HPAC], 2019). IPCP is characterized by effective communication, shared values, respect for diverse disciplines and teamwork among health professionals (IOM, 2015). However, professional silos in practice can foster competition rather than collaboration. Knowledge of HP roles and responsibilities is a primary tenet of IPCP (Interprofessional Educational Collaborative [IPEC], 2011).

PURPOSE An interprofessional education (IPE) approach that combined book …

With Great(Er) Power Comes Great(Er) Responsibility: Indigenous Rights And Municipal Autonomy, Alexandra Flynn

All Faculty Publications

This article asks how the dialogue surrounding greater municipal autonomy intersects with Aboriginal rights and title, recognized under section 35 of the Constitution Act, 1982 (Constitution), with a particular focus on Toronto. The first part of this article sets out the ways in which Toronto sought empowerment following the Better Local Government Act or Bill 5, including judicial consideration of the constitutional role of Canadian municipalities, the legislative advances made by provincial governments, and the yet-implemented possibilities of protection through a little-used mechanism within the Constitution. Part II analyzes the obligations of municipalities in respect of Indigenous Peoples …

Discharge Instructions In The Emergency Department, Josh Jorgensen

Master of Science in Nursing Family Nurse Practitioner

No abstract provided.

Exploring Renewable Energy Futures In Humboldt County Consistent With The Goals Of California’S Renewable Portfolio Standard, Amin M. Younes

Cal Poly Humboldt theses and projects

Humboldt County has abundant wind, solar, and biomass resources, but has made limited progress towards the state’s 2045 requirement of 100% clean electricity. A recently rejected onshore wind project showed that technically and economically viable projects can fall to social and political challenges, emphasizing the need for social considerations in renewable transitions. I therefore integrated community members’ preferences into modeling of RPS-consistent renewable energy scenarios in Humboldt County. My model suggests that offshore wind, utility-scale solar, distributed solar, and biomass power are technically and economically viable sources of significant local generation at varying costs.

In interviews with energy-engaged residents, I …

May All Teachers Be Happy: A Mindfulness Manual For School Staff, Laura Ella Ashley

Cal Poly Humboldt theses and projects

There are many teachers who leave the profession early due to burnout; furthermore, there are many requirements for teachers to support the social emotional wellness of their students. With training provided to teachers as to how to help students as the norm, and no support for helping the teachers who are burnt out, this project aims to bridge this gap. After facilitating and surveying participants in a mindfulness staff group, the results of this study clearly show that teacher well-being can be supported, and enhanced, with a simple mindfulness support group provided on site to school staff.

A Survey On The Status Of Acceptance And Commitment Training In Rural Northern California, Jacqueline A. Morris

Cal Poly Humboldt theses and projects

The interest in acceptance and commitment training (ACT) from within the applied behavior analysis (ABA) community has increased as evidenced by recently published literature addressing the need to examine the acceptability and utilization of ACT within ABA. However, there is limited literature on the perspectives of those working in the field of ABA on the use of ACT. In the present study a survey was conducted of ABA practitioners working in rural northern California to evaluate their level of interest in ACT, their perceptions of ACT being within the scope of practice of ABA, and any perceived challenges in developing …