Digital Commons Network^™

Crystal Structure Of 4-Hydroxynaphtho[2,3-B]Benzofuran-6,11-Dione, C16H8O4, Peng Luo, Amar G. Chittiboyina, Wei Gao Pan, Wan Xing Wei

Faculty and Student Publications

© 2020 Peng Luo et al., published by De Gruyter. 2020. C16H8O4, monoclinic, Pc (no. 7), a = 3.7133(1) Å, b = 9.7214(4) (2) Å, c = 15.5765(6) Å, β = 96.121(2)°, V = 559.08(3) Å3, Z = 2, Rgt(F) = 0.0506, wRref(F2) = 0.1274, T = 150(2) K.

Isolation Of Chemical Compounds And Essential Oil From Agrimonia Asiatica Juz. And Their Antimicrobial And Antiplasmodial Activities, Raushan A. Kozykeyeva, Ubaidilla M. Datkhayev, Radhakrishnan Srivedavyasasri, Temitayo O. Ajayi, Anapiya K. Patsayev, Raikhan A. Kozykeyeva, Samir A. Ross

Faculty and Student Publications

© 2020 Raushan A. Kozykeyeva et al. Agrimonia asiatica is a perennial plant with deep green color and covered with soft hairs and has a slightly aromatic odor. This genus Agrimonia has been used in traditional medicines of China, Greece, and European countries. It was mainly used as a haemostatic, a tonic for asthenia, and an astringent for diarrhea. Agrimony is part of the division Magnoliophyta; class is represented by order Rosales, family Rosaceae, of the genus Agrimonia. Family Rosaceae - or pink eels - is one of the largest families of flowering plants, including about 100 genera and 3000 …

Insecticidal And Biting Deterrent Activities Of Magnolia Grandiflora Essential Oils And Selected Pure Compounds Against Aedes Aegypti, Abbas Ali, Nurhayat Tabanca, Betul Demirci, Vijayasankar Raman, Jane M. Budel, K. Hüsnü Can Baser, Ikhlas A. Khan

Faculty and Student Publications

© 2020 by the authors. In our natural products screening program for mosquitoes, we tested essential oils extracted from different plant parts of Magnolia grandiflora L. for their insecticidal and biting deterrent activities against Aedes aegypti. Biting deterrence of seeds essential oil with biting deterrence index value of 0.89 was similar to N,N-diethyl-3-methylbenzamide (DEET). All the other oils were active above the solvent control but the activity was significantly lower than DEET. Based on GC-MS analysis, three pure compounds that were only present in the essential oil of seed were further investigated to identify the compounds responsible for biting deterrent …

Inhibition Of Inos Induction And Nf-Κβ Activation By Taste Compounds From The Edible Mushroom Tricholoma Caligatum (Viv.) Ricken, Ebru Erol, Zulfiqar Ali, Mehmet Oztürk, Shabana Khan, Ikhlas A. Khan

Faculty and Student Publications

© 2019 ACG Publications. All rights reserved. Tricholoma caligatum (Viv.) Ricken is an edible mushroom that belongs to matsutake group. The first chemical investigation of the three different extracts of Tricholoma caligatum resulted in two new compounds, 8-demethoxylascivol (1) and 8-epi-lascivol (2) and six known compounds, lascivol (3), trametenolic acid (4), ergosterol (5), ergosterol peroxide (6), 5α, 6α-epoxyergosterol (7), and cerebroside B (8). Their structures were elucidated by spectroscopic analyses including 1D and 2D NMR data. The biological activities of all the compounds were evaluated toward multiple targets related to inflammation and metabolic disorder such as NF-κΒ, iNOS and ROS. …

Ocotea Porosa: Anatomy And Histochemistry Of Leaves And Stems, Chemical Composition, Cytotoxicity And Insecticidal Activities Of Essential Oil, Libardone José Ribeiro Brustulim, Luciane Mendes Monteiro, Valter Paes De Almeida, Vijayasankar Raman, Beatriz Helena Lameiro De Noronha Sales Maia, Inaiara Casapula, Kátia Sabrina Paludo, Julia Emília Bussade, Junaid Ur Rehman, Ikhlas Ahmed Kahn, Paulo Vitor Farago, Jane Manfron Budel

Faculty and Student Publications

© 2020 by the authors. Ocotea porosa (Nees & Mart.) Barroso, commonly known as "imbuia", "canela-imbuia" or "imbuiaamarela" in Brazil, is a tree of the Southern Atlantic Forest. The present study investigates the anatomy of leaf and stem, volatile oil chemistry, as well as cytotoxicity and insecticidal activities of the essential oil of O. porosa. Species identification was achieved by anatomy features, mainly due to paracytic and anomocytic stomata; non-glandular trichomes; biconvex midrib and petiole with a collateral open arc vascular bundle; presence of a sclerenchymatous layer, starch grains and crystal sand in the stem; and the presence of phenolic …

Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced Via Hot-Melt Extrusion And Fused Deposition Modeling 3d Printing, Nagi Reddy Dumpa, Suresh Bandari, Michael A. Repka

Faculty and Student Publications

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method. Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC)-based filaments were fabricated using hot-melt extrusion technology and were utilized as feedstock material for printing shells in FDM 3D printing. The directly compressed theophylline tablet was used as the core. The tablet shell to form pulsatile floating dosage forms with different geometries (shell thickness: 0.8, 1.2, 1.6, and 2.0 mm; wall thickness: 0, 0.8, and 1.6 …

Psychometric Analysis Of The Perceived Stress Scale Among Healthy University Students, Shahnawaz Anwer, Md Dilshad Manzar, Ahmad H. Alghadir, Mohammed Salahuddin, Unaise Abdul Hameed

Faculty and Student Publications

© 2020 Anwer et al. Background: There is a gradual increase in the prevalence of stress during professional courses. Previous studies reported a high incidence of stress among university students. The psychometric properties of the perceived stress scale-10 (PSS-10) have been established in different populations. The current study aimed to assess psychometric properties of the PSS10 in Saudi university students. Methods: Healthy university students (n= 192) participated in this cross-sectional study. All the participants were explained about the aim and procedures of the study. Participants were requested to complete the English version of the PSS, the generalized anxiety disorder-7 (GAD-7), …

Nested Adaptation Of Mcmc Algorithms, Dao Nguyen, Perry De Valpine, Yves Atchade, Daniel Turek, Nicholas Michaud, Christopher Paciorek

Faculty and Student Publications

© 2020 International Society for Bayesian Analysis Markov chain Monte Carlo (MCMC) methods are ubiquitous tools for simulation-based inference in many fields but designing and identifying good MCMC samplers is still an open question. This paper introduces a novel MCMC algorithm, namely, Nested Adaptation MCMC. For sampling variables or blocks of variables, we use two levels of adaptation where the inner adaptation optimizes the MCMC performance within each sampler, while the outer adaptation explores the space of valid kernels to find the optimal samplers. We provide a theoretical foundation for our approach. To show the generality and usefulness of the …

An Inequality Related To S-Φ-Convex Functions., Miguel Vivas-Cortez, Yenny Rangel-Oliveros

Applied Mathematics & Information Sciences

Using the notion of s-φ-convex functions as generalization of convex functions, we estimate the difference between the middle and right terms in Hermite- Hadamard-Fejer inequality for differentiable mappings.

Effects Of A Neonicotinoid Insecticide On The Growth Of Honey Bee Gut Microbes, Macee Mitchell, Daniel Franzese, Taylor Morales, Shane Lucht, Jesse Steele, Jenifer Walke

2020 Symposium Posters

The gut microbiome plays an essential role in the overall health of organisms. However, the presence and abundance of these microbes may be altered by environmental factors, such as exposure to pesticides. The goals of this project were to understand 1) the prevalence of pesticide residues in honey bees in eastern Washington, and 2) the impact of pesticides to the honey bee gut microbiome. Accordingly, we tested bees from 24 hives among six sites across eastern Washington. High-performance liquid chromatography-mass spectrometry (HPLC-MS) was used to detect the presence and concentration of six commonly used agricultural pesticides: Carbaryl, Chlorpyrifos, Coumaphos, Cypermethrin, …

Effect Of Sleep Deprivation And Sleep Recovery On Heart Rate And Heart Rate Variability In Males Versus Females, Abrianna Lochner Spt, Elena Crooks Pt, Dpt, Phd, Myles Gordon Finlay Ba, Julie A. Erwin Ms, Kimberly Honn Phd

2020 Symposium Posters

Introduction

Elevated heart rate (HR) and low HR variability (HRV) are indicators of increased sympathetic tone and cardiovascular risk. Here, we assess the effect of one night of sleep deprivation and a subsequent night of recovery sleep on HR and HRV in healthy males versus females.

Methods

Fifty-nine subjects (29.5±8.5y, n=35 female) completed a 4-day/3-night laboratory study. Subjects had a baseline sleep opportunity (22:00–08:00), followed by 38h of sleep deprivation, and a recovery sleep opportunity (22:00–08:00). EKG was monitored via Holter monitors to measure HR and the pNN50 and rMMSD variables of HRV. Time points used for analyses included 09:00–09:20 …

A Preliminary Checklist Of Lichens From Kamiak Butte County Park, Washington State, Emma Sell, Amanda Chandler

2020 Symposium Posters

The semiarid Palouse ecoregion of North America was once dominated by temperate prairies and connects areas of southeast Washington, north-central Idaho, and northeast Oregon. Transformation of nearly all habitats comprising this ecosystem into agricultural lands has drastically reduced extant native grasslands to small, highly fragmented pieces. These land conversion practices, coupled with the subsequent takeover of invasive plant species, have placed the Palouse ecoregion among the most critically endangered ecosystems in the United States, with < 1% of land remaining that is suitable to host native species. The enormous loss of biodiversity across the Palouse has prompted a need for further study regarding a wide variety of organisms. In particular, lichen diversity of the Palouse ecoregion has never been formally characterized, and there are overall very few detailed studies of lichens throughout eastern Washington. To improve knowledge of Palouse lichen diversity, we first reviewed collection data from historical herbarium specimens via the Consortium of North American Lichen Herbaria (CNALH) database. We then collected lichen voucher specimens from Kamiak Butte County Park (KBCP), one of the largest contiguous natural areas within the Palouse ecoregion as its relatively steep, rocky slopes make it ill-suited for agricultural conversion. KBCP consists of 298 acres of mixed Pinus ponderosa (ponderosa pine) and Pseudotsuga menziesii (Douglas fir) forest and native grassland that rises above the surrounding farmland, as well as an east-west ridgeline …

What Makes Bats Special So That They Are Reservoirs For So Many Different Pathogens?, Deion Anderson, Eleanor Gorkovchenko, Nicole Hamada, Carolina Martinez, Lupe Martinez

2020 Symposium Posters

Bats, order Chiroptera, comprise more than 20 percent of all living mammal species with more than 1100 species. Bats are organisms that have high body temperatures and metabolic rates. Therefore, viral adaptation to febrile conditions in the bat host might explain the high reservoir competence that distinguishes these organisms from other mammalian hosts. The purpose of this study is to present a comparative meta-review of the available evidence in order to investigate and identify the reasons or characteristics as to what makes bats special reservoirs for so many different pathogens. Our investigation will not focus on a particular bat species, …

Ungulate Activity: Effects Of Season, Hunting Pressure, And Plant Type, Alex Capone Lopez

2020 Symposium Posters

Quaking Aspen (Populus tremulodies) is considered priority habitat because it supports diverse understory flora and provides critical nesting and foraging habitat for wildlife. Aspen populations in western North America have declined due to fire suppression and browsing. Turnbull National Wildlife Refuge in eastern Washington addressed declining aspen with prescribed burns. However, aspen growth stimulated by burning was offset by browsing, especially by Elk (Cervus elaphus). Increasing elk numbers prompted initiation of a limited hunt to cull and disperse elk off refuge. To address the impact of these management strategies, we used remote video cameras to monitor …

The Effects Of Hiv On Pregnant Women And The Role Of The Placenta In Transmission To The Fetus: A Systematic Literature Review And Meta-Analysis, Kristine Colglazier, Drea Flores, Maksim Kalpakchi, Emma Oaks, Jenna Ryan

2020 Symposium Posters

Sexually transmitted infections (STIs) have major clinical significance around the world and are a topic that is actively researched. Specifically, human immunodeficiency virus (HIV) is a well known STI that has been studied extensively. This study will focus on the effects of HIV in pregnant women, transmission to the fetus, and the role of the placenta as a means of protection. The objective of this study is to analyze and review current literature on the effects of HIV in pregnancy to form a systematic publications review on the topic. With this study, it is hypothesized that administering antiviral drugs during …

Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar

HPD Articles

No abstract provided.

Preliminary Pages And Table Of Contents, Jonathan S. Gore

Kentucky Journal of Undergraduate Scholarship

No abstract provided.

Combined Effects Of Telehealth And Modified Constraint-Induced Movement Therapy For Individuals With Chronic Hemiparesis, Mary Ann Smith, Machiko R. Tomita

Occupational Therapy Collection

Telehealth use allows improved access to services and results in potential cost savings. The purpose of this study was to examine the effectiveness of a combined modified Constrained Induced Movement Therapy (mCIMT) program using telehealth and in-person sessions, for participants with higher (Group 1) and lower (Group 2) functional ability of the hemiparetic upper extremity. Using a pre-experimental design with a 6-week intervention, 28 participants were assessed twice on use of upper extremity via subjective and objective measures. For the Motor Activity Log, the amount of use and quality of use were significant for Groups 1 and 2. Significant improvements …

Change Agents (2020), University Of Missisisppi. Office Of Research And Sponsored Programs.

Publications of the ORSP

This publication highlights a few of the significant research efforts at the University of Mississippi during the past year.

The Rise To Dominance Of Genetic Model Organisms And The Decline Of Curiosity-Driven Organismal Research, Sarah M. Farris

Faculty & Staff Scholarship

Curiosity-driven, basic biological research “…performed without thought of practical ends…” establishes fundamental conceptual frameworks for future technological and medical breakthroughs. Traditionally, curiosity-driven research in biological sciences has utilized experimental organisms chosen for their tractability and suitability for studying the question of interest. This approach leverages the diversity of life to uncover working solutions (adaptations) to problems encountered by living things, and evolutionary context as to the extent to which these solutions may be generalized to other species. Despite the well-documented success of this approach, funding portfolios of United States granting agencies are increasingly filled with studies on a few species …

The Significance Of Tau Aggregates In The Human Brain, Rudy J. Castellani

Faculty & Staff Scholarship

Neurofibrillary degeneration has attracted the attention of neuroscientists as both a hallmark of the disease and a subject for experimentation for more than a century. Recent studies implicate phosphorylated tau (p-tau) directly in neurodegenerative disease pathogenesis, although the human data continue to raise questions. P-tau accumulates with age in a roughly hierarchical manner, but avoids abundance in the neocortex unless co-occurring with amyloid-β. Neurodegenerative tauopathies tend to have p-tau morphologies that differ from aging and Alzheimer’s disease. Tau isoforms (3R vs. 4R) have a tendency to vary with tauopathy phenotype for unknown reasons. Selective vulnerability to p-tau and spatial-temporal disconnect …

Mechanism Of Plant Growth Promotion And Disease Suppression By Chitosan Biopolymer, Moutoshi Chakraborty, Mirza Hasanuzzaman, Mahfuzur Rahman, Md. Arifur Rahman Khan, Pankaj Bhowmik, Nur Uddin Mahmud, Mohsin Tanveer, Tofazzal Islam

Faculty & Staff Scholarship

The chitosan (CHT) biopolymer is a de-acetylated chitin derivative that exists in the outer shell of shrimp, shellfish, lobster or crabs, as well as fungal cell walls. Because of its biodegradability, environmental non-toxicity, and biocompatibility, it is an ideal resource for sustainable agriculture. The CHT emerged as a promising agent used as a plant growth promoter and also as an antimicrobial agent. It induces plant growth by influencing plant physiological processes like nutrient uptake, cell division, cell elongation, enzymatic activation and synthesis of protein that can eventually lead to increased yield. It also acts as a catalyst to inhibit the …

Functional Biology Of The Steel Syndrome Founder Allele And Evidence For Clan Genomics Derivation Of Col27a1 Pathogenic Alleles Worldwide, C. Gonzaga-Jauregui, G. Yesil, H. Nistala, A. Gezdirici, Y. Bayram, K. C. Nannuru, D. Pehlivan, B. Yuan, D. H. Tegay, J. R. Lupski, +27 Additional Authors

Journal Articles

© 2020, The Author(s). Previously we reported the identification of a homozygous COL27A1 (c.2089G>C; p.Gly697Arg) missense variant and proposed it as a founder allele in Puerto Rico segregating with Steel syndrome (STLS, MIM #615155); a rare osteochondrodysplasia characterized by short stature, congenital bilateral hip dysplasia, carpal coalitions, and scoliosis. We now report segregation of this variant in five probands from the initial clinical report defining the syndrome and an additional family of Puerto Rican descent with multiple affected adult individuals. We modeled the orthologous variant in murine Col27a1 and found it recapitulates some of the major Steel syndrome associated …

Pandemic-Related Submissions: The Challenge Of Discerning Signal Amidst Noise, L. J. Kaplan, T. P. Bleck, T. G. Buchman, R. P. Dellinger, C. S. Deutschman, J. C. Marshall, D. M. Maslove, H. Masur, M. M. Parker, J. J. Zimmerman, +4 Additional Authors

Journal Articles

No abstract provided.

Patient And Physician Discordance Of Global Disease Assessment In Juvenile Dermatomyositis: Findings From The Childhood Arthritis & Rheumatology Research Alliance Legacy Registry, H. Tory, D. Zurakowski, S. Kim, L. Abramson, E. Anderson, M. Andrew, N. Battle, M. Becker, B. Gottlieb, M. Simmons, +90 Additional Authors

Journal Articles

© 2020 The Author(s). Background: Global disease activity scores (gVAS) capture patient or family (PF) and physician (MD) assessments of disease. This study sought to measure discordance between PF and MD global activity scores in juvenile dermatomyositis (JDM), and determine factors associated with discordance. Methods: Patients with JDM were included from the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry (N = 563). PF and MD gVAS were assessed for discordance, defined as a ≥ 2-point difference. Factors associated with discordant gVAS were compared in univariate analysis. Multivariable regression analysis was used to identify predictors of discordance. Results: Almost …

Proceedings From The 2NdNext Gen Therapies For Systemic Juvenile Idiopathic Arthritis And Macrophage Activation Syndrome Symposium Held On October 3-4, 2019, S. W. Canna, G. S. Schulert, A. De Jesus, A. Pickering, H. Brunner, M. Gadina, S. Levine, R. Goldbach-Mansky, B. Gottlieb, V. Delgaizo, +20 Additional Authors

Journal Articles

© 2020 The Author(s). For reasons poorly understood, and despite the availability of biological medications blocking IL-1 and IL-6 that have markedly improved overall disease control, children with Systemic Juvenile Idiopathic Arthritis (SJIA) are now increasingly diagnosed with life-threatening chronic complications, including hepatitis and lung disease (SJIA-LD). On October 3-4, 2019, a two-day meeting, NextGen Therapies for Systemic Juvenile Idiopathic Arthritis (SJIA) & macrophage activation syndrome (MAS) organized by the Systemic JIA Foundation (www.systemicjia.org/) in Washington, DC brought together scientists, clinicians, parents and FDA representatives with the objectives (1) to integrate clinical and research findings in MAS and SJIA-LD, and …

The Surviving Sepsis Campaign: Basic/Translational Science Research Priorities∗, C. S. Deutschman, J. Hellman, R. Ferrer Roca, D. De Backer, C. M. Coopersmith

Journal Articles

© 2020 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved. Objectives: Expound upon priorities for basic/translational science identified in a recent paper by a group of experts assigned by the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. Data Sources: Original paper, search of the literature. Study Selection: By several members of the original task force with specific expertise in basic/translational science. Data Extraction: None. Data Synthesis: None. Conclusions: In the first of a series of follow-up reports to the original paper, several members of the original task …

Parnassus 2020

Parnassus

The 2020 edition of the student literary journal, Parnassus, published by Taylor University in Upland, Indiana.

Level 2: La Rentreé / Back To School, Ashley Ayala, Grace Holland

The Global Library

To you, young reader, I dedicate this book. May it encourage you to read, read, and read again!

My name is Grace. I am a student at Kennesaw State University. I live in Georgia in the United States. I study biology to become a doctor. I love animals, I have two dogs.

My name is Ashley. I am a student at Kennesaw State University. I live in the United States, but my parents are from Peru. I study biology because I want to become a doctor. I'm learning French because I would like to help people all around the world. …

The Effects Of An Agricultural Migratory Lifestyle On Children, Deborah Bourland

Integrated Studies

The purpose of this paper to explore medical research journals and interviews with migratory farm workers and their families to explore the effect a migratory lifestyle has on the development of a child as they constantly move from place to place as they, or their parents, seek work following crop timelines in the United States. The articles and interviews used will inform the reader of factors these children face, such as social exclusion, poverty and food insecurities, and how these obstacles affect not only the development of their physical health and growth milestones, but also how they affect the child’s …