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Articles 19741 - 19770 of 24319
Full-Text Articles in Entire DC Network
Physiological And Biochemical Responses Of Almond Rootstocks To Drought Stress, Adnan Nurhan Yildirim, Beki̇r Şan, Fatma Yildirim, Ci̇van Çeli̇k, Berna Bayar, Yaşar Karakurt
Physiological And Biochemical Responses Of Almond Rootstocks To Drought Stress, Adnan Nurhan Yildirim, Beki̇r Şan, Fatma Yildirim, Ci̇van Çeli̇k, Berna Bayar, Yaşar Karakurt
Turkish Journal of Agriculture and Forestry
Water availability is a very important factor for the growth and development of plants, which limits the plant production capacity. Rootstocks are widely utilized to improve plants tolerance to various biotic and abiotic stresses. In this study, physiological and biochemical responses of fifteen almond rootstock candidates to drought stress were investigated under in vitro conditions. The shoot tips from fifteen almond rootstock candidates were cultured in MS medium containing 1.0 mg/L BAP, 0.01 mg/L IBA, 30 g/L sucrose and 7 g/L agar. Plantlets were exposed to 0%, 1% and 2% polyethyleneglycol (PEG) as drought stress levels during four weeks. At …
The Effect Of Different Drying Methods On Nutritional Composition And Antioxidantactivity Of Purslane (Portulaca Oleracea), Hali̇l İbrahi̇m Bi̇ni̇ci̇, İhsan Güngör Şat, Eyad Aoudeh
The Effect Of Different Drying Methods On Nutritional Composition And Antioxidantactivity Of Purslane (Portulaca Oleracea), Hali̇l İbrahi̇m Bi̇ni̇ci̇, İhsan Güngör Şat, Eyad Aoudeh
Turkish Journal of Agriculture and Forestry
The aim of this study was to determine the effect of different drying methods on the nutritional content and antioxidant activity of purslane. Two different purslane samples have been dried using four different methods (sun, vacuum, hot air, and freeze drying). Dried and fresh samples were analyzed for their dry matter, β-carotene content, chlorophyll a and chlorophyll b contents, total flavonoid content, total flavonol content, total phenolic content, %DPPH radical scavenge activity, metal chelating activity, and color. The dry matter content of fresh purslane was 3.86%-5.28%. The β-carotene, chlorophyll a and b amounts varied from 61.31 to 67.08 mg/100 g, …
The First Report About Genetic Diversity Analysis Among Endemic Wild Rhubarb(Rheum Ribes L.) Populations Through Ipbs Markers, Çeknas Erdi̇nç, Ayteki̇n Eki̇nci̇alp, Si̇bel Turan, Meti̇n Koçak, Faheem Shahzad Baloch, Suat Şensoy
The First Report About Genetic Diversity Analysis Among Endemic Wild Rhubarb(Rheum Ribes L.) Populations Through Ipbs Markers, Çeknas Erdi̇nç, Ayteki̇n Eki̇nci̇alp, Si̇bel Turan, Meti̇n Koçak, Faheem Shahzad Baloch, Suat Şensoy
Turkish Journal of Agriculture and Forestry
Approximately 30% of plant species of Turkey, which is among the richest countries in terms of biodiversity, has been endemic. Wild rhubarb (Rheum ribes L.) is a wild vegetable grows especially in the eastern region of Turkey and is an endemic species. In this study, genetic relationships among 80 wild rhubarb genotypes collected from some regions of Lake Van Basin, which are in the distribution area, were tried to be determined by iPBS marker system. At the same time, a commercial variety of R. rhabarbarum, which is a cultivated species, was used as control. PCR studies were conducted with 23 …
An Experimental Analysis Of The Classic Overjustification Effect In Rats: Does The Removal Of “Expected” Rewards Alter Behavior In Rats As It Does In Humans?, Eleah Sunde
Master's Theses and Doctoral Dissertations
The overjustification effect posits that rewards undermine intrinsic motivation, such that an individual’s engagement in previously intrinsically motivating tasks will decrease when a previously reliable reward is withdrawn. This study aimed to determine if this overjustification effect can be demonstrated in rats, with typical confounds related to social and verbal aspects of reward delivery controlled for. Baseline “intrinsic” wheel-running rates of seven SpragueDawley rats were compared to rates that followed administration and withdrawal of a contingent sucrose reward, and to rates of rats in control conditions (n = 7). Consistent with the author’s hypothesis, the reward group’s wheel-running did not …
The Relationship Between Population Dynamics And Dietary Preferences Within Two Snake Genera (Storeria And Thamnophis), Molly M. Dixon
The Relationship Between Population Dynamics And Dietary Preferences Within Two Snake Genera (Storeria And Thamnophis), Molly M. Dixon
Master's Theses and Doctoral Dissertations
Amidst massive losses in biodiversity, it is vital to identify the factors driving species declines. The main objective of this research was to assess dietary differences between Storeria dekayi and Thamnophis sirtalis and their less abundant and more geographically restricted sister species, Storeria occipitomaculata and Thamnophis butleri, in Illinois and Michigan. I hypothesized that greater abundance and more cosmopolitan distribution are associated with consuming a wide variety of prey and more nonnative prey. To assess diets, I conducted field surveys of Storeria and Thamnophis and analyzed DNA metabarcoding data from fecal samples. I found no significant difference in the …
Jackpot Reinforcers And The Operant Behavior Of Siamese Fighting Fish (Betta Splendens), Jackson Carter Fox
Jackpot Reinforcers And The Operant Behavior Of Siamese Fighting Fish (Betta Splendens), Jackson Carter Fox
Capstones and Honors Theses
Jackpot reinforcers are an intriguing yet seldom studied area of operant conditioning with many potential applications in the scope of behavioral research. In this study, two Siamese fighting fish (Betta s.) were presented with the visual stimulus of a mirror upon completion of a target response, providing the opportunity to display an agonistic behavior towards their own mirror image. This opportunity for agonistic display to the mirror served as the primary reinforcer of the target response, which was simply swimming in a particular direction over a bar suspended in the center of the tank. This over-the-bar swimming was …
The Relationships Among Personality Traits, Food Consumption, And Anthropometrics In Healthy People, Chelsea Schwartz
The Relationships Among Personality Traits, Food Consumption, And Anthropometrics In Healthy People, Chelsea Schwartz
Wayne State University Theses
Two out of three people are obese in the United States, but Western culture isn’t the only population suffering from obesity and comorbidities. Many factors contribute to this global epidemic and more recently various research suggests that personality traits can be used to predict eating behaviors. This study investigated the Big Five personality trait’s influence on food consumption to determine what traits contribute to healthy eating and what traits are susceptible to overeating and therefore, poor health consequences. The Big Five personality traits, anthropometric measures, and diet logs were used to assess 38 individuals for health-related behaviors and obesity-related risk …
Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully
Oral Cbd Administration: Assessing Bioavailability And Behavioral Outcomes In A Rodent Model, Jordan Skully
Wayne State University Theses
There has been a recent surge in popularity for cannabidiol (CBD), a major non-psychotropic constituent of cannabis, due to numerous claims of potential therapeutic properties, which include, but are not limited to, anxiolytic, antinociceptive, and anti-inflammatory effects. However, as previous scientific literature on CBD's effectiveness in providing such therapeutic effects is limited, this project was aimed to evaluate the potential beneficial properties of a hemp derived 99% pure CBD compound provided from Ellipse Analytics (Denver, CO) in a rodent model. We analyzed the pharmacokinetics of this CBD product as well as the behavioral outcomes after acute and chronic administration. Pharmacokinetics …
Intercomparisons Of Three Global Bottom-Up Anthropogenic Emission Inventories: Implications For Air Quality, Halima Salah
Intercomparisons Of Three Global Bottom-Up Anthropogenic Emission Inventories: Implications For Air Quality, Halima Salah
Wayne State University Theses
Air pollution from human activities plays an important role in affecting ambient air quality, climate change and human health. To provide changes in global environmental policies to reduce air pollution, emission inventories are critical as they aide in the understanding of air quality impacts across multiple scales. The state-of-the-science global bottom-up anthropogenic emission inventories are the Evaluating the Climate and Air Quality Impacts of Short-Lived Pollutants version 6b (ECLIPSEv6b) for emissions from 1990-2050, Emission Database for Global Atmospheric Research version 5.0 (EDGARv5) for emissions from 1970-2015, and the Community Emissions Data System that was released in April 2021 (CEDS) for …
แนวคิดว่าด้วยศีลธรรมระหว่างประเทศของ Morgenthau และ Bull : ความเหมือน ความต่าง และนัย, มุนินทร วัฒนายากร
แนวคิดว่าด้วยศีลธรรมระหว่างประเทศของ Morgenthau และ Bull : ความเหมือน ความต่าง และนัย, มุนินทร วัฒนายากร
Journal of Social Sciences
บทความชิ้นนี้ศึกษาแนวคิดว่าด้วยศีลธรรมระหว่างประเทศของ Hans J. Morgenthau และ Hedley Bull โดยมุ่งตอบคำถามว่า “ถึงแม้ว่า Morgenthau และ Bull มีสมมติฐานว่ารัฐเป็นตัวแสดงหลักในการเมืองระหว่างประเทศที่มีสภาพเป็นอนาธิปไตย และถึงแม้ว่าทั้งสองตระหนักถึงบทบาทของศีลธรรมในการเมืองระหว่างประเทศ กระนั้น Morgenthau และ Bull มีแนวคิดว่าด้วยศีลธรรมระหว่างประเทศแตกต่างกันอย่างไร?” เมื่อศึกษางานชิ้นเอกของทั้งสองอย่าง Politics Among Nations และ The Anarchical Society ประกอบกับงานที่เกี่ยวข้อง จึงพบความเหมือน 5 ประการและความแตกต่าง 8 ประการ บทความชิ้นนี้เสนอว่าสมมติฐานว่าด้วยศีลธรรมเชิงประจักษ์และการวิเคราะห์ระดับระบบระหว่างประเทศทำให้แนวคิดว่าด้วยศีลธรรมของ Bull มีความคับแคบกว่าแนวคิดของ Morgenthau ที่ตั้งอยู่บนภววิทยาของธรรมชาติมนุษย์และระดับการวิเคราะห์แบบปัจเจกและระดับรัฐ บทความชิ้นนี้ยังมุ่งตอบคำถามที่ว่า “ความแตกต่างของแนวคิดทั้งสองมีนัยอย่างไร?” โดยเลือกศึกษาแนวคิดเรื่องสิทธิมนุษยชน บทความชิ้นนี้จึงเสนอต่อไปว่าแนวคิดว่าด้วยศีลธรรมระหว่างประเทศของ Morgenthau เปิดพื้นที่ให้แก่แนวคิดเรื่องสิทธิมนุษยชนมากกว่าแนวคิดของ Bull ขณะที่แนวคิดของ Bull ระบุถึงสถาบันและกลไกระหว่างประเทศที่สามารถใช้พัฒนาแนวคิดสิทธิมนุษยชนได้มากกว่าแนวคิดของ Morgenthau
ความเชื่อเรื่องนัตกับการเมืองวัฒนธรรม : พหุวัฒนธรรมท่ามกลางกระแสความเป็นเมืองในมัณฑะเลย์, กฤติธี ศรีเกตุ
ความเชื่อเรื่องนัตกับการเมืองวัฒนธรรม : พหุวัฒนธรรมท่ามกลางกระแสความเป็นเมืองในมัณฑะเลย์, กฤติธี ศรีเกตุ
Journal of Social Sciences
งานวิจัยนี้มีวัตถุประสงค์เพื่อวิเคราะห์พหุวัฒนธรรมและประชาธิปไตยเชิงวัฒนธรรมผ่านพื้นที่ความเชื่อเรื่องนัตในพื้นที่มัณฑะเลย์ ประเทศเมียนมา ผลการวิจัยพบว่าในพื้นที่ความเชื่อเรื่องนัตมีหลายฝ่ายเข้ามาเกี่ยวข้อง ทั้งฝ่ายผู้ปกครองและฝ่ายประชาชนผู้นับถือนัต โดยฝ่ายผู้ปกครองพยายามเข้ามาควบคุมจัดการหรือกระทั่งทำลายความเชื่อเรื่องนัตในบางยุค อันเป็นลักษณะของความรุนแรงทางวัฒนธรรม อย่างไรก็ตามการจัดการควบคุมดังกล่าวก็ไม่สามารถทำได้เด็ดขาดในระดับที่ผู้คนรู้สึกเป็นพวกเดียวกันได้ เอกภาพทางวัฒนธรรมความเชื่อไม่เคยเกิดขึ้น ปรากฏเป็นการต่อรองและการประนีประนอมอยู่เสมอ กระทั่งพื้นที่ความเชื่อเรื่องนัตสามารถเปิดรับเอาความหลากหลายเข้ามาอยู่ร่วมกัน แม้การเมืองเมียนมาปัจจุบันจะยังค่อนไปทางเผด็จการ แต่พหุวัฒนธรรมที่สะท้อนให้เห็นในพื้นที่ความเชื่อเรื่องนัต ก็จะเป็นปราการสำคัญในการป้องกันกระแสสุดโต่ง และจะเป็นพื้นฐานสำคัญรองรับกระแสการขยายตัวของเมือง ตลอดจนการพัฒนาประชาธิปไตยของเมียนมาในอนาคต
The Changes In Dietary Patterns Of Saudi Women Residing In Saudi Arabia, South Korea, And The United States: The Effects Of Length Of Residency On Dietary Acculturation, Nouf Alharbi
Wayne State University Dissertations
ABSTRACT
THE CHANGES IN DIETARY PATTERNS OF SAUDI WOMEN RESIDING IN SAUDI ARABIA, SOUTH KOREA, AND THE UNITED STATES: THE EFFECTS OF LENGTH OF RESIDENCY ON DIETARY ACCULTURATION
by
NOUF ABDULLAH ALHARBI
August 2021
Advisor: Dr. Kai-Lin Catherine JenMajor: Nutrition & Food Science Degree: Doctor of Philosophy Given the large and growing numbers of Saudi individuals living abroad, examining how their dietary patterns have changed and influenced by acculturation with host countries, as well as the health consequences of these changes is a research area that needs to be investigated. The primary objectives of the present study were to compare …
Trained And Derived Relational Responding, Jonathan D. Sober
Trained And Derived Relational Responding, Jonathan D. Sober
Wayne State University Dissertations
Introduction: Persons with preclinical Alzheimer’s disease (AD) show impairments in semantic and associative memory years before the onset of clinical symptoms. However, many tasks used to assess these deficits make use of previously learned stimuli, often within well-established semantic networks that may be more resistant to disease-related changes. No research has been conducted examining trained and derived relational responding (TDRR) in older adults or in the presence of AD risk factors. The purpose of this study was to determine whether a novel TDRR task would be sensitive to age-related and disease-risk cognitive changes. Method: Thirty younger adults and 15 older …
An Empirical Assessment Of Homicide And Suicide Outcomes With Red Flag Laws, Rachel Delafave
An Empirical Assessment Of Homicide And Suicide Outcomes With Red Flag Laws, Rachel Delafave
Loyola University Chicago Law Journal
This Article empirically illustrates that red flag laws—laws which permit removal of firearms from a person who presents a risk to themselves or others—contribute to a statistically significant decrease in suicide rates, but do not influence homicide rates. I exploit state-level variation across time in the existence of red flag laws between 1990 and 2018 and find that the existence of a risk-based law reduces firearm-related suicides by 6.4% and overall suicides by 3.7%, with no substitution to non-firearm suicides. Red flag laws are not associated with a statistically significant change in homicides rates. Policymakers should consider red flag laws …
Copyright Versus The Right To Copy: The Civic Danger Of Allowing Intellectual Property Law To Override State Freedom Of Information Law, Frank D. Lomonte
Copyright Versus The Right To Copy: The Civic Danger Of Allowing Intellectual Property Law To Override State Freedom Of Information Law, Frank D. Lomonte
Loyola University Chicago Law Journal
No abstract provided.
Modeling Continental-Scale Outdoor Environmental Sound Levels With Limited Data, Katrina Lynn Pedersen
Modeling Continental-Scale Outdoor Environmental Sound Levels With Limited Data, Katrina Lynn Pedersen
Theses and Dissertations
Modeling outdoor acoustic environments is a challenging problem because outdoor acoustic environments are the combination of diverse sources and propagation effects, including barriers to propagation such as buildings or vegetation. Outdoor acoustic environments are most commonly modeled on small geographic scales (e.g., within a single city). Extending modeling efforts to continental scales is particularly challenging due to an increase in the variety of geographic environments. Furthermore, acoustic data on which to train and validate models are expensive to collect and therefore relatively limited. It is unclear how models trained on this limited acoustic data will perform across continental-scales, which likely …
The Case For A More Inclusive Capitalism By Democratizing The Institutions Of Corporate Finance With The Future Earnings Of Capital, Robert Ashford
The Case For A More Inclusive Capitalism By Democratizing The Institutions Of Corporate Finance With The Future Earnings Of Capital, Robert Ashford
University of the Pacific Law Review
No abstract provided.
Targeting Ros-Dependent Akt/Gsk-3Β/Nf-Κb And Dj-1/Nrf2 Pathways By Dapagliflozin Attenuates Neuronal Injury And Motor Dysfunction In Rotenone-Induced Parkinson’S Disease Rat Model, Marwa Safar
Pharmacy
No abstract provided.
Remnant Or Replacement? Outlining A Possible Apostasy Narrative, Nicholas J. Frederick, Joseph M. Spencer
Remnant Or Replacement? Outlining A Possible Apostasy Narrative, Nicholas J. Frederick, Joseph M. Spencer
BYU Studies
Since early in the twentieth century, it has been common for Latter- day Saints to speak of a “Great Apostasy” that occurred in the centuries following the death and resurrection of Jesus Christ. Such a general apostasy has been viewed as providing the basic motivation for the Restoration, begun in earnest with Joseph Smith’s First Vision in 1820. The traditional apostasy narrative has centered on the argument that the church founded by Jesus Christ once possessed the same organization, doctrine, and authority restored in the nineteenth century but that, over time, these crucial components were either lost or corrupted. It …
“In Their Promised Canaan Stand”: Outlawry, Landscape, And Memory In C. C. A. Christensen’S Mormon Panorama, Jennifer Champoux
“In Their Promised Canaan Stand”: Outlawry, Landscape, And Memory In C. C. A. Christensen’S Mormon Panorama, Jennifer Champoux
BYU Studies
What do Robin Hood and Joseph Smith have in common? This article examines C. C. A. Christensen’s Mormon Panorama according to themes of outlawry in Anglo-Saxon literature, revealing insights into the nineteenth-century Latter-day Saint understanding of exile and sacred space in relation to both the landscape and to America. In Christensen’s paintings, the moral rightness of Latter-day Saints is contrasted with injustice by both government officials and local vigilantes, thereby equating outcast status with righteousness and true justice. In collating early stories of persecution and miracles, and presenting them with an aura of objective truth, the Mormon Panorama helped shape …
Lost Sheep, Lost Coins, And Lost Meanings, Jenny Rebecca Rytting
Lost Sheep, Lost Coins, And Lost Meanings, Jenny Rebecca Rytting
BYU Studies
Three of the best known and most loved of Jesus’s parables occur together in the fifteenth chapter of Luke as a response to the Pharisees’ disapproval of Jesus’s association with sinners: the parables of the lost sheep, the lost coin (also known as the lost drachma or lost groat), and the lost (or prodigal) son. In the teaching and preaching traditions of The Church of Jesus Christ of Latter-day Saints, these parables (especially the first two) have primarily been interpreted as a call for missionary work, particularly reactivation. For example, President David O. McKay suggested that the three parables represent …
Studies Of Insect Temporal Trends Must Account For The Complex Sampling Histories Inherent To Many Long-Term Monitoring Efforts, Ellen A.R. Welti, Anthony Joern, Aaron M. Ellison, David C. Lightfoot, Sydne Record, Nicholas Rodenhouse, Emily H. Stanley, Michael Kaspari
Studies Of Insect Temporal Trends Must Account For The Complex Sampling Histories Inherent To Many Long-Term Monitoring Efforts, Ellen A.R. Welti, Anthony Joern, Aaron M. Ellison, David C. Lightfoot, Sydne Record, Nicholas Rodenhouse, Emily H. Stanley, Michael Kaspari
Biology Faculty Research and Scholarship
Crossley et al. (2020)1 examine patterns of change in insect abundance and diversity across US Long-Term Ecological Research (LTER) sites, concluding “a lack of overall increase or decline”. This is notable if true, given mixed conclusions in the literature regarding the nature and ubiquity of insect declines across regions and insect taxonomic groups2–6. The data analyzed, downloaded from and collected by US LTER sites, represent unique time series of arthropod abundances. These long-term datasets often provide critical insights, capturing both steady changes and responses to sudden unpredictable events. However, a number of the included datasets are not …
A Test Of Species Distribution Model Transferability Across Environmental And Geographic Space For 108 Western North American Tree Species, Noah D. Charney, Sydne Record, Beth E. Gerstner, Cory Merow, Phoebe L. Zarnetske, Brian J. Enquist
A Test Of Species Distribution Model Transferability Across Environmental And Geographic Space For 108 Western North American Tree Species, Noah D. Charney, Sydne Record, Beth E. Gerstner, Cory Merow, Phoebe L. Zarnetske, Brian J. Enquist
Biology Faculty Research and Scholarship
Predictions from species distribution models (SDMs) are commonly used in support of environmental decision-making to explore potential impacts of climate change on biodiversity. However, because future climates are likely to differ from current climates, there has been ongoing interest in understanding the ability of SDMs to predict species responses under novel conditions (i.e., model transferability). Here, we explore the spatial and environmental limits to extrapolation in SDMs using forest inventory data from 11 model algorithms for 108 tree species across the western United States. Algorithms performed well in predicting occurrence for plots that occurred in the same geographic region in …
Ecocomdp: A Flexible Data Design Pattern For Ecological Community Survey Data, Margaret O'Brien, Colin A. Smith, Eric R. Sokol, Corinna Gries, Nina Lany, Sydne Record, Max C. N. Castorani
Ecocomdp: A Flexible Data Design Pattern For Ecological Community Survey Data, Margaret O'Brien, Colin A. Smith, Eric R. Sokol, Corinna Gries, Nina Lany, Sydne Record, Max C. N. Castorani
Biology Faculty Research and Scholarship
The idea of harmonizing data is not new. Decades of amassing data in databases according to community standards - both locally and globally - have been more successful for some research domains than others. It is particularly difficult to harmonize data across studies where sampling protocols vary greatly and complex environmental conditions need to be understood to apply analytical methods correctly. However, a body of longterm ecological community observations is increasingly becoming publicly available and has been used in important studies. Here, we discuss an approach to preparing harmonized community survey data by an environmental data repository, in collaboration with …
Corynebacterium Species Inhibit Streptococcus Pneumoniae Colonization And Infection Of The Mouse Airway, Kadi J Horn, Alexander C Jaberi Vivar, Vera Arenas, Sameer Andani, Edward N Janoff, Sarah E Clark
Corynebacterium Species Inhibit Streptococcus Pneumoniae Colonization And Infection Of The Mouse Airway, Kadi J Horn, Alexander C Jaberi Vivar, Vera Arenas, Sameer Andani, Edward N Janoff, Sarah E Clark
Open Access Publications
The stability and composition of the airway microbiome is an important determinant of respiratory health. Some airway bacteria are considered to be beneficial due to their potential to impede the acquisition and persistence of opportunistic bacterial pathogens such as
Green Nanotechnology Of Mgf‑Aunps For Immunomodulatory Intervention In Prostate Cancer Therapy, Menka Khoobchandani, Aslam Khan, Kavita K. Katti, Velaphi C. Thipe, Amal Y. Al-Yasiri, Darsha K. D. Mohandoss, Michael B. Nicholl, Ademar B. Lugão, Chetan P. Hans, Kattesh V. Katti
Green Nanotechnology Of Mgf‑Aunps For Immunomodulatory Intervention In Prostate Cancer Therapy, Menka Khoobchandani, Aslam Khan, Kavita K. Katti, Velaphi C. Thipe, Amal Y. Al-Yasiri, Darsha K. D. Mohandoss, Michael B. Nicholl, Ademar B. Lugão, Chetan P. Hans, Kattesh V. Katti
Open Access Publications
No abstract provided.
The Sarm1 Tir Nadase: Mechanistic Similarities To Bacterial Phage Defense And Toxin-Antitoxin Systems, Aaron Diantonio, Jeffrey Milbrandt, Matthew D Figley
The Sarm1 Tir Nadase: Mechanistic Similarities To Bacterial Phage Defense And Toxin-Antitoxin Systems, Aaron Diantonio, Jeffrey Milbrandt, Matthew D Figley
Open Access Publications
The Toll/interleukin-1 receptor (TIR) domain is the signature signalling motif of innate immunity, with essential roles in innate immune signalling in bacteria, plants, and animals. TIR domains canonically function as scaffolds, with stimulus-dependent multimerization generating binding sites for signalling molecules such as kinases and ligases that activate downstream immune mechanisms. Recent studies have dramatically expanded our understanding of the TIR domain, demonstrating that the primordial function of the TIR domain is to metabolize NAD
Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology And Demyelination Caused By Hypoperfusion, Mikko T Huuskonen, Qinghai Liu, Krista Lamorie-Foote, Kristina Shkirkova, Michelle Connor, Arati Patel, Axel Montagne, Hans Baertsch, Constantinos Sioutas, Todd E Morgan, Caleb E Finch, Berislav V Zlokovic, William J Mack
Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology And Demyelination Caused By Hypoperfusion, Mikko T Huuskonen, Qinghai Liu, Krista Lamorie-Foote, Kristina Shkirkova, Michelle Connor, Arati Patel, Axel Montagne, Hans Baertsch, Constantinos Sioutas, Todd E Morgan, Caleb E Finch, Berislav V Zlokovic, William J Mack
Open Access Publications
Cerebrovascular pathologies are commonly associated with dementia. Because air pollution increases arterial disease in humans and rodent models, we hypothesized that air pollution would also contribute to brain vascular dysfunction. We examined the effects of exposing mice to nanoparticulate matter (nPM; aerodynamic diameter ≤200 nm) from urban traffic and interactions with cerebral hypoperfusion. C57BL/6 mice were exposed to filtered air or nPM with and without bilateral carotid artery stenosis (BCAS) and analyzed by multiparametric MRI and histochemistry. Exposure to nPM alone did not alter regional cerebral blood flow (CBF) or blood brain barrier (BBB) integrity. However, nPM worsened the white …
Metformin Downregulates Pd-L1 Expression In Esophageal Squamous Cell Catrcinoma By Inhibiting Il-6 Signaling Pathway, Yao Lu, Dao Xin, Lulu Guan, Mengli Xu, Yalan Yang, Yu Chen, Yuanyuan Yang, Andrea Wang-Gillam, Li Wang, Shanggang Zong, Feng Wang
Metformin Downregulates Pd-L1 Expression In Esophageal Squamous Cell Catrcinoma By Inhibiting Il-6 Signaling Pathway, Yao Lu, Dao Xin, Lulu Guan, Mengli Xu, Yalan Yang, Yu Chen, Yuanyuan Yang, Andrea Wang-Gillam, Li Wang, Shanggang Zong, Feng Wang
Open Access Publications
Purpose: To characterize the mechanism by which metformin inhibits PD-L1 expression in esophageal squamous cell carcinoma (ESCC) and to evaluate the effect of metformin on the antitumor immune response.
Methods: The Cancer Genome Atlas (TCGA) database was used to analyze the correlations between IL-6 and prognosis and between IL-6 and PD-L1 gene expression in esophageal cancer. Reverse transcription-quantitative polymerase chain reaction (RT-PCR), Western blotting and immunofluorescence were used to study the mechanism by which metformin affects PD-L1 expression. Additionally, T cell function was assessed in a coculture system containing ESCC cells and peripheral blood mononuclear cells (PBMCs) treated with metformin …
Pharmacokinetics Of Single Domain Antibodies And Conjugated Nanoparticles Using A Hybrid Near Infrared Method, Shiran Su, Thomas J Esparza, Duong Nguyen, Simone Mastrogiacomo, Joong H Kim, David L Brody
Pharmacokinetics Of Single Domain Antibodies And Conjugated Nanoparticles Using A Hybrid Near Infrared Method, Shiran Su, Thomas J Esparza, Duong Nguyen, Simone Mastrogiacomo, Joong H Kim, David L Brody
Open Access Publications
Iron oxide nanoparticles and single domain antibodies from camelids (VHHs) have been increasingly recognized for their potential uses for medical diagnosis and treatment. However, there have been relatively few detailed characterizations of their pharmacokinetics (PK). The aim of this study was to develop imaging methods and pharmacokinetic models to aid the future development of a novel family of brain MRI molecular contrast agents. An efficient near-infrared (NIR) imaging method was established to monitor VHH and VHH conjugated nanoparticle kinetics in mice using a hybrid approach: kinetics in blood were assessed by direct sampling, and kinetics in kidney, liver, and brain …