Digital Commons Network^™

Extracellular Hmgb1: A Therapeutic Target In Severe Pulmonary Inflammation Including Covid-19?, U Andersson, W Ottestad, Kj Tracey

Journal Articles

No abstract provided.

Immunotherapies For Covid-19: Lessons Learned From Sepsis, Ke Remy, Sc Brakenridge, B Francois, T Daix, Cs Deutschman, G Monneret, R Jeannet, Pf Laterre, Rs Hotchkiss, Ll Moldawer

Journal Articles

No abstract provided.

Neutrophil Extracellular Traps In Covid-19., Y Zuo, S Yalavarthi, H Shi, K Gockman, M Zuo, Ja Madison, C Blair, A Weber, Bj Barnes, M Egeblad, Rj Woods, Y Kanthi, Js Knight

Journal Articles

No abstract provided.

Tissue Plasminogen Activator (Tpa) Treatment For Covid-19 Associated Acute Respiratory Distress Syndrome (Ards): A Case Series, J Wang, N Hajizadeh, Ee Moore, Rc Mcintyre, Pk Moore, La Veress, Mb Yaffe, Hb Moore, Cd Barrett

Journal Articles

No abstract provided.

2020-2021 College Catalog, St Norbert College

Course Catalogs

No abstract provided.

Treatment Of Clostridioides Difficile With Fecal Microbiota Transplantation, Brenton Green

Physician Assistant Scholarly Project Posters

Research was performed to discuss the epidemiology and current guidelines of Clostridioides difficile infection (CDI), recurrent C. difficile infection (rCDI), the different modalities of fecal microbiota transplantation (FMT), the donor screening process, as well as the safety and efficacy of treatment.

• Utilizing Clinical Key, NCBI database, Dynamed Plus, Cochrane Review, and the websites for the CDC and FDA, a literature review encompassing recent research and human studies relating to CDI.

• Recent studies within five years were preferred, however since C. difficile has sparsely changed, older data was utilized with updates applied accordingly.

• Oral antibiotics are intended for …

Interaction Of Certain Monoterpenoid Hydrocarbons With The Receptor Binding Domain Of 2019 Novel Coronavirus (2019-Ncov), Transmembrane Serine Protease 2 (Tmprss2), Cathepsin B, And Cathepsin L (Catb/L) And Their Pharmacokinetic Properties, Erman Sali̇h İsti̇fli̇, Arzuhan Şihoğlu Tepe, Cengi̇z Sarikürkcü, Bektaş Tepe

Turkish Journal of Biology

As of June 2020, the coronavirus disease 19 (COVID-19) caused by the 2019 new type coronavirus (2019-nCoV) infected more than 7,000,000 people worldwide and caused the death of more than 400,000 people. The aim of this study was to investigate the molecular interactions between monoterpenoids and spike protein of 2019-nCoV together with the cellular proteases [transmembrane serine protease 2 (TMPRSS2), cathepsin B (CatB), and cathepsin L (CatL)]. As a result of the relative binding capacity index (RBCI) analysis, carvone was found to be the most effective molecule against all targets when binding energy and predicted (theoretical) IC50 data were evaluated …

Envisioning Indigenous Models For Social And Ecological Change In The Anthropocene, James Fenelon, Jennifer Alford

Sociology Faculty Publications

Indigenous societies provide alternatives to hegemonic social institutions that global capitalism spread around the world, contributing to human caused environmental degradation called the Anthropocene, coterminous with the development of the modern world-system. In this work we describe Indigenous communities using ten social spheres, that balance human needs through ecological mindfulness, including spirituality, and then we model how these social spheres can be adapted to contemporary world-systems using a radical imaginary, building off Indigenous works by Fenelon (2015; 2016), social perspectives of Pellow (2017) and Norgaard (2019), and environmental geospatial sciences (Lui, Springer, and Wagner 2008; Jankowski 2009). We identify four …

Macalester Today Winter 2020, Macalester College

Macalester Today

No abstract provided.

Math Pathways Reforms In Maine, Sarah Jessen, Amy F. Johnson Phd

School Improvement

This study of the math pathways movement is designed as a mini-case study to document the status of the reform in progress.

Neighbourhood Socioeconomic Characteristics And Blood Pressure Among Jamaican Youth: A Pooled Analysis Of Data From Observational Studies, Trevor S. Ferguson, Novie O.M. Younger-Coleman, Jasneth Mullings, Damian Francis, Lisa Gaye Greene, Parris Lyew-Ayee, Rainford Wilks

Faculty and Staff Works

Introduction. Neighbourhood characteristics are associated with several diseases, but few studies have investigated the association between neighbourhood and health in Jamaica. We evaluated the relationship between neighbourhood socioeconomic status (SES) and blood pressure (BP) among youth, 15–24 years old, in Jamaica. Methods. A pooled analysis was conducted using data from three studies (two national surveys and a birth cohort), conducted between 2005–2008, with individual level BP, anthropometric and demographic data, and household SES. Data on neighbourhood SES were obtained from the Mona Geo-Informatics Institute. Neighbourhood was defined using community boundaries from the Social Development Commission in Jamaica. Community characteristics (poverty, …

Tools For Monitoring And Study Of Peregrine Pheretimoid Earthworms (Megascolecidae), Timothy S. Mccay, George Brown, Mac A. Callaham, Chih Han Chang, Andrea Dávalos, Annise Dobson, Josef H. Görres, Bradley M. Herrick, Samuel W. James, Marie R. Johnston, Damhnait Mchugh, Tanya Minteer, Jean David Moore, Maryam Nouri-Aiin, Marta Novo, Jaime Ortiz-Pachar, Rebecca A. Pinder, Justin B. Richardson, Bruce A. Snyder

Faculty and Staff Works

Peregrine pheretimoid earthworms, commonly known as jumping worms, are members of the family Megascolecidae that have become widely established outside of their native ranges. In many parts of the world this represents a second wave of earthworm invasions, following the introduction of peregrine European earthworms in the family Lumbricidae during the colonial era. Forest ecologists, turf managers, gardeners, and other land managers are concerned about the observed or presumed negative effects of jumping worms on invaded habitats. Although research on jumping worms has accelerated in recent decades, our understanding of their ecology remains limited. We compiled techniques useful to researchers …

Integrative Framework For Long-Term Activity Monitoring Of Small And Secretive Animals: Validation With A Cryptic Pitviper, Dominic L. Desantis, Vicente Mata-Silva, Jerry D. Johnson, Amy E. Wagler

Faculty and Staff Works

The use of miniature accelerometer (ACT) data-loggers for remote and continuous recording of animal movement behavior is becoming increasingly common. Until recently, size constraints limited most animal-borne ACT applications to large-bodied species. We capitalized on the ongoing miniaturization and advancement of these technologies and associated computational techniques to develop a framework for long-term, low-frequency ACT monitoring of activity in small and secretive terrestrial species. We achieved this by internally implanting coupled radio transmitters and tri-axial ACTs in rattlesnakes (Crotalus atrox). Periodic field-validation observations of behavior were used to train and test supervised learning models (Random Forest, RF; Generalized Linear Elastic …

What Roadkills Did We Miss In A Driving Survey? A Comparison Of Driving And Walking Surveys In Baldwin County, Georgia, Kori A. Ogletree, Alfred J. Mead

Faculty and Staff Works

No abstract provided.

The Herpetofauna Of Hidalgo, Mexico: Composition, Distribution, And Conservation Status, Aurelio Ramírez-Bautista, Uriel Hernández Salinas, Raciel Cruz-Elizalde, Christian Berriozabal-Islas, Israel Moreno-Lara, Domninic L. Desantis, Jerry D. Johnson, Elí García-Padilla, Vicente Mata-Silva, Larry D. Wilson

Faculty and Staff Works

The herpetofauna of Hidalgo, Mexico, is comprised of 203 species, including 42 anurans, 17 caudates, one crocodylian, 137 squamates, and six turtles. Here, the distribution of the herpetofaunal species are catalogued among the four recognized physiographic regions. The total number of species varies from 77 in the Mexican Plateau to 166 in the Sierra Madre Oriental. The individual species occupy from one to four regions (mean = 2.1). About 69% of the Hidalgo herpetofauna is found in only one or two of the four regions, which is of considerable conservation significance. The greatest number of single-region species occupies the Sierra …

Crystallography Case Studies At The Undergraduate Level, Peter Josue Rosado Flores

Faculty and Staff Works

Powder diffraction is not a characterization method alien when it concerns inorganic chemistry and material science. At the undergraduate level, however, it is rare to come upon the teaching of these methods (probably due to the lack of expensive instrumentation that could ascend the $500,000 USD mark), and instructors mostly focus on the theory. This work provides techniques to construct these case studies that could be utilized in a classroom environment, particularly at the intermediate and advance inorganic chemistry level. Therefore, the purpose of this study seeks to contribute implemented ideas to the facilitation of crystallography education at the undergraduate …

Structural Insight Into The Mechanism Of N-Linked Glycosylation By Oligosaccharyltransferase, Smita Mohanty, Bharat P. Chaudhary, David Zoetewey

Faculty and Staff Works

Asparagine-linked glycosylation, also known as N-linked glycosylation is an essential and highly conserved post-translational protein modification that occurs in all three domains of life. This modification is essential for specific molecular recognition, protein folding, sorting in the endoplasmic reticulum, cell–cell communication, and stability. Defects in N-linked glycosylation results in a class of inherited diseases known as congenital disorders of glycosylation (CDG). N-linked glycosylation occurs in the endoplasmic reticulum (ER) lumen by a membrane associated enzyme complex called the oligosaccharyltransferase (OST). In the central step of this reaction, an oligosaccharide group is transferred from a lipid-linked dolichol pyrophosphate donor to the …

Survival Of A Serotype 4b Strain And A Serotype 1/2a Strain Of Listeria T Monocytogenes, Isolated From A Stone Fruit Outbreak Investigation, On Whole Stone Fruit At 4 °C, Antonio J. De Jesus, Ishani Sheth, Hee Jin Kwon, Zhujun Gao, Jessica Palmer, Minji Hur, Thomas S. Hammack, Dumitru Macarisin, Yi Chen

United States Food and Drug Administration: Publications

In the summer of 2014, a multistate outbreak of listeriosis associated with contaminated stone fruit (peach and nectarine) was reported. A serotype 4b variant Listeria monocytogenes (Lm) strain of singleton Sequence Type (ST) 382 was isolated from clinical samples and stone fruit associated with the outbreak. A serotype 1/2b Lm strain of ST5, Clonal Complex 5 was isolated only from outbreak-associated stone fruit, not from clinical samples. Here we investigated the fate of the serotype 4b and 1/2b strains, at two inoculation levels (high level at 3.7 logCFU/fruit and low level at 2.7 logCFU/fruit), on the surfaces of white peach, …

Genomics-Based Re-Examination Of The Taxonomy And Phylogeny Of Human And Simian Mastadenoviruses: An Evolving Whole Genomes Approach, Revealing Putative Zoonosis, Anthroponosis, And Amphizoonosis, June Kang, Ashrafali Mohamed Ismail, Shoaleh Dehghan, Jaya Rajaiya, Marc W. Allard, Haw Chuan Lim, David W. Dyer, James Chodosh, Donald Seto

United States Food and Drug Administration: Publications

With the advent of high-resolution and cost-effective genomics and bioinformatics tools and methods contributing to a large database of both human (HAdV) and simian (SAdV) adenoviruses, a genomics-based re-evaluation of their taxonomy is warranted. Interest in these particular adenoviruses is growing in part due to the applications of both in gene transfer protocols, including gene therapy and vaccines, as well in oncolytic protocols. In particular, the re-evaluation of SAdVs as appropriate vectors in humans is important as zoonosis precludes the assumption that human immune system may be na€ıve to these vectors. Additionally, as impor- tant pathogens, adenoviruses are a model …

Development Of A Nicotinic Acetylcholine Receptor Nachr Α7 Binding Activity Prediction Model, Sugunadevi Sakkiah, Carmine Leggett, Bohu Pan, Wenjing Guo, Luis G. Valerio Jr., Huixiao Hong

United States Food and Drug Administration: Publications

Despite the well-known adverse health effects associated with tobacco use, addiction to nicotine found in tobacco products causes difficulty in quitting among users. Nicotinic acetylcholine receptors (nAChRs) are the physiological targets of nicotine and facilitate addiction to tobacco products. The nAChR-α7 subtype plays an important role in addiction; therefore, predicting the binding activity of tobacco constituents to nAChR-α7 is an important component for assessing addictive potential of tobacco constituents. We developed an α7 binding activity prediction model based on a large training data set of 843 chemicals with human α7 binding activity data extracted from PubChem and ChEMBL. The model …

Perivascular Macrophages In The Neonatal Macaque Brain Undergo Massive Necroptosis After Simian Immunodeficiency Virus Infection, Diana G. Bohannon, Yueying Wang, Colin H. Reinhart, Julian B. Hattler, Jiangtao Luo, Hamid R. Okhravi, Jianshui Zhang, Qingsheng Li, Marcelo J. Kuroda, Woong-Ki Kim

Nebraska Center for Virology: Faculty Publications

We previously showed that rhesus macaques neonatally infected with simian immunodeficiency virus (SIV) do not develop SIV encephalitis (SIVE) and maintain low brain viral loads despite having similar plasma viral loads compared to SIV-infected adults. We hypothesize that differences in myeloid cell populations that are the known target of SIV and HIV in the brain contribute to the lack of neonatal susceptibility to lentivirus-induced encephalitis. Using immunohistochemistry and immunofluorescence microscopy, we examined the frontal cortices from uninfected and SIV-infected infant and adult macaques (n = 8/ea) as well as adults with SIVE (n = 4) to determine differences in myeloid …

Introducing Homeschooling Students To The Librarian Profession And Personality Types, Paul Mclaughlin

Book Chapters

The librarian profession needs diversity in its membership to provide service to the variety of patrons who visit libraries and to have the array of skills needed for a library to succeed. Jaeger and Franklin (2017, 23–24) have encouraged the use of inclusive services and outreach programs that take advantage of the diversity inherent in the United States’ population to stir interest in the librarianship profession. Homeschooling students come from a variety of cultural and social backgrounds and rely on public libraries to gain access to curriculum materials, educational programming, and technology. Librarians can use outreach programs to introduce homeschoolers …

Cayuga County Families Access To Services Team Year Three, Center For Human Services Research, University At Albany

Behavioral Health Services Reports and Research Briefs

In October 2016, Cayuga County received a four-year System of Care Expansion grant from the Substance Abuse and Mental Health Services Administration (SAMHSA) to enhance their current System of Care (SOC) through an initiative called Families Access to Services Team (FAST). Cayuga County developed their SOC in two ways. First, they aimed to improve accessibility to programs for at-risk children/youth and their families through an expanded multi-systems single point of access process. Cayuga County Community Mental Health Center (CCCMHC) leads FAST, in partnership with various providers within Cayuga County, including the Auburn School District, Boards of Cooperative Educational Services (BOCES), …

Seasonal Facilitative And Competitive Trade‐Offs Between Shrub Seedlings And Coastal Grasses, Michael N. Sinclair, Natasha N. Woods, Julie C. Zinnert

Biology Publications

Shrub expansion is occurring in grasslands globally and may be impacted by the balance of competition and facilitation with existing grasses. Along the mid‐Atlantic and Gulf coasts, the native shrub Morella cerifera (wax myrtle) is rapidly expanding and displacing other native coastal species. Recent research suggests that much of this expansion is due to warming winter temperatures, as temperatures below −15°C kill M. cerifera. The objective of this project was to understand the importance of species interactions with grasses on the growth and physiology of M. cerifera at the seedling life stage through both field and laboratory experiments. In …

Apoptosis And Necrosis Drive Muscle Fiber Loss In Lipin1 Deficient Skeletal Muscle, Sandhya Ramani Sattiraju

Browse all Theses and Dissertations

Mutations in lipin1 are suggested to be a common cause of massive rhabdomyolysis episodes in children, however, the molecular mechanism involved in the regulation of myofiber death by lipin1 is not known. In this study, we utilized the skeletal muscle from cell-type-specific lipin1 knockout (Lipin1Myf5cKO) mice to define cell death pathways involved in lipin1 deficient muscles. We observed a significant increase in centrally nucleated fibers and embryonic myosin heavy chain (EMyHC)-positive regenerating fibers in Lipin1Myf5cKO mice compared to wild-type (WT) mice, indicating an increased cycle of degeneration and regeneration in lipin1 deficient muscles. Lipin1 deficient muscles had significantly elevated pro-apoptotic …

Spirituality And Prayer On Teacher Stress And Burnout In An Italian Cohort: A Pilot, Before-After Controlled Study, Francesco Chirico, Manoj Sharma, Salvatore Zaffina, Nicola Magnavita

Walden Faculty and Staff Publications

Teaching is a stressful profession that exposes workers to the risk of burnout. Techniques involving higher mental functions, such as transcendental meditation and prayer, have been used in stress and burnout prevention programs. In this study, we report the results of an experience conducted in a group of teachers of a religious institute, in which prayer was used as a technique to prevent burnout.

Mining The Harvard Caselaw Access Project, Felix B. Chang, Erin Mccabe, James Lee

Faculty Articles and Other Publications

This Essay illustrates how machine learning can disrupt legal scholarship through the algorithmic extraction and analysis of big data. Specifically, we utilize data from Harvard Law School’s Caselaw Access Project to model how courts tackle two thorny question in antitrust: the measure of market power and the balance between antitrust and regulation.

In Search For Potential Antidiabetic Compounds From Natural Sources: Docking, Synthesis And Biological Screening Of Small Molecules From Lycium Spp. (Goji), Chinni Yalamanchili, Amar G. Chittiboyina, Saqlain Haider, Yelkaira Vasquez, Shabana Khan, Jussara M. Do Carmo, Alexandre A. Da Silva, Mark Pinkerton, John E. Hall, Larry A. Walker, Ikhlas A. Khan

Faculty and Student Publications

© 2019 Current clinical antidiabetic drugs, like rosiglitazone 1, have been implicated in some serious side effects like edema, weight gain, and heart failure, making it necessary to find alternative agents. Partial agonists of peroxisome-proliferator activated receptor-gamma (PPARγ) were determined to possess improved insulin sensitivity without undeseirable side-effects when compared to full agonists of PPARγ, like rosiglitazone 1. The traditional Chinese medicine (TCM) plants, Goji (Lycium barbarum and Lycium chinense) are widely used for treating symptoms related to various diseases including diabetes and hypertension. Twenty-seven reported compounds from Goji were docked into both partial- and full-agonist binding sites of PPARγ. …

Panther First Recipients Of 2020, University Of Northern Iowa

UNI Panther First Awards

The Panther First Award identifies and rewards employees who have provided excellent customer service to customers, co-workers, or other members of the UNI community. This is the list of recipients from 2020.

Cardiorespiratory Fitness Normalized To Fat-Free Mass And Mortality Risk, Mary T. Imboden, Leonard A. Kaminsky, James E. Peterman, Haylee L. Hutzler, Mitchell H. Whaley, Bradley S. Fleenor, Matthew P. Harber

Faculty Publications - Department of Kinesiology

Cardiorespiratory Fitness Normalized to Fat-Free Mass and Mortality Risk. Med. Sci. Sports Exerc., Vol. 52, No. 7, pp. 1532–1537, 2020. Purpose: Cardiorespiratory fitness (CRF) is known to be directly related to fat-free mass (FFM), therefore, it has been suggested that normalizing CRF to FFM (V˙O2peakFFM) may be the most accurate expression of CRF as related to exercise performance and cardiorespiratory function. However, the influence of ˙O2peakFFM (mL·kg FFM−1·min−1) on predicting mortality has been largely unexplored. This study aimeVd to primarily assess the relationship between V˙O2peakFFM and all-cause and disease-specific mortality risk in apparently healthy adults. Further, this study sought to …