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Biophysical Effects Of Altered Myosin Binding Protein Stoichiometry In Atrial Myofilaments, Kelly N. Araujo

Dissertations

Cardiomyopathies, such as hypertrophic and dilated subtypes, are leading causes of heart failure and are often driven by genetic mutations that disrupt the structure and function of the cardiac sarcomere. While much of the research has focused on ventricular involvement, the role of atrial sarcomere dysfunction remains unexplored. The regulation of contractile function by sarcomeric proteins in the atria remains poorly understood, especially the impact of protein stoichiometry among myosin binding proteins. Cardiac myosin binding protein-C (cMyBP-C) and its atrial paralog, myosin binding protein H-like (MyBP-HL), have been shown to have a stoichiometric relationship within the atrial sarcomere. These two …

Holographic Scaling And Cosmological Correlators, He Li

Dissertations - ALL

It is well-established that the two-point correlator of a scalar field in AdS follows either of two scaling laws, ∆± =d/2 ± ν, where ν =Sqrt((d/2)^2+ m^2) is a function of the scalar bulk mass. The transition between these two scalings occurs in the renormalization group evolution from the UV to the IR of a dual 4D conformal theory deformed by a relevant double-trace deformation. In this thesis, we identify a new holographic scaling law, ∆UV = ν, in the context of the AdS/CFT correspondence where there exists a UV cutoff brane. Specifically, when ν > 1, the ∆− scaling that …

A Multimodal Approach To Assess A Liposomal Carrier’S Biodistribution, Stability, And Clearance, Cayla A Wood, Claire E Jones, Ananthakrishnan Soundaram Jeevarathinam, Riley Watson, Sangheon Han, Jennifer Meyer, Konstantin V Sokolov, Richard R Bouchard

Faculty, Staff and Student Publications

Liposomal carriers, used for site-specific drug delivery, are being investigated for diagnostic approaches by replacing the therapeutic with an imaging contrast agent, exploring potential for selective treatment planning. There remains a critical need to improve in vivo assessment of biodistribution, stability, and clearance kinetics of liposomal carriers. This pilot study presents a multimodal approach in which liposome-encapsulated J-aggregated indocyanine green (ICG) dye (Lipo-JICG) is imaged with high spatial resolution using both in vivo photoacoustic (PA) imaging, to assess the absorbance characteristics of JICG and monomeric ICG, and ex vivo cryofluorescence tomography (CFT), to measure ICG fluorescence. An in vitro assay …

Prolonging Lung Cancer Response To Egfr Inhibition By Targeting The Selective Advantage Of Resistant Cells, Lisa Brunet, David Alexandre, Jiyoung Lee, Maria Del Mar Blanquer-Rosselló, David Bracquemond, Alexis Guernet, Houssein Chhouri, Mathilde Goupil, Zoulika Kherrouche, Arnaud Arabo, Maicol Mancini, Dorthe Cartier, Shen Yao, David Godefroy, Julie Dehedin, Jian-Rong Li, Céline Duparc, Philippe Jamme, Audrey Vinchent, Caroline Bérard, David Tulasne, Sabrina Arena, Alberto Bardelli, Chao Cheng, Byoung Chul Cho, Olivier Wurtz, Cédric Coulouarn, Antonio Maraver, Stuart A Aaronson, Alexis B Cortot, Youssef Anouar, Luca Grumolato

Faculty, Staff and Students Publications

Non-small cell lung cancers (NSCLCs) treated with tyrosine kinase inhibitors (TKIs) of the epidermal growth factor receptor (EGFR) almost invariably relapse in the long term, due to the emergence of subpopulations of resistant cells. Through a DNA barcoding approach, we show that the clinically approved drug sorafenib specifically abolishes the selective advantage of EGFR-TKI-resistant cells, while preserving the response of EGFR-TKI-sensitive cells. Sorafenib is active against multiple mechanisms of resistance/tolerance to EGFR-TKIs and its effects depend on early inhibition of MAPK-interacting kinase (MKNK) activity and signal transducer and activator of transcription 3 (STAT3) phosphorylation, and later down-regulation of MCL1 and …

La Maternidad Desmitificada En El Matrimonio De Los Peces Rojos De Guadalupe Nettel Y Casas Vacías De Brenda Navarro, Luis Alberto De Loera

Cuaderna Vía

No abstract provided.

Parole, Parole, Parole, Margarita V. Salazar Canseco, Noé Pozos

Cuaderna Vía

No abstract provided.

Full Issue, Cuaderna Vía Editors

Cuaderna Vía

No abstract provided.

El Perro Que Dijo ¡Miau!, Matias Ortiz

Cuaderna Vía

No abstract provided.

Había Una Vez Una Tortuga Y Un Lobo, Carlos Reyes

Cuaderna Vía

No abstract provided.

En El Bosque, Julia Reyes

Cuaderna Vía

No abstract provided.

La Expresión Metafórica En “Pueblo Negro” Y “Mulata-Antilla” De Luis Palés Matos, Guillermo S. Ríos

Cuaderna Vía

No abstract provided.

Prologue, Dr. Amy Austin

Cuaderna Vía

No abstract provided.

Full Issue, Cuaderna Vía Editors

Cuaderna Vía

No abstract provided.

Effectiveness Of Glucagon-Like Peptide 1 Receptor Agonists In The Treatment Of Heart Failure, Lisa Kristen Schloemann

SIU Journal of Medical Science Scholarly Works

ABSTRACT

Purpose: The purpose of this article is to review the use of glucagon-like peptide 1 receptor agonists (GLP-1 RA) in heart failure (HF) treatment considering the HF phenotype and comorbidities, including type 2 diabetes mellitus (DM) and obesity.

Method: A PubMed and Google Scholar literature search was conducted with search terms, HF and GLP-1 RA. Seven pertinent articles were retrieved and served as the basis for this clinical review.

Results: The efficacy of GLP-1 RA therapy in patients with heart failure with reduced ejection fractions (HFrEF) is unclear, with one study showing increased adverse cardiac events including tachyarrhythmias, and …

In Silico Investigation Of The Anticancer Activity Of Natural Isoquinoline Alkaloids Targeting The Monoamine Oxidase A Enzyme, Reham A. Al-Anssari, Anwar H. Ali, Ola Adel Al-Saad, Shaker A.N. Al-Jadaan

AUIQ Complementary Biological System

Monoamine oxidase A (MAO-A) has recently been identified as a candidate for cancer therapy due to its roles in tumor development and growth. Conventional approaches for the discovery of MAO-A inhibitors are both costly and time-consuming. The objective of this work was to apply in silico methods to predict natural isoquinoline alkaloids capable of acting as potent MAO-A inhibitors, and to establish this class of compounds as potential sources of a cost-effective anticancer therapy. Twenty-one natural isoquinoline alkaloids were subjected to a multistep computer-aided drug discovery protocol. The compounds were initially screened for pharmacokinetic (ADME), toxicity, and drug-likeliness properties by …

Computed Tomography Features For Differentiating Mast Cell Tumors And Soft Tissue Sarcomas In Subcutaneous Masses In Dogs, Seri Hong, Daji Noh, Kija Lee, Hojung Choi, Youngwon Lee, Sooyoung Choi

The Thai Journal of Veterinary Medicine

This study aimed to investigate the computed tomography (CT) features of mast cell tumors (MCTs) and soft tissue sarcomas (STSs) in subcutaneous masses of dogs and to identify distinguishing characteristics between these two tumor types. This retrospective, multicenter study included 22 dogs with subcutaneous masses diagnosed as MCTs (n = 11) or STSs (n = 11) via fine needle aspiration or excisional biopsy. The CT features were evaluated based on four categories: location, morphological characteristics (including shape, margin, capsulation, size, and long axis to short axis (L/S) ratio of the lesion), internal parenchymal characteristics (including cavitation, vascularization, mineralization, homogeneity and …

Issue 470: August 21-September 4, 2025, The Local Voice

The Local Voice

No abstract provided.

The Indiana Statesman, August 21, 2025, Indiana State University

Student Newspaper

Welcome Freshmen! Convocation embraces freshman class; Letter from the President; Party at the Fountain concludes Sycamore Sunday

From The River To The Sea: Environmental Ecocide In Palestine, Isabela Pizarro

Student Theses 2015-Present

This paper investigates the environmental and ecological toll of Israel’s current occupation and genocide of Palestine through ecological, historical, philosophical, and legal lenses. Chapter 1 explores the ecological impacts that Israel’s prolonged military operations have had on Gaza and the West Bank since October 7, 2023. Chapter 2 provides a comprehensive examination of the ideological motivations and historical context for Israel’s colonization of Palestine. The chapter also provides a pre-colonial history of Palestine’s indigenous agriculture and land management practices, highlighting its self-sufficiency and sustainability prior to the occupation. Chapter 3 explores different environmental philosophies between indigenous Palestinians and the State …

Native Ticks As A Model For The Effectiveness Of Fire As A Tool For The Management Of Cattle Fever Ticks In South Texas, Lauren P. Maestas, Sarah E. Mays Maestas, Kathleen M. Yeater, Manuel Zavala, Reyes Garcia, John A. Goolsby

School of Integrative Biological & Chemical Sciences Faculty Publications

The species of cattle fever ticks (CFT) present in North America, Rhipicephalus (=Boophilus) annulatus, and R. microplus, remain an important agricultural and economic burden. The use of acaricides to control CFT has been a common practice over the past half century. However, alternative strategies for control are needed to improve the options for sustainable pest control. Fire is a tool to manage vegetation, and some evidence supports its potential for use to control ticks. We evaluated the effectiveness of fire as a management tool for ticks in South Texas. Our site was a 28.2-ha property in Cameron …

Riparian Restoration Increases Soil Microbial Biomass In Marin County Rangelands, But Soil Carbon Stock Is Less Responsive, Sherilyn Kathryn Reinhart

Master's Theses

Land use change has caused the degradation of 70% of the Earth’s soils, directly altering soil microbial communities and carbon cycling. Interest in carbon farming practices is growing, but studies that document the nuances of soil carbon flux in specific bioregions are still too few. In this study, I examined how one practice, riparian restoration, alters soil carbon stock and microbial community structure over time. Using a paired sampling time series design, I collected soil samples from twelve riparian forests and adjacent rangelands near Marin County, California. Young and mature sites ranged from five to 29 years since restoration, and …

Green Synthesis Of Mgo Nanoparticles Via Two Different Methods And Studying Their Structural, Morphological, And Optical Properties, Athraa Hadi Obead, Nada K. Abbas

Baghdad Science Journal

Magnesium oxide nanoparticles (MgO NPs) have been prepared by a green synthesis using the leaves of Ficus carica extract, which can be easily used for various biomedical applications. Magnesium oxide nanoparticles (MgO NPs) prepared by a green synthesis are non-toxic, biocompatible, and environmentally friendly. Fig extract functions as a reducing and stabilizing agent. The precursors used for preparation are from Magnesium Nitrate MgO(n) and bulk magnesium oxide MgO(b) by two different methods. The MgO(n) prepared from Magnesium Nitrate and MgO(b) prepared from bulk magnesium oxide nanoparticles were characterized using UV-visible spectroscopy (UV-Vis) to analyze the absorption patterns, The energy band …

Biodegradable Nanocomposites Thin Films For Recyclability Electronic Covering, Ban Jawad, Ammar Emad Al-Kawaz, Hanaa Jawad, Nabeel Hasan, Balqees Mohammed

Baghdad Science Journal

In this study, the nanocomposite thin films were prepared from polyvinyl alcohol (PVA) that reinforced with different proportions of carbon nanotubes (CNTs) via hand casting method . The current work aims to create the connection between improving surface characteristics for high efficiency electronic covering and biodegradability. The nature of bonding between the PVA and CNTs were studied by Fourier-transform infrared spectroscopy (FTIR). Wettability properties were studied via contact angle analyzer. The two dimensions' morphology of nanocomposites was studied using atomic force microscopy (AFM). Biodegradable tests of nanocomposites were performed via burial in soil for seven days. According to the contact …

Dragon Guitars And Sexy Zombies: Tracing The Meta-Motion Of The Naga Motif In Northeast Thailand, Aaron Michael Stanley

Dartmouth College Master’s Theses

Abstract

This thesis traces the evolving symbolism of the Naga motif (a mythic water serpent) in Northeast Thailand through a framework I call meta-motion, which maps symbolic persistence of this cultural signifier and boundary marker across four cultural horizons—animist (Z), Hindu–Khmer (B), Buddhist (A), and modern/global (C). Like electrons in quantum super position, symbolic motifs circulate as overlapping “waves” of potential meaning and are concretized into cultural “particles” only when recruited for specific ritual, commercial, or political purposes. I add a bookend extension to Chang’s Hindu-Buddhist (B/A) typology with the addition of Horizons Z and C in order to make …

Statistical Analysis Of Multi-Endpoint Phenotypic Screening Increases Sensitivity Of Planarian Neurotoxicity Testing, Danielle Ireland, L. J. Word, Eva-Maria S. Collins

Biology Faculty Works

There is an urgent need for high-throughput screening (HTS) models to replace, refine, and/or reduce (“3Rs”) vertebrate toxicity testing. Replacing in vivo animal studies is challenging for neurotoxicity and developmental neurotoxicity (DNT), where the functional relevancy of adverse outcomes needs to be assessed on the whole organism. We previously screened the NTP 87-compound library (NTP87), consisting of known and suspected developmental neurotoxicants, and showed that planarian HTS can identify known (developmental) neurotoxicants. Because analysis methods can impact screening results, and our original analysis used the lowest-observed-effect-level (LOEL) only, we hypothesized that the use of state-of-the-art statistical analysis would increase the …

Dclk1 Isoform (Dclk1-S) As A Critical Player In Promoting Inflammation, Tissue Remodeling, And Emt In Mouse Models Of Colitis., Kafayat Yusuf, Badal C. Roy, William L. Hauser, Mazin Al-Kasspooles, Sierra Sanchez, Thomas M. Attard, Dong Pei, Venkatesh Sampath, Shrikant Anant, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIMS: The Doublecortin-like kinase-1 (DCLK1) plays a chemosensory role in the gut. It's role in the context of inflammatory diseases including inflammatory bowel disease (IBD), has not been thoroughly investigated. This study explored the role of the DCLK1 isoform (DCLK1-S) in promoting infectious/chemical colitis by utilizing high-throughput imaging mass cytometry (IMC).

METHODS: Transgenic mice were either infected with Citrobacter rodentium (CR) or received DSS and tissues/cells were processed via standard techniques. IMC workflow was adapted by Fluidigm (renamed Standard BioTools). Raw data was fed to Multiplexed Cell Dataset (MCD) Viewer for image generation and analyzed via histoCAT. Promoters …

Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, Brandon L Brown, Yaowen Chang, Blanca Díaz-Castro, Jonathan V Sweedler, Xinzhu Yu

Faculty, Staff and Student Publications

Accumulating evidence has supported diverse regulatory functions of astrocytes in different neural circuits as well as various aspects of complex behaviors. However, little is known about how astrocytes regulate different neuronal subpopulations that are linked to specific behavioral aspects within a single brain region. Here, we show that astrocytes in the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues in freely behaving mice. Silencing mPFC astrocyte Ca

Circzfr/Ythdf3 Axis Drives Lymph Node Metastasis In Cervical Cancer Via Fasn Translation, Mingyi Zhou, Yan Gao, Yong Zhang, Lian He, Bo Gao, Yue Zhang, Francois X Claret, George A Calin, Danbo Wang

Faculty, Staff and Student Publications

Background: Lymph node metastasis is a key driver of poor outcomes in cervical cancer. However, the molecular mechanisms of circular RNAs (circRNAs) driving cervical cancer lymph node metastasis remain unclear.

Methods: We identified circZFR, fatty acid synthase (FASN) and YTH N6-methyladenosine RNA binding protein F3 (YTHDF3) protein expression in the cervical cancer patients with long and short disease-free survival (DFS). Functional experiments were performed to investigate the function of circZFR, FASN and YTHDF3 on cell migration and invasion. MeRIP-qPCR, RNA pulldown, RNA Immunoprecipitation (RIP), and Co-Immunoprecipitation (Co-IP) assays were executed to investigate the mechanism of circZFR regulating FASN protein expression. …

Tort Liability For Failure To Age Gate: A Promising Regulatory Response To Digital Public Health Hazards, Matthew B. Lawrence, Brett Frischmann, Avi Sholkoff

Faculty Publications

Tort liability for failure to “age gate” is a promising legal response to the public health hazards of AI, social media, sports gambling, and other digital spaces. Tort liability for failure to “age gate” hinges liability for harms to minors on an app’s failure to take reasonable steps to prevent minors from gaining access or otherwise to apply appropriate governance rules, such as privacy-protective default settings or ensuring genuine parental consent. While no one legal response is a panacea, tort liability for failure to age gate carries several distinctive advantages that make it a particularly promising option at this stage …

Molecular Identification Of Acinetobacter Baumannii Isolated From Clinical Samples In Iraq By Using Multiplex Pcr, Yaseen Ismael Mamoori, Ibrahim Abdulla Ahmed, May Ridha Jaafer, Ayat Muneam Ali, Sabreen Ali Hadi

Baghdad Science Journal

Acinetobacter baumannii is one of the most clinically significant pathogens that cause severe nosocomial infections. Rapid identification of this bacterial species is essential so that proper treatment can be provided and outbreaks can be controlled. In this study, a multiplex PCR was used to identify A. baumannii. Twenty clinical isolates of A. baumannii and three each of Gram+ve (Staphylococcus aureus, Bacillus licheniformis, Micrococcus yunnanensis) and Gram−ve (Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacterial isolates were subjected to singleplex and multiplex PCR reactions using three sets of species-specific primers (P-Ab-ITS-F, P-Ab-ITS-R; …