The Economic Costs Of Biological Invasions Around The World, R. D. Zenni, F. Essl, E. García-Berthou, Shana M. Mcdermott

Economics Faculty Research

No abstract provided.

Role Of Mkp-2 In Glucose Metabolism And Stress-Induced Insulin Resistance, Yanthrawaduge Savanie Sulakshana Devsirini Fernando

Theses

The function of MKP-2 in metabolism and metabolic diseases remains largely unknown. In obese conditions mitogen-activated protein kinase (MAPK) pathway get dysfunctional and MAP kinase phosphatases (MKPs) play major roles in regulating the activities of MAPKs. We examined the regulation of MKP-2 expression in vivo, under physiological and pathological conditions, in the liver and other insulin responsive tissues using diet-induced obesity models using novel MKP-2 knockout mice. Also, we examined MKP-2 expression in vitro using insulin sensitive cell lines. We found that MKP-2 is expressed in insulin-sensitive tissues/cells and overexpression may delay muscle cell differentiation. Our novel data demonstrate that …

The Book Of Moses As A Temple Text, Jeffrey M. Bradshaw

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

In this fascinating article, Jeff Bradshaw details how the Book of Moses might be understood as a temple text, including elements of temple architecture, furnishings, and ritual in the story of the Creation and the Fall. Bradshaw shows how the second half of the Book of Moses follows a general pattern of a specific sequence of covenants that will resonate with members of the Church who have received the temple endowment. The story of Enoch and his people provides a vivid demonstration of the final steps on the path that leads back to God and exaltation.

Task Adherence: An Agentic Perspective On Task-Focused Dedication In An Interrupting Work Environment, Tanner Skousen, Justin Ames, James Gaskin

Faculty Publications

Purpose – Knowledge workers live and work in a technology-enabled, push-notification world full of interruptions that create information overload, often requiring these workers to utilize task switching as a mechanism to meet multiple competing tasks’ demands. Previous research has examined both the positive and, more often, negative effects from interruptions and task switching on knowledge workers’ performance. However, this paper aims to examine knowledge workers’ agentic approach to managing interruption signals and consequent task switching to remain dedicated to the task at hand.

Design/methodology/approach – Using an inductive grounded theory approach, we analyzed data from semi-structured interviews with knowledge workers …

Journalism As A Public Good: How The Nonprofit News Model Can Save Us From Ourselves, Rosalie Westenskow, Edward L. Carter

Faculty Publications

At a time when many U.S. newspapers find themselves at the edge of a financial precipice, The Salt Lake Tribune’s recent transformation into a 501(c)(3) public charity presents a potentially promising route to economic safety for other daily newspapers. Although the nonprofit, tax-exempt model has been an increasingly popular one for new media outlets, the IRS’s bestowal of such status on a major daily newspaper marks an historic event—one that other newspapers, and their legal counsel, can learn from. This Article outlines several issues such practitioners and owners should be aware of as they consider taking the leap to …

Human Retinal Organoids Release Extracellular Vesicles That Regulate Gene Expression In Target Human Retinal Progenitor Cells, Jing Zhou, Miguel Flores‑Bellver, Jianbo Pan, Alberto Benito‑Martin, Cui Shi, Onyekwere Onwumere, Jason Mighty, Jiang Qian, Xiufeng Zhong, Tasmim Hogue, Baffour Amponsah‑Antwi, Linda Einbond, Rajendra Gharbaran, Hao Wu, Bo‑Juen Chen, Zhiliang Zheng, Tatyana Tchaikovskaya, Xusheng Zhang, Hector Peinado, Maria Valeria Canto‑Soler, Stephen Redenti

Publications and Research

The mechanisms underlying retinal development have not been completely elucidated. Extracellular vesicles (EVs) are novel essential mediators of cell‑to‑cell communication with emerging roles in developmental processes. Nevertheless, the identification of EVs in human retinal tissue, characterization of their cargo, and analysis of their potential role in retina development has not been accomplished. Three‑dimensional retinal tissue derived from human induced pluripotent stem cells (hiPSC) provide an ideal developmental system to achieve this goal. Here we report that hiPSC‑derived retinal organoids release exosomes and microvesicles with small noncoding RNA cargo. EV miRNA cargo‑predicted targetome correlates with Gene Ontology (GO) pathways involved in …

Evolving Perspectives: How Research, Age, And A Global Pandemic Alters The Mind's Eye In Costume Design, Audrey Reed

Theses and Dissertations

This thesis explores how various factors can affect how something is viewed and appreciated. It specifically relates to James and the Giant Peach the musical as it is as a halted production for the VCU theatre due to COVID-19. This document encompasses facts about Roald Dahl’s life, details about my designs for the production, as well as how a global pandemic affected the life of theatre. Included in this document are research and renderings.

The Therapeutic Potential Of Glycosaminoglycan Directed Metalloglycomics: Elucidating New Targets And Mechanisms For Polynuclear Platinum Complexes, James D. Hampton

Theses and Dissertations

Cancer remains a serious clinical problem and in order to continue to improve patient health outcomes, novel treatment strategies must continue to be developed. Platinum chemotherapies remain as one of the most widely successful classes of cancer therapeutic, with over 50% of cancer patients receiving a platinate at some point over the span of their treatment. However, intrinsic and extrinsic resistances limit their effectiveness, long term efficacy, and broad applicability to multiple cancer subtypes. Therefore, the development of new agents and strategies which can overcome these limitations are crucial for patient health. To this end a novel class of polynuclear …

Preclinical Pharmacokinetic Studies Of Pterostilbene, And Its Human Pharmacokinetic Prediction Using Physiologically Based Pharmacokinetic Modeling, Palak S. Phansalkar

Theses and Dissertations

This dissertation research aimed to determine the preclinical pharmacokinetics of pterostilbene in vitro and develop a physiologically based pharmacokinetic (PBPK) model to simulate the animal and human PK profiles for pterostilbene. The in vitro PK characteristics of pterostilbene, including Caco-2 cell permeability, plasma protein binding, and metabolic stability were determined using rat and human intestinal & hepatic S9 subcellular fractions. The in vitro metabolic parameters determined in rat subcellular fractions were extrapolated to in vivo values to predict the oral bioavailability (F_oral) in rats. The predicted F_oral was found to be 43.0 %, which is similar to …

Searching For Gold: Using A Novel Land Cover Classification To Identify Multiscale Drivers Of Site Occupancy By A Flagship Species For Early-Successional Habitat Conservation, Baron Lin

Theses and Dissertations

Understanding habitat selection at multiple scales is an important step in guiding conservation programs and reversing species declines. This, however, is difficult for species that occupy early-successional habitats (ESH) due to a lack of accurate representation of shrub cover in publicly available land cover data. The Golden-winged Warbler (Vermivora chrysoptera; GWWA) is a threatened species of conservation concern and a flagship for ESH conservation. We used a novel, LIDAR-derived land cover classification that accurately identifies shrubs at a fine resolution (1m) to investigate how habitat composition and configuration influence GWWA site occupancy. We aggregated this same land cover …

Owning Our Story: An Interior Exploration To Foster Self-Reflection, Hannah Bulow

Theses and Dissertations

With emerging technologies in the 21st century, Millennial and Gen Z adults have a complicated relationship with these new technologies when it comes to creating and sustaining personal relationships (Dalessandro, 2018). When persons aged 18-35 forged new relationships without the presence of technology, relationships were more organic, natural, and led to less conflicts. Neuroimaging of the brain has also shown that neurocognitive development during early adolescence and adulthood contributes to self-consciousness and vulnerability. Adolescents are called to develop their own identity separate from their parents and understanding how others are actually evaluating them (Sebastian, 2008)

Brene Brown states that most …

Structural Reorganization Of The Cisternal Organelle In Neuroinflammatory Disease, Myshak S. Abdi

Theses and Dissertations

The axon initial segment (AIS), an axonal sub compartment located immediately distal to the soma, is an important structure in mediating action potential generation and modulation. The morphology of this domain can be altered by a wide variety of activity-dependent, environmental, and pathological triggers. Dysregulation of axonal calcium (Ca²⁺) concentrations, and subsequent enzymatic degradation of AIS cytoskeletal architecture have been reported to underlie structural modifications of the AIS. Moreover, pharmacological inhibition of neuronal Ca²⁺ channels have been shown to mitigate the disruptive effects of neuroinflammation on AIS structural integrity. Here we investigate the Cisternal Organelle (CO), a …

Yolkkh: The Story Of My People, Amna Zelimkha Yandarbin

Theses and Dissertations

The name of my project is: Yolkkh, The Story of My People. With this project I present a series of scarves each one bearing an illustrated scene in order to tell a story – my story and the story of the Noxci people. Noxci are the people who are referred to as “Chechens” by Russians and are generally known by that title. As a Muslim, I have witnessed the way Western media tend to dehumanize my community. In order to contrast this dehumanizing process, I thought that telling the story of my family would help reverse Islamophobic tendencies and raise …

Radioimmunoconjugate For Cancer Molecular Imaging, Nouri Elmekharam

Theses and Dissertations

Over expression of Sperm Acrosomal SLLP1 Binding protein (SAS1B) on the surface of uterine cancer and the availability of different anti-SAS1B monoclonal antibodies (mAbs) that specifically bind to it, offered an opportunity to label these antibodies with radionuclides for cancer imaging. Although optimizing in vivo stable radiolabeling is challenging, imaging this type of aggressive cancer will improve the treatment strategy. The objective of this work is to develop a radiolabeled anti-SAS1B antibodies with Zircunum-89 (⁸⁹Zr) and Copper-67 (⁶⁷Cu) and determine, in vitro and in vivo their uptake and biodistribution. Two anti-SAS1B monoclonal antibodies (SB2, and SB5) …

Copper Sulfide Manganese Nanoparticles For Multimodality Imaging And Therapy, Ali S. Gawi Ermi

Theses and Dissertations

Abstract

COPPER SULFIDE MANGANESE NANOPARTICLES FOR MULTIMODALITY IMAGING AND THERAPY

By Ali S. Gawi Ermi, MSc

Inorganic nanoparticles (NPs) are compatible with metal-based multi-modality molecular imaging and targeted therapy. Copper sulfide nanoparticles (CuS NPs) are attractive photoacoustic and photothermal agents and are amenable to incorporation of radionuclides and paramagnetic elements to facilitate image-guided therapy. The aim of this work is to develop manganese (Mn)- doped CuS NP, intrinsically radiolabeled with radionuclides such as (Zirconium-89 (⁸⁹Zr), Copper-64/67 (^64/67Cu) and Manganese-52/55 (^52/55Mn)). This novel approach combines Photoacoustic (PA), Positron emission tomography (PET), Single-photon emission computed tomography …

A Mechanism Behind The Mechanotransduction Of Surface Characteristics In Osteoblasts, Otto J. Juhl Iv

Theses and Dissertations

Biomaterials for use in bone regeneration and healing range from metal and metal alloy implants to hydrogel-based solutions. These materials can be optimized to increase bone healing and integration by improving the mechanical and biological properties. Regardless of the material itself, the cell-substrate interaction is key to the success of the biomaterial once implanted. Substrate surface characteristics such as roughness, wettability, and particle density are well-known contributors to a substrate’s overall osteogenic potential, and therefore the substrate's overall success. Unfortunately, it is still unknown how these substrate surface characteristics are transduced into intracellular signals by cells, preventing specific tailoring of …

Grief, Loss, And Climate Change: Validation Of A Solastalgia Scale, Claire Luce

Theses and Dissertations

Climate change has been identified as a defining issue of this century (United Nations, n.d.). Climate change impacts human wellbeing including mental health. While much research has focused on the way that the effects of climate change cause increases in common mental disorders, mental health is not just the absence of these disorders (World Health Organization, 2014). Non-pathologized mental health responses to climate change, such as the grief and loss that results from climate change impacts, are a growing consideration for researchers. Solastalgia, or the distress experienced in the absence of the solace once provided by the environment in the …

Beyond The Social: Artist Project Spaces, 2003 To 2016., Clare L. Van Loenen

Theses and Dissertations

This research examines storefront project spaces in the early 2000s that offered alternative approaches to the programming, organizing, and archiving found in conventional museums. I propose that such sites impacted participatory visual culture by offering a reformulatory role for arts’ practices, one that organized itself across disciplinary boundaries, chose a collaborative rather than competitive approach, and processed the ideological implications of their group work. Focused on three specific sites—Machine Project in Los Angeles, Elsewhere in Greensboro, and Mess Hall in Chicago—this study details the museological, pedagogical, and archival challenges of these artist-convened organizations. My interdisciplinary investigation offers a reference point …

The Algorithmic Mashrabiya: Reimagining The Traditional Islamic Screen, Ahmed Nour

Theses and Dissertations

Traditionally, a mashrabiya was an ornate wooden structure attached to the side of an Arabian building or house, with small, intricately patterned openings to provide both ventilation and privacy for the people inside. The patterns, following the geometric rules of Islamic ornament, lent a distinctive appearance to buildings in the region. A mashrabiya converted the house into a safe, private sanctuary, providing a magical scene inside, characterized by linear sun rays, filtered points of light and shadow. Over time, as building technology changed and the number of skilled craftsmen dwindled, the traditional mashrabiya has all but vanished. The aim of …

Third Culture Kids - Playing To Heal, Amna Sana

Theses and Dissertations

With increased globalization and a large expat population, Qatar is home to increasing numbers of Third Culture Kids (TCKs). TCKs are children who live in a country where their parents are non-native, children who grow up between cultures. Young TCKs, especially children between the ages of three and seven, do not possess the skills to adequately vocalize their feelings, but fortunately, play therapy allows them to articulate problems and feelings on their own terms. This thesis addresses the emotional hurdles facing TCKs, using concepts derived from play therapy and offering a series of interactive objects designed to reflect emotional expression …

The Living Theatre Of Horror: Examining How Centuries Of Western Theatrical Practice And Theory Inform The Modern-Day Haunted House, Scott Dittman

Theses and Dissertations

This work will discuss the growing modern phenomenon of theme park and regional haunt events in the United States. In it, we will explore the history of how horror has been presented on stage, the themes within horror that creators grapple with, and how by using traditional theatrical elements creators of modern haunt events are able to make the audience a part of the story, transforming them from passive observers of the scenarios presented to complicit participants. How does the history of horror theatre inform the production of modern haunt events (and how has a global pandemic affected them), what …

No Graphic Design Will Contain You, Julia P. Dann

Theses and Dissertations

let this book serve as an archive of my tender uncoiling; a thesis in that the work has begun, though no problems will be solved here. a search for ripe language; an opening; a threshold.

You Wouldn't Download An Art, Rice Evans

Theses and Dissertations

To quote the late Alaskan Senator Ted Stevens, “The internet is a series of tubes.” Like my art practice, these tubes meander through concepts, techniques, and mediums to arrive at a messy, confusing, and overwhelming shared experience of digital life. It is here where we find humor, creativity, and most importantly our own folk culture.

Earth Tone Sigh Spell, Martha Glenn

Theses and Dissertations

A written accompaniment to the artist’s thesis exhibition titled Earth Tone Sigh Spell, conceived during the years 2020-21 and installed at The Anderson Gallery, Richmond from May 1–15, 2021.

The following thesis explores themes of personal memory, geo-theory, myth, symbol, and historical event. The artist uses research and stream of consciousness writing methods as a way to weave these concepts together and tie them back to her own practice with installation, sculpture, and new media.

When We Breathe: Re-Envisioning Safety And Justice In A Post-Floyd Era, Aya Gruber

Publications

10th Annual David H. Bodiker Lecture on Criminal Justice delivered on Wed., Oct. 21, 2020 at Ohio State University Moritz College of Law.

Living The Sacred: Indigenous Peoples And Religious Freedom, Kristen A. Carpenter

Publications

No abstract provided.

Testing The Effect Of Aquarium-Based Learning On Patron Acceptance Of Evolutionary Theory, Jamie Jensen, Ethan R. Tolman, Spencer G. Shumway, Liam S. Williams

ScholarsArchive Data

This is data collected prior to and directly following an intervention at a public aquarium in Idaho surrounding the reconciliation of evolution with religious audiences.

Evaluation On Reducing Toxicity Of Fluoxastrobine With Doped Tio$_{2}$ Nanoparticles, Abbas Güngördü, Nesri̇n Özmen, Sema Erdemoğlu, Duygu Özhan Turhan, Meltem Asi̇ltürk, Emrah Akgeyi̇k, Murat Özmen

Turkish Journal of Zoology

In this study, toxic effects caused by the degradation of fluoxastrobin, which is a commonly used fungicide where newly synthesized manganese or sulfur-doped TiO$_{2}$ nanoparticles exist were evaluated. The characterization study of nanoparticles was performed by scanning an electron microscopy (SEM), X-ray diffractometry, Brunau-Emmet-Teller analysis, X-ray fluorescence spectroscopy, and UV-Vis (ultraviolet-visible) reflectance spectra. Subsequently, the photocatalytic performance of nanoparticles, their toxicity, and the photocatalytic degradation products of fluoxastrobin with the same nanoparticles were tested during the two development stages of Xenopus laevis. The LC$_{50}$s of fluoxastrobin were determined on test organisms, and a 5 mg L$^{-1}$ fluoxastrobin was selected to …

Do Castanea Sativa Wild Provenances Influence Dryocosmus Kuriphilus Yasumatsu(Hymenoptera: Cynipidae) Infestations?, Mario Contarini, Luca Rossini, Romina Caccia, Silvia Morelli, Isacco Beritognolo, Muriel Gaudet, Fiorella Villani, Bruno Paparatti, Stefano Speranza

Turkish Journal of Zoology

The Asian chestnut gall wasp (ACGW), Dryocosmus kuriphilus, native to China was accidentally introduced into many countries worldwide, including Italy. Different susceptibilities have been reported in literature among cultivated plants belonging to different gene pools worldwide, but this aspect has not been sufficiently explored among wild chestnut populations. The aims of this multiyear study were (i) to assess differences in susceptibility to ACGW in wild C. sativa plants coming from different parts of Europe grown in an experimental plot in Central Italy, (ii) to preliminarily analyse the relationships between temperature, relative humidity and rain variables of winter and summer and …

Investigation Of The Effect Of Silymarin On Oxidative Dna Damageand Inflammatory Markers In Ischemia/Reperfusion Injuryfollowing Experimental Testicular Torsion/Detorsion In Rats, Saadet Belhan, Serkan Yildirim, Caner Kayikci, Ahmet Ufuk Kömüroğlu, Uğur Özdek, Yağmur Kuşcu

Turkish Journal of Zoology

The aim of the present study was to clarify the effects of silymarin on experimental testicular ischemia / reperfusion injury. A total of 40 Wistar albino rats (10-12 weeks of age, weighing 280-300 g) were randomly divided into five groups. Control group: No surgical procedures were performed. Torsion 3 h / detorsion 3 h group; torsion 3 h / detorsion 24 h group; torsion 3 h / detorsion 3 h + silymarin (250 mg/kg) group; and torsion 3 h / detorsion 24 h + silymarin (250 mg/kg) group. In the study, 720° torsion was applied to the left testicle. At …