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2020

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Mutations Associated With A 17-Gene Leukemia Stem Cell Score And The Score’S Prognostic Relevance In The Context Of The European Leukemianet Classification Of Acute Myeloid Leukemia, M. Bill, D. Nicolet, J. Kohlschmidt, C. J. Walker, K. Mrózek, A. K. Eisfeld, D. Papaioannou, X. Rong-Mullins, J. E. Kolitz, C. D. Bloomfield, +8 Additional Authors Jan 2020

Mutations Associated With A 17-Gene Leukemia Stem Cell Score And The Score’S Prognostic Relevance In The Context Of The European Leukemianet Classification Of Acute Myeloid Leukemia, M. Bill, D. Nicolet, J. Kohlschmidt, C. J. Walker, K. Mrózek, A. K. Eisfeld, D. Papaioannou, X. Rong-Mullins, J. E. Kolitz, C. D. Bloomfield, +8 Additional Authors

Journal Articles

© 2020 Ferrata Storti Foundation. Leukemia stem cells (LSC) are more resistant to standard chemotherapy and their persistence during remission can cause relapse, which is still one of the major clinical challenges in the treatment of acute myeloid leukemia (AML). A better understanding of the mutational patterns and the prognostic impact of molecular markers associated with stemness could lead to better clinical management and improve patients’ outcomes. We applied a previously described 17-gene expression score comprising genes differently expressed between LSC and leukemic bulk blasts, for 934 adult patients with de novo AML, and studied associations of the 17-gene LSC …

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Cll Intraclonal Fractions Exhibit Established And Recently Acquired Patterns Of Dna Methylation, B. A. Bartholdy, X. Wang, X. Yan, M. Pascual, M. Fan, J. Barrientos, S. L. Allen, K. R. Rai, N. Chiorazzi, S. Roa, +2 Additional Authors Jan 2020

Cll Intraclonal Fractions Exhibit Established And Recently Acquired Patterns Of Dna Methylation, B. A. Bartholdy, X. Wang, X. Yan, M. Pascual, M. Fan, J. Barrientos, S. L. Allen, K. R. Rai, N. Chiorazzi, S. Roa, +2 Additional Authors

Journal Articles

No abstract provided.

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Evidence Supporting The Use Of Peptides And Peptidomimetics As Potential Sars-Cov-2 (Covid-19) Therapeutics, S. Vanpatten, M. He, A. Altiti, K. F Cheng, M. H. Ghanem, Y. Al-Abed Jan 2020

Evidence Supporting The Use Of Peptides And Peptidomimetics As Potential Sars-Cov-2 (Covid-19) Therapeutics, S. Vanpatten, M. He, A. Altiti, K. F Cheng, M. H. Ghanem, Y. Al-Abed

Journal Articles

© 2020 Newlands Press. During a disease outbreak/pandemic situation such as COVID-19, researchers are in a prime position to identify and develop peptide-based therapies, which could be more rapidly and cost-effectively advanced into a clinical setting. One drawback of natural peptide drugs, however, is their proteolytic instability; peptidomimetics can help to overcome this caveat. In this review, we summarize peptide and peptide-based therapeutics that target one main entry pathway of SARS-CoV-2, which involves the host ACE2 receptor and viral spike (S) protein interaction. Furthermore, we discuss the advantages of peptidomimetics and other potential targets that have been studied using peptide-based …

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Histopathological Evaluation Of Placentas After Diagnosis Of Maternal Sars-Cov-2 Infection., M. Gulersen, L. Prasannan, H. T. Tam, C. N. Metz, B. Rochelson, N. Meirowitz, W. Shan, M. Edelman, K. A. Millington Jan 2020

Histopathological Evaluation Of Placentas After Diagnosis Of Maternal Sars-Cov-2 Infection., M. Gulersen, L. Prasannan, H. T. Tam, C. N. Metz, B. Rochelson, N. Meirowitz, W. Shan, M. Edelman, K. A. Millington

Journal Articles

Background:The impact of maternal SARS-CoV-2 infection on placental histopathology is not well known. Objectives:To determine if significant placental histopathological changes occur after diagnosis of SARS-CoV-2 infection in pregnancy and whether these changes are correlated with the presence or absence of symptoms associated with infection. Study Design:Retrospective cohort study of women diagnosed with SARS-CoV-2 infection who delivered at a single center from April 9th to April 27th, 2020, and had placental specimens reviewed by pathology. Women with singleton gestations and laboratory-confirmed SARS-CoV-2 infection were eligible for inclusion. Historical controls selected from a cohort of women who delivered 6 months prior to …

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How Mental Health Care Should Change As A Consequence Of The Covid-19 Pandemic, C. Moreno, T. Wykes, S. Galderisi, M. Nordentoft, N. Crossley, N. Jones, M. Cannon, C. U. Correll, L. Byrne, C. Arango, +14 Additional Authors Jan 2020

How Mental Health Care Should Change As A Consequence Of The Covid-19 Pandemic, C. Moreno, T. Wykes, S. Galderisi, M. Nordentoft, N. Crossley, N. Jones, M. Cannon, C. U. Correll, L. Byrne, C. Arango, +14 Additional Authors

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No abstract provided.

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Predictors Of Gestational Weight Gain In A Low-Income Hispanic Population: Sociodemographic Characteristics, Health Behaviors, And Psychosocial Stressors, C. D. Dolin, R. S. Gross, A. L. Deierlein, L. T. Berube, M. Katzow, Y. Yaghoubian, S. G. Brubaker, M. J. Messito Jan 2020

Predictors Of Gestational Weight Gain In A Low-Income Hispanic Population: Sociodemographic Characteristics, Health Behaviors, And Psychosocial Stressors, C. D. Dolin, R. S. Gross, A. L. Deierlein, L. T. Berube, M. Katzow, Y. Yaghoubian, S. G. Brubaker, M. J. Messito

Journal Articles

No abstract provided.

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The Α7 Nicotinic Acetylcholine Receptor Agonist, Gts-21, Attenuates Hyperoxia-Induced Acute Inflammatory Lung Injury By Alleviating The Accumulation Of Hmgb1 In The Airways And The Circulation, R. A. Sitapara, A. G. Gauthier, S. I. Valdés-Ferrer, M. Lin, V. Patel, M. Wang, A. T. Martino, K. J. Tracey, V. A. Pavlov, L. L. Mantell, +2 Additional Authors Jan 2020

The Α7 Nicotinic Acetylcholine Receptor Agonist, Gts-21, Attenuates Hyperoxia-Induced Acute Inflammatory Lung Injury By Alleviating The Accumulation Of Hmgb1 In The Airways And The Circulation, R. A. Sitapara, A. G. Gauthier, S. I. Valdés-Ferrer, M. Lin, V. Patel, M. Wang, A. T. Martino, K. J. Tracey, V. A. Pavlov, L. L. Mantell, +2 Additional Authors

Journal Articles

© 2020 The Author(s). Background: Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation of high mobility group box 1 (HMGB1) in the airways. We previously showed that airway HMGB1 mediates hyperoxia-induced lung injury in a mouse model of ALI. Cholinergic signaling through the α7 nicotinic acetylcholine receptor (α7nAChR) attenuates several inflammatory conditions. The aim of this study was to determine whether 3-(2,4 dimethoxy-benzylidene)-anabaseine dihydrochloride, GTS-21, an α7nAChR partial agonist, inhibits hyperoxia-induced HMGB1 accumulation in …

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Estimating And Interpreting Nonlinear Receptive Field Of Sensory Neural Responses With Deep Neural Network Models, M. Keshishian, H. Akbari, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani Jan 2020

Estimating And Interpreting Nonlinear Receptive Field Of Sensory Neural Responses With Deep Neural Network Models, M. Keshishian, H. Akbari, B. Khalighinejad, J. L. Herrero, A. D. Mehta, N. Mesgarani

Journal Articles

No abstract provided.

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Multiple Myeloma In A Young Female Presenting With Neurological Symptoms., M. Lee, X. Zhang, V. Nguyen, M. Hartley-Brown Jan 2020

Multiple Myeloma In A Young Female Presenting With Neurological Symptoms., M. Lee, X. Zhang, V. Nguyen, M. Hartley-Brown

Journal Articles

Background:Multiple myeloma is overall the 14th most common malignancy but is rarely seen in those younger than 35 years. Those in the younger age group have been shown to have a more aggressive course but reportedly have had similar responses to treatment compared to older cohorts. Extramedullary plasmacytomas are discrete soft tissue masses of neoplastic monoclonal plasma cells that often occur in patients with multiple myeloma. Case:This case entails a young female with new diagnosis of multiple myeloma and multiple extramedullary plasmacytomas presenting with neurological symptoms. She was treated with CyBorD regimen but was refractory and progressed. Treatment was changed …

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Insulin Resistance And Cancer-Specific And All-Cause Mortality In Postmenopausal Women: The Women's Health Initiative, K. Pan, R. A. Nelson, J. Wactawski-Wende, D. J. Lee, J. A. Manson, A. K. Aragaki, J. E. Mortimer, L. S. Phillips, G. Y. Ho, R. T. Chlebowski, +6 Additional Authors Jan 2020

Insulin Resistance And Cancer-Specific And All-Cause Mortality In Postmenopausal Women: The Women's Health Initiative, K. Pan, R. A. Nelson, J. Wactawski-Wende, D. J. Lee, J. A. Manson, A. K. Aragaki, J. E. Mortimer, L. S. Phillips, G. Y. Ho, R. T. Chlebowski, +6 Additional Authors

Journal Articles

© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected]. BACKGROUND: Insulin resistance has been proposed as a mediator of the increased cancer incidence and mortality associated with obesity. However, prior studies included limited cancer deaths and had inconsistent findings. Therefore, we evaluated insulin resistance and cancer-specific and all-cause mortality in postmenopausal women participating in the Women's Health Initiative (WHI). METHODS: Eligible were a subsample of 22 837 WHI participants aged 50-79 years enrolled at 40 US clinical centers from 1993 to 1998 who had baseline fasting glucose and insulin levels. Baseline insulin …

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Obesity And Sting1 Genotype Associate With 23-Valent Pneumococcal Vaccination Efficacy, M. Sebastian, C. J. Hsiao, H. S. Futch, R. S. Eisinger, L. Dumeny, S. Patel, M. Gobena, D. S. Katikaneni, L. Spiryda, M. L. Brantly, +4 Additional Authors Jan 2020

Obesity And Sting1 Genotype Associate With 23-Valent Pneumococcal Vaccination Efficacy, M. Sebastian, C. J. Hsiao, H. S. Futch, R. S. Eisinger, L. Dumeny, S. Patel, M. Gobena, D. S. Katikaneni, L. Spiryda, M. L. Brantly, +4 Additional Authors

Journal Articles

© 2020, Sebastian etal. BACKGROUND. Obesity has been associated with attenuated vaccine responses and an increased risk of contracting pneumococcal pneumonia, but no study to our knowledge has assessed the impact of obesity and genetics on 23-valent pneumococcal vaccine (PPSV23) efficacy. We assessed the relationship of obesity (primary analysis) and stimulator of interferon genes (STING1) genotype (secondary analysis) on PPSV23 efficacy. METHODS. Nonobese (BMI 22-25 kg/m2) and obese participants (BMI ≥30 kg/m2) were given a single dose of PPSV23. Blood was drawn immediately prior to and 4-6 weeks after vaccination. Serum samples were used to assess PPSV23-specific antibodies. STING1 genotypes …

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Racial Disparity In Pregnancy Risks And Complications In The Us: Temporal Changes During 2007-2018, E. Bornstein, Y. Eliner, F. A. Chervenak, A. Grunebaum Jan 2020

Racial Disparity In Pregnancy Risks And Complications In The Us: Temporal Changes During 2007-2018, E. Bornstein, Y. Eliner, F. A. Chervenak, A. Grunebaum

Journal Articles

No abstract provided.

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Professionally Responsible Counseling When A Fetal Anomaly Is Diagnosed By Ultrasound, F. A. Chervenak, L. B. Mccullough, A. Kurjak Jan 2020

Professionally Responsible Counseling When A Fetal Anomaly Is Diagnosed By Ultrasound, F. A. Chervenak, L. B. Mccullough, A. Kurjak

Journal Articles

© The Author(s). 2020. Ethics plays an essential role in the clinical management of pregnancies complicated by fetal anomalies diagnosed by ultrasound. Utilizing the prima facie ethical principles of beneficence and respect for autonomy, this paper first explicates the ethical concept of the fetus as a patient. This ethical concept provides the basis for a comprehensive approach to counseling pregnant women about the management of pregnancies complicated by fetal anomalies. Practical, ethically justified guidance is given for counseling about decisions both before and after viabilities.

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Epithelial Cells In Endometriosis And Adenomyosis Upregulate Sting Expression, H. Qu, L. Li, T. Wang, T. Seckin, J. Segars, I. Shih Jan 2020

Epithelial Cells In Endometriosis And Adenomyosis Upregulate Sting Expression, H. Qu, L. Li, T. Wang, T. Seckin, J. Segars, I. Shih

Journal Articles

No abstract provided.

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A Pilot Study Of Ex-Vivo Mri-Pdff Of Donor Livers For Assessment Of Steatosis And Predicting Early Graft Dysfunction, S. K. Satapathy, H. C. Gonzalez, J. Vanatta, A. Dyer, W. Angel, S. S. Nouer, M. Kocak, S. K. Kedia, Y. Jiang, J. D. Eason, +11 Additional Authors Jan 2020

A Pilot Study Of Ex-Vivo Mri-Pdff Of Donor Livers For Assessment Of Steatosis And Predicting Early Graft Dysfunction, S. K. Satapathy, H. C. Gonzalez, J. Vanatta, A. Dyer, W. Angel, S. S. Nouer, M. Kocak, S. K. Kedia, Y. Jiang, J. D. Eason, +11 Additional Authors

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No abstract provided.

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A Near-Infrared Probe For Non-Invasively Monitoring Cerebrospinal Fluid Flow By F-18-Positron Emitting Tomography And Fluorescence, H. Guo, H. Kommidi, C. C. Lekaye, J. Koutcher, M. S. Judenhofer, S. R. Cherry, A. P. Wu, O. Akin, M. M. Souweidane, R. Ting, +2 Additional Authors Jan 2020

A Near-Infrared Probe For Non-Invasively Monitoring Cerebrospinal Fluid Flow By F-18-Positron Emitting Tomography And Fluorescence, H. Guo, H. Kommidi, C. C. Lekaye, J. Koutcher, M. S. Judenhofer, S. R. Cherry, A. P. Wu, O. Akin, M. M. Souweidane, R. Ting, +2 Additional Authors

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No abstract provided.

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Brucella Exposure Risk Events In 10 Clinical Laboratories, New York City, Usa, 2015 To 2017, J. Ackelsberg, A. Liddicoat, T. Burke, W. A. Szymczak, M. H. Levi, B. Ostrowsky, E. A. Mitchell, W. Lowe, R. Khare, M. Layton, +34 Additional Authors Jan 2020

Brucella Exposure Risk Events In 10 Clinical Laboratories, New York City, Usa, 2015 To 2017, J. Ackelsberg, A. Liddicoat, T. Burke, W. A. Szymczak, M. H. Levi, B. Ostrowsky, E. A. Mitchell, W. Lowe, R. Khare, M. Layton, +34 Additional Authors

Journal Articles

Copyright © 2020 American Society for Microbiology. All Rights Reserved. From 2015 to 2017, 11 confirmed brucellosis cases were reported in New York City, leading to 10 Brucella exposure risk events (Brucella events) in 7 clinical laboratories (CLs). Most patients had traveled to countries where brucellosis is endemic and presented with histories and findings consistent with brucellosis. CLs were not notified that specimens might yield a hazardous organism, as the clinicians did not consider brucellosis until they were notified that bacteremia with Brucella was suspected. In 3 Brucella events, the CLs did not suspect that slow-growing, small Gram-negative bacteria might …

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Presentation And Outcomes Among Inflammatory Bowel Disease Patients With Concurrent Pneumatosis Intestinalis: A Case Series And Systematic Review, Y. Gao, M. Uffenheimer, M. Ashamallah, G. Grimaldi, A. Swaminath, K. Sultan Jan 2020

Presentation And Outcomes Among Inflammatory Bowel Disease Patients With Concurrent Pneumatosis Intestinalis: A Case Series And Systematic Review, Y. Gao, M. Uffenheimer, M. Ashamallah, G. Grimaldi, A. Swaminath, K. Sultan

Journal Articles

© 2020 Korean Association for the Study of Intestinal Diseases. Background/Aims: Inflammatory bowel disease (IBD) involves chronic inflammation of the colon with ulcerative colitis (UC), and the colon and/or small intestine with Crohn's disease (CD). Pneumatosis intestinalis (PI), characterized by compromise of the intestinal wall with gas-filled cysts, has rarely been reported with IBD. The presentation, best management and outcomes of PI with IBD are poorly defined. Methods: We conducted a search for PI in all abdominal computed tomography (CT) reports at 2 large tertiary care hospitals from January 1, 2010 to December 31, 2017, cross referenced to ICD codes …

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A Comprehensive Review Of Contemporary Literature For Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer And Their Toxicity, C. S. Lee, S. Sharma, E. Miao, C. Mensah, K. Sullivan, N. Seetharamu Jan 2020

A Comprehensive Review Of Contemporary Literature For Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors In Non-Small Cell Lung Cancer And Their Toxicity, C. S. Lee, S. Sharma, E. Miao, C. Mensah, K. Sullivan, N. Seetharamu

Journal Articles

© 2020 Lee et al. Mutations in the epidermal growth factor receptor (EGFR) are common amongst those with non-small cell lung cancer and represent a major factor in treatment decisions, most notably in the advanced stages. Small molecule tyrosine kinase inhibitors (TKIs) that target the EGFR, such as erlotinib, gefitinib, icotinib, afatinib, dacomitinib and osimertinib, have all shown to be effective in this setting. Osimertinib, a third-generation EGFR TKI, is a favorable option, but almost all patients develop resistance at some time point. There are no effective treatment options for patients who progress on osimertinib, but ongoing trials will hopefully …

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Menstruation: Science And Society, H. O. Critchley, E. Babayev, S. E. Bulun, S. Clark, I. Garcia-Grau, P. K. Gregersen, A. Kilcoyne, J. Y. Kim, C. N. Metz, L. G. Griffith, +11 Additional Authors Jan 2020

Menstruation: Science And Society, H. O. Critchley, E. Babayev, S. E. Bulun, S. Clark, I. Garcia-Grau, P. K. Gregersen, A. Kilcoyne, J. Y. Kim, C. N. Metz, L. G. Griffith, +11 Additional Authors

Journal Articles

© 2020 The Authors Women's health concerns are generally underrepresented in basic and translational research, but reproductive health in particular has been hampered by a lack of understanding of basic uterine and menstrual physiology. Menstrual health is an integral part of overall health because between menarche and menopause, most women menstruate. Yet for tens of millions of women around the world, menstruation regularly and often catastrophically disrupts their physical, mental, and social well-being. Enhancing our understanding of the underlying phenomena involved in menstruation, abnormal uterine bleeding, and other menstruation-related disorders will move us closer to the goal of personalized care. …

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Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus, H. Enocsson, L. Wirestam, C. Dahle, L. Padyukov, A. Jönsen, M. B. Urowitz, D. D. Gladman, C. Aranow, M. Mackay, C. Sjöwall, +36 Additional Authors Jan 2020

Soluble Urokinase Plasminogen Activator Receptor (Supar) Levels Predict Damage Accrual In Patients With Recent-Onset Systemic Lupus Erythematosus, H. Enocsson, L. Wirestam, C. Dahle, L. Padyukov, A. Jönsen, M. B. Urowitz, D. D. Gladman, C. Aranow, M. Mackay, C. Sjöwall, +36 Additional Authors

Journal Articles

© 2019 The Authors Objective: The soluble urokinase plasminogen activator receptor (suPAR) has potential as a prognosis and severity biomarker in several inflammatory and infectious diseases. In a previous cross-sectional study, suPAR levels were shown to reflect damage accrual in cases of systemic lupus erythematosus (SLE). Herein, we evaluated suPAR as a predictor of future organ damage in recent-onset SLE. Methods: Included were 344 patients from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort who met the 1997 American College of Rheumatology classification criteria with 5-years of follow-up data available. Baseline sera from patients and age- and sex-matched controls …

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Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang Jan 2020

Elevated Matrix Metalloproteinase-9 Levels In Neuronal Extracellular Vesicles In Alzheimer's Disease, D. Gu, F. Liu, M. Meng, L. Zhang, M. L. Gordon, Y. Wang, L. Cai, N. Zhang

Journal Articles

No abstract provided.

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Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology, M. S. Kwak, H. S. Kim, B. Lee, Y. H. Kim, M. Son, J. S. Shin Jan 2020

Immunological Significance Of Hmgb1 Post-Translational Modification And Redox Biology, M. S. Kwak, H. S. Kim, B. Lee, Y. H. Kim, M. Son, J. S. Shin

Journal Articles

© Copyright © 2020 Kwak, Kim, Lee, Kim, Son and Shin. Most extracellular proteins are secreted via the classical endoplasmic reticulum (ER)/Golgi-dependent secretion pathway; however, some proteins, including a few danger-associated molecular patterns (DAMPs), are secreted via non-classical ER/Golgi-independent secretion pathways. The evolutionarily conserved high mobility group box1 (HMGB1) is a ubiquitous nuclear protein that can be released by almost all cell types. HMGB1 lacks signal peptide and utilizes diverse non-canonical secretion mechanisms for its extracellular export. Although the post-translational modifications of HMGB1 were demonstrated, the oxidation of HMGB1 and secretion mechanisms are not highlighted yet. We currently investigated that …

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Insights Into The Pathophysiology Of Cellulite: A Review, L. S. Bass, M. S. Kaminer Jan 2020

Insights Into The Pathophysiology Of Cellulite: A Review, L. S. Bass, M. S. Kaminer

Journal Articles

BACKGROUND: The etiology of cellulite is unclear. Treatment of cellulite has targeted adipose tissue, dermis, and fibrous septae with varying degrees of success and durability of response. OBJECTIVE: Results from clinical trials that target different anatomical aspects of cellulite can provide insights into the underlying pathophysiology of cellulite. MATERIALS AND METHODS: A search of the PubMed database and ClinicalTrials.gov website was conducted to identify clinical trials that have investigated treatments for cellulite. RESULTS: A lack of trial protocol standardization, objective means for quantification of improvement and reported cellulite severity, and short-term follow-up, as well as variation in assessment methods have …

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Acthar Gel (Repository Corticotropin Injection) For Persistently Active Sle: Study Design And Baseline Characteristics From A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial, A. D. Askanase, E. Zhao, J. Zhu, E. Connolly-Strong, R. A. Furie Jan 2020

Acthar Gel (Repository Corticotropin Injection) For Persistently Active Sle: Study Design And Baseline Characteristics From A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial, A. D. Askanase, E. Zhao, J. Zhu, E. Connolly-Strong, R. A. Furie

Journal Articles

© 2020 Author(s). Objective SLE is a chronic inflammatory autoimmune disease characterised by the excessive production of autoantibodies, immune complexes and proinflammatory cytokines. Repository corticotropin injection (RCI) is a naturally sourced complex mixture of adrenocorticotropic hormone analogues and other pituitary peptides. RCI is approved by the US Food and Drug Administration for use during an exacerbation or as maintenance therapy in select cases of SLE. This paper discusses the design and baseline characteristics of a multicentre, double-blind, randomised, placebo-controlled, 24-week clinical trial evaluating the effect of RCI in reducing disease activity for patients with persistently active SLE despite moderate-dose corticosteroid …

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Tumor-Associated Macrophages And Macrophage-Related Immune Checkpoint Expression In Sarcomas, A. R. Dancsok, D. Gao, A. F. Lee, S. E. Steigen, J. Blay, D. M. Thomas, R. G. Maki, T. O. Nielsen, E. G. Demicco Jan 2020

Tumor-Associated Macrophages And Macrophage-Related Immune Checkpoint Expression In Sarcomas, A. R. Dancsok, D. Gao, A. F. Lee, S. E. Steigen, J. Blay, D. M. Thomas, R. G. Maki, T. O. Nielsen, E. G. Demicco

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No abstract provided.

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Study Of Alteplase For Respiratory Failure In Sars-Cov2/Covid-19: Study Design Of The Phase Iia Stars Trial., H. B. Moore, C. D. Barrett, E. E. Moore, R. Jhunjhnuwala, R. C. Mcintyre, P. K. Moore, J. Wang, N. Hajizadeh, A. Sauaia, M. B. Yaffe, +1 Additional Author Jan 2020

Study Of Alteplase For Respiratory Failure In Sars-Cov2/Covid-19: Study Design Of The Phase Iia Stars Trial., H. B. Moore, C. D. Barrett, E. E. Moore, R. Jhunjhnuwala, R. C. Mcintyre, P. K. Moore, J. Wang, N. Hajizadeh, A. Sauaia, M. B. Yaffe, +1 Additional Author

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Background:The COVID-19 pandemic has caused a large surge of acute respiratory distress syndrome (ARDS). Prior phase I trials (non COVID-19) demonstrated improvement in pulmonary function in ARDS patients using fibrinolytic therapy. A follow-up trial using the widely available tissue-plasminogen activator (alteplase) is now needed to assess optimal dosing and safety in this critically ill patient population. Objective:To describe the design and rationale of a Phase IIa trial to evaluate the safety and efficacy of alteplase treatment for moderate/severe COVID-19-induced ARDS. Patients/Methods:A rapidly adaptive, pragmatic, open label, randomized, controlled, phase IIa clinical trial will be conducted with three groups: intravenous(IV) alteplase …

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Outcomes In Patients With Severe Covid-19 Disease Treated With Tocilizumab: A Case-Controlled Study, G. Rojas-Marte, M. Khalid, O. Mukhtar, A. T. Hashmi, M. A. Waheed, S. Ehrlich, A. Aslam, S. Siddiqui, C. Agarwal, J. Shani, +8 Additional Authors Jan 2020

Outcomes In Patients With Severe Covid-19 Disease Treated With Tocilizumab: A Case-Controlled Study, G. Rojas-Marte, M. Khalid, O. Mukhtar, A. T. Hashmi, M. A. Waheed, S. Ehrlich, A. Aslam, S. Siddiqui, C. Agarwal, J. Shani, +8 Additional Authors

Journal Articles

© The Author(s) 2020. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: [email protected]. BACKGROUND: COVID-19 is an ongoing threat to society. Patients who develop the most severe forms of the disease have high mortality. The interleukin-6 inhibitor tocilizumab has the potential to improve outcomes in these patients by preventing the development of cytokine release storm. AIMS: To evaluate the outcomes of patients with severe COVID-19 disease treated with the interleukin-6 inhibitor tocilizumab. METHODS: We conducted a retrospective, case-control, single-center study in patients with severe to critical COVID-19 disease treated …

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A Review Of Maternal Prenatal Exposures To Environmental Chemicals And Psychosocial Stressors-Implications For Research On Perinatal Outcomes In The Echo Program, A. M. Padula, C. Monk, P. A. Brennan, A. Borders, E. S. Barrett, C. T. Mcevoy, S. Foss, P. K. Gregersen, B. Diamond, K. N. Botteron, +125 Additional Authors Jan 2020

A Review Of Maternal Prenatal Exposures To Environmental Chemicals And Psychosocial Stressors-Implications For Research On Perinatal Outcomes In The Echo Program, A. M. Padula, C. Monk, P. A. Brennan, A. Borders, E. S. Barrett, C. T. Mcevoy, S. Foss, P. K. Gregersen, B. Diamond, K. N. Botteron, +125 Additional Authors

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No abstract provided.

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A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease, D. González-Serna, E. Ochoa, E. López-Isac, A. Julià, F. Degenhardt, N. Ortego-Centeno, T. R. Radstake, P. K. Gregersen, A. T. Lee, A. Gabrielli, +78 Additional Authors Jan 2020

A Cross-Disease Meta-Gwas Identifies Four New Susceptibility Loci Shared Between Systemic Sclerosis And Crohn’S Disease, D. González-Serna, E. Ochoa, E. López-Isac, A. Julià, F. Degenhardt, N. Ortego-Centeno, T. R. Radstake, P. K. Gregersen, A. T. Lee, A. Gabrielli, +78 Additional Authors

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© 2020, The Author(s). Genome-wide association studies (GWASs) have identified a number of genetic risk loci associated with systemic sclerosis (SSc) and Crohn’s disease (CD), some of which confer susceptibility to both diseases. In order to identify new risk loci shared between these two immune-mediated disorders, we performed a cross-disease meta-analysis including GWAS data from 5,734 SSc patients, 4,588 CD patients and 14,568 controls of European origin. We identified 4 new loci shared between SSc and CD, IL12RB2, IRF1/SLC22A5, STAT3 and an intergenic locus at 6p21.31. Pleiotropic variants within these loci showed opposite allelic effects in the two analysed diseases …

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