Digital Commons Network^™

Development Of Adjunctive Agents For Difluoromethylornithine Anti-Cancer Therapy, Aiste Dobrovolskaite

Electronic Theses and Dissertations, 2020-2023

The native polyamines putrescine, spermidine, and spermine are small positively-charged molecules that can interact with negatively-charged macromolecules like DNA, RNA and proteins. These interactions aid in nucleic acid and protein conformational stability, thereby, making polyamines essential building blocks for cells. Polyamines are involved in various cellular functions including gene regulation, protein synthesis, and cell proliferation. Rapidly-proliferating cells, such as cancer cells, utilize high polyamine levels for cell growth. Targeting the polyamine addiction of cancers is a validated anti-cancer strategy. To achieve the maximal reduction of polyamine levels, polyamine blocking therapy (PBT) employs several compounds in combination. First, one can inhibit …

Aquatic Macrophyte Communities In Five Sibley County (Minnesota) Lakes And The Factors That Affect Their Distribution, Samuel A. Schmid

All Graduate Theses, Dissertations, and Other Capstone Projects

The purposes of this study are to 1) quantify the shifts in the macrophyte community structure of five lakes in Sibley County, and 2) to assess the relationships between the macrophyte communities and abiotic factors in these five lakes. In both the early and late growing season of 2019, point-intercept surveys were conducted on High Island Lake, Titlow Lake, Schilling Lake, Silver Lake, and Clear Lake. At each point, water depth was recorded, and all macrophytes sampled were identified and recorded as “present.” There was not a late season survey conducted for High Island Lake in 2019 due to a …

Mediating The German Case System Through Concept-Based Instruction In An Online Learning Environment, Lea Pienkoss

All Graduate Theses, Dissertations, and Other Capstone Projects

The English language clarifies the role of nouns through sentence structures, something German does through a case system consisting of four cases that are dependent on gender, form, and quantity (Stocker & Young, 2012). This complexity of the concept of cases often results in difficulties German language learners encounter when identifying and producing the correct forms in the new language. Thus, Ritterbusch et al. (2006) suggested teaching the case system concept-based, allowing a holistic understanding of the cases and their meaning. This case study reacts to the call to action by developing and analyzing the teaching of the meaning of …

The Kiwanis Site: A Multi-Method Geophysical Approach To Investigating Mound Features, Luke Burds

All Graduate Theses, Dissertations, and Other Capstone Projects

Subtle mound-like landforms can be genetically ambiguous features within a landscape. A variety of geomorphological and anthropological processes can result in these equifinal forms being difficult to interpret. Being able to reliably and noninvasively differentiate them is important for legal as well as cultural and spiritual reasons. A suite of non-invasive geophysical methods were thus used on mounds at the Kiwanis site in western Wisconsin in order to determine if culturally diagnostic indicators could be recorded in geophysical data. Genesis of these mounds is ambiguous given the presence of aeolian landforms in immediate proximity. As a control, the same geophysical …

Effects Of Voluntary Exercise On Pressure-Induced Natriuresis In Hypertensive Female And Male Rats, Keshari Sudasinghe

All Graduate Theses, Dissertations, and Other Capstone Projects

Hypertension (HT) is one of the major diseases associated with the circulatory system and remains a public health problem with a high rate of prevalence in the adult population in the USA. The pressure natriuresis mechanism which is Na+ excretion in respond to rise in blood pressure acts as a long-term regulator of arterial blood pressure. Recent studies have demonstrated that impairment of this long-term pressure natriuresis mechanism is involved in hypertension (HT) and many other renal disorders. Exercise is a nonpharmacological treatment to help control HT, and exercise has a beneficial effect on vascular health, endothelial functions, arterial stiffness, …

Review: "The Deportation Machine: America’S Long History Of Expelling Immigrants" (2020), By Adam Goodman, Guillermo Yrizar Barbosa, Audrey Hudgins

International Studies Faculty Scholarship

No abstract provided.

Equine West Nile Virus In Kentucky: Characteristics Of Historical Testing And Analysis Of Causal Factors, Kaelyn Short

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

As the arbovirus with the highest incidence in both humans and horses in the United States, West Nile Virus (WNV) presents a significant risk to the equine population of Kentucky. Widespread infection has the potential to cause a significant economic impact to the state and long-term health complications for the horses. To better understand the burden of equine WNV, historical diagnostic testing archives the University of Kentucky Veterinary Diagnostic Lab were analyzed along with environmental and census data collected from additional sources. A total of 2146 test results were analyzed utilizing descriptive statistics, chi-square tests of independence, and binary logistic …

The Legal Man In The Moon: Exploring Environmental Personhood For Celestial Bodies, William B. Altabef

Chicago Journal of International Law

The rise of the commercial space industry endangers the preservation of environments, such as the lunar surface and other celestial bodies, with the threat of contamination and resource exploitation. In the coming decades, flights to space will become commonplace—but at present, there is no way to hold outer space polluters accountable. The existing international legal regime is weak, with the United Nations’ space treaties offering limited enforcement mechanisms against offenders. The increasingly popular concept of environmental personhood offers a solution by rethinking the meaning of a juridical person within the text of the United Nations Outer Space, Space Liability, and …

Accumbens Cholinergic Interneurons Mediate Cue-Induced Nicotine Seeking And Associated Glutamatergic Plasticity, Jonna M. Leyrer-Jackson, Michael Holter, Paula F. Overby, Jason M. Newbern, Michael D. Scofield, M. Foster Olive, Cassandra D. Gipson

Family and Community Medicine Faculty Publications

Nicotine, the primary addictive substance in tobacco, is widely abused. Relapse to cues associated with nicotine results in increased glutamate release within nucleus accumbens core (NAcore), modifying synaptic plasticity of medium spiny neurons (MSNs), which contributes to reinstatement of nicotine seeking. However, the role of cholinergic interneurons (ChIs) within the NAcore in mediating these neurobehavioral processes is unknown. ChIs represent less than 1% of the accumbens neuronal population and are activated during drug seeking and reward-predicting events. Thus, we hypothesized that ChIs may play a significant role in mediating glutamatergic plasticity that underlies nicotine-seeking behavior. Using chemogenetics in transgenic rats …

Applying Mixed-Effects Modeling To Behavioral Economic Demand: An Introduction, Brent A. Kaplan, Christopher T. Franck, Kevin Mckee, Shawn P. Gilroy, Mikhail N. Koffarnus

Family and Community Medicine Faculty Publications

Behavioral economic demand methodology is increasingly being used in various fields such as substance use and consumer behavior analysis. Traditional analytical techniques to fitting demand data have proven useful yet some of these approaches require preprocessing of data, ignore dependence in the data, and present statistical limitations. We term these approaches “fit to group” and “two stage” with the former interested in group or population level estimates and the latter interested in individual subject estimates. As an extension to these regression techniques, mixed-effect (or multilevel) modeling can serve as an improvement over these traditional methods. Notable benefits include providing simultaneous …

Characteristics Of Wild Florida Manatee (Trichechus Manatus Latirostris) Vocalizations In Different Sized Groups, Emily Garcia

Theses & ETDs

Florida manatees (Trichechus manatus latirostris) are semi-social animals that are most often found in groups. They produce generally tonal, short vocalizations that vary in structure and temporal characteristics based on age, sex, and activity. In this study, the frequency and temporal characteristics of Florida manatee vocalizations found alone or in groups of various sizes were compared. These vocalizations were recorded via digital acoustic tags deployed on wild manatees in Florida. Eleven tagged manatees and nearby manatee conspecifics were recorded in the southwest region of Florida. High-quality vocalizations (n = 225) that were considered ‘clean’ with a minimum signal-to-noise ratio of …

Waste Clearance In The Brain, Jasleen Kaur, Lara M. Fahmy, Esmaeil Davoodi-Bojd, Li Zhang, Guangliang Ding, Jiani Hu, Zhenggang Zhang, Michael Chopp, Quan Jiang

Neurology Articles

Waste clearance (WC) is an essential process for brain homeostasis, which is required for the proper and healthy functioning of all cerebrovascular and parenchymal brain cells. This review features our current understanding of brain WC, both within and external to the brain parenchyma. We describe the interplay of the blood-brain barrier (BBB), interstitial fluid (ISF), and perivascular spaces within the brain parenchyma for brain WC directly into the blood and/or cerebrospinal fluid (CSF). We also discuss the relevant role of the CSF and its exit routes in mediating WC. Recent discoveries of the glymphatic system and meningeal lymphatic vessels, and …

Fluorescence-Guided High-Grade Glioma Surgery More Than Four Hours After 5-Aminolevulinic Acid Administration, Georgios A. Maragkos, Alexander J. Schüpper, Nikita Lakomkin, Panagiotis Sideras, Gabrielle Price, Rebecca Baron, Travis Hamilton, Sameah A. Haider, Ian Lee, Constantinos G. Hadjipanayis, Adam Robin

Neurosurgery Articles

No abstract provided.

Black Grouper (Mycteroperca Bonaci) Neurocranium, Celeste Jaworski, David W. Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Neurocranium from 7.5 cm total length. Black Grouper (Mycteroperca bonaci), collected from Denny's Seafood Market on 15/10/2021 by Celeste Jaworski.

Gafftopsail Catfish Neurocranium, Allison J. Soucier

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

Gafftopsail Catfish (Bagre marinus), neurocranium length: 11.5 cm, collected from Keewaydin Island in Marco Florida on 15/9/2021 by Allison Soucier.

Nature’S Awakening Agents: The Relationship Between Classic Psychedelics, Mystical Experience, And The Increase Of Nature-Relatedness, Alexandra Mars

Theses & ETDs

The recent revival of psychedelic research has revealed that classic psychedelics (LSD, Psilocybin, DMT, and Mescaline) have the potential to increase nature-relatedness during and after receiving the substance, particularly when the recipient has a mystical experience during the session. This thesis is an assessment of classic psychedelics and psychedelic triggered mystical experience as a means to increase long term connection with nature and environmental lifestyle change. This will be executed through the examination of prehistoric to modern use of classic psychedelics, their profound effects, recent research and qualitative interviews with individuals. In the interviews, 90% of the participants mentioned nature …

Frog Eyes And Pig Butts: The North Carolina Stalking Statute's Constitutional Dilemma And How To Remedy It, Nathan W. Wilson

North Carolina Law Review

No abstract provided.

How Bavinck Responds To The Challenges Of The Theory Of Evolution: The Primacy Of Biblical Revelation, Isaias D'Oleo Ochoa

CTS Student Publications and Creative Works

In his discussion of evolution, Bavinck offers a modified theory of development, rooted not under a mechanistic and naturalistic worldview, as Darwin does, but under a “theistic-friendly” framework. This article argues that Bavinck’s discussion of evolution as a whole endorses a modified Aristotelian/ Thomistic framework in order to understand the theory of development, and thus overcomes the challenges raised by Darwin’s naturalistic worldview to biblical revelation.

Even Rocks Are Alive: Christian Animist Disruptions Of The Species Divide, Mark I. Wallace

Religion Faculty Works

No abstract provided.

Annual Report Of Research And Creative Productions By Faculty And Staff, January To December, 2021, Office Of Research And Sponsored Programs. Morehead State University.

Office of Research and Sponsored Programs Reports and Publications

Annual Report of Research and Creative Productions by Faculty and Staff, January to December, 2021.

Integrating Environmental Protection Into Asean Trading System, Kittinut Supsoontornkul

Dissertations & Theses

Integrating environmental protection into ASEAN trading system is pivotal for ensuring long-term economic development and environmental sustainability. Due to its resource-based economy, ASEAN's economic performance highly depends on the sustainable condition of the environment. The ASEAN approach prioritizing economic growth without environmental consideration leads to environmental degradation and economic loss. Many transboundary environmental problems in ASEAN result from unsustainable production methods aiming to maximize advantages in trade competition. There are growing international efforts in addressing production and process methods as a part of the sustainable development goal. Major trading partners of ASEAN increasingly employ unilateral environmental trade measures and environmental …

Communicative Functions In Human-Computer Interface Design: A Taxonomy Of Functional Animation, Raquel Ávila Muñoz, Jorge Clemente Mediavilla, María José Pérez-Luque

Artículos científicos

Cada vez que un usuario realiza una tarea o se comunica a través de su computadora o dispositivo, se le guía mediante señales visuales para interactuar exitosamente con la interfaz. Esta interacción persona-computadora está, por tanto, mediada por la comunicación que se establece entre diseñador y usuario a través de los textos, elementos gráficos y animaciones que componen el diseño visual de la interfaz. La animación es un elemento del lenguaje visual de los elementos gráficos de una interfaz. Este estudio tiene como objetivo establecer las funciones de la animación. Revisamos la literatura y discutimos las deficiencias identificadas en las …

Agresiones A Mujeres A Través De Los Videojuegos, M. Mar Martínez-Oña, Ana M. Muñoz Muñoz

Artículos científicos

INTRODUCCIÓN: El videojuego, es un producto multimedia de comunicación que entre otros valores, fomenta valores sociales; sin embargo hay que plantearse ¿Qué sucede cuando el usuario/jugador de videojuegos, se debe convertir en el violador más peligroso de la ciudad? Se normaliza entonces, el abuso violento y sexual contra las mujeres, se fomenta y desarrolla una cultura de la violación -Rape cultureque es confirmada y asimilada a través del silencio de la sociedad, quedando así las mujeres sometidas, vejadas y utilizadas. OBJETIVO: Cuando la violación hacia las mujeres se normaliza e incluso se convierte en un juego, es necesario denunciar determinados …

Las Primeras Obras De Jesús De Perceval, M. Mar Martínez-Oña

Artículos científicos

El presente artículo se centra en la figura del artista Jesús de Perceval (1915-1985), quien elaboró un completo legado artístico y cultural que se extiende desde pintura, escultura, dibujos, fotografías y diseño gráfico. Toda una creación artística, que culminó con el nacimiento de la Teoría de los Saros que fue la base teórica del Movimiento Indaliano. Excepcionalmente, las primeras pinturas del artista poseen unas características estéticas diferentes a toda la posterior obra del autor, por ello se presenta un estudio independiente, siendo el objetivo principal de este artículo analizar a través del método iconográfico la primera etapa de la obra …

Gráfica Fuera De Los Límites: Hacía Una Xilografía De Campo Expandido, Eva Santín Álvarez, Gema Navarro Goig

Artículos científicos

El grabado está viviendo en la actualidad una renovación sin precedentes, producto de un proceso de actualización en el arte gráfico contemporáneo, impulsado no solo por nuevas técnicas y tecnologías, sino también por una concepción más interdisciplinar. Por otra parte, algunos artistas, adeptos a las técnicas más puristas, apuestan por estrategias que cuestionan los fundamentos del grabado tradicional, encaminándose hacia una gráfica de campo expandido que rompe con los límites establecidos: la redefinición de la serie, la experimentación con soportes alternativos, la superación del plano bidimensional hacia la instalación gráfica, la hibridación y transdisciplinariedad, etc. Tecnologías diversas han irrumpido en …

Evaluation Of Methods For The Restoration Of Native Grasslands On Abandoned Center Pivots In The Sandsage Prairies Of Southwestern Kansas, Alonso Barragan-Martinez

Master's Theses or Doctor of Nursing Practice

Throughout southwestern Kansas thousands of acres of native grassland have been converted to cropland for agricultural use, reducing native prairie by over 60% in the sandsage prairie. Due to low precipitation and arid conditions, much of these croplands are irrigated by center pivot irrigation systems fed by the Ogallala Aquifer. These fields are abandoned when the aquifers dry up, resulting in erosion of the unused farmland. Conservation programs such as the Conservation Reserve Enhancement Program (CREP) were established to address this problem but have been unsuccessful in restoring native grasslands in abandoned croplands in southwestern Kansas. We hypothesized that insect …

“No Earlier Confession To Repeat”: Seibert, Dixon, And Question-First Interrogations, Lee S. Brett

Washington and Lee Law Review

The Supreme Court’s 2004 decision in Missouri v. Seibert forbade the use of so-called question-first interrogations. In a question-first interrogation, police interrogate suspects without giving Miranda warnings. Once the suspect makes incriminating statements, the police give the warnings and induce the suspect to repeat their earlier admissions.

Lower courts are increasingly interpreting a per curiam Supreme Court case, Bobby v. Dixon, to significantly limit the scope and applicability of Seibert. These courts claim that postwarning statements need only be suppressed under Seibert when there is an “earlier confession to repeat.” In this Note, I argue that this reading …

Classical Models, Anwar Shaikh Phd

Archives of Anwar Shaikh

22-17_Classical Models.pdf You said: as an archivist detailing a new entry, analyze the uploaded file and give an outline of the material with all dates standardized, all bullet-point item formatting, and sentence case for titles, and italics for all titles, 1.5 spacing between paragraphs, and expand the published items into full apa references with publisher details and journal information but without internet links, or further description, standardize the handwritten notes, emails, and comments into full apa-style manuscript citations so they match the level of formality of the published and class paper with all handwritten notes credited to anwar shaikh, phd …

"Our Most Sacred Legal Commitments": A Digital Exploration Of The U.S. Supreme Court Defining Who We Are And How They Should Opine, Eric C. Nystrom, David S. Tanenhaus

Scholarly Works

This Article focuses on uncovering the multiple meanings of the word "our" in the published opinions of the U.S. Supreme Court from Chisholm to modern times. To do so, we use a digital legal history approach, combining robust court data, text mining techniques, and expert word classification, using a set of custom open-source tools and open data.

Assimilation, Removal, Discipline, And Confinement: Native Girls And Government Intervention, Addie C. Rolnick

Scholarly Works

A full understanding of the roots of child separation must begin with Native children. This Article demonstrates how modern child welfare, delinquency, and education systems are rooted in the social control of indigenous children. It examines the experiences of Native girls in federal and state systems from the late 1800s to the mid-1900s to show that, despite their ostensibly benevolent and separate purposes, these institutions were indistinguishable and interchangeable. They were simply differently styled mechanisms of forced assimilation, removal, discipline, and confinement. As the repeating nature of government intervention into the lives of Native children makes clear, renaming a system …