Numerical Modelling Of The 1 July 2022 Flooding Event, Southwest Huvadhoo Atoll, Maldives: Implications For The Future, Gerd Masselink, Tim Poate, Timothy Scott, Floortje Roelvink, Robert Mccall

School of Biological and Marine Sciences

Low-lying atoll islands are among the world's most vulnerable coastal environments to sea-level rise (SLR). Global application of coastal flooding models suggests that centennial flood events may become annual events by 2050 in tropical regions. This article addresses this claim by modelling an island flooding event that occurred in the Maldives on 1 July 2022 as a result of a distant-swell event coinciding with an extra high spring tide. Hydrodynamic data collected after the event on one of the affected islands were used to calibrate and validate a one-dimensional non-hydrostatic XBeach model. The model overpredicted wave setup and underpredicted the …

Inhibition Of Osteosarcoma Lung Metastases By Β-Glucan And Cd40 Agonist Is Mediated By Activation Of Macrophages And Nk Cells, Pradeep Shrestha, Rejeena Shrestha, Eugenie S Kleinerman

Faculty, Staff and Student Publications

Background: Osteosarcoma (OS) lung metastases remain a significant therapeutic challenge. Innate immune activation is a promising therapeutic approach. Innate immune agonists can modulate the tumor immune microenvironment and improve therapeutic response.

Methods: Using an experimental syngeneic OS lung metastasis BALB/c mouse model with K7M3-luc OS cells, we evaluated the antitumor effects of yeast-derived particulate β-glucan in prevention and therapeutic settings. We then assessed whether the CD40 agonist (CD40a) in combination with β-glucan increased therapeutic response in two different immune-competent mouse models of OS lung tumor burden.

Results: In the pretreatment settings, mice treated with β-glucan prior to OS cell infusion …

Performing "Manly" Worship Music: Gender And Timbre At Mars Hill Church, Maren Haynes Marchesini

Yale Journal of Music & Religion

Ten years ago, Mars Hill boasted fifteen campuses and 15,000 members. Amid mounting allegations of abuse and mismanagement leveled against founding pastor Mark Driscoll, the church famously collapsed, closing its doors at the end of 2014. Driscoll had built Mars Hill’s core brand around his opposition to the perceived feminization of the Christian mainstream, and appointing himself the “leader of a heterosexual male backlash” in the church and broader culture. While Driscoll’s muscular Christianity stands in a wide historical stream, Mars Hill long led the charge in establishing a youth-oriented, hipster brand of hypermasculine Calvinism. And while rhetoric and theology …

Dynamics Of Infanticides Among The Ngoni Of Tanzania, 1850s-1916, Andrew S. Kasambala, Oswald J. Masebo

Zamani: A Journal of African Historical Studies

Infanticide is one of the key factors in explaining changes in human populations since the antiquity. This paper examines dynamics of infanticide practices among the Ngoni of Tanzania from the late pre- colonial to the end of German colonial rule in 1916. Relying on primary and secondary sources, it argues that while infanticide remained a critical problem in Songea from the 19th century to the end of German colonialism in 1916, the context in which it was practiced and the interventions devised to alleviate it changed over time. While it was primarily practiced in Songea by pre-Ngoni communal based clans …

Decoding Genetic And Network Signatures Of Susceptibility To Orthodontic Root Resorption: Toward Predictive And Personalized Orthodontics, Casey Morishige, Morgan Mecham, Gabriel Eisenhuth, Shilpa Bhandi, Frank Licari, Shankargouda Patil

Annual Research Symposium

No abstract provided.

25 Conference Program - Electrophoretic Deposition Viii: Fundamentals And Applications, Aldo R. Boccaccini, Begoña Ferrari, Andrew J. Pascall, Fabien Grasset, Kiyofumi Katagiri

Electrophoretic Deposition VIII: Fundamentals and Applications (EDP)

No abstract provided.

Functional Roles Of The Complement Immune System In Cardiac Inflammation And Hypertrophy, Kathryn D Hok, Haydn E Rich, Anthony Shadid, Lavanya Gunamalai, Tingting Weng-Mills, Rajarajan A Thandavarayan, Nirmal K Banda, Marie-Francoise Doursout, Marcos I Restrepo, Pooja Shivshankar

The Brown Foundation: Institute of Molecular Medicine

Cardiac inflammation and hypertrophy develop as a pathologic response to an array of insults, such as myocardial infarctions, chronic systemic hypertension, and valvular defects. Due to the high prevalence of such conditions, there is an increasing need to prevent and halt cardiac hypertrophy. Because cardiac damage and subsequent remodeling can lead to arrhythmias, heart failure, and even sudden cardiac death, inhibition of cardiac hypertrophy is key to reducing cardiovascular-related mortality. The immune system is the driving force behind inflammatory reactions. All three pathways of complement system activation-classical, lectin, and alternative-are implicated in developing cardiac damage, inflammation, and hypertrophy due to …

Precision Assessment Of Facial Asymmetry Using 3d Imaging And Artificial Intelligence, Mohamed Adel, Katie Jo Hunt, Daniel Lau, James K Hartsfield, Hugo Reyes-Centeno, Cynthia S Beeman, Tarek Elshebiny, Lina Sharab

Anthropology Faculty Publications

Objectives: There is a growing interest among practitioners in employing artificial intelligence (AI) to enhance the precision and efficiency of diagnostic methods. The objective of this study is to assess the precision of an AI-based method for facial asymmetry assessment using 3D facial images. Methods: The study included 130 patients (84 female, 46 male), analyzing 3D facial images from the Vectra ® M3 imaging system using both manual and AI-based methods. Seven bilateral facial landmarks were identified for manual analysis, calculating the asymmetry index for facial symmetry assessment. An AI-based program was developed to automate the identification of the same …

Genetic Engineering Of Esophageal Organoids: Crispr-Based Knock-In For Cell Lineage Tracing, Kyung-Pil Ko, Jae-Il Park

Faculty, Staff and Student Publications

Esophageal organoids serve as powerful systems to study epithelial lineage hierarchies and cancer biology. Gene manipulation in these organoids has traditionally involved overexpression or knockout strategies. However, CRISPR-/Cas9-based knock-in (KI) approaches now enable precise cell lineage tracing and live imaging. Here, we describe protocols to generate fluorescent KI organoids from murine esophageal epithelium by tagging Krt13 (BFP) and Sox2 (mNeon). These dual-reporter organoids allow direct monitoring of growth dynamics and differentiation trajectories. We outline CRISPR/Cas9 design, donor construction using homology-independent approaches (CRISPaint), delivery into organoid cells, enrichment and single-clone isolation, and validation by fluorescence. For organoids, homology-directed repair (HDR) can …

Re-Survey Of Blastocystis Infection In Free-Living Birds From Urban Xinxiang City, Xuehan Liu, Yingying Cao, Di An, Chengshui Liao, Ruibiao Wang, Bo Wen, Chunling Zhu, Huarun Sun, Longfei Zhang, Baoliang Qin, Yanhui Wang, Jianhe Hu, Yueyu Bai, Ke Ding, Lei Wang

The Thai Journal of Veterinary Medicine

Blastocystis is the most ubiquitous intestinal protozoan parasite found in humans and animals worldwide. Commonly, ST7 and ST6 are the major Blastocystis subtypes reported in birds, and their frequencies fluctuate greatly with various factors. However, little literature is available on the prevalence and subtype characteristics of this parasite in free-living wild birds in the same city. For this purpose, a total of 114 fresh fecal specimens were collected from wild free-living birds in urban districts of Xinxiang city and tested for Blastocystis using PCR of the barcoding region of the small subunit ribosomal RNA (SSU rRNA) gene. The positive isolates …

Eleanor Arnason’S Fantastic Mitochondrial Humor, Sandra J. Lindow

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Eleanor Arnason’s Fantastic Mitochondrial Humor

In this essay I explore Brian Attebery’s description of mitochondrial fantasy to explain how humor works in Eleanor Arnason’s short fantastic fiction. Mitochondria are the energy powerhouses in cells. They are symbiotic creatures that once were separate but became an evolutionary part of a female egg cell, providing a history that can be traced to a Mitochondrial Eve. In Fantasy: How It Works, Attebery uses mitochondria metaphorically to explain how fantastic ideas evolve. Attebery describes fantastic mitochondria as “a cellular dynamo that lives within the tissues” of a story (91). He demonstrates how stories lead …

Lothlórien: Gendered Spaces, Cartographic Nominalism, And Galadriel’S Queerness, Bo Kampmann Walther

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Tolkien’s portrayal of Lothlórien is layered with complexities that reflect broader tensions between the feminine landscape and the masculine impulse to understand, name, and rationalize the world. This article examines the ‘fight’ over Lothlórien and its entitlement to truth from both female and male perspectives. It combines a close reading of passages from The Fellowship of the Ring with theories of name-giving, power, and mapping. The article concludes by evaluating these insights through the lens of Kristeva’s concept of the “abject” and discussing what ‘queer’ might mean in the Tolkien oeuvre.

Elopement And Marriage Among The Shakers, Tom Sakmyster

Communal Societies

No abstract provided.

2017 - Appalachian Student Research Forum Award Winners, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

Review Of The Benedictine Option: A Strategy For Christians In A Post-Christian Nation, Etta Madden

Communal Societies

No abstract provided.

Primary Hyperaldosteronism, Joanna Lam

The Kabod

This paper will give an overview of primary hyperaldosteronism, which is a condition characterized by the excess production of aldosterone from the adrenal glands. Since its discovery in 1954 by James Conn, primary hyperaldosteronism has been discovered to have a variety of causes, with the more common ones being either benign tumors or inherited disorders such as congenital adrenal hyperplasia. Affected patients display conditions such as hypertension or hypokalemia, which may lead to symptoms including headaches, blurred vision, or dizziness. This paper will cover the anatomy of the adrenal glands, along with the normal physiology and synthesis of aldosterone. Aldosterone’s …

(((Qpie))) Prior Art 2 Of 9 Resonance Science, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE))) Prior Art Disclosure Part 2 of 9

(((QPIE))) Prior Art Disclosure - Frontiers & Strategic Coherence

(((QPIE)))33 Resonance Science Edition

(CREDIT: (((QPIE))) Created by Teddy Burroughs with Inspirational contributions by: Aleah Burroughs, Reya Burroughs April Saunders, Claudette Clare, Perry Mason, Shomari Chinnery

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#Avision4Change #Vision2Funding #Charity2Roi #TedFunding #QPIE

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(All funds to help us expand our Resonance Frameworks can be …

(((Qpie))) Prior Art 1 Of 9 Quantum Perspective Is Everything, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPIE))) Prior Art Disclosure Part 1 of 9

(((QPIE))) Quantum Perspective Is Everything

Prior Art /IP Declaration

https://quteframework.wordpress.com/2025/09/22/qpie-qpie-prior-art-part-1-of-9/

https://www.linkedin.com/pulse/qpie-prior-art-disclosure-part-1-9-teddy-burroughs-kdr4c

(CREDIT: (((QPIE))) Created and discovered by Teddy Burroughs with significant contributions by: Kaiya Burroughs, Aleah Burroughs, April Saunders and Perry Mason ([email protected]) Avision4Change Vision2Funding #Charity2Roi

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(Formatted as defensible prior art disclosure)

Abstract

This document discloses (((QPIE)))—Quantum Perspective Is Everything—a resonance-based grand unifying framework that harmonizes mental, physical, and emotional dimensions of human and …

2025 October 10 - State Of The University Address, Office Of The President, East Tennessee State University

Office of the President Speeches

No abstract provided.

Crayfishes Of Kansas: List Of Taxa, Synonyms, And References, Mark E. Eberle

Sternberg Museum of Natural History Faculty Publications

There are 14 species of crayfishes (Decapoda: Cambaridae) reported from Kansas, although there are questions about the systematics of some taxa. These species are listed by their current names and the synonyms under which they have been reported since 1885, along with their conservation status. Published references that include each species in Kansas are also noted. In addition, information about species with type localities in Kansas and unresolved taxonomic issues are summarized. The list of species has been updated in 2025 to include two species introduced to Kansas and other new information.

The Impacts Of Chronic Infections On Shaping Cellular Senescence, Ashley Johnson, Troy Rought, Jacob Aronov, Princess Pokharel, Angelina Chiu, Azadeh Nasuhidehnavi

Pharmacy Faculty Scholarship

Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype. While senescence is traditionally associated with aging, growing evidence reveals that chronic infections such as viral, bacterial, and protozoan parasites can serve as powerful inducers of senescence, contributing to premature aging and long-term tissue damage. This review explores the diverse mechanisms by which persistent pathogens trigger or sustain senescence in host cells. We highlight how these chronic infections manipulate host DNA repair, mitochondrial dynamics, telomere maintenance, oxidative stress, and immune function to promote senescence and immunosenescence. Emerging …

Draft Genome Sequences Of Burkholderia And Paraburkholderia Strains Isolated From Panicum Virgatum Soil And Roots At The Lux Arbor Reserve In Michigan, Usa, H. Kehlet-Delgado, R. H. Petipas, A. A. Antoch, Jeffrey S. Norman, X. Li, R. A. White Iii, S. E. Evans, L. K. Tiemann, M. L. Friesen

Biology Faculty Works

We present draft genomes of two Paraburkholderia strains and two Burkholderia strains. Three strains were isolated from surrounding soils and one from roots of switchgrass (Panicum virgatum) in Michigan, USA.

The Potential Of National Parks And Protected Areas In The Anthropocene: Emerging Incubators Of Environmental Justice And Co-Stewardship Conservation, Yolonda Youngs

Geography and Environmental Studies Faculty Publications

National parks are often praised as natural labs for physical science researchers and scholars. They are also cultural labs where ideas about public lands management, use, and access are reformulated and revised. In the Anthropocene, these sites hold special relevance. Within this context, parks can serve as active and evolving incubators of social and climate resilience guided by just conservation initiatives. Yet few studies have explored the new models of collaboration and partnerships between the U.S. National Park Service and Tribal Nations that seek to create co-stewardship conservation. This article addresses that gap with a qualitative and historical case study …

Board Of Trustees Agenda, Oct. 10 2025, Indiana State University Board Of Trustees

Board of Trustees

No abstract provided.

Predictors Of Lower-Limb Arterial Occlusion Pressure Across Commonly Used Cuff Widths, Isaac J. Wedig, Isaac M. Lennox, Erich J. Petushek, John J. Durocher, John Mcdaniel, Steven J. Elmer

Michigan Tech Publications

We compared predictors of lower-limb arterial occlusion pressure (AOP) across commonly used blood flow restriction (BFR) cuff widths (11, 13, 18 cm) and developed prediction equations to estimate AOP for each cuff. Participants (n = 116) underwent measurements of thigh circumference (TC), systolic (SBP) and diastolic (DBP) blood pressure, and AOP was assessed using Doppler ultrasound in a seated position. Multiple linear regression models with commonality analysis and mixed-effects models were used to identify and compare predictors of AOP between each cuff. LASSO regression with bootstrap resampling was used to develop and internally validate prediction equations. TC, SBP, DBP, age, …

Representation, Dynamics And Optimization Of Physical Structures, Fan Feng

Dartmouth College Ph.D Dissertations

Computational tools play a vital role in structural analysis and design, enabling engineers and researchers to optimize performance, reduce material usage, and explore novel configurations across solids and fluids. Capturing, analyzing, and optimizing these structures while balancing efficiency, stability, and adaptability remains a central challenge. This thesis proposes three complementary methods that advance representation, simulation, and optimization. We present an impulse (gauge) fluid formulation that utilizes the impulse gauge variable to reduce numerical diffusion and better preserve coherent flow features such as vorticity at practical resolutions. We introduce a differentiable Voronoi representation for cellular solids that provides smooth implicit boundaries …

Discriminative Accuracy Of Cha2ds2-Vasc Score, And Development Of Predictive Accuracy Model Using Machine Learning For Ischemic Stroke Risk In Cardiac Amyloidosis And Atrial Fibrillation, Waqas Ullah, Abhinav Nair, Eric Warner, Salman Zahid, Mansoor Rahman, Palwasha Khan, Indranee Rajapreyar, Sridhara S. Yaddanapudi, M. Chadi Alraies, Said Ashraf, Jeffery Van Hook, Yegeny Brailovsky

Department of Medicine Faculty Papers

BACKGROUND: CHA2DS2-VASc score in cardiac amyloidosis (CA) with atrial fibrillation (AF) is believed to underestimate ischemic stroke risk, necessitating a better predictive model.

METHODS: Data were obtained from the National Readmission Database (NRD). Outcomes between CA-AF and no-CA-AF were compared using multivariate regression analysis to calculate adjusted odds ratios (aORs). AutoScore, an interpretable machine learning framework, was used to develop a stroke risk prediction model, and its predictive accuracy was evaluated with an area under the curve (AUC) using the receiver operating characteristic analysis.

RESULTS: A total of 11,860,804 (CA-AF 22,687 (0.19%) and no-CA-AF 11,838,117) patients were identified from 2015 …

Embung Desa Dan Adaptasi Perubahan Iklim: Analisis Empiris Perlindungan Lahan Pertanian Indonesia Dari Ancaman Kekeringan, Danan Perri Sandria, Asri Yuliani

Jurnal Kebijakan Ekonomi

This study analyzes the contribution of village ponds to mitigating agricultural land damage caused by drought in Indonesia. Using quantitative methods with linear regression models on data from 78.291 villages, the research tests the effectiveness of micro-water infrastructure as a disaster mitigation instrument. Findings indicate that village ponds significantly reduce the area of crop failure, although their effectiveness declines during extreme droughts due to limited storage capacity. Policy implications emphasize transforming physical pond construction into adaptive management through integrated closed distribution technology and strengthened local institutions to ensure farmers' economic resilience against global climate anomalies.

Evaluation Of An In Situ Forming Composite Hydrogel Based On Gelatin–Sodium Alginate– Polyethylene Oxide For Biomedical Applications: Effect Of Incorporated Sophora Japonica On Hydrogel Performance, Samar A. Salim

Nanotechnology Research Centre

Hydrogels are ideal candidates for biomedical applications such as wound healing, tissue engineering, and bone regeneration due to their porosity and similarity to the extracellular matrix of humans. A gelatin/ sodium alginate (SA) hydrogel with the inclusion of polyethylene oxide (PEO) was utilized to achieve enhanced mechanical strength. Hydrogels were prepared at different ratios of polymer solutions to select the hydrogel that exhibited an optimal gelation time. Sophora japonica, a plant leaf extract (SJLE) rich in flavonoids and isoflavonoids, was added to the hydrogel to enhance tissue repair. The developed hydrogels were extensively characterized for their morphology, porosity, and swelling …

Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman

Student Papers, Posters & Projects

The BCL2 family of proteins plays a pivotal role in regulating apoptosis and cellular homeostasis, making them critical therapeutic targets in cancer and other diseases characterized by pathological cell survival. BH3 mimetics, small molecules that selectively inhibit anti-apoptotic BCL2 family members, have achieved significant clinical success, particularly in hematologic malignancies. However, several challenges remain, including resistance mechanisms, toxicity (such as MCL1 inhibitor-associated cardiotoxicity), and the intricate balance between apoptotic and non-apoptotic functions. This review provides a comprehensive overview of BCL2 family biology, the development and clinical application and outcomes of BH3 mimetics, and the emerging resistance mechanism known as double-bolt …