Digital Commons Network^™

A Progressive Addiction Recovery Approach, Sara Meuth

Integrated Studies

Abstract

Addiction is a complex chronic disease that plagues our society today. Understanding addiction requires a deep understanding of the relationship between the brain, mind, body, soul and others; in turn, its solution requires the same. Current research has made much progress and replaced the previous biomedical model for health and well-being with a biopsychosocial model. This same multi-dimensional approach is beginning to be applied to addiction recovery; however, there is much opportunity for progressive treatments to incorporate new components into current intervention models. Although there have been some studies to research the effects of the psychological component to recovery, …

Human Impact On Global Extinction, Ashley Carter

Integrated Studies

For this project, I wanted to look at how heavily humans are impacting the current rate of global extinction. Many scientists and experts believe that Earth is either on the brink of experiencing a sixth mass extinction or that is it already occurring. The rate of extinction is argued to be happening at a much faster rate than during the Earth’s five previous mass extinctions which were before the evolution of humans. This project explores the different ways that humans are impacting global extinction, between a significant contribution to global warming, poaching, deforestation, and other factors. There is a limited …

Understanding Drugs, Michelle Rustin

Integrated Studies

Abstract

The first time someone drinks alcohol or takes a drug, it is a voluntary choice. At some point during use, brain flips a switch and use is no longer voluntary. The drug, rerouting its reward circuit, hijacks the brain. Anyone can become addicted to drugs. After the initial exposure to drugs, no one chooses how their brain will react. Addiction is not a choice, a moral failing, a character flaw, or something that only bad people do. Scientists and experts agree that it is a disease caused by biology, environment, and other factors. Understanding drugs and their harmful effects …

“When I Came To Germany, Everything Changed”: Adolescent Migrant Narratives On Shifting Identities, Societal Integration, Language Learning, And Citizenship Pathways, Scott Brauer

Human Development Honors Papers

This ethnographic study incorporated participant observation field notes and narrative interview analyses of migrant adolescent students (N = 12) from diverse national and cultural backgrounds who arrived in Lübeck, Germany within 3 years. Situated within the current German migration context following the advent of the ‘Refugee Crisis’ in 2015, the study sought to understand how migrant students responded to shifting notions of ‘Germanness’ in relation to language learning to adapt to their new lives. A dynamic process-oriented acculturation model was employed to demonstrate how the participants altered their adaptive strategies in different contexts to achieve life goals and exhibit individual …

Drought In Temperate Mesic Regions Leads To Micro-Density Anomalies In White Pine, Elise Miller

CSB and SJU Distinguished Thesis

Wood density and wood volume determine the amount of carbon fixed by trees; however, while we are beginning to understand normal seasonal variation in wood density, anomalies are common, and their drivers are poorly understood. In conifers, wood density normally increases continuously throughout the season, but intra-annual fluctuations in wood density can occur and have been linked to climatic events. The causes of these fluctuations in density at the micro-scale (hereafter micro-density anomalies) are still debated.

Mesic regions are experiencing more droughts, but micro-density anomalies are rarely studied in these ecosystems. This study examined micro-density anomaly distribution within the boles …

Identifying Rare Genetic Variation In Obsessive-Compulsive Disorder, Sarah Abdallah

Yale Medicine Thesis Digital Library

Obsessive-compulsive disorder (OCD) is a neuropsychiatric developmental disorder with known heritability (estimates ranging from 27%-80%) but poorly understood etiology. Current treatments are not fully effective in addressing chronic functional impairments and distress caused by the disorder, providing an impetus to study the genetic basis of OCD in the hopes of identifying new therapeutic targets. We previously demonstrated a significant contribution to OCD risk from likely damaging de novo germline DNA sequence variants, which arise spontaneously in the parental germ cells or zygote instead of being inherited from a parent, and we successfully used these identified variants to implicate new OCD …

Comparative Examination Of The Empatica E4 To Record Heart Rate Variability Metrics, Andres Rosero

Honors Undergraduate Theses

The increased accessibility of cyber technology has resulted in advancements in international communications and information sharing never seen in human history. With this new age of digital software comes the proliferation of illegal online activity and cyber terrorism. Repercussions of cyber-attacks have ranged from identity theft to leaks of classified state secrets. To combat this threat, the Department of Defense (DoD) established the Cyber Mission Force (CMF) to head operations in the interests of protecting against cyber-attacks. One of the CMF’s initial projects involves the creation of a Performance Assessment Suite (PAS), a training program designed to improve the training …

2019 Touro College & University System Faculty Publications, Touro College & University System

Faculty Publications Books

2019 edition of the Faculty Publications Book of the Touro College & University System. This bibliography contains the published works of TCUS affiliated authors during 2019, arranged by academic unit.

Is Fecal Microbiota Transplantation A Safe And Effective Treatment For Gastrointestinal Diseases?, Shaindel Pinsky

The Science Journal of the Lander College of Arts and Sciences

Fecal microbiota transplantation (FMT) is a method of transferring feces from an individual with a healthy microbiome to a patient whose healthy gut bacteria is deficient. While this method is not a new one, it is constantly being explored and studied to determine if it can be an effective way to treat patients with different bowel diseases. The main target of most of these studies are patients with recurrent Clostridium difficile infections. Many studies were done to determine if the method is safe, and which method is most effective, as well as who can be a good donor or recipient …

Santa Clara Review, Vol. 107, No. 1, Santa Clara University

Santa Clara Review

No abstract provided.

Incels, Compulsory Sexuality, And Fascist Masculinity, Casey Ryan Kelly, Chase Aunspach

Department of Communication Studies: Faculty Publications

Incel, the now-widely circulated portmanteau for involuntary celibacy, denotes a growing community of mostly cisgender men who are unable to find sexual partners or forge romantic relationships. Organizing in online networks, these men blame their exile from sexual relations on everything from feminism and sexual liberation to genetics and natural laws of attraction. In this essay, we offer an asexual critique of compulsory sexuality in online incel communities to illustrate how the sexual imperatives that animate fascism and the politics of the alt-right rest on myths of an insatiable male sex drive. We argue that incel discourse repurposes liberal conceptions …

The Ivy Vine July 2020 - Vol. 3 No. 7, Alpha Kappa Alpha Sorority, Inc. Alpha Delta Omega Chapter, Nashville, Tn

Alpha Delta Omega Chapter 2020 Newsletters

No abstract provided.

Histopathologic Evaluation Of Placentas After Diagnosis Of Maternal Severe Acute Respiratory Syndrome Coronavirus 2 Infection., M. Gulersen, L. Prasannan, H. Tam Tam, C. N. Metz, B. Rochelson, N. Meirowitz, W. Shan, M. Edelman, K. A. Millington

Journal Articles

Background: The impact of maternal severe acute respiratory syndrome coronavirus 2 infection on placental histopathology is not well known.

Objective: To determine if any significant placental histopathologic changes occur after the diagnosis of severe acute respiratory syndrome coronavirus 2 infection during pregnancy and whether these changes are correlated with the presence or absence of symptoms associated with the infection.

Study Design: A retrospective cohort study of women diagnosed as having severe acute respiratory syndrome coronavirus 2 infection who delivered at a single center from April 9, 2020 to April 27, 2020, and had placental specimens reviewed by the Department of …

Targeting Potential Drivers Of Covid-19: Neutrophil Extracellular Traps., Bj Barnes, Jm Adrover, A Baxter-Stoltzfus, A Borczuk, J Cools-Lartigue, Jm Crawford, J Daßler-Plenker, P Guerci, A Weber, M Egeblad, +13 Additional Authors

Journal Articles

No abstract provided.

Characteristics, Cardiac Involvement, And Outcomes Of Multisystem Inflammatory Disease Of Childhood (Mis-C) Associated With Sars-Cov-2 Infection., Ca Capone, A Subramony, T Sweberg, J Schneider, S Shah, L Rubin, C Schleien, S Epstein, Jc Johnson, A Kessel, N Misra, E Mitchell, N Palumbo, S Rajan, J Rocker, K Williamson, Kw Davidson

Journal Articles

No abstract provided.

Thrombotic Microangiopathy In A Patient With Covid-19., Kd Jhaveri, Lr Meir, Bs Flores Chang, R Parikh, R Wanchoo, Ml Barilla-Labarca, V Bijol, N Hajizadeh

Journal Articles

No abstract provided.

Iglv3-21∗01 Is An Inherited Risk Factor For Cll Through The Acquisition Of A Single-Point Mutation Enabling Autonomous Bcr Signaling, P. C. Maity, M. Bilal, M. T. Koning, M. Young, C. A. Van Bergen, V. Renna, A. Nicolò, A. N. Mazzarello, N. Chiorazzi, H. Jumaa, +28 Additional Authors

Journal Articles

© 2020 National Academy of Sciences. All rights reserved. The prognosis of chronic lymphocytic leukemia (CLL) depends on different markers, including cytogenetic aberrations, oncogenic mutations, and mutational status of the immunoglobulin (Ig) heavy-chain variable (IGHV) gene. The number of IGHV mutations distinguishes mutated (M) CLL with a markedly superior prognosis from unmutated (UM) CLL cases. In addition, B cell antigen receptor (BCR) stereotypes as defined by IGHV usage and complementaritydetermining regions (CDRs) classify ∼30% of CLL cases into prognostically important subsets. Subset 2 expresses a BCR with the combination of IGHV3-21-derived heavy chains (HCs) with IGLV3- 21-derived light chains (LCs), …

Integrated Urine Proteomics And Renal Single-Cell Genomics Identify An Interferon-Γ Response Gradient In Lupus Nephritis., A. Fava, J. P. Buyon, C. Mohan, T. Zhang, H. M. Belmont, P. Izmirly, A. Arazi, A. Davidson, B. Diamond, M. Petri, +12 Additional Authors

Journal Articles

Lupus nephritis, one of the most serious manifestations of systemic lupus erythematosus (SLE), has both a heterogeneous clinical and pathological presentation. For example, proliferative nephritis identifies a more aggressive disease class that requires immunosuppression. However, the current classification system relies on the static appearance of histopathological morphology which does not capture differences in the inflammatory response. Therefore, a biomarker grounded in the disease biology is needed to understand the molecular heterogeneity of lupus nephritis and identify immunologic mechanism and pathways. Here, we analyzed the patterns of 1000 urine protein biomarkers in 30 patients with active lupus nephritis. We found that …

Eda2r Mediates Podocyte Injury In High Glucose Milieu, X. Lan, V. Kumar, A. Jha, R. Aslam, H. Wang, K. Chen, Y. Yu, W. He, A. Malhotra, P. C. Singhal, +2 Additional Authors

Journal Articles

© 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) EDA2R is a member of the large family of tumor necrosis factor receptor (TNFR). Previous studies suggested that EDA2R expression might be increased in the kidneys of diabetic mice. However, its mRNA and protein expression in kidneys were not analyzed; moreover, its role in the development of diabetic kidney disease was not explored. Here we analyzed the mRNA and protein expressions of EDA2R in diabetic kidneys and examined its role in the podocyte injury in high glucose milieu. By analysis with real-time PCR, Western blotting, we found …

Steroid Resistance In Diamond Blackfan Anemia Associates With P57(Kip2) Dysregulation In Erythroid Progenitors, R. J. Ashley, H. Yan, N. Wang, J. Hale, B. M. Dulmovits, J. Papoin, M. E. Olive, A. Vlachos, J. M. Lipton, L. Blanc, +8 Additional Authors

Journal Articles

No abstract provided.

Correcting Smad1/5/8, Mtor, And Vegfr2 Treats Pathology In Hereditary Hemorrhagic Telangiectasia Models, S. Ruiz, H. Zhao, P. Chandakkar, J. Papoin, P. K. Chatterjee, Y. Al-Abed, P. Wang, C. N. Metz, L. Blanc, P. Marambaud, +8 Additional Authors

Journal Articles

No abstract provided.

Lupus Autoantibodies Act As Positive Allosteric Modulators At Glun2a-Containing Nmda Receptors And Impair Spatial Memory, K. Chan, J. Nestor, T. S. Huerta, N. Certain, G. Moody, C. Kowal, P. T. Huerta, B. T. Volpe, B. Diamond, L. P. Wollmuth

Journal Articles

No abstract provided.

Irf5 Genetic Risk Variants Drive Myeloid-Specific Irf5 Hyperactivation And Presymptomatic Sle, D. Li, B. Matta, S. Song, V. Nelson, K. Diggins, K. R. Simpfendorfer, P. K. Gregersen, P. Linsley, B. J. Barnes

Journal Articles

No abstract provided.

Pharmacological Prevention Of Surgery-Accelerated Metastasis In An Animal Model Of Osteosarcoma, M. P. Kallis, C. Maloney, B. Blank, S. Z. Soffer, M. Symons, B. M. Steinberg

Journal Articles

No abstract provided.

Aid Overlapping And Polη Hotspots Are Key Features Of Evolutionary Variation Within The Human Antibody Heavy Chain (Ighv) Genes, C. Tang, D. Bagnara, N. Chiorazzi, M. D. Scharff, T. Maccarthy

Journal Articles

© Copyright © 2020 Tang, Bagnara, Chiorazzi, Scharff and MacCarthy. Somatic hypermutation (SHM) of the immunoglobulin variable (IgV) loci is a key process in antibody affinity maturation. The enzyme activation-induced deaminase (AID), initiates SHM by creating C → U mismatches on single-stranded DNA (ssDNA). AID has preferential hotspot motif targets in the context of WRC/GYW (W = A/T, R = A/G, Y = C/T) and particularly at WGCW overlapping hotspots where hotspots appear opposite each other on both strands. Subsequent recruitment of the low-fidelity DNA repair enzyme, Polymerase eta (Polη), during mismatch repair, creates additional mutations at WA/TW sites. Although …

Advanced Neuroimaging In Neuropsychiatric Systemic Lupus Erythematosus, M. Mackay, C. C. Tang, A. Vo

Journal Articles

PURPOSE OF REVIEW: Neuropsychiatric lupus (NPSLE) comprises a disparate collection of syndromes affecting the central and peripheral nervous systems. Progress in the attribution of neuropsychiatric syndromes to SLE-related mechanisms and development of targeted treatment strategies has been impeded by a lack of objective imaging biomarkers that reflect specific neuropsychiatric syndromes and/or pathologic mechanisms. The present review addresses recent publications of neuroimaging techniques in NPSLE. RECENT FINDINGS: Imaging studies grouping all NPSLE syndromes together are unable to differentiate between NPSLE and non-NPSLE. In contrast, diffusion tensor imaging, FDG-PET, resting, and functional MRI techniques in patients with stable non-NPSLE demonstrate abnormal network …

Inhibition Of Irf5 Cellular Activity With Cell-Penetrating Peptides That Target Homodimerization, J. Banga, D. Srinivasan, C. Sun, C. D. Thompson, F. Milletti, K. Huang, S. Song, B. Matta, D. Li, B. J. Barnes, +17 Additional Authors

Journal Articles

No abstract provided.

Anodal Block Permits Directional Vagus Nerve Stimulation, U. Ahmed, U. Ahmed, Y. C. Chang, M. Cracchiolo, M. F. Lopez, J. N. Tomaio, T. Datta-Chaudhuri, T. P. Zanos, L. Rieth, Y. Al-Abed, S. Zanos

Journal Articles

© 2020, The Author(s). Vagus nerve stimulation (VNS) is a bioelectronic therapy for disorders of the brain and peripheral organs, and a tool to study the physiology of autonomic circuits. Selective activation of afferent or efferent vagal fibers can maximize efficacy and minimize off-target effects of VNS. Anodal block (ABL) has been used to achieve directional fiber activation in nerve stimulation. However, evidence for directional VNS with ABL has been scarce and inconsistent, and it is unknown whether ABL permits directional fiber activation with respect to functional effects of VNS. Through a series of vagotomies, we established physiological markers for …

The Resilience Of Radiation Oncology In The Covid Era And Beyond, S. Teckie, D. Koffler, L. Potters

Journal Articles

No abstract provided.

Comparative Survival Analysis Of Immunomodulatory Therapy For Coronavirus Disease 2019 Cytokine Storm., S. Narain, D. G. Stefanov, A. S. Chau, A. G. Weber, G. Marder, B. Kaplan, P. Malhotra, O. Bloom, A. Liu, M. M. Lesser, N. Hajizadeh, Northwell Covid-19 Research Consortium

Journal Articles

BACKGROUND:Cytokine storm is a marker of coronavirus disease 2019 (COVID-19) illness severity and increased mortality. Immunomodulatory treatments have been repurposed to improve mortality outcomes. RESEARCH QUESTION:Do immunomodulatory therapies improve survival in patients with COVID-19 cytokine storm (CCS)? STUDY DESIGN AND METHODS:We conducted a retrospective analysis of electronic health records across the Northwell Health system. COVID-19 patients hospitalized between March 1, 2020, and April 24, 2020, were included. CCS was defined by inflammatory markers: ferritin, > 700 ng/mL; C-reactive protein (CRP), > 30 mg/dL; or lactate dehydrogenase (LDH), > 300 U/L. Patients were subdivided into six groups: no immunomodulatory treatment (standard of care) and …