Digital Commons Network^™

Young Carers In Early Childhood - Exploring Experience With The Power Threat Meaning Framework, Carly Ellicott, Alyson Norman, Helen Lloyd, Felicity Dewsbery, Sarah Jones, Shoshana Jones

School of Psychology

This paper presents the first exploration of young carers in early childhood (YCEC), in the context of whole family support, through the application of the Power Threat Meaning Framework (PTMF). Existing contributions to young carer research have shaped social policy, legislation, and practice concerned with whole family approaches to the identification, assessment, and support for young carers globally. To date, the literature has predominantly focused on young carers in middle childhood to young adulthood, contributing to socially constructed Eurocentric ideologies of who young carers are likely to be. As such, YCEC remain disempowered in broader young carer and family science …

Factors Influencing Plant Community Structure And Composition Of Restored Tamaulipan Thornscrub Forests, Jerald T. Garrett, Audrey J. Hicks, Christopher A. Gabler

School of Earth, Environmental, & Marine Sciences Faculty Publications

The Lower Rio Grande Valley (LRGV) of Texas is a biodiversity hotspot due to its high alpha, beta, and gamma diversity and high regional endemism, which are at high risk of degradation. The region has lost 95% of its native thornforest habitat primarily due to agricultural and urban expansion. This study aims to evaluate the current vegetative structure and composition of restored thornforest sites located in the LRGV to identify restoration methods and site characteristics that affect forest restoration outcomes. Twelve restored thornforest sites were selected for this study that varied in time since restoration, patch size, degree of isolation, …

Glucagon-Like Peptide 1 Receptor Agonists And The Clinical Outcomes Of Inflammatory Bowel Disease: A Systematic Review And Meta-Analysis, Ahmed B. Bayoumy, Lindsay M. Clarke, Parakkal Deepak, Aakash Desai, Priya Sehgal, Uri Gorelik, Haggai Bar-Yoseph, Marie Villumsen, Chris J. J. Mulder, Dirk J. Stenvers, Maarten E. Tushuizen, Nanne K. H. De Boer

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: Prior studies showed worse outcomes in obese inflammatory bowel disease (IBD) patients, especially those related to hospitalizations, surgery, and steroid-free remission. Glucagon-like peptide-1 receptor agonists (GLP1-RAs) have demonstrated significant metabolic benefits for patients with type 2 diabetes mellitus (T2DM) and obesity. Hence, GLP1-RAs may improve clinical outcomes in patients with IBD, especially those with obesity. The objective was to systematically evaluate the impact of GLP1-RAs on clinical outcomes in patients with IBD.

METHODS: A comprehensive literature search was performed using the databases PubMed, Embase, Web of Science, and Cochrane Library from inception to March 15, 2025. Studies reporting outcomes …

Just-In-Time Adaptive Intervention To Improve Hiv Prevention And Substance Use In Youth Experiencing Homelessness (My-Ride): Protocol For A Randomized Controlled Trial, Diane Santa Maria, Nikhil Padhye, Michael Businelle, Natasha Slesnick, Stefani Ricondo, Marguerita Lightfoot

Faculty, Staff and Students Publications

Background: Youth who are experiencing homelessness face a higher risk of HIV infection compared to their housed peers, and suicide and overdose remain the leading causes of death among homeless youth. Just-in-Time Adaptive Interventions (JITAIs) are gaining momentum for HIV prevention and substance use research. Yet, most interventions for homeless youth have not addressed modifiable real-time factors.

Objective: This paper describes the development and implementation of a randomized attention-controlled trial to assess the efficacy of motivating youth to reduce infections, disconnections, and emotional dysregulation (MY-RIDE), a JITAI to improve HIV prevention and substance use in homeless youth.

Methods: This study …

Dna Methylation And Machine Learning: Challenges And Perspective Toward Enhanced Clinical Diagnostics, Erfan Aref-Eshghi, Arash B Abadi, Mohammad-Erfan Farhadieh, Amirreza Hooshmand, Fatemeh Ghasemi, Leila Youssefian, Hassan Vahidnezhad, Taylor Martin Kerrins, Xiaonan Zhao, Mahdi Akbarzadeh, Hakon Hakonarson, Amir Hossein Saeidian

Faculty, Staff and Students Publications

DNA methylation is an epigenetic modification that regulates gene expression by adding methyl groups to DNA, affecting cellular function and disease development. Machine learning, a subset of artificial intelligence, analyzes large datasets to identify patterns and make predictions. Over the past two decades, advances in bioinformatics technologies for arrays and sequencing have generated vast amounts of data, leading to the widespread adoption of machine learning methods for analyzing complex biological information for medical problems. This review explores recent advancements in DNA methylation studies that leverage emerging machine learning techniques for more precise, comprehensive, and rapid patient diagnostics based on DNA …

Vaccine And Treatment Evaluation Units: A Historical Perspective, Robert B Belshe, David I Bernstein, Kathryn M Edwards, Sharon E Frey, Wendy A Keitel, Myron M Levine, John J Treanor, Peter F Wright

Faculty, Staff and Students Publications

On 27 February 1962, Surgeon General Luther Terry announced a new vaccine development program within the National Institute of Allergy and Infectious Diseases (NIAID). Initially, the plan had three components: (1) special laboratories and facilities for development of prototype vaccines; (2) pilot lot production facilities and preliminary vaccine trial sites; and (3) larger lot production capacity and expanded human testing. Respiratory viruses were targeted as the top priority for vaccine development. Over 5 decades, this program has evolved and expanded to include multiple academic vaccine evaluation sites within the network, now labeled as the Vaccine and Treatment Evaluation Units (VTEUs). …

Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Hui Yan, Rui Wang, Suryavathi Viswanadhapalli, Christian Cervantes, Funan He, Shuai Wu, Azad Khosh, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Exing Wang, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu

Faculty, Staff and Student Publications

B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27–IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 …

The Effect Of Type 2 Diabetes Genetic Predisposition On Non-Cardiovascular Comorbidities, Ana Luiza Arruda, Ozvan Bocher, Henry J Taylor, Davis Cammann, Satoshi Yoshiji, Xianyong Yin, Chi Zhao, Jingchun Chen, Alexis C Wood, Ken Suzuki, Josep M Mercader, Cassandra N Spracklen, James B Meigs, Marijana Vujkovic, George Davey Smith, Jerome I Rotter, Benjamin F Voight, Andrew P Morris, Eleftheria Zeggini

Faculty, Staff and Students Publications

Type 2 diabetes is associated with a range of non-cardiovascular non-oncologic comorbidities. To move beyond associations and evaluate causal effects between type 2 diabetes genetic predisposition and 21 comorbidities, we apply Mendelian randomization analysis using genome-wide association studies across multiple genetic ancestries. Additionally, leveraging eight mechanistic clusters of type 2 diabetes genetic profiles, each representing distinct biological pathways, we investigate causal links between cluster-stratified type 2 diabetes genetic predisposition and comorbidity risk. We identify causal effects of type 2 diabetes genetic predisposition driven by distinct genetic clusters. For example, the risk-increasing effects of type 2 diabetes genetic predisposition on cataracts …

Navigating Night Shift: The Role Of A Clinical Resource Nurse, Jodie Gord, Ashley Burbey

Nursing

No abstract provided.

Development Of Students Worksheet Based On Project-Based Learning To Train Critical Thinking Skills At Vocational High School, Dia Ayu Permatasari, Harun Nasruddin

Jurnal Pendidikan Sains

Critical thinking is a cognitive skill that helps identify problems and generate solutions, leading to logical decisions or considerations for solving those problems. Students' critical thinking skills can be trained through learning activities to further improve students' critical thinking skills with learning tools. Therefore, this research intends to produce a student worksheet based on project-based learning to train students' critical thinking skills on the colligative properties of solutions. The development research uses the 4D development model from Thiagarajan, limited to the development stage. A limited trial was conducted with 30 students of industrial chemical engineering expertise at Vocational High School …

Development Of Digital Comic Learning Media Based On Mobile Learning On Media: Making Media Materials In Plant Tissue Culture, Sufina Intan Pertiwi, Fauziyah Harahap, Aline Gusti Yolanda Harahap, Marsya Amira Indrawati, Aline Jelita Christiani Simanullang, Yanda Febry Gracea Br Tarigan, Maureen Efriyanti Sitinjak

Jurnal Pendidikan Sains

his research was conducted based on student needs analysis, analysis of learner characteristics, and curriculum analysis, namely the lack of visualization and presentation of concepts and the lack of utilization of interactive technology in the learning process on media material and media making in tissue culture for college students. This study intends to develop digital comic media based on mobile learning and making media materials in tissue culture. This research method used research and development (R&D) with the ADDIE model: analyze, design, develop, implement, and evaluate. The subjects of this study were students of the Department of Biology, Universitas Negeri …

Problem-Based Learning Assisted By Augmented Reality On The Respiratory System Topic: A Study Of Students’ Critical Thinking Skills And Learning Motivation, Nyimas Dilviana, Ade Yeti Nuryantini, Sumiyati Sa'adah

Jurnal Pendidikan Sains

This study aims to examine the effectiveness of the Problem-Based Learning (PBL) model assisted by Augmented Reality (AR) technology regarding the respiratory system in improving students’ critical thinking skills and learning motivation. The research method used was a quasi-experimental design with a one-group pretest-posttest model. The subjects were 30 eleventh-grade students from a public high school in Garut City. Research instruments included a critical thinking test and a learning motivation questionnaire. The results showed a significant improvement in students’ critical thinking scores after the implementation of PBL with AR support. Additionally, learning motivation data analyzed from 16 statement items revealed …

2017 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2016 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2015 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2014 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2013 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2012 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2011 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2010 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2008 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2006 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2005 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Identifying And Examining Access And Barriers To Healthcare For The Transgender And Nonbinary Individual, Allison Gould

Doctor of Education Program Dissertations

The purpose of this qualitative phenomenological study was to explore the lived experiences of transgender and nonbinary (TNB) individuals related to their access to basic healthcare. Currently, the TNB population is experiencing disparities in accessing general and preventative healthcare in comparison to their cisgendered counterparts. I developed the research questions to explore how TNB individuals describe their access to general and preventative healthcare, identify what were perceived as barriers in seeking basic healthcare, and describe what was subjectively identified as a positive healthcare experiences. My personal and professional interest as a physical therapist combined with a thorough literature review, and …

Impact Of Seasonal Exercise Training On Cardiometabolic Risk In Adults With Obesity, I Chee, E Heiston, S Malin Facsm

International Journal of Exercise Science: Conference Proceedings

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Legliz, Lekòl, Lakay: A Pilot Study Assessing Aging Biomarkers In Haitian Immigrants, S Dorceus, K Gillis, M Smith

International Journal of Exercise Science: Conference Proceedings

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Mind Over Age: How Sex And Exercise Shape Cognitive Aging, K Gillis, S Dorceus, T Larocca, M Smith

International Journal of Exercise Science: Conference Proceedings

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Age-Varying Associations Between Disrupted Circadian Rest-Activity Rhythms And Frailty Among 7,236 U.S. Adults, J Kim, J Kenyon, J Geller, E Park, J Lee, D Kirkman, L Sargent, Y Kim

International Journal of Exercise Science: Conference Proceedings

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