Digital Commons Network^™

The Pharmacokinetics Of A Novel Anti-Renalase Antibody Used For The Treatment Of Melanoma In A Congenic Mouse Species, Oriyomi Alimi

Yale Medicine Thesis Digital Library

The pharmacokinetics of a humanized anti-RNLS monoclonal antibody used for the treatment of melanoma in a congenic mouse species

Authors: Oriyomi Alimi1, Gary Desir1

1Department of Internal Medicine, Yale School of Medicine, New Haven, CT

Cancer cells can overcome signaling that restrains their growth and promotes senescence and cell death. Renalase (RNLS) is a secreted flavoprotein that functions as a survival factor after ischemic and toxic injury, signaling through the plasma calcium channel PMCA4b to activate the PI3K/AKT and MAPK pathways. In addition, recent studies, indicate that dysregulated RNLS signaling promotes survival of melanoma cells due to its capacity to …

Full Issue: Volume 13, Number 2

The Science Journal of the Lander College of Arts and Sciences

Complete .pdf file of Volume 13, number 2 of The Science Journal of the Lander College of Arts and Sciences

Causes And Mechanisms Of Crohn’S Disease, Chana Weis

The Science Journal of the Lander College of Arts and Sciences

Crohn’s disease and ulcerative colitis are the two most prevalent inflammatory bowel diseases (IBDs) in Jewish and Caucasian populations, affecting as many as one in 250 individuals. Nevertheless, the underlying causes of both disorders are not yet fully understood and remain unknown. However, current evidence suggests that the exaggerated inflammatory response, more commonly referred to as IBD, is believed to arise from dysregulation of the gastrointestinal (GI) immune system in genetically predisposed individuals who are exposed to environmental triggers. Recent advances have identified multiple IBD susceptibility genes; however, only a few environmental determinants of IBD have been consistently identified. The …

Treating Carcinomas Through Integrin Α6Β4 Modification And Inhibition, Pearl Singer

The Science Journal of the Lander College of Arts and Sciences

Integrin α6β4 is a membrane protein which is expressed in both normal and cancerous epithelia. In normal cells, it is involved in adhesion to the basal membrane. In carcinomas, however, it takes on cell signaling roles related to survival and migration. Due to its key role in cancer progression, it is now being considered as a therapeutic target. This paper examines how we can affect integrins, with a specific focus on integrin α6β4, to reinforce their ability to prevent migration of cancer cells and progress toward metastasis.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Adding Value To A Field-Based Course With A Science Communication Module On Local Perceptions Of Climate Change, Lorelei E. Patrick, Seth Thompson, Aud Halbritter, Brian J. Enquist, Vigdis Vandvik, Sehoya Cotner

Biological Sciences Faculty Publications

Field courses, while generally considered as beneficial for students, are challenging to implement and can lead to strained relationships between local residents and visiting scientists. Thus, it is critical to both maximize the educational value of field courses and help students develop contextualized science communication skills. We report on the development of a science communication module, integrated into an existing field-based ecology course, which aims to add value to an international field course enrolling students from multiple countries. Specifically, students surveyed local residents about their knowledge and perceptions of climate change, and then discussed their findings.

Annonex2embl: Automatic Preparation Of Annotated Dna Sequences For Bulk Submissions To Ena, Michael Gruenstaeudl

Biological Sciences Faculty Publications

The submission of annotated sequence data to public sequence databases constitutes a central pillar in biological research. The surge of novel DNA sequences awaiting database submission due to the application of next-generation sequencing has increased the need for software tools that facilitate bulk submissions. This need has yet to be met with the concurrent development of tools to automate the preparatory work preceding such submissions.The author introduce annonex2embl, a Python package that automates the preparation of complete sequence flatfiles for large-scale sequence submissions to the European Nucleotide Archive. The tool enables the conversion of DNA sequence alignments that are co-supplied …

Tennessee State University Brown-Daniel Library Milestones, Tennessee State University

Tennessee State University Library Centennial and History

No abstract provided.

Grow Well/Crecer Bien: A Protocol For Research On Infant Feeding Practices In Low-Income Families, Ann M. Cheney, Tanya Nieri, Ana Ramirez Zarate, Gretel Garcia, Lucero Vaca, Esmirna Valencia, Colleen Versteeg, Arlene Molina, Michael Castillo, Alison Tovar

Nutrition Faculty Publications

Background

The prevalence of obesity among children remains high. Given obesity’s significant lifelong consequences, there is great interest in preventing obesity early in life. There is a need to better understand the relation of common infant feeding styles and practices to obesity in infants using longitudinal study designs. There is also an urgent need to understand the role of caregivers other than mothers in feeding. A better understanding of variation in feeding styles and practices can inform the identification of risk groups and the tailoring of interventions to them.

Methods

In partnership with Early Head Start programs across four counties …

Healthy Sleep Leads To Improved Nutrition And Exercise In College Females, Sue K. Adams, Elizabeth Dimond, Matthew J. Delmonico, Emily Sylvester, Chelsea Accetta, Carley Domos, Ingrid E. Lofgren

Nutrition Faculty Publications

Diet, sleep quality, and exercise are important determinants of physical, mental, and emotional health. College students are particularly vulnerable to impaired health, as they experience multiple unique stressors associated with college life that impact their ability to engage in healthy sleep, diet, and exercise habits. Our results found that exercise significantly mediated the association between sleep quality and diet. Improved sleep habits may increase a young woman's ability and desire to exercise, thus impacting her diet and nutrition. Findings suggest that clinicians can use a person's motivation in any one domain, or multiple domains, to impact other health domains.

Food Insecurity Is Associated With Increased Risk Of Obesity In Us College Students, Aseel El Zein, Sarah E. Colby, Wenjun Zhou, Karla P. Shelnutt, Geoffrey W. Greene, Tanya M. Horacek, Melissa D. Olfert, Anne E. Mathews

Nutrition Faculty Publications

Background

Food insecurity affects millions of Americans and college students are especially vulnerable. Little is known about the relation of food insecurity with weight status and dietary intake during this critical phase of emerging adulthood. Objectives

We aimed to examine the sex-specific associations of food insecurity with obesity and dietary intake among college students. The study also explored these associations by meal plan (MP) enrollment. Methods

This cross-sectional study included 683 second-year students at 8 universities in the United States. Food security status and dietary intake were assessed using the USDA Adult Food Security Survey and the Dietary Screener Questionnaire, …

Prefrontal Cortical Activation In Naturalistic Walking, Aimee L. Klaschus

Honors Undergraduate Theses

Tasks and environments that demand greater attention resources result in greater activation of the prefrontal cortex (PFC). To explore this effect in a naturalistic setting, we used functional near-infrared spectroscopy (fNIRS) to record the PFC activation of six undergraduate participants while they walked in a busy environment (attention-demanding) and quiet environment (non-attention-demanding). Walking speed was recorded as a behavioral correlate. Results indicated that there was no statistically significant difference in walking speed or cortical activity between busy and quiet conditions, though the trend was in favor of the hypotheses. This is likely because crowd density within each condition was not …

The Birds And The Trees, Branden Lawson

McNair Scholars

Modification of natural habitats used by native organisms is occurring more rapidly due to the increasing human population. American Robins (Turdus migratorius) are common in urban and non-urban areas and can serve as useful indicators of human activities' effects on wildlife. To create an urban environment, the removal of trees from non-urban habitats is necessary but causes radical alteration of the presence of native avifauna. This study, therefore, examined the influence of tree cover within urban and non-urban sites and how trees' characteristics affected the survival rate of American Robin chicks. Data collection occurred during the 2019 breeding …

Testing The Iron Deficiency Anemia Hypothesis Using P-Xrf, Eduardo Maya

McNair Scholars

One controversy within the field of bioarchaeology revolves around theories that describe what environmental factors and illnesses could be causing cribra orbitalia (CO) and porotic hyperostosis (PH). These two pathological conditions, which are identified by porosities on the human cranium, are used by bioarchaeologists to estimate the health of archaeological remains. In the past, iron deficiency anemia (IDA) was widely believed to be causing these conditions. A range of factors, such as parasitic infections and lack of iron through dietary consumption, cause IDA. Because of the hypothesis connecting CO and PH to IDA, archaeological remains with visible porosities have had …

Modeling The Potential Productivity Of Urban Agriculture And Its Impacts On Soil Quality Through Experimental Research On Scale-Appropriate Systems, John R. Taylor

Plant Sciences and Entomology Faculty Publications

Urban agriculture could play a central role in local and regional food sovereignty in developed countries, but in many cities, a lack of space and competition with other land uses limit production. Options for meaningfully advancing food sovereignty goals include sustainable intensification of existing urban farms and gardens; (2) expansion of production into interstitial and other underutilized spaces undevelopable for other purposes; and (3) expansion of production in protected environments. Observational studies suggest that–like smallholder agriculture in the Global South–urban home, community, and market gardens in the developed world can be highly productive–but often are not. Research on scale-appropriate systems …

The Effects Of Black And White Plastic Mulch On Soil Temperature And Yield Of Crisphead Lettuce In Southern New England, Rahmatallah Gheshm, Rebecca Brown

Plant Sciences and Entomology Faculty Publications

Annually, Americans consume an average of 24.5 lb of lettuce (Lactuca sativa) per capita, more than half of which is head lettuce. This study examined the impacts of using black and white-on-black polyethylene mulches on three crisphead lettuce cultivars for spring production in the open field, with data collected on the soil temperature and lettuce yields. Black polyethylene, white-on-black polyethylene, and bare ground were compared for effects on soil temperature, lettuce yields, and lettuce head height and diameter. Mean soil temperatures at a 5 cm depth were 18.9 °C under black polyethylene, 17.7 °C under white-on-black polyethylene, and …

Development Of Early Social Interactions In Infants Exposed To Artificial Intelligence From Birth, Anna Vest

2020 Honors Symposium

Emersion in a ‘smart’ world of technology starts the day an infant enters the door of a home shared with Amazon Alexa, Siri, Nest, and perhaps a smart baby bassinet. This exposure raises a question about how artificial intelligence might yield a different experience in social and interactive life for infants that have been exposed to it from their earliest days.

Ethical Imperatives Critical To Effective Disease Control In The Coronavirus Pandemic: Recognition Of Global Health Interdependence As A Driver Of Health And Social Equity, George A. Gellert Md, Mph, Mpa

Journal of Health Ethics

Ethical imperatives critical to effective disease control in the coronavirus pandemic: Recognition of global health interdependence as a driver of health and social equity

George A. Gellert MD, MPH, MPA

ABSTRACT

Decades into the era of emerging infectious diseases, the 2019-2020 coronavirus pandemic has caught the world, and the United States in particular, poorly prepared to engage effective public health disease prevention and control measures. In part, this reflects poor public health planning, response, logistical preparation and pandemic readiness, and complacency by governments and disease control agencies. In terms of future responses to emerging infection pandemics, these deficiencies can be …

Arkansas Razorback Women's Track & Field Media Guide, 2020, University Of Arkansas, Fayetteville. Athletics Media Relations

Arkansas Women's Track and Field

No abstract provided.

Annual Report, 2019-2020, Mack-Blackwell National Rural Transportation Study Center (U.S.)

Mack Blackwell Rural Transportation Center Annual Report

No abstract provided.

Vindicating The Feminism Of Mary Wollstonecraft, Olivia Moskot

AWE (A Woman’s Experience)

No abstract provided.

An Overview Of Recent Findings On The Effect Of Light On Circadian Rhythms, Ben Ransley

SDAR* Journal of Sustainable Design & Applied Research

No abstract provided.

New Approximate Solution Of The Time-Fractional Nagumo Equation Involving Fractional Integrals Without Singular Kernel, H. M. Srivastava, Khaled M. Saad

Applied Mathematics & Information Sciences

Caputo-Fabrizio-Caputo fractional integral (CFCFI), Atangana-Baleanu-Caputo fractional integral (ABCFI), Graphical representations. In this paper, we present an algorithm by using the Adomian Decomposition Method (ADM) in order to solve the time-fractional Nagumo equation (TFNE) based upon the Liouville-Caputo type Caputo-Fabrizio fractional integral (CFCFI) and the Liouville-Caputo type Atangana-Baleanu fractional integral (ABCFI). We compute the residual error function and derive remarkably efficient results. By means of graphical representations, we show the behavior of the time-fractional Nagumo equation (TFNE) for different values of the involved parameters α and μ in our present investigation.

Effects Of Slip Velocity And Hall Currents On Peristaltic Transport Of Bingham-Papanastasiou Fluid With Heat Transfer, Nabil T. M. Eldabe, Amira S. A. Asar, Hameda M. Shawky

Applied Mathematics & Information Sciences

In this paper , we study the effects of slip boundary condition and Hall currents on peristaltic motion of a non-Newtonian fluid which follows Bingham-Papanastasiou model, with heat transfer taking into account the thermal radiation and heat generation, through an asymmetric channel. This phenomena is modeled mathematically by a system of governing equations which are continuity, momentum and heat equations. These equations are solved analytically under low Reynolds number condition and long wavelength approximation. The stream function and temperature distribution are obtained as functions of physical parameters of the problem. The effects of the parameters on these solutions are discussed …

Preserving Finite-Volume Schemes For Two-Time Reaction-Diffusion Model, A. El Harrak, A. Bergam

Applied Mathematics & Information Sciences

In this paper, we propose an auto adaptive time-step finite volume scheme for a class of two-time reaction-diffusion models of spatially structured population dynamics. Under specific assumptions, we prove that the privileged scheme preserves, at the discrete level, the main features of the continuous problem, namely the non-negativity of the solutions, monotonicity and boundedness. Finally, we present some numerical results to illustrate the efficiency of the proposed algorithm and the behaviour of the model and of the scheme.

Stability Analysis Of A Waterborne Infectious Disease Model With Infectious Saturation Effect On Bacterial Disease Transmission, Cemil Bu ̈Yu ̈Kadalı

Applied Mathematics & Information Sciences

This paper considers a waterborne infectious disease model with infectious saturation effect on bacterial disease transmission. For this model we find sufficient conditions for global stability of disease free equilibrium. We verify the result using appropriate numerical simulations.

An Accurate Analytical Solution To Strongly Nonlinear Differential Equations, G. M. Ismail, M. Abul-Ez, N. M. Farea

Applied Mathematics & Information Sciences

The study presents an alternative analytical method called Newton Harmonic Balance Method (NHBM) to provide an analytical solution for two nonlinear differential equations that appear in specific dynamics. This method is based on combining Newton’s method and the harmonic balance method. Because the periodic solution is analytically proved, the relation between the natural frequency and the amplitude is obtained in an analytical form. The study compares the present results with the previous ones obtained by other methods to ensure the quality of the NHBM. Comparisons with Runge-Kutta numerical integration solutions are also made and excellent agreement has been observed. The …