Digital Commons Network^™

Bacillus Sp. Sw14 Isolated From Arid Mangroves Sediments Enhances Tomato Plant Growth: Insights From Genome Analysis And Greenhouse Evaluation, Balamurugan Sadaiappan, Qurban Ali, Mahideen Afridi, Munawwar Ali Khan, Sunil Mundra

All Works

Mangroves grow in arid regions with high temperatures, low precipitation, and evaporation. Despite low humidity and high salt concentration, these arid mangroves support diverse microorganisms, including salt-and temperature tolerant. The bacteria isolated from these arid mangroves have potential applications in arid agronomy, which alleviate plant stress and enhance plant growth. In this study, we characterize the genome of previously reported PGP and stress-tolerating bacteria, Bacillus sp. SW14, isolated from mangrove sediments of Umm Al Quwain, United Arab Emirates. Further, we investigated its effects on tomato seed germination and plant growth. Genome size of the strain SW14 is 4.25 MB, with …

Structural Variation, Selection, And Diversification Of The Npip Gene Family From The Human Pangenome., Philip C. Dishuck, Katherine M. Munson, Alexandra P. Lewis, Max L. Dougherty, Jason G. Underwood, William T. Harvey, Pinghsun Hsieh, Tomi Pastinen, Evan E. Eichler

Manuscripts, Articles, Book Chapters and Other Papers

The NPIP gene family is among the most positively selected gene families in humans/apes and drives independent duplication in primate lineages. These duplications promote genetic instability, leading to recurrent disease-associated microduplication and microdeletion syndromes. Despite its importance, little is known about its function or variation in humans, as short-read sequencing cannot distinguish high-identity duplications. Using long-read assemblies of 169 human haplotypes, we find extreme variation in the content and organization of NPIP loci. We identify fixed and polymorphic paralogs and observe ongoing positive selection. With long-read RNA sequencing (RNA-seq), we create paralog-specific gene models, the majority of which were not …

One-Sided Matching Portal (Osmp): A Tool To Facilitate Rare Disease Patient Matchmaking., Matthew Osmond, E Magda Price, Orion J. Buske, Mackenzie Frew, Madeline Couse, Taila Hartley, Conor Klamann, Hannah G B H Le, Jenny Xu, Delvin So, Anjali Jain, Kevin Lu, Kevin Mo, Hannah Wyllie, Erika Wall, Hannah G. Driver, Warren A. Cheung, Ana S A Cohen, Emily G. Farrow, Isabelle Thiffault, Care Rare Canada Consortium, Andrei L. Turinsky, Tomi Pastinen, Michael Brudno, Kym M. Boycott

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Genomic matchmaking-the process of identifying individuals with overlapping phenotypes and rare variants in the same gene-is an important tool facilitating gene discoveries for unsolved rare genetic disease (RGD) patients. Current approaches are two-sided, meaning both patients being matched must have the same candidate gene flagged. This limits the number of RGD patients eligible for matchmaking. One-sided matchmaking, in which a gene of interest is queried in the genome-wide sequencing data of RGD patients, would make matchmaking possible for previously undiscoverable individuals. However, platforms and workflows for this approach have not been well established.

RESULT: We released a beta version …

Synaptic Transmission Promotes Brain Metastatic Outgrowth In Breast Cancer, Jayanta Mondal, Patrick Nylund, Prit Benny Malgulwar, William E Johnson, Jason T Huse

Faculty, Staff and Student Publications

This work demonstrates that normal neuron-to-neuron signaling machinery is hijacked by metastasizing cancer cells during their outgrowth in the central nervous system.

Quiescent Oxphos-High Triple-Negative Breast Cancer Cells That Persist After Chemotherapy Depend On Bcl-Xl For Survival, Slawomir Andrzejewski, Marie Winter, Leandro Encarnacao Garcia, Olusiji Akinrinmade, Francisco Madeira Marques, Emmanouil Zacharioudakis, Anna Skwarska, Julio Aguirre-Ghiso, Marina Konopleva, Guangrong Zheng, Susan A Fineberg, Daohong Zhou, Evripidis Gavathiotis, Tao Wang, Eugen Dhimolea

Faculty, Staff and Student Publications

The persistent residual tumor cells that survive after chemotherapy are a major cause of treatment failure, but their survival mechanisms remain largely elusive. These cancer cells are typically characterized by a quiescent state with suppressed activity of MYC and MTOR. We observed that the MYC-suppressed persistent triple-negative breast cancer (TNBC) cells are metabolically flexible and can upregulate mitochondrial oxidative phosphorylation (OXPHOS) genes and respiratory function ("OXPHOS-high" cell state) in response to DNA-damaging anthracyclines such as doxorubicin, but not to taxanes. The elevated biomass and respiratory function of mitochondria in OXPHOS-high persistent cancer cells were associated with mitochondrial elongation and remodeling, …

Synthetically Expressive: Evaluating Gesture And Voice For Emotion And Empathy In Vr And 2d Scenarios, Haoyang Du, Kiran Chhatre, Christopher Peters, Brian Keegan, Rachel Mcdonnell, Cathy Ennis

Conference papers

The creation of virtual humans increasingly leverages automated synthesis of speech and gestures, enabling expressive, adaptable agents that effectively engage users. However, the independent development of voice and gesture generation technologies, alongside the growing popularity of virtual reality (VR), presents significant questions about the integration of these signals and their ability to convey emotional detail in immersive environments. In this paper, we evaluate the influence of real and synthetic gestures and speech, alongside varying levels of immersion (VR vs. 2D displays) and emotional contexts (positive, neutral, negative) on user perceptions. We investigate how immersion affects the perceived match between gestures …

Pathologist-Like Explainable Ai For Interpretable Gleason Grading In Prostate Cancer, Gesa Mittmann, Nidia Messias, Et Al.

2020-Current year OA Pubs

No abstract provided.

Hydroxyapatite Microspheres Induce Durable Pleurodesis And Are Rapidly Cleared By Pleural Osteoclasts, Yusuke Tanaka, Yuki Takahashi, Yuma Shindo, Lori B. Pitstick, Steven L. Teitelbaum, Wei Zou, Xiangning Wang, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Francis X. Mccormack

2020-Current year OA Pubs

Talc pleurodesis is highly effective for preventing recurrence of pneumothorax and pleural effusion, but it can be complicated by dissemination, acute lung injury, lead exposure, and foreign body-induced chronic inflammation and pain. Our objective is to develop a safe, biodegradable, contaminant-free particle for pleurodesis. We used mouse models of pneumothorax and malignant pleural effusion to compare the efficacy and safety of pleurodesis with talc and hydroxyapatite microspheres (HAM). Intrapleural instillation of microspheres induced pleural adhesions, fibrosis, and symphysis as effectively as talc and resulted in more durable protection from experimental pneumothorax. HAM and talc both induced an osteoclastogenic, inflammatory, and …

Re: Butte Priority Soil Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp): Bres No. 177 – North Alice Culvert, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Gabaergic Interneurons Contribute To The Fatal Seizure Phenotype Of Cln2 Disease Mice, Keigo Takahashi, Nicholas R. Rensing, Elizabeth M. Eultgen, Letitia L. Williams, Sophie H. Wang, Hemanth R. Nelvagal, Steven Q. Le, Marie S. Roberts, Balraj Doray, Edward B. Han, Patricia I. Dickson, Michael Wong, Mark S. Sands, Jonathan D. Cooper

2020-Current year OA Pubs

The cellular etiology of seizures in CLN2 disease, a childhood-onset neurodegenerative lysosomal storage disorder caused by a deficiency of tripeptidyl peptidase 1 (TPP1), remains elusive. Given that Cln2R207X/R207X mice display fatal spontaneous seizures and an early loss of several cortical GABAergic interneuron populations, we hypothesized that these 2 events might be causally related. To study the cell-autonomous effects of interneuron-specific TPP1 deficiency, we first generated transgenic mice expressing loxP-flanked lysosomal membrane-tethered TPP1 (TPP1LAMP1 mice) on the Cln2R207X/R207X genetic background, and then crossed TPP1LAMP1 mice with Vgat-Cre mice. These Vgat-Cre; TPP1LAMP1 mice accumulated storage material in cortical and striatal interneurons. Vgat-Cre; …

What Can Bird Poop Teach Us About The History Of U.S. Imperialism?: Guano Islands And Manifest Destiny Beyond Continental Borders, Eliot Fackler

The Councilor: A National Journal of the Social Studies

In high school and college history courses, Manifest Destiny is often taught as a period when the United States expanded across the North American continent in the decades before the Civil War. This article outlines an inquiry-driven lesson examining the Antebellum guano rush and its devastating consequences to show that Manifest Destiny was also characterized by extracontinental imperial ambitions. It highlights the lasting impacts of the 1856 Guano Islands Act and links the guano rush to subsequent empire-building efforts, U.S. militarism, and ecological destruction. The article provides relevant background history, descriptions of possible class activities and assessments, and options for …

2023 - Appalachian Student Research Forum Poster Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2023 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

A Deep Dive Into The Nazis’ Animal World: Facilitating The Holocaust Through Symbolization, Filippa V. Frogner

The Downtown Review: An Interdisciplinary Journal Written and Peer-Reviewed by Mandel Honors College Students at Cleveland State University

This paper examines the use of animal symbolism in Nazi propaganda as a tool to dehumanize Jewish individuals and facilitate the Holocaust. Through an analysis of propaganda posters, films, and literature, it highlights how Jews were consistently depicted as animals such as rats, cockroaches, and monkeys—symbols associated with filth, disease, and inferiority. These portrayals, often reinforced by explicit textual messages, stripped Jews of their humanity and encouraged widespread acceptance of their persecution and extermination.

By exploring the methods, extent, and consequences of this dehumanizing propaganda, the paper sheds light on the critical role of animal symbolism in shaping public perception …

Review Of How God Found Me: Memoirs Of An American Guru, Jennifer Greene

Communal Societies

No abstract provided.

Review Of Sex And Sects: The Story Of Mormon Polygamy, Shaker Celibacy, And Oneida Complex Marriage, Cheryl Coulthard

Communal Societies

No abstract provided.

2024 - Appalachian Student Research Forum Oral Presentation Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2024 - Appalachian Student Research Forum Poster Presentation Award Winners, Applachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Effect Of Driftwood On The Hydraulic Performance Of A-Type Piano Key Weirs Situated In-Stream Or At Reservoirs, Pascal Venetz, Michael Pfister

4th International Workshop on Labyrinth and Piano Key Weirs

Driftwood is a natural part of most river ecosystems. The knowledge of its interaction with hydraulic structures, such as PKWs, is essential for two reasons: To (1) avoid uncontrolled inundations because of the level rise initiated by trapped driftwood (reducing the weir discharge coefficient), and (2) initiate the passage of the wood over the PKW, so that it remains in the river to further fulfill its environmental services. Knowledge of the conditions motivating driftwood to block at a PKW is essential. The present study accordingly focuses on the blocking probability of driftwood at PKWs and the resulting head increase – …

Hematologic Recovery In Ehrlichia-Infected Dogs: A Meta-Analysis Of Doxycycline’S Therapeutic Impact, Mahmoud Kandeel, Mohamed Marzok, Maryam Mahmoud, Khalid M. Al Khodair

The Thai Journal of Veterinary Medicine

Canine monocytic ehrlichiosis (CME), caused by Ehrlichia canis, is a globally prevalent tick-borne disease with significant hematologic manifestations, including anemia and thrombocytopenia. Doxycycline is the first-line treatment, but its effects on hematologic recovery remain inconsistently reported. This meta-analysis evaluates the impact of doxycycline on hematologic parameters in E. canis-infected dogs. A systematic search was conducted across PubMed, Scopus, Web of Science, and EMBASE. Five studies (one randomized controlled trial, four non-randomized trials) involving 116 dogs were included. Data on erythrocytes, leukocytes (neutrophils, eosinophils, monocytes, and lymphocytes), platelets, hemoglobin, and hematocrit were extracted. Heterogeneity was assessed using I² statistics, …

2021 - Appalachian Student Research Forum Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2021 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Unified, Site-Selectable Waterless Cooling Architecture For High-Density Ai Data Centers, Joseph Jm Walker

Defensive Publications Series

This disclosure describes a unified cooling architecture for AI-intensive data centers that achieves near-zero consumptive water use (WUE ≈ 0). The design modularizes heat capture into 1 MW_IT pods and provides a site-selectable rejection manifold that can simultaneously or alternatively employ (A) dry coolers, (B) closed-loop borefield geoexchange, (C) natural-water plate heat exchangers (non-consumptive intake/outfall), and (D) optional heat reuse via district heating or industrial offtake.

The novelty lies in tri-path blending + revenue-aware reuse, seasonal recharge of geothermal baselines, and permit-aware plume control in real-time supervisory logic. The system is engineered for high-density GPU loads, modular scale-out, and resilient …

Morphological And Biological Properties Of Platelet Rich Fibrin Membrane Producing From Different Centrifugation Protocols, Vannarut Satitpitakul Md, Sarisa Tangkhunchaisaeng

Chulalongkorn Medical Journal

Background: Platelet-rich fibrin (PRF) membranes represent a promising tool for corneal epithelial disease treatment, though a standardized protocol remains unestablished. Objective: This study aimed to evaluate the morphological and biological properties of Platelet-Rich Fibrin (PRF) membranes producing from different centrifugation protocols Methods: Four distinct low speed centrifugation protocols (100g/5min, 200g/5min, 100g/10min, and 200g/10min) were established for PRF production from 3 healthy volunteers. We assessed fibrin and membrane dimensions, white blood cell and platelet concentrations, kinetic release of growth factors (TGF-, PDGF-BB, VEGF, IGF-1), and inflammatory cytokines (IL-6, IL-1, TNF-). In vitro degradation and bacterial contamination were also examined. Results: All …

Effectiveness Of Vitamin D3 In Facilitating The Therapeutic Progression Of Healing Diabetic Foot Ulcers, Fatemeh Nouri, Sara Aghaei, Gülüzar Özbolat, Yusuf Döğüş, Mahdi Mirhamidi, Reza Rahimi Barghani, Amin Daemi

Chulalongkorn Medical Journal

Background: Today’s, diabetes and its complications have afflicted a large population all over the world, so that it is estimated that its prevalence in all age groups will reach from 2.8% in 2000 to 4.4% in 2030. It is well known that vitamin D may cause rapid wound healing and anti-inflammatory.

Objective: Regarding the importance of the quality of life of diabetic patients and the improvement of chronic diabetic foot ulcers, this paper aims to investigate the efficacy of vitamin D3 on the healing of diabetic foot ulcers. The present research is conducted as a randomized controlled trial.

Methods: …

9th Gsep Research Symposium - 2025

GSEP Research Symposium

The Ninth Annual GSEP Research Symposium, themed "Building Bridges to Elevate Humanity: Innovations and Insights in Education and Psychology", was hosted by the Pepperdine University Graduate School of Education and Psychology (GSEP) on June 19–20, 2025, at the historic Château d’Hauteville in Switzerland and virtually via Zoom.

This hybrid symposium convened a vibrant global community of students, alumni, faculty, and scholars to share research that addresses real-world challenges, advances scholarly inquiry, and builds pathways for inclusive collaboration and leadership. Spanning a wide array of topics—from artificial intelligence and mental health to trauma-informed practices, educational equity, social justice, and cross-cultural leadership—the …

An Ode-Based Analytical Approach To Rayleigh Flow Of Kelvin–Voigt Fluid, Kamille Garcia, Mahanthesh Basavarajappa

CODEE Journal

We present some results from a project carried out in the Under- graduate Research in Mathematics (MATH 4380) course at TAMIU. The main goal of this study is to demonstrate that analytical solutions for a system of partial differential equations (PDEs) can be obtained using methods typically taught in an undergraduate ordinary differential equations (ODE) course, such as power series, undetermined coefficients, and Laplace transforms. In this study, we provide semi-analytical solutions for Rayleigh flow type problem utilizing the Kelvin-Voigt fluid model, which describes the behavior of vis- coelastic materials by incorporating both elastic and viscous properties. Heat transfer analysis …

Alumni Association Announces 2025 Award Recipients, Jim Urbanek

University of Mississippi News

OXFORD, Miss. – The Ole Miss Alumni Association will recognize eight distinguished University of Mississippi alumni with its highest annual awards as part of Homecoming activities.

Post-Traumatic Stress Disorder (Ptsd) In Zoulfa Katouh’S As Long As The Lemon Trees Grow, Mai Hazem El Gebali

English Language and Literature

This paper aims to analyze the representation of Post-traumatic Stress Disorder (PTSD) in Zoulfa Katouh’s novel, As Long as the Lemon Trees Grow (2022). Katouh, a Canadian-Syrian author who specializes in drug sciences, sets her debut novel against the backdrop of the war in Syria in the aftermath of the Arab Spring. The protagonist, Salama, a teenage girl pursuing an undergraduate degree in pharmacy, faces the harrowing realities of war and volunteers as a surgical assistant amidst the chaos of bombings and sniper attacks. As a result of the war, Salama tragically loses almost all her family members, and in …

Design Principles For Deployable Fibers Inspired By Hagfish Defense, Mohammad Tanver Hossain, Wonsik Eom, Pallab Layak, Jeongmin Kim, Carolyn Darling, Andrew Lowe, Douglas S. Fudge, Sameh H. Tawfick, Randy Ewoldt

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Hagfish produce extraordinary slime as a defense mechanism, releasing exudate from glands that rapidly form a fibrous, soft, ultra-dilute, water-capturing network upon contact with seawater (up to 10 000 times its original volume). The gland thread cell (GTC) produces high-strength protein threads (filament diameter df = 1–3 µm) meticulously coiled into skeins (coil diameter Do ∼ 150 µm) that rapidly unravel upon deployment to reveal their hidden length (Lf = 15 cm), forming a cohesive fibrous slime network through interaction with mucin vesicles and seawater. To date, no engineered material is able to replicate the fiber …