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Mathematical Models And Tools To Understand Coupled Circadian Oscillations And Limit Cycling Systems, Guangyuan Liao

Dissertations

The circadian rhythm refers to an internal body process that regulates many body processes including the sleep-wake cycle, digestion and hormone release. The ability of a circadian system to entrain to the 24-hour light-dark cycle is one of the most important properties. There are several scenarios in which circadian oscillators do not directly receive light-dark forcing. Instead they are part of hierarchical systems in which, as \peripheral" oscillators, they are periodically forced by other \central" circadian oscillators that do directly receive light input. Such dynamics are modeled as hierarchical coupled limit cycle systems. Those models usually have a large population, …

Efficient Approximations For Stationary Single-Channel Calcium Nanodomains, Yinbo Chen

Dissertations

Mathematical and computational modeling plays an important role in the study of local Ca2+ signals underlying many fundamental physiological processes such as synaptic neurotransmitter release and myocyte contraction. Closed-form approximations describing steady-state distribution of Ca2+ in the vicinity of an open Ca2+ channel have proved particularly useful for the qualitative modeling of local Ca2+ signals. This dissertation presents several simple and efficient approximants for the equilibrium Ca2+ concentration near a point source in the presence of a mobile Ca2+ buffer, which achieve great accuracy over a wide range of model parameters. Such approximations provide an efficient method for estimating Ca2+ …

Global Optimization Algorithms For Image Registration And Clustering, Cuicui Zheng

Dissertations

Global optimization is a classical problem of finding the minimum or maximum value of an objective function. It has applications in many areas, such as biological image analysis, chemistry, mechanical engineering, financial analysis, deep learning and image processing. For practical applications, it is important to understand the efficiency of global optimization algorithms. This dissertation develops and analyzes some new global optimization algorithms and applies them to practical problems, mainly for image registration and data clustering.

First, the dissertation presents a new global optimization algorithm which approximates the optimum using only function values. The basic idea is to use the points …

In Partnership? Pedestrian Plazas In New York City, Topal Vardi Topal

Dissertations

Traditional public spaces —such as public parks, streets, and public squares—have long been part of the urban landscape. In today’s congested cities, however, creating such public spaces is difficult because they require capital investment, vacant land, and ongoing maintenance. Possibly in response to these obstacles, new types of urban public spaces have emerged.

Pedestrian plazas, one of these new types, is the topic of this research, with a focus on the New York City Plaza Program, which was the first such program in the U.S. For this research, the design, management, and use characteristics of five completed pedestrian plazas were …

Genetic Population Structure And Microbiome Of German Cockroaches In Urban Environments, Xueyang Fan

Dissertations

Pests of human habitats may harbor and disperse pathogens that cause human disease. One such pest is the German cockroach (Blattella germanica), which is known to harbor numerous pathogens, including Klebsiella and Pseudomonas. The aim of this study is to reveal the importance of the German cockroach as a potential vector of human medically important diseases. To do so, this study investigates German cockroach population structure and their associated bacterial microbiome in urban residential environments. Ninety German cockroaches are collected from three residential apartment buildings in three New Jersey cities. Samples are caught by glue traps and stored at -20°C. …

1,4-Dioxane Biodegradation In Propanotrophs: Molecular Foundations And Implications For Environmental Remediation, Li Fei

Dissertations

1,4-Dioxane (dioxane) has emerged with an escalating concern given its human carcinogenicity and widespread occurrence in groundwater. Bioremediation is promising as an effective and cost-efficient treatment alternative for in situ or ex situ cleanup of dioxane and co-existing pollutants in the field. Soluble di-iron monooxygenases (SDIMOs) are reputed for their essential roles in initiating the cleavage of dioxane and other pollutants. In this doctoral dissertation, molecular foundations for SDIMOs-mediated dioxane biodegradation are untangled to promote the development and implication of site-specific bioremediation and natural attenuation strategies. This dissertation focused on propanotrophic bacteria given their pivotal roles in dioxane metabolism and …

Integrate Structural Analysis, Isoform Diversity, And Interferon-Inductive Propensity Of Ace2 To Predict Sars-Cov2 Susceptibility In Vertebrates, Eric R. Sang, Yun Tian, Yuanying Gong, Laura C. Miller, Yongming Sang

Agricultural and Environmental Sciences Faculty Research

The current new coronavirus disease (COVID-19) has caused globally over 0.4/6 million confirmed deaths/infected cases across more than 200 countries. As the etiological coronavirus (a.k.a. SARS-CoV2) may putatively have a bat origin, our understanding about its intermediate reservoir between bats and humans, especially its tropism in wild and domestic animals are mostly unknown. This constitutes major concerns in public health for the current pandemics and potential zoonosis. Previous reports using structural analysis of the viral spike protein (S) binding its cell receptor of angiotensin-converting enzyme 2 (ACE2), indicate a broad potential of SARS-CoV2 susceptibility in wild and particularly domestic animals. …

2020 A Year That No One Could Predict, Anonymous Carleton Staff Member

Covid-19 Archive: Documents

Photo Descriptions: Registrar's Office July 31, 2020 (with winter decorations still up). Playing with Strangers from NY in Mexico 2 weeks before lockdown.

Permethrin Residual Activity Against Ambrosia Beetle (Coleoptera: Curculionidae: Scolytinae) Attacks Following Field Aging And Simulated Rainfall Weathering, Matthew S. Brown, Karla M. Addesso, Fulya Baysal-Gurel, Nadeer N. Youssef, Jason B. Oliver

Agricultural and Environmental Sciences Faculty Research

Adult ambrosia beetles (Coleoptera: Curculionidae: Scolytinae) bore into ornamental nursery trees resulting in trunk vascular tissue damage, which can potentially kill trees. Ambrosia beetle exposure to surface-applied insecticides is minimal after internal trunk galleries are formed, so effective management requires insecticide treatments to be applied near the time of infestation or to have residual activity on the bark. Tree trunk sections (bolts) were used to determine the effect of field aging or irrigation (i.e., simulated rainfall weathering) on permethrin residual activity against ambrosia beetles. In all experiments, 30-cm-long bolts from Liriodendron tulipifera L. (Magnoliales: Magnoliaceae) were hollowed and filled with …

Biomechanical Loading Changes Between Species In Mild Blast-Induced Traumatic Brain Injury, Jose Juan Rodriguez

Dissertations

Blast-induced traumatic brain injury (bTBI) has become one of the leading injury modalities in military personnel and is considered a signature injury in veterans returning from conflicts in the Middle East. One of the main concerns in studying bTBI is translating animal experiments to clinical applications that can service veterans. Significant advances have been made using animal models in relating external shock waves to emerging neuropathophysiological and behavioral outcomes. However, it is unknown if these results are applicable to humans; and if so, can an interspecies transfer function be developed based on size, shape, and material response. This work aims …

Microglia Induced Neuroinflammation Through The Nlrp3 Inflammasome Following Blast Traumatic Brain Injury, Daniel Younger

Dissertations

The incidence of traumatic brain injury (TBI) among military personnel have been steadily increasing with modern conflicts. A recent RAND report estimated 320,000 service members, totaling 20% of deployed forces, suffer from TBI. However, of this population roughly 60% have not seen a medical professional specifically for TBI. Unlike the civilian population, the primary cause of TBI for active-duty military personnel is blast exposure. Blasts now account for over 70% of all US military casualties in operation Iraqi Freedom (OIF) and Operation enduring freedom (OEF) and are the major cause of TBI. Among many pathological mechanisms associated with blast TBI, …

Chen Publishes 3 Papers With Alumni Richardson, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Hua Lab Uncovers Broad Spectrum Of Intracellular Activities Involving Protein Degradation, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Proses Asesmen Berbasis Kompetensi Bagi Communityworker Di Lembaga Sertifikasi Profesi Fasilitator Pemberdayaan Masyarakat (Lsp Fpm), Chamiyatus Sidqiyah, Ety Rahayu

Jurnal Pembangunan Manusia

Community workers have roles and functions in empowering communities, especially those who are disadvantaged, poor, or lacking access to increased prosperity. Since 2000, the Indonesian Government has developed poverty alleviation programmes with community empowerment approaches and many Community Worker personnel recruited as PNPM Mandiri facilitators in rural and urban areas in various regions in Indonesia. Currently, the number of Community workers has reached tens of thousands but the future of this profession has a problem because the policy and law labor regulation demands that every profession that works should be able to demonstrate its competence through assessment based competency with …

A Novel Mucosal Vaccine Platform For Immunization Against Plague, Christina D'Arco

NYMC Student Theses and Dissertations

Yersinia pestis, the causative agent of plague, has killed millions throughout human history. Today, it remains a significant threat for use as a bioweapon. Naturally occurring antibiotic resistance has been observed in Y. pestis isolates, and resistant strains have been engineered for use in biological warfare. Vaccines remain our best means of protection against plague, as well as countless other global contagions. We have developed a vaccine consisting of two Y. pestis virulence proteins, LcrV (V) and F1, conjugated to Tobacco Mosaic Virus (TMV), a safe, non-replicating plant virus that can be administered mucosally, providing complete protection against pneumonic plague, …

Study Of A Putative Niche Adapting Operon In Microbes Inhabiting The Gut Of Blood Digesting Animals, Marlene Abouaassi

University Scholar Projects

The sialic acid utilization (SAU) operon is a horizontally acquired gene set that allows bacteria to utilize sialic acid as an alternate source of carbon and nitrogen in the guts of blood eating animals. Sialic acid often occurs as a terminal sugar in complex glycoproteins. It functions in cell signaling and adhesion. Sialic acid is an important component of the cellular envelope of animals. Some microorganisms have evolved to decorate their own surface with sialic acid to evade the host’s immune response (molecular mimicry). The SAU operon encodes enzymes that hydrolyze sialic acid from glycoproteins, transport sialic acid into the …

Preclinical Studies On Intranasal Npy And Selective Npy Receptor Agonists In Rodent Ptsd Model: Focus On Locus Coeruleus Noradrenergic System, Chiso Nwokafor

NYMC Student Theses and Dissertations

Post-traumatic stress disorder (PTSD) is a debilitating psychological disorder that develops in a subset of individuals after exposure to a traumatic stress. Neuropeptide Y (NPY) an endogenous 36 amino acid neuropeptide expressed in many areas of the brain and periphery especially those involved in stress may confer resilience to the harmful effect of stress. We demonstrated changes in the Single Prolonged Stress (SPS) PTSD model and potential for their modulation by delivery of intranasal NPY to the brain. There was a progressive worsening of anxiety symptoms at two weeks compared to one week after SPS. Previously we showed that 150µg …

Plants Collection Enrichment Of Purwodadi Botanic Garden Through Exploration In Alas Purwo National Park, Deden Mudiana, Elga Renjana, Elok Rifqi Firdiana, Linda Wige Ningrum, Melisnawati H Angio, Rony Irawanto

Jurnal Penelitian Kehutanan Wallacea

Purwodadi Botanic Garden (KR Purwodadi) is an exsitu conservation institution for dry climate lowland plants aiming at saving and protecting biodiversity from extinction. In supporting exsitu conservation efforts, plant exploration activities in their natural habitat need to be carried out. Alas Purwo National Park has a lowland forest area with abundant plant diversity. In addition to functioning as a conservation forest, this area is also a natural and religious tourist attraction, so it is likely to undergo ecosystem damage. Therefore, this plant diversity study with theactivity of plants exploration and collection was carried out for the purpose of ex situ …

Isolation And Potency Of Symbiotic Nitrogen Fixation Bacteria From Nodules Of Falcataria Moluccana (Miq.) Barneby & J.W.Grimes For Supporting Nickle Postmining Area Reclamation, Ramdana Sari, Retno Prayudyaningsih

Jurnal Penelitian Kehutanan Wallacea

Nickel mine is one of the contributors foreign to exchange earners in Indonesia. However, the former mining area creates a complex problem in the physical, chemical, and biological soil properties which directly affect the ability of plant growth for restoration. The planting of legume species, one of them is sengon laut (Falcataria moluccana), in the reclamation of ex-mining land aims to improve soil properties. Legume plants have low C/N ratio so the introduction of nitrogen-fixing soil microorganisms is one alternative that can be used to improvesoil fertility. Nitrogen fixing bacteria can provide nitrogen compounds that can be directly utilized by …

Population Of Potential Rattan In Bukit Tiban Protection Forest, Batam, Indonesia, Rizki Ary Fambayun, Titi Kalima

Jurnal Penelitian Kehutanan Wallacea

Rattan is one of the promising non-timber forest products which grow widely in Indonesia. The occurrence of rattan species, especially the commercial species, is threatened due to illegal over-exploitation. The study has been done in the Bukit Tiban Protection Forest (BTPF) to investigate the occurrence of rattan species and observe the characteristic of morphology properties and their utilization. In this study, a descriptive exploration method was applied and we performed an interview with local people in the field regarding the utilization. Morphological characteristics observed including habitus, leaves (such as color, leaflets, leaf arrangement, knee, ocrea, and climbing organ/cirrus/flagellum), and fruit. …

Residual Stand Damage Due To Timber Harvesting In Pt Tunas Timber Lestari, Papua, Yuniawati, Dulsalam

Jurnal Penelitian Kehutanan Wallacea

Timber harvesting activities can cause damage to residual stands, this can occur due to improper timber harvesting techniques. The study was conducted at one of PT Tunas Timber Lestari’s IUPHHK-HA in Papua Province. The results showed that: 1). The number of trees felled and skidded on 3 logging compartment with each of the 3 plot of observation sample has an area of 2 ha (the total area of the research is 18 ha) is 16 trees on average; 2). The average number of residual stand (trees with a diameter of ≥ 20 cm) damaged by logging is 26 trees (13.00%) …

Earthworm Diversity And Biomass In Different Fallow System In The Kelimutu National Park Areas, Agustinus J. P A Saga

Jurnal Penelitian Kehutanan Wallacea

Earthworms have a role as bioindicators so that their existence is very sensitive to changes in the environment. The decreasing of land quality caused by continuous use (horticultural agriculture) will also decrease the diversity of earthworms. To anticipate degradation of land quality, the land needs to be rested (bero) so that it will facilitate natural recovery. Indicators of land restoration include the diversity and importance index of earthworms. Therefore, the research aim wasto determine the diversity of earthworm in the fallow system lands at KelimutuNational Parkareas. The monolith random sampling method at three soil depths was applied to several fields …

Relationship Between Spirituality And Acceptance Of Illness Level In Bipolar Patients, Olga Putri Atsira, Erikavitri Yuliati, Atika Atika, Abdurachman Abdurachman, Margarita Maria Maramis

Kesmas

Bipolar disorder is a chronic mental condition that affects patients’ quality of life. The management process is affected by acceptance of illness. The ability to accept the illness is related to the spirituality level which is something that is held strongly by Indonesian people. There has been very little research related to the relationship between spirituality with bipolar disorder. This study aimed to analyze relationship between spirituality levels with acceptance of illness in patients with bipolar disorder. This study is a correlational study using questionnaire from bipolar disorder patients contacted through Harmony in Diversity online community as a sample. Samples …

Resistance Exercise Intensity Does Not Influence Neurotrophic Factors Response In Equated Volume Schemes, Leandro Lodo, Alexandre Moreira, Reury Frank P Bacurau, Carol D. Capitani, Wesley P. Barbosa, Marcelo Massa, Brad J. Schoenfeld, Marcelo S. Aoki

Publications and Research

The aim of the present study was to evaluate the effects of 2 different intensities of resistance training (RT) bouts, performed with the equated total load lifted (TLL), on the acute responses of neurotrophic factors (NFs) (brain-derived neurotrophic factor [BDNF]; and nerve growth factor [NGF]), as well as on metabolic (lactate concentration) and hormonal (salivary cortisol concentration) responses. Thirty participants (males, 22.8 ± 2.3 years old, 177 ± 6.8 cm, 75.5 ± 7.9 kg, n = 15; and females, 22.2 ± 1.7 years, 163.7 ± 6.5 cm, 57 ± 7.6 kg, n = 15) performed 2 separate acute RT bouts …

In Memoriam: Honoring Longtime Usu Supporter Rex Plaizier, Usu College Of Engineering

College of Engineering News

Aug. 31, 2020 — Students, faculty and staff at Utah State University are saddened by the loss of friend and mentor Rex Plaizier who died Aug. 27 after an 8-year battle with cancer. He was 61.

The Rider (2020-08-31), Jacqueline Peraza

The Rider Archives

Vol.6 No.2

Second Round Of Urgent Covid-19 Research Launches, Selwyn M. Vickers Md

Browse All News

No abstract provided.

Epigenetic Diet To Modulate Immune Response Against Sars-Cov-2, Andika Andika, Risa Ahdyani, Linda Erlina, Azminah Azminah, Arry Yanuar

Pharmaceutical Sciences and Research

The COVID-19 pandemic has spread to various parts of the world and caused many deaths. The victims are infected by SARS-CoV-2, a new type of coronavirus that has appeared since December 2019 and caused respiratory symptoms, fever, coughing, and shortness of breath. In addition to social distancing, wearing masks and washing hands, diet is important as a defense of the body against SARS-CoV-2. In this review, researchers conducted epigenetic diet studies that could potentially inhibit SARS-CoV-2, and can be consumed and used on a daily basis.

Antioxidant And Elastase Inhibitor Potential Of Petals And Receptacle Of Rose Flower (Rosa Damascena), Evi Mawarni, Chrismis Novalinda Ginting, Linda Chiuman, Ermi Girsang, Rr. Anisa Siwianti Handayani, Wahyu Widowati

Pharmaceutical Sciences and Research

Free radicals can cause damage to cells or tissues, autoimmune diseases, degenerative diseases, or cancer. Therefore, the body needs important substances, namely antioxidants that can help protect the body by reducing negative effect from free radicals. Rose flower (Rosa damascena) has anthocyanin pigment which belongs to flavonoid group which has a function as antioxidant or free radical scavenger. This study aims to determine antioxidant and anti-elastase potentials of rose petals and receptacles. The method used in this study was a qualitative phytochemical test to determine the compounds contained in the Rose Petal Extract (RPE) and Rose Receptacle Extract (RRE), ABTS …

Crow's Nest, August 31, 2020, Crow's Nest Staff

Crow's Nest

The August 31, 2020, issue of the Crow's Nest.