Digital Commons Network^™

Capsaicin Is A Negative Allosteric Modulator Of The 5-Ht3 Receptor, Eslam El Nebrisi, Tatiana Prytkova, Dietrich Ernst Lorke, Luke Howarth, Asma Hassan Alzaabi, Keun-Hang Susan Yang, Frank Christopher Howarth, Murat Oz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

In this study, effects of capsaicin, an active ingredient of the capsicum plant, were investigated on human 5-hydroxytryptamine type 3 (5-HT₃) receptors. Capsaicin reversibly inhibited serotonin (5-HT)-induced currents recorded by two-electrode voltage clamp method in Xenopus oocytes. The inhibition was time- and concentration-dependent with an IC₅₀ = 62 μM. The effect of capsaicin was not altered in the presence of capsazepine, and by intracellular BAPTA injections or trans-membrane potential changes. In radio-ligand binding studies, capsaicin did not change the specific binding of the 5-HT₃ antagonist [³H]GR65630, indicating that it is a noncompetitive inhibitor of …

Study Of A Putative Niche Adapting Operon In Microbes Inhabiting The Gut Of Blood Digesting Animals, Marlene Abouaassi

Honors Scholar Theses

The sialic acid utilization (SAU) operon is a horizontally acquired gene set that allows bacteria to utilize sialic acid as an alternate source of carbon and nitrogen in the guts of blood eating animals. Sialic acid often occurs as a terminal sugar in complex glycoproteins. It functions in cell signaling and adhesion. Sialic acid is an important component of the cellular envelope of animals. Some microorganisms have evolved to decorate their own surface with sialic acid to evade the host’s immune response (molecular mimicry). The SAU operon encodes enzymes that hydrolyze sialic acid from glycoproteins, transport sialic acid into the …

The Perceived Effectiveness Of School-Based Accommodations For Students With Systemic Lupus Erythematosus, Maryann Seng

Education (PhD) Dissertations

Pediatric patients with systemic lupus erythematosus battle a chronic, autoimmune illness which can be life-threatening in cases of vital organ involvement. Disease activity and severity is harsher during the developmental period of childhood and adolescence than during adulthood. Lupus symptoms and medication side effects may cause patients to experience neurocognitive and/or physical impairment. The cyclical nature of the illness consists of flare and remission phases. The present study explored the topic of pediatric lupus in the school setting due to the severe impact of the illness on youth. It examined the accommodations provided to students, as well as the patients' …

Ell Teachers Guide To Pronunciation: A Contrastive Analysis Of S'Gaw Karen And American English Phonetics And Phonology, Shana Lee

School of Education and Leadership Student Capstone Projects

Lee, S. ELLTeachers Guide to Pronunciation: A Contrastive Analysis of S’gaw Karen and American English Phonetics and Phonology (2020)

The purpose of this study (Lee, 2020) was to determine the phonological features of English that provide the largest challenge to the pronunciation of S’gaw Karen speaking ELL students in order to inform the development of a curricular resource meant to help educators increase the comprehensible speech output in English. A review of literature revealed a gap of academic work around the S’gaw language especially pertaining to instructional methodologies for language teachers. To guide the development of this resource, the author …

Why Is There A Growing Number Of Ell Students With Learning Delays, Being Diagnosed With Autism Spectrum Disorder, Or Qualifying For Special Education?, Heidi Anderson

School of Education and Leadership Student Capstone Projects

Anderson, H. Why is there a growing number of ELL students with learning delays, being diagnosed with Autism Spectrum Disorder, or qualifying for Special Education? (2020)

The research question addressed in this project was why is there a growing number of ELL students with learning delays, being diagnosed with Autism Spectrum Disorder, or qualifying for Special Education? The research focused on English language learner’s social, emotional and academic needs. The research provides information on cultural and linguistic awareness, and the importance of how cultural and language needs to be recognized in the criteria for assessing or evaluating English language learners …

How Can Middle School Science Teachers Differentiate Instruction To Support All Learners In An Inclusive Classroom?, Jacqueline Barker

School of Education and Leadership Student Capstone Projects

Barker, J. How Can Middle School Science Teachers Differentiate Instruction To Support All Learners In An Inclusive Classroom? (2020)

The research question addressed in this capstone was, how can middle school science teachers differentiate instruction to support all learners in an inclusive classroom? Research was compiled in regards to the composition of an inclusive classroom, the mindset of teachers, differentiation as a philosophy, and differentiation as a means to modifying instruction. The information obtained was utilized for a culminating project in the form of curriculum for an eighth grade science classroom. The curriculum was envisioned for use in a public …

The Implementation Of The 5e Learning Cycle In Stem Freedom School Curriculum, Natasha Semanko

School of Education and Leadership Student Capstone Projects

The project titled “Implementation of the 5E Learning Cycle in STEM Freedom School Curriculum” was completed by Natasha Semanko in the summer of 2020. For this project, two weeks of new curriculum was created for STEM Freedom School. Each lesson followed the 5E inquiry cycle and focused on topics within the theme of Environmental Studies and Sustainability. Lesson topics included the water cycle, groundwater contamination, pollution in lakes/rivers/oceans, overfishing, and the food chain. In this curriculum, students create a presentation or poster of the material to share with families and visitors at the End of Year Showcase. The key influences …

A Collaborative Approach At Building Professional Development Around Inclusive Science Classrooms, Erin Lappen

School of Education and Leadership Student Capstone Projects

Lappen, E. (2020). A collaborative approach at building professional development around inclusive science classrooms.

This project examines the best practices to utilize secondary science teachers, special education teachers, and paraprofessionals in a secondary level science classroom. It was developed as a four-hour professional development with supplementary materials, designed to be implemented during August teacher workshop week. This project was created to address the intimidating environment the science class can be for educators and to start a dialogue collaboration that will continue throughout the school year. The professional development is intended for the science department and special education teachers and paraprofessionals …

Comparison Of Longitudinal Changes In Resting State Functional Magnetic Resonance Imaging Between Alzheimer’S And Healthy Controls, Berk Can Yilmaz

Theses

Resting State Functional Magnetic Resonance Imaging (rs-fMRI) is a technique that is widely used for analyzing brain function using different approaches and methods. This study involves rs-fMRI analysis of Blood Oxygenation Level Dependent (BOLD) signals acquired from Alzheimer’s disease (AD) Patients and Healthy Controls (HC). Each subject in the study had both functional and anatomical images with at least one rs-fMRI scan with their Anatomical (T1) scans. Previous rs-fMRI studies have demonstrated that AD shows differences in Amplitude of Low Frequency (<0.1 Hz) Fluctuations (ALFF), and Regional Homogeneity (ReHo) measures according to HCs.

The aim of the study is to investigate individual and group level differences using ReHo and mALFF related …

Physiological Factors And Physical Activity Contribute To The Incidence Of Type 2 Diabetes Mellitus In Indonesia, Demsa Simbolon, Afriyana Siregar, Ruzita Abd Talib

Kesmas

Type 2 diabetes mellitus (T2DM) is the sixth highest cause of death in Indonesia. Thus, it must be prevented and overcome with appropriate management. This study aimed to determine the contribution of physiological factors and physical activities to the incidence of T2DM. The study used a cohort retrospective design using secondary data from the Indonesian Family Life Survey (IFLS) from 2007 to 2014, which included a sample of 14,517 people involved for more than 20 years. Data analysis was performed using multiple logistic regressions. The results revealed a 3.8% incidence of T2DM in Indonesia. Record of hypertension risk increased the …

"Fish In A Barrel": Workplace Violence And Posttraumatic Stress Symptoms Among Psychiatric Nurses, Sheila M. Herrera

Nursing Theses and Dissertations

This work explores the psychiatric nurses’ experiences of workplace violence perpetrated by psychiatric patients. Working with patients with psychiatric disorders can be challenging. Violent behaviors can sometimes escalate and lead to coercive measures such as physical restraint or seclusion. The first manuscript in this portfolio, To Use or Not to Use: Physical Restraint in Adult Psychiatry, will present evidence for and evidence against the nurse’s conscientious objection to follow the doctor’s order to restrain the patient after the patient immediately stopped the aggressive behavior. The second manuscript, Workplace Violence Interventions for Psychiatric Nurses, discusses different interventions for psychiatric …

Hypusination Of Eif5a Regulates Cytoplasmic Tdp-43 Aggregation And Accumulation In A Stress-Induced Cellular Model, Shayna Smeltzer, Zainuddin Quadri, Abraian Miller, Frank Zamudio, Jordan Hunter, Nicholas J.F. Stewart, Sheba Saji, Daniel C. Lee, Dale Chaput, Maj-Linda B. Selenica

Sanders-Brown Center on Aging Faculty Publications

TAR DNA-binding protein 43 (TDP-43) is a nuclear RNA/DNA binding protein involved in mRNA metabolism. Aberrant mislocalization to the cytoplasm and formation of phosphorylated/aggregated TDP-43 inclusions remains the hallmark pathology in a spectrum of neurodegenerative diseases, including frontotemporal disorders and Alzheimer's disease. Eukaryotic Translation Initiation Factor 5A undergoes a unique post-translation modification of lysine to hypusine (K50), which determines eIF5A binding partners. We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5A^HypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule. Our proteomics and functional data provide evidence that eIF5A interacts …

"Made Of Queer Magic": Understanding The Experiences Of Pregnancy For Queer Women, Lindsey Rogers

Doctoral Dissertations

Queer families are deciding to use donor insemination or medically assisted reproductive treatments to become pregnant and start their families. Previous research indicates that the process of using medically assisted reproductive treatments may be a stressful experience for queer families due to cisheteronormativity within the system. In addition, research has also revealed that stress during the process of conceiving can impact mental health experiences during pregnancy. However, there is a lack of research on the specific mental health experiences of pregnancy for queer women. The present study used a qualitative research design guided by constructivist grounded theory to examine the …

How To Design Genetically Modified Food Labeling Regulation In Indonesia - Taking Science, Trade Law, And Indonesian Demands Seriously, Dasep Wahidin, Kai Peter Purnhagen

Indonesia Law Review

The paper critically evaluates the current Indonesian genetically modified (GM) food labeling regime as it is embedded in the international trade law and policy system. This research proposes a GM food labeling regulation for Indonesia based on the socio-economic demands of Indonesia on the one hand and the demands of international trade law and policy on the other. It answers the following research questions: What are the legislative requirements for labelling of genetically modified organisms (GMOs) according to Indonesian law? How should Indonesian law on GM food labelling be designed to meet the interests of its peoples and provide access …

Vitamin D And Reduced Academic Stress Of Health Students, Yuni Kusmiyati, Emy Suryani, Lucky Herawati, Amalia Firdausi

Kesmas

Stress conditions can reduce academic ability, influencing student grade point averages and encouraging negative behaviors. The object of this research was to discern the influence of vitamin D in the reduction of academic stress of health students. The study used a randomized controlled trial (RCT). The population was midwifery students who lived in the Health Polytechnic dormitory, Ministry of Health, Yogyakarta, in 2017. Samples were 77 students of midwifery who did not suffer from any chronic disease, nor did they experience academic stress. They all agreed to become research subjects. Samples were 39 respondents in a treatment group who were …

Effect Of The Covid-19 Pandemic On Eating Habits And Food Purchasing Behaviors Of University Students, Hacı Ömer Yilmaz, Ramazan Aslan, Cihan Unal

Kesmas

COVID-19 disease, which spread rapidly all over the world after the first case was detected, became the primary agenda of the countries. Radical measures have been taken by governments to prevent the spread of the disease. Precautions and warnings to prevent disease caused some changes on daily life activities of people. University students who have to stop education are among the groups most affected by this disease sociologically, psychologically and physiologically. The aim of this study was planned and conducted to determine the effect of COVID-19 on university students' eating habits and food purchasing behavior. The study was completed with …

August 31, 2020

The Gavel Gazette

No abstract provided.

Relentless Predation On Gunnison’S Prairie Dogs (Cynomys Gunnisoni) By A Single American Badger (Taxidea Taxus), Samantha M. Kagel, Rachel S. Ziejka, Lauren M. L. Averilla, Brittany A. Minnig, John L. Hoogland

Western North American Naturalist

Predation affects the demography and population dynamics of prey species. Because predators commonly stalk prey from concealed routes, attack quickly, and frequently avoid areas with human observers, documenting predation under natural conditions is often difficult. An adult female American badger (Taxidea taxus) with offspring moved into a colony of Gunnison’s prairie dogs (Cynomys gunnisoni) living under natural conditions at Valles Caldera National Preserve in New Mexico, United States, and provided an excellent opportunity to record predations over a period of 33 consecutive days in June–July 2018. Badgers are commonly nocturnal, but the badger at our study …

Viscoelastic Properties Of Ecm-Rich Embryonic Microenvironments, Zsuzsa Akos, Dona Greta Isai, Sheeja Rajasingh, Edina Kosa, Saba Ghazvini, Prajnaparamita Dhar, Andras Czirok

Faculty and Staff Publications

The material properties of tissues and their mechanical state is an important factor in development, disease, regenerative medicine and tissue engineering. Here we describe a microrheological measurement technique utilizing aggregates of microinjected ferromagnetic nickel particles to probe the viscoelastic properties of embryonic tissues. Quail embryos were cultured in a plastic incubator chamber located at the center of two pairs of crossed electromagnets. We found a pronounced viscoelastic behavior within the ECM-rich region separating the mesoderm and endoderm in Hamburger Hamilton stage 10 quail embryos, consistent with a Zener (standard generalized solid) model. The viscoelastic response is about 45% of the …

Shamanic Performancesjoseph Beuys's Der Eurasier, Eurasia Siberian Symphony, And Auschwitz Demonstration, Caroline Rupprecht

Publications and Research

No abstract provided.

Acquisitions Unit Annual Report 2019-2020, Andrée J. Rathemacher

Technical Services Reports and Statistics

Annual Report of the Acquisitions Unit, University Libraries, University of Rhode Island for FY2020. Covers personnel, work flow, special projects, and serial, monograph, and e-resource acquisitions. Supplemental files include data on library materials expenditures by a number of variables as well as important working documents from the year.

Week Of August 31, 2020, New York Medical College

InTouch

• NYMC Creates Intergenerational Community Around New Benjamin Rush Institute Chapter

From Gene To Function: A Safe Laboratory Exercise Promoting The Learning Of The Central Dogma Of Biology For The Undergraduate Biology Curriculum., Manuela Tripepi, Morgan Clear, Jack Lyons Bondi, Elvira Brunelli, Arianna Berardi

College of Life Sciences Faculty Papers

No abstract provided.

Dinamika Hubungan Keterasingan Dengan Transmisi Memori Dalam Novella Tempête Karya J. M. G. Le Clézio: Telaah Postmemory, Nadya Annisa Noer, Wening Udasmoro, Subiyantoro Subiyantoro

Bahasa dan Seni: Jurnal Bahasa, Sastra, Seni, dan Pengajarannya

The concept of postmemory, introduced by Hirsch (2012), focuses on the processes through which memories—particularly traumatic memories— of a historical tragedy, “Holocaus”, which is transmitted across generations. Drawing on the elements supporting inter-individual memory transmission, this paper examines the dynamics of human memory within Novel Prize-winning French-Mauritian author J. M. G. Le Clézio's novella entitled “Tempête”. Using a qualitative approach, this study aims to examine the individual forms of memory transmission that are rooted in conditions of isolation, and developed through one trauma site as the memory connector. The presence of semiotics within the story also builds the narration of …

Effect Of Maternal Retinol Status At Time Of Term Delivery On Retinol Placental Concentration, Intrauterine Transfer Rate, And Newborn Retinol Status, Melissa K. Thoene, Haley Haskett, Jeremy Furtado, Maranda Thompson, Matthew Van Ormer, Corrine K. Hanson, Ann Anderson-Berry

Journal Articles: Pediatrics

Retinol (vitamin A) is essential, so the objective of this Institutional Review Board approved study is to evaluate retinol placental concentration, intrauterine transfer, and neonatal status at time of term delivery between cases of maternal retinol adequacy, insufficiency, and deficiency in a United States population. Birth information and biological samples were collected for mother-infant dyads (n = 260). Maternal and umbilical cord blood retinol concentrations (n = 260) were analyzed by HPLC and categorized: deficient (≤0.7 umol/L), insufficient (>0.7-1.05 umol/L), adequate (>1.05 umol/L). Intrauterine transfer rate was calculated: (umbilical cord blood retinol concentration/maternal retinol concentration) × …

Estimating Economic Minimums Of Mowing, Fertilizing, And Irrigating Turfgrass, Douglas J. Soldat, James T. Brosnan, Ambika Chandra, Roch E. Gaussoin, Alec Kowalewski, Bernd Leinauer, Frank S. Rossi, John C. Stier, J Bryan Unruh

Department of Agronomy and Horticulture: Faculty Publications

The public health crisis and economic recession caused by the COVID-19 pandemic have forced turfgrass industry professionals to re-evaluate standard practices. Minimum costs required to fertilize, irrigate, and mow turfgrasses can be roughly estimated using climate data, turfgrass physiology information, and resource costs. Although the actual minimum costs vary situationally and regionally, mowing golf putting greens optimally requires about US$34 per acre per month, whereas other turfgrass areas cost less than US$11 per acre per growing month. Fertilizer applications to turfgrass cost US$22 or less per acre per growing month. Irrigation costs (water and electricity for pumping) vary widely, with …

Concurrent Heart Rate Validity Of Wearable Technology Devices During Trail Running, James W. Navalta, Jeffrey Montes, Nathaniel G. Bodell, Robert W. Salatto, Jacob W. Manning, Mark Debeliso

Kinesiology and Nutrition Sciences Faculty Research

Validation of heart rate responses in wearable technology devices is generally composed of laboratory-based protocols that are steady state in nature and as a result, high accuracy measures are returned. However, there is a need to understand device validity in applied settings that include varied intensities of exercise. The purpose was to determine concurrent heart rate validity during trail running. Twenty-one healthy participants volunteered (female n = 10, [mean (SD)]: age = 31 [11] years, height = 173.0 [7] cm, mass = 75.6 [13] kg). Participants were outfitted with wearable technology devices (Garmin Fenix 5 wristwatch, Jabra Elite Sport earbuds, …

Nanomaterials And Nanorobotics In Dentistry: A Review, Yelda Kasimoglu, Derya Tabakcilar, Zeynep A. Guclu, Seiko Yamamoto-Nemoto, Elif B. Tuna, Bugra Ozen, Tamer Tuzuner, Gökhan Ince

Journal of Dentistry Indonesia

Nanotechnology is a branch of science focusing on the manipulation of materials measured on the nanoscale (size = 1–100 nm). Recent advances in the field of nanodentistry have resulted in the development of alternative treatment plans for common dental problems, bringing about a paradigm shift in dentistry. Nanorobots, also known as “nanites” or “nanomachines,” are theoretical microscopic devices that may be used for the diagnosis and treatment of oral health problems. This paper aims to discuss the latest innovations in the field of nanodentistry.

Effect Of Short- And Long-Term Use Of Home And In-Office Bleaching With Carbamide Peroxide And Hydrogen Peroxide On Enamel Microhardness, Nazila Ameli, Niloofar Kianvash Rad, Farzane Nikpour, Raheb Ghorbani, Shadi Mohebi

Journal of Dentistry Indonesia

Bleaching is a well-known esthetic dental treatment performed to lighten the tooth shade. Among different cosmetic dental procedures, including direct and indirect tooth-colored restorations, bleaching is likely the most conservative approach. Bleaching has been accepted well by patients and proven as a safe and effective approach. Objective: Tooth bleaching can be conducted at home or in offices. This study was performed to compare the enamel microhardness before bleaching and one and eight weeks after the application of different bleaching agents. Methods: Forty human premolars were randomly divided into four groups, and their buccal surface underwent a Vickers microhardness test …

Oral Rehabilitation Of A Patient With Congenital Erythropoietic Porphyria: A Rare Case Report, Raif Alan, Hakkı Çelebi, Fahriye Kilinc, Recep Dursun

Journal of Dentistry Indonesia

Congenital erythropoietic porphyria (CEP) is an extremely rare disorder involved in chronic porphyrias. One of the recommended evaluations to determine disease severity and needs of a person with CEP is dental assessment. Objective: To present a case of CEP and its oral rehabilitation. Case Report: A 32-year-old female patient was admitted to the clinic with hyperkeratinization, skin fragility, fissures, and wounds in her perioral region and hands. Intraoral gingival bleeding, mucogingival stress, and missing teeth were recorded. After medical consultation, phase I and II periodontal therapies were performed. The patient expressed satisfaction of the results of the procedures in terms …