Digital Commons Network^™

Covid-19 Clinical Research., J. Chi, D. Chitty, M. Lee, N. Hakim, S. Lakhani, L. Rajdev, X. Zhu, M. W. Saif

Journal Articles

Introduction:While the global COVID-19 pandemic has challenged the entire humanity and health systems, it also triggered researchers to urgently perform clinical trials to assess the safety and efficacy of many agents and modalities to combat COVID-19. As of April 22, over 650 clinical studies have been registered both in USA and internationally. Results from these studies are also coming at a brisk pace in this unprecedented emergency. Areas covered:We searched the NCI website and Medline and summarize various national and international clinical trials and summarize few of the pivotal ones in this paper, including those specific to oncology population. Two …

Novel Approaches To Arteriovenous Access Creation, Maturation, Suitability, And Durability For Dialysis, M. V. Devita, S. K. Khine, H. Shivarov

Journal Articles

© 2020 Since the arteriovenous fistula (AVF) was first conceived over 50 years ago, the goal to create a vascular conduit with predictable and reproducible maturation and durability continues to elude caregivers. Recently, however, advances in the understanding of vascular biology and new technologies now provides us with some optimism; we are moving toward a viable solution. A quickly maturing, sustainable, and durable arteriovenous access may soon be attainable. This review will discuss these advances. There are novel approaches to AVF creation and devices to enhance maturation, advances in arteriovenous graft material(s), and devices to safely prolong the use of …

Pretreatment Nutritional Status And Response To Checkpoint Inhibitors In Lung Cancer., C. Lee, C. E. Devoe, X. Zhu, J. S. Fishbein, N. Seetharamu

Journal Articles

Background:Checkpoint inhibitors are integral to non-small-cell lung cancer treatment. Existing data suggests that nutritional status may play a role in antitumor immunity. Materials & methods:This retrospective study of 106 non-small-cell lung cancer patients who started checkpoint inhibitors between 2014 and 2017 at our institution assessed relationship of nutritional parameters to overall survival (OS) and progression-free survival. Results:Mean age was 68.7 ± 9.2 years and 59.4% patients were male. On multivariate analysis for OS, hypoalbuminemia and significant weight loss were prognostic at p-values of 0.0005 and 0.0052, respectively. We noted a parabolic association between age and OS (p = 0.026, 0.0025). …

Engineer Operations, United States Army

United States Army: Field Manuals

Engineer Operations, United States Army Field Manual FM 3-34

Deregulation Of Polycomb Repressive Complex-2 In Mantle Cell Lymphoma Confers Growth Advantage By Epigenetic Suppression Of, Christos Demosthenous, Shiv K Gupta, Jing Sun, Yongsen Wang, Tammy P Troska, Mamta Gupta

Biochemistry and Molecular Medicine Faculty Publications

The polycomb repressive complex 2 (PRC2) maintains the transcriptional repression of target genes through its catalytic component enhancer of zeste homolog 2 (EZH2). Through modulating critical gene expression, EZH2 also plays a role in cancer development and progression by promoting cancer cell survival and invasion. Mutations in EZH2 are prevalent in certain B-cell lymphoma subtypes such as diffuse large cell lymphoma and follicular lymphoma; while no EZH2 mutation has been reported in the mantle cell lymphoma (MCL). Here we demonstrate that the PRC2 components EZH2, EED and SUZ12 are upregulated in the MCL cells as compared to normal B-cells. Moreover, …

07 Intern Assignment Biological Adaptations, Christopher F. Bauer

Student Work Products

WELCOME to WINDOWS on the INQUIRY CLASSROOM!

You have landed on a piece of a National Science Foundation Project (DUE 1245730) directed by Professor Chris Bauer, Chemistry Department, University of New Hampshire. This is one part of a completely documented inquiry-based university science course called “Fire & Ice” which explores the nature of heat and temperature. There are multiple video perspectives and commentary from instructors and students, and documents of all course materials (agenda, instructions, student work). It’s too complicated to explain here. Take a look at the user orientation document at this link.

Computational Assessment Of Aortic Valve Function And Mechanics Under Hypertension, Saurav Kadel

Browse all Theses and Dissertations

Calcific aortic valve disease (CAVD), the most common valvular heart disorder, is associated with complications such as stroke, heart attack, aortic aneurysm, left ventricular hypertrophy, and ultimately death. While hypertension has been identified as a major risk factor for CAVD, the mechanisms by which it may promote calcification are still unknown. Given the sensitivity of valvular tissue to mechanical stress alterations, the hemodynamic abnormalities linked to hypertension may play a role in the development of CAVD. Further, the effects of hypertension on the left ventricular functionality and coronary flow resistance remain largely uninvestigated. Hence, the objectives of this thesis were …

Identification Of Causes Of Death Of Baikal Seal (Pusa Sibirica Gmelin, 1788), Nina Ryadinskaya, Ivan Meltsov, Maria Tabakova, Inna Anikienko, Svetlana Sayvanova, Alena Molkova, Olga Ilyina, Tatyana Pomoinitskaya

Turkish Journal of Zoology

The Baikal seal is the only endemic mammal of Lake Baikal. In late October 2017, 132 dead Baikal seals were found on the shore of the lake. To identify causes of death, postmortem necropsy, virological, chemical toxicological, microbiological, and parasitological studies were carried out. Several hypotheses for explaining the causes of the deaths were put forward. The most probable causes are heart failure and asphyxia due to echo sounders (sonar). The causes were confirmed by the results of histological examination of the hearts and lungs of a large number of dead seals found on the southern shore of Lake Baikal …

Latinx Boys And Juvenile Delinquency, Judy Van Wyk

Sociology and Anthropology Faculty Publications

This study examines Latinx boys in the juvenile justice system and addresses acculturation theory to assess whether or not adjudicated foreign-born Latinx boys are more delinquent than others before adjudication, and whether or not these boys are a bigger burden on the juvenile justice system than others. The present study addresses data and methodological issues that plague the current research using the Ocean Tides Database containing multi-year (1975–2019) cross sectional data for 1,083 adjudicated boys. Multivariate analyses confirm that Latinx immigrant youth who are delinquent pose no greater threats to the American public either before or after adjudication than US-born …

We, Anelise Leishman

Inscape

So, who's older?

People love to ask this question. The script is one we've memorized well: My sister was born first, but there's just one minute between us, so it doesn't count. It was a C-section, my mother explains, and they were side by side. Really, it just came down to whose foot the doctor grabbed first.

Is Pnc-27 And Pnc-28 The Best Way To Cure Cancer?, Miriam Silberstein

The Science Journal of the Lander College of Arts and Sciences

Immunotherapeutic agents have been researched for many decades as an alternative treatment for cancer. Current research demonstrates that immunotherapy is safer than radiotherapy or chemotherapy. This is attributed to immunotherapy’s mechanism of utilizing the body’s own defense system, as opposed to absorbing harmful chemicals. Two forms of immunotherapy that have been effective in curing cancer without the added danger of chemical toxicity are PNC-27 and PNC-28. These peptides were created by a supercomputer at SUNY Downstate Medical Center in New York in 2000. PNC-27 and PNC-28 work with the MDM2 -P53 tumor suppressor complex. It acts as a competitive inhibitor …

University Of Texas Health Science Center At Tyler Catalog, 2020 - 2022, University Of Texas Health Science Center At Tyler

Catalogs

No abstract provided.

Galliformes Specialist Group Annual Report 2020, John P. Carroll, Rahul Kaul

Galliformes Specialist Group and Affiliated Societies: Reports and Other Materials

Annual report of the IUCN SSC Galliformes Specialist Group, 2020.

Stress Perception And Measurement In Missionary Populations, Laurie A. Tone, Fernando Garzon, John C. Thomas, Brigitte Ritchey, Mike Malek-Ahmadi

Faculty Publications and Presentations

Christian missionaries experience numerous stressors across multiple domains. To understand their unique experiences, a targeted assessment is required. There is no known psychometrically tested measure that captures the nuances of stress for this population. To that end, as part of a larger study, the quantitative CHOPS Stress Inventory, a new tool for measuring missionary stress was developed and showed good initial psychometric qualities when compared to an established stress measure. Furthermore, the Analysis of covariance (ANCOVA) of survey findings on 267 cross-cultural evangelical missionaries noted that both age and sex demonstrated significant effects on perceived stress scores. Implications for missionary …

Nanoformulation Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, Prevents Its Acute Hypotensive Response, Sarah L. Schlichte, Svetlana Romanova, Kenichi Katsurada, Elizabeth A. Kosmacek, Tatiana K. Bronich, Kaushik K. Patel, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

Scavenging superoxide (O₂^•-) via overexpression of superoxide dismutase (SOD) or administration of SOD mimics improves outcomes in multiple experimental models of human disease including cardiovascular disease, neurodegeneration, and cancer. While few SOD mimics have transitioned to clinical trials, MnTnBuOE-2-PyP⁵⁺ (BuOE), a manganese porphyrin SOD mimic, is currently in clinical trials as a radioprotector for cancer patients; thus, providing hope for the use of SOD mimics in the clinical setting. However, BuOE transiently alters cardiovascular function including a significant and precipitous decrease in blood pressure. To limit BuOE's acute hypotensive action, we developed a mesoporous silica nanoparticle …

Hydrogeology And Geology Of The Lower North And South Platte Rivers Of Nebraska: Nebraska Geological Society Field Trip 2020, Douglas R. Hallum, Paul R. Hanson, Shane Tucker, Robert F. Diffendal Jr.

Robert F. Diffendal, Jr., Publications

The 2020 Nebraska Geological Society field trip will visit central Nebraska, and explore the geology and hydrogeology of the upper Platte, Lower South Platte and Lower North Platte rivers. The field trip area consists of a roughly east-west strip of land, approximately 100 kilometers long, and generally less than 10 kilometers north and south of the Platte, North Platte and South Platte rivers’ channels over most of the reach; from Brady, NE, upstream to Big Springs on the South Platte River and Lewellen on the North Platte River (Map 1). In addition to the river valleys, participants will observe alluvial …

Journal Of Big History (Volume 4, Number 1), David R. Blanks

Faculty Publications - History & Political Science

The Journal of Big History is a publication of the International Big History Association. The mission of the International Big History Association is to promote Big History. Big History Big History seeks to understand the integrated history of the Cosmos, Earth, Life, and Humanity, using the best available empirical evidence and scholarly methods.

November 2020, Nova Southeastern University

KPCOM SGA Rounds

No abstract provided.

Remote Sensing Applications In Monitoring Of Protected Areas：A Bibliometric Analysis, Peili Duan, Yeqiao Wang, Peng Yin

Natural Resources Science Faculty Publications

The development of remote sensing platforms and sensors and improvement in science and technology provide crucial support for the monitoring and management of protected areas. This paper presents an analysis of research publications, from a bibliometric perspective, on the remote sensing of protected areas. This analysis is focused on the period from 1991 to 2018. For data, a total of 4546 academic publications were retrieved from the Web of Science database. The VOSviewer software was adopted to evaluate the co-authorships among countries and institutions, as well as the co-occurrences of author keywords. The results indicate an increasing trend of …

The Effects Of Dietary Linoleic Acid And Hydrophilic Antioxidants On Basal, Peak, And Sustained Metabolism In Flight‐Trained European Starlings, Wales A. Carter, Kristen J. Demoranville, Barbara J. Pierce, Scott R. Mcwilliams

Natural Resources Science Faculty Publications

Dietary micronutrients have the ability to strongly influence animal physiology and ecology. For songbirds, dietary polyunsaturated fatty acids (PUFAs) and antioxidants are hypothesized to be particularly important micronutrients because of their influence on an individual's capacity for aerobic metabolism and recovery from extended bouts of exercise. However, the influence of specific fatty acids and hydrophilic antioxidants on whole‐animal performance remains largely untested. We used diet manipulations to directly test the effects of dietary PUFA, specifically linoleic acid (18:2n6), and anthocyanins, a hydrophilic antioxidant, on basal metabolic rate (BMR), peak metabolic rate (PMR), and rates of fat catabolism, lean catabolism, and …

Implanted Satellite Transmitters Affect Sea Duck Movement Patterns At Short And Long Timescales, Juliet S. Lamb, Peter W. C. Paton, Jason E. Osenkowski, Shannon S. Badzinski, Alicia M. Berlin, Tim Bowman, Chris Dwyer, Luke J. Fara, Scott G. Gilliland, Kevin Kenow, Christine Lepage, Mark L. Mallory, Glenn H. Olsen, Matthew C. Perry, Scott A. Petrie, Jean-Pierre L. Savard, Lucas Savoy, Michael Schummer, Caleb S. Spiegel, Scott R. Mcwilliams

Natural Resources Science Faculty Publications

Studies of the effects of transmitters on wildlife often focus on survival. However, sublethal behavioral changes resulting from radio-marking have the potential to affect inferences from telemetry data and may vary based on individual and environmental characteristics. We used a long-term, multi-species tracking study of sea ducks to assess behavioral patterns at multiple temporal scales following implantation of intracoelomic satellite transmitters. We applied state-space models to assess short-term behavioral patterns in 476 individuals with implanted satellite transmitters, as well as comparing breeding site attendance and migratory phenology across multiple years after capture. In the short term, our results suggest an …

Plant Genome Size Influences Stress Tolerance Of Invasive And Native Plants Via Plasticity, Laura A. Meyerson, Petr Pyšek, Magdalena Lučanová, Sarah Wigginton, Cao‐Tri Tran, James T. Cronin

Natural Resources Science Faculty Publications

Plant genome size influences the functional relationships between cellular and whole‐plant physiology, but we know little about its importance to plant tolerance of environmental stressors and how it contributes to range limits and invasion success. We used native and invasive lineages of a wetland plant to provide the first experimental test of the Large Genome Constraint Hypothesis (LGCH)—that plants with large genomes are less tolerant of environmental stress and less plastic under stress gradients than plants with small genomes. We predicted that populations with larger genomes would have a lower tolerance and less plasticity to a stress gradient than populations …

Supportive Wind Conditions Influence Offshore Movements Of Atlantic Coast Piping Plovers During Fall Migration, Pamela H. Loring, James D. Mclaren, Holly F. Goyert, Peter W C Paton

Natural Resources Science Faculty Publications

In advance of large-scale development of offshore wind energy facilities throughout the U.S. Atlantic Outer Continental Shelf (OCS), information on the migratory ecology and routes of federally threatened Atlantic Coast Piping Plovers (Charadrius melodus melodus) is needed to conduct risk assessments pursuant to the Endangered Species Act. We tagged adult Piping Plovers (n = 150) with digitally coded VHF transmitters at 2 breeding areas within the southern New England region of the U.S. Atlantic coast from 2015 to 2017. We tracked their migratory departure flights using a regional automated telemetry network (n = 30 stations) extending across a portion of …

Mitochondrial Dna Analysis Of Critically Endangered Chinese Pangolins (Manis Pentadactyla) From Nepal, Sandeep Shrestha, Ashish Bashyal, Ashna Dhaka, Thomas J. Mcgreevy Jr., Bill Buffum, Jyoti Joshi, Hemanta Kumari Chaudhary, Sanjay Nath Khanal

Natural Resources Science Faculty Publications

Chinese Pangolins (Manis pentadactyla) are Critically Endangered and one of the most illegally traded mammals globally. We generated first COI sequences from five individuals of this species from Nepal. BLASTn search of our 600bp sequences at GenBank showed pair-wise identity between 99.17% and 100% to M. pentadactyla. There were three haplotypes and a total of five variable sites among five M. pentadactyla sequences. Neighbor-joining tree revealed that all M. pentadactyla from Nepal clustered into same group further splitting into two sub-groups albeit with low bootstrap value, suggesting potential multiple geographic origins. The K2P distance was 0.3% within …

Effectiveness Of Advanced Nitrogen-Removal Onsite Wastewater Treatment Systems In A New England Coastal Community, Bianca Ross, Kevin P. Hoyt, George W. Loomis, José A. Amador

Natural Resources Science Faculty Publications

Wastewater is a major source of nitrogen (N) to groundwater and coastal waterbodies, threatening both environmental and public health. Advanced N-removal onsite wastewater treatment systems (OWTS) are used to reduce effluent N concentration; however, few studies have assessed their effectiveness. We evaluated the total N (TN) concentration of effluent from 50 advanced N-removal OWTS in Charlestown, Rhode Island, USA for 3 years. We quantified differences in effectiveness as a function of N-removal technology and home occupancy pattern (seasonal vs. year-round use), and examined the relationship between wastewater properties and TN concentration. RX30 systems produced the lowest median TN concentration (mg …

Community Forestry: Sustainability And Equity Issues, Bill Buffum

Natural Resources Science Faculty Publications

Governments around the world are increasingly handing over the authority for the management of national forests to the local communities. By 2016, governments in 62 countries had given communities legal rights to manage 732 million hectares of national forest. This approach has been particularly widespread in South Asia. Nepal and India have the oldest and largest programs in the region: community forest user groups in Nepal managed 22 million hectares of national forest in 2016, while forest protection committees in India managed 17 million ha of national forest in 2011. The experience of Nepal and India in the 1980s and …

The Hydrostatics And Hydrodynamics Of Prominent Heteromorph Ammonoid Morphotypes And The Functional Morphology Of Ammonitic Septa, David Joseph Peterman

Browse all Theses and Dissertations

Ammonoid cephalopods have chambered shells that regulated buoyancy. The morphology of their shells strongly influenced the physical properties acting on these animals during life. Heteromorph ammonoids, which undergo changes in coiling throughout ontogeny, are the focus of this dissertation. The biomechanics of these cephalopods are investigated in a framework involving functional morphology, paleoecology, and possible modes of life. Constructional constraints were investigated for the marginally-corrugated septal walls within the chambered ammonoid shell. These constraints governed the positive relationship between septal complexity and terminal size. Furthermore, increased septal complexity facilitated liquid retention via surface tension. More complex septa would have increased …

Assessment Of Salt Marsh Change On Assateague Island National Seashore Between 1962 And 2016, Anthony Campbell, Yeqiao Wang

Natural Resources Science Faculty Publications

Salt marshes provide extensive ecosystem services, including high biodiversity, denitrification, and wave attenuation. In the mid-Atlantic, sea level rise is predicted to affect salt marsh ecosystems severely. This study mapped the entirety of Assateague Island with Very High Resolution satellite imagery and object-based methods to determine an accurate salt marsh baseline for change analysis. Topobathy-metric light detection and ranging was used to map the salt marsh and model expected tidal effects. The satellite imagery, collected in 2016 and classified at two hierarchical thematic schemes, were compared to determine appropriate thematic richness. Change analysis between this 2016 map and both a …

Between A Loc And A Hard Place: A Socio-Historical, Legal, And Intersectional Analysis Of Hair Discrimination And Title Vii, Dena Elizabeth Robinson, Tyra Robinson

University of Maryland Law Journal of Race, Religion, Gender and Class

No abstract provided.

From Removal To Incarceration: How The Modern Child Welfare System And Its Unintended Consequences Catalyzed The Foster Care-To-Prison Pipeline, Sydney L. Goetz

University of Maryland Law Journal of Race, Religion, Gender and Class

No abstract provided.