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2020

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Articles 165901 - 165930 of 169292

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Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model, Sertaç Hancioğlu, Berat Di̇lek Demi̇rel, Ünal Biçakci, Seda Gün, Mehmet Ender Aritürk, Nurşen Aritürk Jan 2020

Histopathological And Mechanical Effects Of Ankaferd Blood Stopper® On Wound Healing In Rats: An Experimental Model, Sertaç Hancioğlu, Berat Di̇lek Demi̇rel, Ünal Biçakci, Seda Gün, Mehmet Ender Aritürk, Nurşen Aritürk

Turkish Journal of Medical Sciences

Background/aim: To evaluate the histopathological and mechanical effects of Ankaferd Blood Stopper (ABS) application on wound healing.Materials and methods: A total of 24 Wistar albino rats were randomly divided into three equal groups. In each group, a 3 cm-long midline vertical skin incision was performed in the back of the rats. In Group 1, the incision was sutured primarily. In Group 2, incision was left to secondary healing. In Group 3, ABS was applied to the incision. On the 10th day, burst pressure width was measured, and rats were sacrificed. The tissue samples were examined histopathologically. Statistical analysis was conducted …

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Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat, İbrahi̇m Celaletti̇n Haznedaroğlu, Mustafa Çelebi̇er Jan 2020

Antiinfective And Wound-Healing Pleiotropic Actions Of Ankaferd Hemostat, İbrahi̇m Celaletti̇n Haznedaroğlu, Mustafa Çelebi̇er

Turkish Journal of Medical Sciences

To the Editor,We read with great interest the article entitled "An evaluation of the effects of caffeic acid phenethyl ester and Ankaferd blood stopper on secondary wound healing of oral mucosal tissue", published recently in the Journal[1]. The authors indicated that Ankaferd Hemostat (Ankaferd Blood Stopper, ABS) and caffeic acid phenethyl ester had positive effects on the oral wound healing process. Since ABS has already been used in dental surgery for years, it is known as not irritable to the oral mucosa [2]. ABS antibacterial, antiinfective, and cellular features are also established [3]. More importantly, ABS is clinically effective in …

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Radiological Approaches To Covid-19 Pneumonia, Furkan Ufuk, Recep Savaş, Tuncay Hazirolan Jan 2020

Radiological Approaches To Covid-19 Pneumonia, Furkan Ufuk, Recep Savaş, Tuncay Hazirolan

Turkish Journal of Medical Sciences

No abstract provided.

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Determination Of Related Factors About Diagnostic And Treatment Delays In Patients With Smear-Positive Pulmonary Tuberculosis In Turkey, Mustafa Hami̇dullah Türkkani, Tarkan Özdemi̇r, Çi̇ğdem Özdi̇lekcan Jan 2020

Determination Of Related Factors About Diagnostic And Treatment Delays In Patients With Smear-Positive Pulmonary Tuberculosis In Turkey, Mustafa Hami̇dullah Türkkani, Tarkan Özdemi̇r, Çi̇ğdem Özdi̇lekcan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to analyze delays in diagnosis and treatment by defining the related demographic and clinical factors, to reveal obstacles, and to develop essential attempts to help reduce treatment delays.Materials and methods: We created a questionnaire on the subject of delays in diagnosis and treatment in tuberculosis (TB) control to be administered to the patients. The forms were distributed to dispensaries across the country by the General Directorate of Public Health via an official letter. Results: The study included 853 new patients with smear-positive pulmonary TB. The mean patient delay was 18.06 ± 22.27 days, the mean diagnosis …

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Protective Effects Of Apocynin On Damaged Testes Of Rats Exposed To Methotrexate, Kübra Kavram Sarihan, Melda Yardimoğlu Yilmaz, Fatma Ceyla Eraldemi̇r, Yusufhan Yazir, Esra Acar Jan 2020

Protective Effects Of Apocynin On Damaged Testes Of Rats Exposed To Methotrexate, Kübra Kavram Sarihan, Melda Yardimoğlu Yilmaz, Fatma Ceyla Eraldemi̇r, Yusufhan Yazir, Esra Acar

Turkish Journal of Medical Sciences

Background/aim: Methotrexate (MTX), widely used as a drug in cancer, has many adverse effects on tissues. Apocynin (APO) is a NADPH oxidase inhibitor and is known with many antioxidant properties. In this study, we aimed to evaluate the adverse effects of MTX on testicular tissue and the protective effects of APO at two different doses (20 mg/kg and 50 mg/kg) on MTX-induced testicular damage.Materials and methods: Fifty adult male Wistar albino rats (8 weeks old and weighing 200-250 g) were divided into five groups of 10 rats each: 1. saline control, 2. dimethyl sulfoxide (DMSO) control, 3. MTX, 4. APO-20 …

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Characteristics Of The Initial Patients Hospitalized For Covid-19: A Single-Center Report, Alpay Medetali̇beyoğlu, Naci̇ Şenkal, Gazi̇ Çapar, Murat Köse, Tufan Tükek Jan 2020

Characteristics Of The Initial Patients Hospitalized For Covid-19: A Single-Center Report, Alpay Medetali̇beyoğlu, Naci̇ Şenkal, Gazi̇ Çapar, Murat Köse, Tufan Tükek

Turkish Journal of Medical Sciences

No abstract provided.

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Response To Letter To The Editor: Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay Jan 2020

Response To Letter To The Editor: Radiological Approaches To Covid-19 Pneumonia, Müşerref Şule Akçay

Turkish Journal of Medical Sciences

No abstract provided.

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Cover And Contents Jan 2020

Cover And Contents

Turkish Journal of Medical Sciences

No abstract provided.

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Development Of Albumin Macroinitiator For Polymers To Use In Dna Origami Coating, Aykut Bi̇li̇r, Ezgi̇ Emül, Necdet Sağlam Jan 2020

Development Of Albumin Macroinitiator For Polymers To Use In Dna Origami Coating, Aykut Bi̇li̇r, Ezgi̇ Emül, Necdet Sağlam

Turkish Journal of Medical Sciences

Background/aim: DNA nanostructures have many advantages over polymers and lipid based drug delivery agents such as biodegradability and biocompatibility. However their transfection rates and stability still limit their widely use in nanomedicine. In this study highly versatile and straightforward albumin coating preparation method is showed for DNA nanostructures.Materials and methods: N-methylolmaleimide was esterified with a-bromoisobutyrl bromide (BiBB) to achive bromine functional structure. Then it was attached to bovine serum albumin (BSA) via cysteine-maleimide bond further to use as macroinitiator for atom transfer radical polymerization (ATRP). Cationic polymers can be synthesized from this end further to use as binding domain for …

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Melatonin Attenuates Ovarian Ischemia Reperfusion Injury In Rats By Decreasing Oxidative Stress Index And Peroxynitrite, Şenol Kalyoncu, Bülent Yilmaz, Mustafa Demi̇r, Meltem Tuncer, Zehra Bozdağ, Onur Ince, Mehmet Aki̇f Bozdayi, Hasan Ulusal, Seyi̇than Taysi Jan 2020

Melatonin Attenuates Ovarian Ischemia Reperfusion Injury In Rats By Decreasing Oxidative Stress Index And Peroxynitrite, Şenol Kalyoncu, Bülent Yilmaz, Mustafa Demi̇r, Meltem Tuncer, Zehra Bozdağ, Onur Ince, Mehmet Aki̇f Bozdayi, Hasan Ulusal, Seyi̇than Taysi

Turkish Journal of Medical Sciences

Background/aim: To evaluate the protective effect of melatonin on ovarian ischemia reperfusion injury in a rat model. Materials and methods: Forty-eight rats were separated equally into 6 groups. Group 1: sham; Group 2: surgical control with 3-h bilateral ovarian torsion and detorsion; Group 3: intraperitoneal 5% ethanol (1 mL) just after detorsion (as melatonin was dissolved in ethanol); Group 4: 10 mg/kg intraperitoneal melatonin 30 min before 3-h torsion; Group 5:10 mg/kg intraperitoneal melatonin just after detorsion; Group 6:10 mg/kg intraperitoneal melatonin 30 min before torsion and just after detorsion. Both ovaries and blood samples were obtained 7 days after …

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Handheld Dermatoscopy As An Easy-To-Use Capillaroscopic Instrument In Rheumatoid Arthritis: A Cross-Sectional Study, Ömer Faruk Elmas, Mehmet Okçu, Abdullah Demi̇rbaş, Necmetti̇n Akdeni̇z Jan 2020

Handheld Dermatoscopy As An Easy-To-Use Capillaroscopic Instrument In Rheumatoid Arthritis: A Cross-Sectional Study, Ömer Faruk Elmas, Mehmet Okçu, Abdullah Demi̇rbaş, Necmetti̇n Akdeni̇z

Turkish Journal of Medical Sciences

Background/aim: Nailfold video capillaroscopy is considered as a reliable method for evaluating peripheral microangiopathy in rheumatologic diseases. In this study, we aimed to demonstrate the utility of handheld dermatoscopy as an easy-to-use nailfold capillaroscopic instrument in patients with rheumatoid arthritis. Materials and methods: This cross-sectional study included patients with rheumatoid arthritis and healthy subjects. A handheld dermatoscopic examination of proximal nail fold was performed in each subject. The possible correlation of capillaroscopic findings with disease activity was evaluated using the disease activity score 28 (DAS28). Results: A total of 59 patients with rheumatoid arthritis and 60 healthy subjects were enrolled …

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Neuropeptide Y1 Receptor Antagonist But Not Neuropeptide Y Itself Increased Bone Mineral Density When Locally Injected With Hyaluronic Acid In Male Wistar Rats, Muhammer Özgür Çevi̇k, Petek Korkusuz, Feza Korkusuz Jan 2020

Neuropeptide Y1 Receptor Antagonist But Not Neuropeptide Y Itself Increased Bone Mineral Density When Locally Injected With Hyaluronic Acid In Male Wistar Rats, Muhammer Özgür Çevi̇k, Petek Korkusuz, Feza Korkusuz

Turkish Journal of Medical Sciences

Background/aim: The nervous system controls bone mass via both the central (CNS) and the peripheral (PNS) nervous systems. Intriguingly, neuropeptide Y (NPY) signaling occurs in both. Less is known on how the PNS stimulated NPY signaling controls bone metabolism. The objective of this study was to evaluate whether NPY or NPY1 receptor antagonist changes local bone mineral density (BMD) when injected into a Wistar rat tibia. Materials and methods: Tibial intramedullary area of 24 wild type male Wistar rats (average weight = 350 ± 50 g, average age = 4 ± 0.5 months) were injected with NPY (1 × 10-5 …

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Urinay Neutrophil Gelatinase-Associated Lipocalin As A Biomarker In Different Renal Problems, Di̇dem Turgut, Serhan Vahi̇t Pi̇şki̇npaşa, Ezgi̇ Çoşkun Yeni̇gün, Ni̇hal Aydemi̇r, Fati̇h Dede Jan 2020

Urinay Neutrophil Gelatinase-Associated Lipocalin As A Biomarker In Different Renal Problems, Di̇dem Turgut, Serhan Vahi̇t Pi̇şki̇npaşa, Ezgi̇ Çoşkun Yeni̇gün, Ni̇hal Aydemi̇r, Fati̇h Dede

Turkish Journal of Medical Sciences

Background/aim: Neutrophil gelatinase-associated lipocalin (NGAL) is used previously to estimate the etiology, severity, and clinical outcomes of acute kidney injury (AKI). However, the role of urinary NGAL (uNGAL) in the postrenal setting is not clear. In our study, we aimed to discover the cut-off value of uNGAL that can be used in the differential diagnosis of underlying AKI etiologies. Materials and methods: In this prospective cross-sectional study, we examined 82 subjects in four groups: patients that had (1) postrenal AKI; (2) AKI other than postrenal etiologies; (3) stable chronic kidney disease; and (4) healthy subjects. A renal function assessment was …

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The Assessment Of The Serum Levels Of Tweak And Prostaglandin F2∝ In Covid - 19, Demet Yalçin Kehri̇bar, Mustafa Ci̇hangi̇roğlu, Emi̇ne Sehmen, Bahatti̇n Avci, Mustafa Çapraz, Maruf Boran, Caner Günaydin, Meti̇n Özgen Jan 2020

The Assessment Of The Serum Levels Of Tweak And Prostaglandin F2∝ In Covid - 19, Demet Yalçin Kehri̇bar, Mustafa Ci̇hangi̇roğlu, Emi̇ne Sehmen, Bahatti̇n Avci, Mustafa Çapraz, Maruf Boran, Caner Günaydin, Meti̇n Özgen

Turkish Journal of Medical Sciences

Background/aim: It is claimed that aberrant immune response has a more important role than the cytopathic effect of the virus in the morbidity and mortality of the coronavirus disease 2019 (COVID-19). We aimed to investigate the possible roles of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/Fn14 pathway and leukotrienes (LT) in uncontrolled immune response that occurs in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Materials and methods: This study included 25 asymptomatic patients and 35 patients with lung involvement who were diagnosed with COVID-19 as well as 22 healthy volunteers. Lung involvement was determined using computed-tomography. Serum TWEAK, LTE4, …

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The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu Jan 2020

The Factors Predicting Pneumonia In Covid-19 Patients: Preliminary Results From Auniversity Hospital In Turkey, Hasan Selçuk Özger, Pinar Aysert Yildiz, Ümmügülsüm Gaygisiz, Asi̇ye Uğraş Di̇kmen, Zehra Demi̇rbaş Gülmez, Mehmet Yildiz, Esi̇n Şenol, Kenan Hizel, Özlem Güzel Tunçcan, Kayhan Çağlar, Gülendam Bozdayi, Nurdan Köktürk, Tansu Ulukavak Çi̇ftçi̇, Şahender Gülbi̇n Aygencel Bikmaz, Melda Türkoğlu

Turkish Journal of Medical Sciences

Background/aim: Pneumonia is the most serious clinical presentation of COVID-19. This study aimed to determine the demographic, clinical, and laboratory findings that can properly predict COVID-19 pneumonia. Materials and methods: This study was conducted in the Gazi University hospital. All hospitalized patients with confirmed and suspected SARS-CoV-2 infection between 16 March 2020 and 30 April 2020 were analyzed retrospectively. COVID-19 patients were separated into two groups, pneumonia and nonpneumonia, and then compared to determine predicting factors for COVID-19 pneumonia. Variables that had a P-value of less than 0.20 and were not correlated with each other were included in the logistic …

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Comparison Of Ischemic Preconditioning And Botulinuma Toxin Injection For The Prevention Of Ischemia-Reperfusion Injury In Musculocutaneous Flaps, Handan Derebaşinlioğlu, Anil Demi̇röz, Yağmur Aydin, Hakan Ekmekçi̇, Özlem Balci Ekmekçi̇, Övgü Aydin, Levent Cankorkmaz Jan 2020

Comparison Of Ischemic Preconditioning And Botulinuma Toxin Injection For The Prevention Of Ischemia-Reperfusion Injury In Musculocutaneous Flaps, Handan Derebaşinlioğlu, Anil Demi̇röz, Yağmur Aydin, Hakan Ekmekçi̇, Özlem Balci Ekmekçi̇, Övgü Aydin, Levent Cankorkmaz

Turkish Journal of Medical Sciences

Background/aim: The aim of the study was to evaluate the protective effect of Botulinum A toxin injection against ischemia-reperfusion injury. Materials and methods: Thirty-two Sprague-Dawley rats were divided into: control, ischemia-reperfusion, ischemic preconditioning, and botulinum groups. In all groups the musculocutaneous pedicle flap was occluded for 4 h, and then reperfused to induce ischemia- reperfusion injury. Serum and tissue myeloperoxidase (MPO) and nitric oxide (NO) levels were measured at 24 h and at 10 days. Results: Tissue MPO levels did not differ significantly between the ischemic preconditioning and botulinum groups at 24 h but was significantly lower in the botulinum …

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Is 48 H A Critical Cut-Off Point For Mortality In Geriatric Hip Fractures?, Ahmet Emre Paksoy, Keri̇m Öner, Ferdi̇ Polat, Serhat Durusoy Jan 2020

Is 48 H A Critical Cut-Off Point For Mortality In Geriatric Hip Fractures?, Ahmet Emre Paksoy, Keri̇m Öner, Ferdi̇ Polat, Serhat Durusoy

Turkish Journal of Medical Sciences

Background/aim: In this study, our objective was to evaluate the mortality in geriatric hip fracture patients who were operated within 48 h after admission or after the 48th h. Materials and methods: A total of 194 patients who had undergone surgery for hip fracture between 2016 and 2018 were retrospectively evaluated. Patient information was obtained from the hospital?s database using the ICD codes 81.52, 82.00?82.09, and 82.10. Radiological examination reports were collected from the patient files. Information on mortality was obtained from the Death Notification System of the Turkish Ministry of Health. First-year mortality rates of patients operated within 48 …

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Assessment Of Treatment Efficacy Of Diphenylcyclopropenone (Dpcp) For Alopecia Areata, Zekayi̇ Kutlubay, Ayşegül Sevi̇m, Övgü Aydin Ülgen, Suphi̇ Vehi̇d, Server Serdaroğlu Jan 2020

Assessment Of Treatment Efficacy Of Diphenylcyclopropenone (Dpcp) For Alopecia Areata, Zekayi̇ Kutlubay, Ayşegül Sevi̇m, Övgü Aydin Ülgen, Suphi̇ Vehi̇d, Server Serdaroğlu

Turkish Journal of Medical Sciences

Background/aim: Alopecia areata (AA) is an inflammatory disease with a genetic and autoimmune basis. Herein, it was aimed to study the efficacy and safety of an immunomodulatory therapeutic agent, diphenylcyclopropenone, while manifesting its association with histopathological features, prognostic factors, and side effects. Materials and methods: In this retrospective study, 98 patients (60 males, 38 females) with alopecia, who were referred to the Hair Disease Polyclinic at the Department of Dermatology, between 2011 and 2015, were included. Together with medical histories and dermatological examinations, a skin biopsy for histopathological examination was conducted for all of the patients prior to therapy. Therapeutic …

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A Single Center Cohort Of 40 Severe Covid-19 Patients Who Were Treated Withconvalescent Plasma, Ali̇i̇hsan Gemi̇ci̇, Hülya Bi̇lgen, Cem Erdoğan, Abdullah Kansu, Oktay Olmuşçeli̇k, Hüseyi̇n Saffet Beköz, Rumeysa Çakmak, Ali̇ Mert, Ömür Gökmen Sevi̇ndi̇k Jan 2020

A Single Center Cohort Of 40 Severe Covid-19 Patients Who Were Treated Withconvalescent Plasma, Ali̇i̇hsan Gemi̇ci̇, Hülya Bi̇lgen, Cem Erdoğan, Abdullah Kansu, Oktay Olmuşçeli̇k, Hüseyi̇n Saffet Beköz, Rumeysa Çakmak, Ali̇ Mert, Ömür Gökmen Sevi̇ndi̇k

Turkish Journal of Medical Sciences

Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or a vaccine to treat COVID-19. Convalescent plasma (CP) was previously used successfully to treat SARS-CoV-1 and MERS infections. Health authority in Turkey has published a guideline to integrate this promising option in the treatment process of patients who are prone to high risk of developing severe COVID 19. Materials and Methods: Forty consecutive patients who had received CP at our center were included in the study. Demographics, COVID-19 specific parameters, biomarkers to detect the severity …

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Influence Of Aluminum Salts On Covid-19 Infected Patients, Ali̇ Demi̇r, İbrahi̇m Erayman, Oğuz Doğan, Murat Keki̇lli̇ Jan 2020

Influence Of Aluminum Salts On Covid-19 Infected Patients, Ali̇ Demi̇r, İbrahi̇m Erayman, Oğuz Doğan, Murat Keki̇lli̇

Turkish Journal of Medical Sciences

Background/aim: Based on the antiviral and antibacterial properties of aluminum salts, we aimed to find out the influence of aluminum salts on COVID-19 infected patients. Materials and methods: We performed an observational retrospective cohort study which includes the patients diagnosed as COVID-19 and received aluminum salts in addition to actual treatments during hospitalization as the treatment group (Alum Group). Patients who received standard COVID-19 treatment protocols in the Infectious Diseases Clinics were included as the Control Group. Clinical findings, laboratory parameters, length of stay, survival, radiological follow-up, intensive care and mechanical ventilation needs, the presence of comorbidity, polymerase chain reaction …

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Covid-19 And Dermatology, Ülker Gül Jan 2020

Covid-19 And Dermatology, Ülker Gül

Turkish Journal of Medical Sciences

Background/aim: Sars-CoV-2 virus infection (COVID-19) was observed in China in the last months of 2019. In the period following, this infection spread all over the world. In March 2020 the World Health Organization announced the existence of a pandemic. The aim of this manuscript is to investigate skin diseases associated with COVID-19 under three main headings: skin problems related to personal protective equipment and personal hygiene measures, skin findings observed in SARS-CoV-2 virus infections, and skin findings due to COVID-19 treatment agents. Materials and methods: In PubMed, Google Scholar databases, skin lesions related to personal protective equipment and personal hygiene …

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Covid-19-Related Anxiety In People Living With Hiv: An Online Cross-Sectional Study, Özlem Kuman Tunçel, Hüsnü Pullukçu, Hüseyi̇n Aytaç Erdem, Behi̇ce Kurtaran, Seli̇n Ece Taşbakan, Meltem Taşbakan Jan 2020

Covid-19-Related Anxiety In People Living With Hiv: An Online Cross-Sectional Study, Özlem Kuman Tunçel, Hüsnü Pullukçu, Hüseyi̇n Aytaç Erdem, Behi̇ce Kurtaran, Seli̇n Ece Taşbakan, Meltem Taşbakan

Turkish Journal of Medical Sciences

Background/aim: The emergence of the coronavirus disease 2019 (COVID-19) outbreak has had an enormous emotional impact on some vulnerable groups, such as people living with human immunodeficiency virus (HIV) (PLHIV). This study was planned with the aim of assessing the anxiety levels of PLHIV and the sources of their anxiety. Materials and methods: A web-based questionnaire was sent to PLHIV using the virtual snowball sampling method. The questionnaire included questions about sociodemographic status, information about HIV infection, and the Beck Anxiety Inventory (BAI). Additionally, some opinions of the participants about COVID-19 were asked. Results: A total of 307 respondents, with …

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Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç Jan 2020

Covid-19 Experience Of The Major Pandemic Response Center In The Capital: Results Ofthe Pandemic's First Month In Turkey, Hati̇ce Rahmet Güner, İmran Hasanoğlu, Bi̇rcan Kayaaslan, Adalet Aypak, Ayşe Kaya Kalem, Fatma Eser, Burcu Özdemi̇r, Eli̇f Muki̇me Saricaoğlu, Müge Ayhan, Yeşi̇m Aybar Bi̇li̇r, Işil Özkoçak Turan, Deni̇z Erdem, Nevzat Mehmet Mutlu, Turan Buzğan, Bedi̇a Di̇nç

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to evaluate the epidemiological and clinical characteristics and parameters that determined the clinical course and prognosis of the COVID-19 patients admitted to Ankara City Hospital during the first month of the pandemic in Turkey. Materials and methods: SARS-CoV-2 PCR positive patients who were hospitalized between March 10 and April 10, 2020 were included. Results: Among 222 patients, mean age was higher in severe acute respiratory illness (SARI)/critical disease group (P < 0.001). Median time from illness onset to admission and presence of comorbidity, especially coronary artery disease and chronic obstructive pulmonary disease, were significantly higher in the SARI/critical disease group (P < 0.05). Cough and fever were the most common symptoms, while anosmia and loss of taste were observed in 8.6% and 7.7% patients, respectively. The mortality rate was 5.4%. A high neutrophil/lymphocyte ratio; low lymphocyte, monocyte, and platelet count; elevated liver enzymes; low GFR; and high levels of muscle enzymes, ferritin, and IL-6 on admission were found to be associated with SARI/critical disease (P < 0.05). Bilateral ground-glass opacity and patchy infiltration were more frequently seen in the SARI/critical disease group (P < 0.001). Patients older than 65 years had an 8-fold increased risk for development of SARI/critical disease. Conclusion: This cohort study regarding COVID-19 cases in Turkey reveals that older age, presence of comorbidity, bilateral infiltration on CT, high neutrophil/lymphocyte ratio, low monocyte and platelet count, elevated liver enzymes, low GFR, high levels of muscle enzymes, and high levels of ferritin and IL-6 on admission are predictors of SARI and severe disease.

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Survival Analysis And Factors Affecting Survival In Patients Who Presented To The Medicaloncology Unit With Non-Small Cell Lung Cancer, Özgür Önal, Murat Koçer, Hande Nur Eroğlu, Servet Derya Yilmaz, İsmet Eroğlu, Di̇lek Karadoğan Jan 2020

Survival Analysis And Factors Affecting Survival In Patients Who Presented To The Medicaloncology Unit With Non-Small Cell Lung Cancer, Özgür Önal, Murat Koçer, Hande Nur Eroğlu, Servet Derya Yilmaz, İsmet Eroğlu, Di̇lek Karadoğan

Turkish Journal of Medical Sciences

Background/aim: This study aimed to investigate the effect of clinical and pathological indicators at the time of the diagnosis on overall survival in patients recently diagnosed with non-small cell lung cancer. Materials and methods: The study population consisted of patients who were diagnosed at the Faculty of Medicine at Isparta Süleyman Demirel University Hospital between January 1, 2010 and December 31, 2017 and presented to the medical oncology outpatient clinic. Results: A total of 518 patients were evaluated, including 260 patients with squamous cell carcinoma, 207 patients with adenocarcinoma, 50 patients with non-small cell lung cancer-not otherwise specified, and 1 …

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Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe Jan 2020

Effects Of Immunization Program On Morbidity And Mortality Rates Ofvaccine-Preventable Diseases In Turkey, Tufan Nayi̇r, Ersi̇n Nazlican, Musa Şahi̇n, Fati̇h Kara, Emi̇ne Alp Meşe

Turkish Journal of Medical Sciences

Background/aim: This study aims to serve as a unique consolidated source in Turkey's vaccination history and as an example for other countries by objectively revealing the change in mortality and morbidity rates in Turkey following the beginning of vaccination without asserting any claim on the benefits or risks of vaccines. This unbiased research will also help health professionals identify the challenges more easily when they face with the people who hesitate to vaccinate their children. Materials and methods: Descriptive research design is adopted in this study. The coverages of vaccinations, mortality, and morbidity rates were identified through a retrospective analysis …

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Correlation Between Serum Vitamin D Level And Dichotomous Distribution Ofhematological Parameters In A Cohort Of 12709 Patients, Oktay Olmuşçeli̇k, Ömür Gökmen Sevi̇ndi̇k Jan 2020

Correlation Between Serum Vitamin D Level And Dichotomous Distribution Ofhematological Parameters In A Cohort Of 12709 Patients, Oktay Olmuşçeli̇k, Ömür Gökmen Sevi̇ndi̇k

Turkish Journal of Medical Sciences

Background/aim: Recent evidence suggests that Vitamin D deficiency may be associated with varying degrees of peripheral blood cytopenia(s). However, the effect of Vitamin D on hematopoiesis is largely unknown. According to predefined inclusion criteria, here we analyzed the correlation between serum Vitamin D level and hematological parameters. Materials and methods: In the present cohort study, a total of 12.709 patients were screened. In the first data set, all patients were included. However, in the second one, only patients (9.936) with no complete blood count (CBC) abnormality and any nutritional deficiency (Iron, Vitamin B12 and Folic acid) were evaluated. According to …

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Serum Paraoxonase 1 And 3 Activities In Benign And Malignant Diseases Of The Prostateand Changes In Levels Following Robotic-Assisted Laparoscopic Radical Prostatectomy, Fevzi̇ Bedi̇r, Hüseyi̇n Kocatürk, Mehmet Sefa Altay, Engi̇n Şebi̇n, Banu Bedi̇r Jan 2020

Serum Paraoxonase 1 And 3 Activities In Benign And Malignant Diseases Of The Prostateand Changes In Levels Following Robotic-Assisted Laparoscopic Radical Prostatectomy, Fevzi̇ Bedi̇r, Hüseyi̇n Kocatürk, Mehmet Sefa Altay, Engi̇n Şebi̇n, Banu Bedi̇r

Turkish Journal of Medical Sciences

Background/aim: This study aimed to examine serum paraoxonase 1 and 3 (PON1 and PON3) activities in benign and malignant diseases of the prostate, to determine lipid profile and malondialdehyde (MDA) levels, and to investigate changes in levels following robotic-assisted laparoscopic radical prostatectomy (RALRP). Materials and methods: A total of 137 patients, including a control group, were enrolled in the study and assigned into four groups. Group 1 (n = 33) consisted of patients previously undergoing RALRP with no recurrence, group 2 (n = 36) consisted of patients diagnosed with prostate cancer (PCa) and undergoing RALRP, and group 3 (n = …

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Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen Jan 2020

Rare Occurrence Of Common Filaggrin Mutations In Turkish Children With Food Allergyand Atopic Dermatitis, Neşe Vardar Acar, Özlem Cavkaytar, Ebru Arik Yilmaz, Ayşe Betül Büyükti̇ryaki̇, Özge Uysal Soyer, Ümi̇t Murat Şahi̇ner, Bülent Eni̇s Şekerel, İbrahi̇m Çağatay Karaaslan, Cansin Saçkesen

Turkish Journal of Medical Sciences

Background/aim: Filaggrin is a protein complex involved in epidermal differentiation and skin barrier formation. Mutations of the filaggrin gene (FLG) are associated with allergen sensitization and allergic diseases like atopic dermatitis (AD), allergic rhinitis, food allergy (FA), and asthma. The aim of the study is to reveal the frequency of change in the FLG gene and determine the association between FLG loss-of-function (LOF) mutations and FA and/or AD in Turkish children. Materials and methods: Four FLG loss-of-function (LOF) mutations known to be common in European populations were analyzed in 128 healthy children, 405 food-allergic children with or without atopic dermatitis, …

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Cross-Sectional Study: Long Term Follow-Up Care For Pediatric Cancer Survivors In Adeveloping Country, Turkey: Current Status, Challenges, And Future Perspectives, Sonay İncesoy Özdemi̇r, Nurdan Taçyildiz, Ali̇ Varan, Reji̇n Kebudi̇, Osman Bülent Zülfi̇kar, Tüli̇n Tiraje Celkan, Gürses Şahi̇n, Funda Vesi̇le Çorapcioğlu, Zuhal Keski̇n Yildirim, Faruk Güçlü Pinarli, Hati̇ce Nur Olgun, Neriman Sari, Ayhan Dağdemi̇r, Derya Özyörük, Tuba Eren Jan 2020

Cross-Sectional Study: Long Term Follow-Up Care For Pediatric Cancer Survivors In Adeveloping Country, Turkey: Current Status, Challenges, And Future Perspectives, Sonay İncesoy Özdemi̇r, Nurdan Taçyildiz, Ali̇ Varan, Reji̇n Kebudi̇, Osman Bülent Zülfi̇kar, Tüli̇n Tiraje Celkan, Gürses Şahi̇n, Funda Vesi̇le Çorapcioğlu, Zuhal Keski̇n Yildirim, Faruk Güçlü Pinarli, Hati̇ce Nur Olgun, Neriman Sari, Ayhan Dağdemi̇r, Derya Özyörük, Tuba Eren

Turkish Journal of Medical Sciences

Aim: The main purpose of this study is to determine the current status of long-term follow-up (LTFU) for childhood cancer survivors and the challenges of LTFU for pediatric cancer survivors at pediatric oncology institutions in Turkey. Material and methods: A questionnaire was e-mailed to the directors of 33 pediatric oncology centers (POCs) registered in the Turkish Pediatric Oncology Group (TPOG). Of these 33 active TPOG institutions, 21 participated in the study and returned their completed questionnaires. Results: Only 1 of the 21 participating centers had a separate LTFU clinic. The remaining centers provided LTFU care for childhood cancer survivors at …

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Validity And Reliability Of The Turkish Version Of The Multidimensional Dyspnea Profile Inoutpatients With Respiratory Disease, Buse Özcan Kahraman, Turhan Kahraman, İsmai̇l Özsoy, Ayli̇n Tanriverdi̇, Asli Papurcu, Nazeni̇n Hande Sezgi̇n, Karya Polat, Serap Acar, Ayli̇n Özgen Alpaydin, Can Sevi̇nç, Sema Savci Jan 2020

Validity And Reliability Of The Turkish Version Of The Multidimensional Dyspnea Profile Inoutpatients With Respiratory Disease, Buse Özcan Kahraman, Turhan Kahraman, İsmai̇l Özsoy, Ayli̇n Tanriverdi̇, Asli Papurcu, Nazeni̇n Hande Sezgi̇n, Karya Polat, Serap Acar, Ayli̇n Özgen Alpaydin, Can Sevi̇nç, Sema Savci

Turkish Journal of Medical Sciences

Background/aim: Dyspnea is the subjective feeling of breathing discomfort, which is a significant problem for patients with heart and respiratory disease and also an important determinant of exercise tolerance, quality of life, and mortality in various diseases. Most of the scales are not enough to investigate the multidimensional effects of dyspnea; therefore, the Multidimensional Dyspnea Profile (MDP) was developed and validated in many languages. This study aimed to translate and culturally adapt the MDP into Turkish and investigate the psychometric properties of this adapted version in outpatients with respiratory disease. Materials and methods: The MDP was translated and culturally adapted …

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