Digital Commons Network^™

Space Telescope And Optical Reverberation Mapping Project. Ix. Velocity–Delay Maps For Broad Emission Lines In Ngc5548, Dirk Grupe

Faculty Research at Morehead State University

In this contribution, we achieve the primary goal of the active galactic nucleus (AGN) STORM campaign by recovering velocity–delay maps for the prominent broad emission lines (Ly, C IV, He II, and H) in the spectrum of NGC5548. These are the most detailed velocity–delay maps ever obtained for an AGN, providing unprecedented information on the geometry, ionization structure, and kinematics of the broad-line region. Virial envelopes enclosing the emission-line responses show that the reverberating gas is bound to the black hole. A stratified ionization structure is evident. The He II response inside 5–10 light days has a broad single-peaked velocity …

Engaging Student Interest Through Modeling, Sowmya Anjur

Faculty Publications & Research

No abstract provided.

The Genetic Algorithm: Using Biology To Compute Liquid Crystal Director Configurations, Shouzhuo Yang , '23, Peter J. Collings

Physics & Astronomy Faculty Works

The genetic algorithm is an optimization routine for finding the solution to a problem that requires a function to be minimized. It accomplishes this by creating a population of solutions and then producing “offspring” solutions from this population by combining two “parental” solutions in much the way that the DNA of biological parents is combined in the DNA of offspring. Strengths of the algorithm include that it is simple to implement, no trial solution is required, and the results are fairly accurate. Weaknesses include its slow computational speed and its tendency to find a local minimum that does not represent …

Telomere Length In Young Patients With Acute Myocardial Infarction Without Conventional Risk Factors: A Pilot Study From A South Asian Population, Mohit D. Gupta, Manjula Miglani, Ankit Bansal, Vardhmaan Jain, Sameer Arora, Sameer Kumar, Salim S. Virani, Ankur Kalra, Rakesh Yadav, Q Pasha

Office of the Provost

Background: There is need to identify novel markers that lead to an early occurrence of myocardial infarction (MI) in young South Asian population. This population has different risk profile as compared with others. Telomere length is known to be a marker of aging, and shorter telomeres have been reported in cardiovascular diseases (CVDs). We aimed to identify the association of telomere length in young nonsmokers and non-diabetic MI patients.
Methods: In a case-control study of 154 subjects (n = 77 cases (ages 18-45 years, non-diabetic, non-smoker patients with MI) and n = 77, age and sex matched healthy controls), DNA …

Sleep And Its Relation With Academic Performance Among Adolescents: An Analytical Cross Sectional Study In Gulshan Town, Karachi, Zainab Mohammad Anjarwala, Niloufer Sultan Ali, Kashmira Nanji, Anum Arshad Beg, Veena Kumari Karmani

Department of Family Medicine

Objective: To determine the prevalence of sleep patterns and their relationship with academic performance among adolescents.
Methods: The analytical cross-sectional study was conducted from March to August 2015 in Gulshan Town of Karachi and comprised students in grades 6 to 8 who were selected from six government and private schools. Data was collected regarding their sleeping time, wake-up time, sleep latency and total sleep duration. Paediatric Daytime Sleepiness Scale was administered to calculate daytime sleepiness. Academic performance of students was taken from school academic records. Data was analysed using SPSS 22.
Results: Of the 440 subjects, 234 (53.2%) were boys …

The Banner - V. 155, No. 10 - (November 2020), Christian Reformed Church In North America

The Banner

No abstract provided.

Academic Procrastination And Self-Efficacy Among A Group Of Dental Undergraduate Students In Malaysia, Eswara Uma, Chia Lee, Siti Shapiai, Anis Binti Mat Nor

Open Access archive

BACKGROUND: Undergraduate dental students have to do multiple tasks as part of their extensive curriculum in order to achieve the proficiencies expected of them. During the course of their study, a tendency to procrastinate and question their self-efficacy is detrimental for the students. The aim of this study was to evaluate the level of procrastination and self-efficacy and its related factors among dental undergraduate students. SUBJECTS AND METHODS: This cross-sectional study was conducted among all (n = 361) consented dental undergraduate students of our dental school. A twenty-item Lay's Procrastination Scale for student population and a ten-item General Self-Efficacy Scale …

A Case Report Of Androgen Receptor Inhibitor Therapy In Recurrent High-Grade Serous Ovarian Cancer, Sewanti Limaye, Prashant Kumar, Ramya Pragya, Janani Sambath

Open Access archive

Ovarian cancer is common gynaecological malignancy and a leading cause of death among women. Despite the advances in treatment strategies, majority of patients present with recurrence after first- or second-line treatment. Targeted therapy that has proven to be effective in other advanced or metastatic solid tumors have also demonstrated its efficacy in ovarian cancer. Recent studies have shown that the androgen receptor (AR) signalling is involved in pathogenicity and progression of cancer. Current observations suggest AR could be a potential target in managing the disease. In this case report we present a patient with high grade serous ovarian cancer (HGSOC) …

Haplotype Of Rnase 3 Polymorphisms Is Associated With Severe Malaria In An Indian Population, Benudhar Mukhi, Himanshu Gupta, Samuel C. Wassmer, Anupkumar R. Anvikar

Open Access archive

Severe malaria (SM) caused by Plasmodium falciparum (Pf) infection has been associated with life-threatening anemia, metabolic acidosis, cerebral malaria and multiorgan dysfunction. It may lead to death if not treated promptly. RNASE 3 has been linked to Pf growth inhibition and its polymorphisms found associated with SM and cerebral malaria in African populations. This study aimed to assess the association of RNASE 3 polymorphisms with SM in an Indian population. RNASE 3 gene and flanking regions were amplified followed by direct DNA sequencing in 151 Indian patients who visited Wenlock District Government Hospital, Mangalore, Karnataka, India. Allele, genotype and haplotype …

Structural And Molecular Basis Of The Interaction Mechanism Of Selected Drugs Towards Multiple Targets Of Sars-Cov-2 By Molecular Docking And Dynamic Simulation Studies- Deciphering The Scope Of Repurposed Drugs, Sinosh Skariyachan, Dharshini Gopal, Shweta Chakrabarti, Priya Kempanna

Open Access archive

The repurposing of FDA approved drugs is presently receiving attention for COVID-19 drug discovery. Previous studies revealed the binding potential of several FDA-approved drugs towards specific targets of SARS-CoV-2; however, limited studies are focused on the structural and molecular basis of interaction of these drugs towards multiple targets of SARS-CoV-2. The present study aimed to predict the binding potential of six FDA drugs towards fifteen protein targets of SARS-CoV-2 and propose the structural and molecular basis of the interaction by molecular docking and dynamic simulation. Based on the literature survey, fifteen potential targets of SARS-CoV-2, and six FDA drugs (Chloroquine, …

State Transition Modeling Of Complex Monitored Health Data, Jörn Schulz, Jan Terje Kvaløy, Kjersti Engan, Trygve Eftestol, Samwel Jatosh, Hussein Kidanto, Hege Ersdal

Faculty of Health Sciences, East Africa

This article considers the analysis of complex monitored health data, where often one or several signals are reflecting the current health status that can be represented by a finite number of states, in addition to a set of covariates. In particular, we consider a novel application of a non-parametric state intensity regression method in order to study time-dependent effects of covariates on the state transition intensities. The method can handle baseline, time varying as well as dynamic covariates. Because of the non-parametric nature, the method can handle different data types and challenges under minimal assumptions. If the signal that is …

Antifungal Drug Repurposing, Jong H. Kim, Luisa W. Cheng, Kathleen L. Chan, Christina C. Tam, Noreen Mahoney, Mendel Friedman, Mikhail Martchenko Shilman, Kirkwood M. Land

College of the Pacific Faculty Articles

Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including the generation of reactive oxygen species. Moreover, increased incidences of fungal resistance to the classes of azoles, such as fluconazole, itraconazole, voriconazole, or posaconazole, or echinocandins, including caspofungin, anidulafungin, or micafungin, have been documented. Of note, certain azole fungicides such as propiconazole or tebuconazole that are applied to agricultural fields have the same mechanism of antifungal action as clinical azole drugs. Such long-term application of azole …

Surveying The Safety Culture Of Academic Laboratories, Emily Faulconer, Zachary Dixon, John C. Griffith, Hayden Frank

Publications

The university traditionally has been the foundation for young adults’ professional development, yet the proclivity toward safety culture has garnered less focus in higher education than in the workforce. A survey of faculty at a medium-sized, research-active, private institution revealed specific areas of policy noncompliance as well as specific safety attitudes that can be targeted for interventions. Albeit a snapshot view, the survey implies that safety needs better representation in the classroom, teaching laboratories, and research facilities at universities. Safety is not abandoned by any means, and there is a strong presence of safety-oriented individuals, but the data show barriers …

November 2020 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Caring For Children In Foster And Kinship Care During A Pandemic: Lessons Learned And Recommendations, Hilda Loria, Jill Mcleigh, Erinne Conner, Valerie Smith, Rachel Keefe, Christopher Greeley, Kristin Wolfe

Health Status, Outcomes, and Literacy and Healthcare Utilization

Through qualitative feedback from professionals in healthcare, mental health, and child welfare, this study explored the impact of the COVID-19 pandemic on the health and well-being of children in the child welfare system. Positive outcomes and challenges related to the care of children in foster or kinship care in Texas during the COVID-19 pandemic are described. Themes identified included disparities in the child welfare system; utilization of telehealth; cross-sector communication and collaboration; safety considerations; and placement stability and support. The article concludes with recommendations in each of these areas for ensuring the health and well-being of children in foster and …

Hitting The Bullseye: Are Extracellular Vesicles On Target?, Nicole Noren Hooten, María Yáñez-Mó, Rachel M. Derita, Ashley Russell, Peter Quesenberry, Bharat Ramratnam, Paul D Robbins, Dolores Di Vizio, Sicheng Wen, Kenneth W Witwer, Lucia R Languino

Department of Cancer Biology Faculty Papers

No abstract provided.

Annual Report Of The Indiana Universiy Maurer School Of Law Digital Repository, 2019/20, Richard Vaughan

Digital Repository Annual Reports

A brief annual report documenting the use and growth of the Indiana University Maurer School of Law, Jerome Hall Law Library, Digital Repository. Includes lists of the most downloaded documents and attached Excel spreadsheets of data

The Influence Of Social-Grouping On Territorial Defense Behavior In The Black-Crested Titmouse (Baeolophus Atricristatus), Mirjam J. Borger, Lauren E. Johnson, Nathaly O. Salazar, Cameron L. Dreghorn, J. Komdeur, Troy G. Murphy

Biology Faculty Research

Abstract: Status signals have evolved for individuals to avoid energetic and physical costs of resource defense. These signals reflect an individual’s competitive ability and therefore influence competitors’ decisions on how to invest in a fight. We hypothesized that the response of receivers to status signals will depend on the social context. During territorial defense, group members may provide support to a territory owner by participating in defense. We investigated whether the presence of juveniles—who group together with territorial males—alters the territorial male’s attack decisions and level of aggression in the black-crested titmouse (Baeolophus atricristatus). Crest-length in this species …

Modeling The Effects Of Hyaluronic Acid Degradation On The Regulation Of Human Astrocyte Phenotype Using Multicomponent Interpenetrating Polymer Networks (Mipns), Andrea C. Jimenez-Vergara, Rachel Van Drunen, Tyler Cagle, Dany J. Munoz-Pinto

Engineering Faculty Research

Hyaluronic acid (HA) is a highly abundant component in the extracellular matrix (ECM) and a fundamental element to the architecture and the physiology of the central nervous system (CNS). Often, HA degradation occurs when an overreactive inflammatory response, derived from tissue trauma or neurodegenerative diseases such as Alzheimer’s, causes the ECM in the CNS to be remodeled. Herein, we studied the effects of HA content as a key regulator of human astrocyte (HAf) reactivity using multicomponent interpenetrating polymer networks (mIPNs) comprised of Collagen I, HA and poly(ethylene glycol) diacrylate. The selected platform facilities the modulation of HA levels independently of …

Peer-Assisted Learning (Pal): An Innovation Aimed At Engaged Learning For Undergraduate Medical Students, Hasan Salman Siddiqi, Rehana Rehman, Farzeen Fatma Syed, Russell S. Martins, Muhammad Talal Ibrahim, Faiza Alam

Department of Biological & Biomedical Sciences

Objective: To evaluate the effectiveness of Peer Assisted Learning in teaching at undergraduate level and to assess its effects on Peer Leaders and Peer Learners.
Methods: The cross-sectional study was conducted at the Aga Khan University, Karachi, from May to October 2017, and comprised Peer Learners who were trained by faculty members in workshops and pre-run of experiments. Students were divided into two groups; Group A had Peer Learners taught by Peer Leaders, and Group B had those taught by trained lab technologists. Knowledge of the groups was assessed by a quiz using Kahoot. Post-session feedback questionnaires were also filled …

From Ace2 To Covid-19: A Multiorgan Endothelial Disease, Richard A. Stein, Lauren M. Young

Publications and Research

Editorial

Interactions 2020, Thomas J. Long School Of Pharmacy

Interactions

In each issue of Interactions, the School’s annual magazine you will find stories about students, faculty and alumni from each of our disciplines. Learn about the ways our students, faculty and alumni are impacting their communities through health care outreach. Read about their research and how they are contributing to advances in patient care. Meet our Alumni of the Year and get to know our faculty.

Draft Peir For Humboldt Bay Sediment Management, Icf

Local Reports and Publications

This Draft Program Environmental Impact Report (PEIR) assesses the potential environmental effects of implementing the Humboldt Bay Sediment Management Program (Proposed Program). The objective of this PEIR is to explore alternatives and provide an environmental analysis of dredging methods, sediment processing, and sediment placement at beneficial-use sites that would guide implementation of the Coastal Regional Sediment Management Plan for the Eureka Littoral Cell (CRSMP) and steer sediment management for Locally Maintained Sites (LMSs) toward achievement of the objectives of the CRSMP.

Depot Medroxyprogesterone Acetate Use And Blood Lead Levels In A Cohort Of Young Women, Kristen Upson, Quaker E. Harmon, Renee Heffron, Janet E. Hall, Lauren A. Wise, Ganesa Wegienka, Erik J. Tokar, Donna D. Baird

Public Health Sciences Articles

BACKGROUND: Injectable contraceptive use is common, with 74 million users worldwide. Use of the injectable contraceptive depot medroxyprogesterone acetate (DMPA) is associated with bone mineral density loss. We hypothesize that increased bone resorption with DMPA use allows for mobilization of the toxic metal lead stored in bone to blood, presenting users with increased systemic exposure to lead.

OBJECTIVE: The objective of our study was to investigate the association between current DMPA use and blood lead concentrations.

METHODS: We conducted a cross-sectional analysis using enrollment data from the Study of Environment, Lifestyle & Fibroids (SELF), a cohort of 1,693 African-American women …

Social Media Weaponization: The Biohazard Of Russian Disinformation Campaigns, Sarah Jacobs Gamberini

Articles and Op-Eds

In a renewed era of Great Power competition, the United States is faced with adversaries engaging across multiple domains without the traditional distinctions of war and peace. America’s competitors are regularly operating below the threshold that would warrant a military response, including on the information battlefield. The blurred red lines that result from covert information operations waged by foreign actors on the Internet will force a change in how the United States operates and how its society consumes information. Russia used tactics of influence and coercion long before social media allowed for nearly ubiquitous access to its targets and a …

Transfusion Of Blood Components Containing Abo-Incompatible Plasma Does Not Lead To Higher Mortality In Civilian Trauma Patients, Jansen N. Seheult, Nancy M. Dunbar, John R. Hess, Erin E. Tuott, Mohammad Bahmanyar, Jessica Campbell, Magali Fontaine, Jenna Khan, Ara Ko, Jian Mi, Michael F. Murphy, Tara Nykoluk, Jessica Poisson, Jay S. Raval, Andrew Shih, Jason L. Sperry, Julie Staves, Michelle Wong, Matthew T S Yan, Alyssa Ziman, Mark H. Yazer

Pathology Research and Scholarship

BACKGROUND: This study investigated the effect on mortality of transfusing ABO-incompatible plasma from all sources during trauma resuscitation.

METHODS: Demographic, transfusion, and survival data were retrospectively extracted on civilian trauma patients. Patients were divided by receipt of any quantity of ABO-incompatible plasma from any blood product (incompatible group) or receipt of solely ABO-compatible plasma (compatible group). The primary outcome was 30-day mortality, while other outcomes included 6- and 24-hour mortality. Mixed-effects logistic regression was used to model the effect of various predictor variables, including receipt of incompatible plasma, on mortality outcomes.

RESULTS: Nine hospitals contributed data on a total of …

The Granulate Cutworm (Lepidoptera: Noctuidae): Biological Parameters Under Controlled Conditions, Host Plants, And Distribution In The Americas, Alexandre Specht, Fernando M. S. Dias, Germán San Blas, Vânia F. Roque-Specht, Mirna M. Casagrande, Olaf H. H. Mielke, Débora Goulart Montezano, Izailda Barbosa Santos, Silvana Vieira De Paula Moraes, Thomas E. Hunt, Juaci V. Malaquias, Felipe A. D. Bonfin, Paulo V. M. Vieira

Department of Entomology: Faculty Publications

Feltia subterranea (Fabricius), commonly known as the granulate cutworm, is a common species of owlet moths (Noctuidae) of major agricultural importance, widely distributed in Nearctic and Neotropical regions. This study was conducted to determine the species biological parameters, gather information about its larval host plants, and assess the agricultural significance of this species in the Americas. The viability of the egg, larval, pupal stages, and prepupal period was 98, 98, and 100%, respectively, under laboratory conditions. The average duration of the egg, larval, pupal stages, and prepupal period was 3, 17, 4, and 13 d, respectively. All laboratory-reared larvae developed …

Challenges Of Measuring Abyssal Temperature And Salinity At The Kuroshio Extension Observatory, Nathan D. Anderson, Kathleen A. Donohue, Makio C. Honda, Meghan F. Cronin, Dongxiao Zhang

Graduate School of Oceanography Faculty Publications

The deep ocean is severely undersampled. Whereas shipboard measurements provide irregular spatial and temporal records, moored records establish deep ocean high-resolution time series, but only at limited locations. Here, highlights and challenges of measuring abyssal temperature and salinity on the Kuroshio Extension Observatory (KEO) mooring (32.3°N, 144.6°E) from 2013 to 2019 are described. Using alternating SeaBird 37-SMP instruments on annual deployments, an apparent fresh drift of 0.03–0.06 psu was observed, with each newly deployed sensor returning to historical norms near 34.685 psu. Recurrent salinity discontinuities were pronounced between the termination of each deployment and the initiation of the next, yet …

A Comparison Of Two Protein Supplements On The Healing Of Stage Iii And Iv Pressure Injuries In Enterally Fed, Ventilator Dependent Long – Term Care Residents, Kalli Talaska

Master's Theses

The purpose of this study was to evaluate the change in stage III or IV pressure injury size of enterally fed, ventilator dependent, long-term care residents after receiving one of two protein supplements in addition to enteral feeding meeting 100% of calculated needs. The two protein supplements were Beneprotein™ (powder) and Pro T Gold™ (liquid). The injuries were evaluated for change in size at two weeks and four weeks post initiation of protein supplement. Sixty subjects were reviewed – 30 for each supplement. Subjects included 20 males (33%) and 40 females (67%). The analysis indicated for the total sample, a …

Maternal Hookworm Infection And Its Effects On Maternal Health: A Systematic Review And Meta-Analysis, Tara E Ness, Vedika Agrawal, Kathryn Bedard, Lara Ouellette, Timothy A Erickson, Peter Hotez, Jill E Weatherhead

Library Staff Publications

Hookworm is an intestinal parasite that infects nearly 230 million people, with another 5.1 billion at risk, especially in poverty-stricken tropical and subtropical regions. Pregnancy is an especially vulnerable time for hookworm infection because of its effect on both maternal and subsequently fetal health. A systematic review and meta-analysis was conducted. The meta-analysis was performed on the association between maternal hookworm and maternal anemia, as well as maternal hookworm coinfection with malaria. The prevalence of hookworm ranged from 1% to 78% in pregnant women, whereas malaria prevalence ranged from 11% to 81%. Pregnant women with hookworm infection were more likely …